Josephine H. Cox

CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: Use of multiple peptide sets increases the detectable breadth of the CTL response (2006)

Currier, Jeffrey R, Visawapoka, Unchalee, Tovanabutra, Sodsai, Mason, Carl J, Birx, Deborah L, McCutchan, Francine E, ...

Abstract Background Subtype A is a major strain in the HIV-1 pandemic in eastern Europe, central Asia and in certain regions of east Africa, notably in rural Kenya. While considerable effort has been...

CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway

Schubert, Ulrich, Antón, Luis C., Bačík, Igor, Cox, Josephine H., Bour, Stéphane, Bennink, Jack R., ...

The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a type I anchored integral membrane phosphoprotein with two independent functions. First, it regulates virus release from a...

Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -CW0304 Alleles

Currier, Jeffrey R., DeSouza, Mark, Chanbancherd, Penprapa, Bernstein, Wendy, Birx, Deborah L., Cox, Josephine H.

For this report, the rapid identification and characterization of human immunodeficiency virus type 1 (HIV-1)-derived broadly cross-subtype-reactive CD8 cytotoxic T lymphocyte (CTL) epitopes were...

CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway

Schubert, Ulrich, Antón, Luis C., Bačík, Igor, Cox, Josephine H., Bour, Stéphane, Bennink, Jack R., ...

The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a type I anchored integral membrane phosphoprotein with two independent functions. First, it regulates virus release from a...

Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -CW0304 Alleles

Currier, Jeffrey R., DeSouza, Mark, Chanbancherd, Penprapa, Bernstein, Wendy, Birx, Deborah L., Cox, Josephine H.

For this report, the rapid identification and characterization of human immunodeficiency virus type 1 (HIV-1)-derived broadly cross-subtype-reactive CD8 cytotoxic T lymphocyte (CTL) epitopes were...

Peptide Impurities in Commercial Synthetic Peptides and Their Implications for Vaccine Trial Assessment▿

Currier, Jeffrey R., Galley, Lynee M., Wenschuh, Holger, Morafo, Vivian, Ratto-Kim, Silvia, Gray, Clive M., ...

The advent of T-cell assay methodologies that are amenable to high throughput coupled with the availability of large libraries of overlapping peptides have revolutionized the fields of vaccine...

Magnitude, Breadth, and Functional Profile of T-Cell Responses during Human Immunodeficiency Virus Primary Infection with B and BF Viral Variants▿

Turk, Gabriela, Gherardi, María Magdalena, Laufer, Natalia, Saracco, Mónica, Luzzi, Renata, Cox, Josephine H., ...

The molecular pattern of the human immunodeficiency virus (HIV) epidemic in Argentina provides an appropriate scenario to study cellular immune responses in patients with non-clade B infection. We...

Concordant Proficiency in Measurement of T-Cell Immunity in Human Immunodeficiency Virus Vaccine Clinical Trials by Peripheral Blood Mononuclear Cell and Enzyme-Linked Immunospot Assays in Laboratories from Three Continents ▿

Boaz, Mark J., Hayes, Peter, Tarragona, Tony, Seamons, Laura, Cooper, Andrew, Birungi, Josephine, ...

The gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay is used routinely to evaluate the potency of human immunodeficiency virus (HIV) vaccine candidates and other vaccine candidates....