NPAS2 and PER2 are linked to risk factors of the metabolic syndrome (2009)
Englund, Ani, Kovanen, Leena, Saarikoski, Sirkku T, Haukka, Jari, Reunanen, Antti, Aromaa, Arpo, ...
Abstract Background Mammalian circadian clocks control multiple physiological events. The principal circadian clock generates seasonal variations in behavior as well. Seasonality elevates the risk...
Lähteenmäki, Sini, Aalto-Setälä, Terhi, Suokas, Jaana T, Saarni, Suoma E, Perälä, Jonna, Saarni, Samuli I, ...
Abstract Background We tested the validity of the SCOFF, a five-question screening instrument for eating disorders, in a general population sample. Methods A random sample of 1863 Finnish young...
Sharon Grimaldi, Ani Englund, Timo Partonen, Jari Haukka, Sami Pirkola, Antti Reunanen, ...
We tested which environmental, social, lifestyle, and health related factors of the individual contribute to the seasonal variations in mood and behavior and whether these influence the risks of the...
Executive Functioning in Twins with Bipolar I Disorder and Healthy Co-Twins (2009)
Juselius, Susanna, Kieseppä, Tuula, Kaprio, Jaakko, Lönnqvist, Jouko, Tuulio-Henriksson, Annamari
The aims of the study were to compare performance of twins with bipolar disorder (BPD) and healthy co-twins in neuropsychological tests assessing various aspects of executive functioning and to...
Sini Lahteenmaki, Jaana T Suokas, Suoma E Saarni, Jonna Perala, Samuli I Saarni, Hillevi Aro, ...
PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Validation of the Finnish version of the SCOFF...
Muhonen, Leea H, Lahti, Jari, Sinclair, David, Lönnqvist, Jouko, Alho, Hannu
Abstract Background Alcohol dependence comorbid with major depressive disorder poses a major challenge in the clinical setting. The results in the treatment with selective serotonin re-uptake...
Grimaldi, Sharon, Partonen, Timo, Saarni, Samuli I, Aromaa, Arpo, Lönnqvist, Jouko
Abstract Objective Seasonal changes in mood and behavior are common in a general population, being of relevance to public health. We wanted to analyze whether the HRQoL is associated with the...
Daylight saving time transitions and hospital treatments due to accidents or manic episodes (2008)
Lahti, Tuuli A, Haukka, Jari, Lönnqvist, Jouko, Partonen, Timo
Abstract Background Daylight saving time affects millions of people annually but its impacts are still widely unknown. Sleep deprivation and the change of circadian rhythm can trigger mental illness...
Lahti, Tuuli A, Leppämäki, Sami, Lönnqvist, Jouko, Partonen, Timo
Abstract Background The aim of this study was to analyze the effects of transition out of and into daylight saving time on the rest-activity cycles and sleep. Rest-activity cycles of nine healthy...
Saarni, Samuli I., Joutsenniemi, Kaisla, Koskinen, Seppo, Suvisaari, Jaana, Pirkola, Sami, Sintonen, Harri, ...
Aims: To examine the associations between alcohol consumption and utility-based health-related quality of life (HRQoL), subjective quality of life (QoL), self-rated health (SRH), and mental distress....
Circadian Phenotype in Patients with the Co-Morbid Alcohol Use and Bipolar Disorders (2008)
Hätönen, Taina, Forsblom, Sebastian, Kieseppä, Tuula, Lönnqvist, Jouko, Partonen, Timo
Aims: Alcohol misuse is associated with bipolar disorder. Abnormalities in the circadian clockwork play a role in the pathogenesis of bipolar disorder. Alcohol intake is likely to affect the...
Haukka, Jari, Suominen, Kirsi, Partonen, Timo, Lönnqvist, Jouko
Suicide is among the 10 leading causes of death. Attempted suicide is 10–40 times more frequent than completed suicide and is the strongest single predictor of subsequent suicide. The current study...
The use of seclusion and restraint during 15 years – a nationwide study in Finland (2007)
Keski-Valkama, Alice, Sailas, Eila, Eronen, Markku, Lönnqvist, Jouko, Kaltiala-Heino, Riittakerttu
No abstract available.
Palo, Outi M., Antila, Mervi, Silander, Kaisa, Hennah, William, Kilpinen, Helena, Soronen, Pia, ...
Bipolar disorder (BPD) and schizophrenia (SCZ) have at least a partially convergent aetiology and thus may share genetic susceptibility loci. Multiple lines of evidence emphasize the role of...
Hennah, William, Tomppo, Liisa, Hiekkalinna, Tero, Palo, Outi M., Kilpinen, Helena, Ekelund, Jesper, ...
We have previously reported a robust association between an allelic haplotype of ‘Disrupted in Schizophrenia 1’ (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia...
Psychosis among "healthy" siblings of schizophrenia patients (2006)
Arajärvi, Ritva, Ukkola, Jonna, Haukka, Jari, Suvisaari, Jaana, Hintikka, Jukka, Partonen, Timo, ...
Abstract Background Schizophrenia aggregates in families and accurate diagnoses are essential for genetic studies of schizophrenia. In this study, we investigated whether siblings of patients with...
Transition into daylight saving time influences the fragmentation of the rest-activity cycle (2006)
Lahti, Tuuli A, Leppämäki, Sami, Ojanen, Sanna-Maria, Haukka, Jari, Tuulio-Henriksson, Annamari, Lönnqvist, Jouko, ...
Abstract Background Daylight saving time is widely adopted. Little is known about its influence on the daily rest-activity cycles. We decided to explore the effects of transition into daylight saving...
Hennah, William, Tomppo, Liisa, Hiekkalinna, Tero, Palo, Outi M, Kilpinen, Helena, Ekelund, Jesper, ...
We have previously reported a robust association between an allelic haplotype of DISC1 and schizophrenia in a nationwide collection of Finnish schizophrenia families. This specific DISC1 allele was...
Family structure and risk factors for schizophrenia: case-sibling study (2004)
Haukka, Jari K, Suvisaari, Jaana, Lönnqvist, Jouko
Abstract Background Several family structure-related factors, such as birth order, family size, parental age, and age differences to siblings, have been suggested as risk factors for schizophrenia....
Poikolainen, Kari, Aalto-Setälä, Terhi, Tuulio-Henriksson, Annamari, Marttunen, Mauri, Lönnqvist, Jouko
Abstract Background Evidence on the relation between fear of war and mental health is insufficient. We carried out a prospective cohort study to find out whether fear of nuclear war is related to...
Food and nutrient intake in relation to mental wellbeing (2004)
Hakkarainen, Reeta, Partonen, Timo, Haukka, Jari, Virtamo, Jarmo, Albanes, Demetrius, Lönnqvist, Jouko
Abstract Background We studied food consumption and nutrient intake in subjects with depressed mood, anxiety and insomnia as indices of compromised mental wellbeing. Methods The study population...
Leppämäki, Sami, Haukka, Jari, Lönnqvist, Jouko, Partonen, Timo
Abstract Background Combining bright light exposure and physical exercise may be an effective way of relieving depressive symptoms. However, relatively little is known about individual factors...
Family-based clusters of cognitive test performance in familial schizophrenia (2004)
Hoti, Fabian, Tuulio-Henriksson, Annamari, Haukka, Jari, Partonen, Timo, Holmström, Lasse, Lönnqvist, Jouko
Abstract Background Cognitive traits derived from neuropsychological test data are considered to be potential endophenotypes of schizophrenia. Previously, these traits have been found to form a valid...
Suominen, Kirsi, Isometsä, Erkki, Ostamo, Aini, Lönnqvist, Jouko
Abstract Background The aim of this study was to comprehensively examine clinical risk factors, including suicide intent and hopelessness, for suicide and risk of death from all causes after...
Paunio, Tiina, Tuulio-Henriksson, Annamari, Hiekkalinna, Tero, Perola, Markus, Varilo, Teppo, Partonen, Timo, ...
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analysed genomewide data for 168 schizophrenia families using...
Paunio, Tiina, Tuulio-Henriksson, Annamari, Hiekkalinna, Tero, Perola, Markus, Varilo, Teppo, Partonen, Timo, ...
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analyzed genome-wide data for 168 schizophrenia families using...
Paunio, Tiina, Tuulio-Henriksson, Annamari, Hiekkalinna, Tero, Perola, Markus, Varilo, Teppo, Partonen, Timo, ...
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analysed genomewide data for 168 schizophrenia families using...
with light exposure and physical exercise [ISRCTN36478292] (2004)
Jari Haukka, Jouko Lönnqvist, Timo Partonen, Open Access, Timo Partonen
Drop-out and mood improvement: a randomised controlled trial
BMC Psychiatry BioMed Central (2004)
Jari K Haukka, Jaana Suvisaari, Jouko Lönnqvist
Research article Family structure and risk factors for schizophrenia: case-sibling study
Effect of simulated dawn on quality of sleep – a community-based trial (2003)
Leppämäki, Sami, Meesters, Ybe, Haukka, Jari, Lönnqvist, Jouko, Partonen, Timo
Abstract Background Morning light exposure administered as simulated dawn looks a promising method to treat Seasonal Affective Disorder, but it may moreover help with resetting the inaccurate...
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia (2003)
Lewis, Cathryn M, Levinson, Douglas F, Wise, Lesley H, DeLisi, Lynn E, Straub, Richard E, Hovatta, Iiris, ...
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Seasonal changes, sleep length and circadian preference among twins with bipolar disorder (2003)
Hakkarainen, Reeta, Johansson, Carolina, Kieseppä, Tuula, Partonen, Timo, Koskenvuo, Markku, Kaprio, Jaakko, ...
Abstract Background We aimed at studying the seasonal changes in mood and behaviour, the distribution of hospital admissions by season, and the persistence of the circadian type in twins with bipolar...
Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder (2003)
Ekholm, Jenny M., Kieseppä, Tuula, Hiekkalinna, Tero, Partonen, Timo, Paunio, Tiina, Perola, Markus, ...
We performed a genome-wide scan for susceptibility loci in bipolar disorder in a study sample colleted from the isolated Finnish population, consisting of 41 families with at least two affected...
Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...
Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...
Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...
BMC Psychiatry BioMed Central (2003)
Reeta Hakkarainen, Carolina Johansson, Timo Partonen, Markku Koskenvuo, Jaakko Kaprio, Jouko Lönnqvist, ...
Research article Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
Chromosome 1 loci in Finnish schizophrenia families (2001)
Ekelund, Jesper, Hovatta, Iiris, Parker, Alex, Paunio, Tiina, Varilo, Teppo, Martin, Rory, ...
We have earlier reported evidence for linkage to two regions on chromosome 1q32–q42 in schizophrenia families collected for two separate studies in Finland. Here we report the results of a fine...
Poikolainen, Kari, Tuulio-Henriksson, Annamari, Aalto-Setälä, Terhi, Marttunen, Mauri, Lönnqvist, Jouko
— Relative contributions of earlier drinking and smoking vs mental health risk factors in predicting alcohol intake and heavy drinking in young adulthood were assessed. Higher average alcohol...
Ekelund, Jesper, Lichtermann, Dirk, Hovatta, Iiris, Ellonen, Pekka, Suvisaari, Jaana, Terwilliger, Joseph D., ...
We report the results of a four-stage genome-wide scan in a schizophrenia study sample consisting of 134 affected sib-pairs collected in Finland. In stage I we genotyped 370 markers from the Weber 6...
Suicide Risk in Schizophrenia: An Analysis of 17 Consecutive Suicides (1999)
Saarinen, Pirjo Irmeli, Lehtonen, Johannes, Lönnqvist, Jouko
The aim of this study was to investigate interactional factors related to the recognition of suicide risk in patients with schizophrenia. The study focused on 17 schizophrenia patients who had...
Cost-Effectiveness/Utility Analysis of Two Drug Regimens in the Treatment of Depression (1994)
Sintonen, Harri, Lönnqvist, Jouko, Kiviruusu, Olli
This paper compares the cost-effectiveness/utility of drug regimens based on fluoxetine and moclobemide in the treatment of depression in Finland. The outcome data are based on a 6 week double-blind...
Cost-Effectiveness/Utility Analysis of Two Drug Regimens in the Treatment of Depression (1994)
Sintonen, Harri, Lönnqvist, Jouko, Kiviruusu, Olli
This paper compares the cost-effectiveness/utility of drug regimens based on fluoxetine and moclobemide in the treatment of depression in Finland. The outcome data are based on a 6 week double-blind...
Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
Hakkarainen, Reeta, Johansson, Carolina, Kieseppä, Tuula, Partonen, Timo, Koskenvuo, Markku, Kaprio, Jaakko, ...
Effect of simulated dawn on quality of sleep – a community-based trial
Leppämäki, Sami, Meesters, Ybe, Haukka, Jari, Lönnqvist, Jouko, Partonen, Timo
Family-based clusters of cognitive test performance in familial schizophrenia
Hoti, Fabian, Tuulio-Henriksson, Annamari, Haukka, Jari, Partonen, Timo, Holmström, Lasse, Lönnqvist, Jouko
Food and nutrient intake in relation to mental wellbeing
Hakkarainen, Reeta, Partonen, Timo, Haukka, Jari, Virtamo, Jarmo, Albanes, Demetrius, Lönnqvist, Jouko
Poikolainen, Kari, Aalto-Setälä, Terhi, Tuulio-Henriksson, Annamari, Marttunen, Mauri, Lönnqvist, Jouko
Hovatta, Iiris, Varilo, Teppo, Suvisaari, Jaana, Terwilliger, Joseph D., Ollikainen, Vesa, Arajärvi, Ritva, ...
Schizophrenia is a severe mental disorder affecting ∼1% of the world's population. Here, we report the results from a three-stage genomewide screen performed in a study sample from an internal...
Transition into daylight saving time influences the fragmentation of the rest-activity cycle
Lahti, Tuuli A, Leppämäki, Sami, Ojanen, Sanna-Maria, Haukka, Jari, Tuulio-Henriksson, Annamari, Lönnqvist, Jouko, ...
Psychosis among "healthy" siblings of schizophrenia patients
Arajärvi, Ritva, Ukkola, Jonna, Haukka, Jari, Suvisaari, Jaana, Hintikka, Jukka, Partonen, Timo, ...
Tiihonen, Jari, Walhbeck, Kristian, Lönnqvist, Jouko, Klaukka, Timo, Ioannidis, John P A, Volavka, Jan, ...
Objective To study the association between prescribed antipsychotic drugs and outcome in schizophrenia or schizoaffective disorder in the community.
Seasonal changes, sleep length and circadian preference among twins with bipolar disorder
Hakkarainen, Reeta, Johansson, Carolina, Kieseppä, Tuula, Partonen, Timo, Koskenvuo, Markku, Kaprio, Jaakko, ...
Effect of simulated dawn on quality of sleep – a community-based trial
Leppämäki, Sami, Meesters, Ybe, Haukka, Jari, Lönnqvist, Jouko, Partonen, Timo
RHD Maternal-Fetal Genotype Incompatibility Increases Schizophrenia Susceptibility
Palmer, Christina G. S., Turunen, Joni A., Sinsheimer, Janet S., Minassian, Sonia, Paunio, Tiina, Lönnqvist, Jouko, ...
Fetal events and obstetric complications are associated with schizophrenia. Here we report the results of a family-based candidate-gene study that assesses the role of maternal-fetal genotype...
Family-based clusters of cognitive test performance in familial schizophrenia
Hoti, Fabian, Tuulio-Henriksson, Annamari, Haukka, Jari, Partonen, Timo, Holmström, Lasse, Lönnqvist, Jouko
Food and nutrient intake in relation to mental wellbeing
Hakkarainen, Reeta, Partonen, Timo, Haukka, Jari, Virtamo, Jarmo, Albanes, Demetrius, Lönnqvist, Jouko
Poikolainen, Kari, Aalto-Setälä, Terhi, Tuulio-Henriksson, Annamari, Marttunen, Mauri, Lönnqvist, Jouko
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Lewis, Cathryn M., Levinson, Douglas F., Wise, Lesley H., DeLisi, Lynn E., Straub, Richard E., Hovatta, Iiris, ...
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Segurado, Ricardo, Detera-Wadleigh, Sevilla D., Levinson, Douglas F., Lewis, Cathryn M., Gill, Michael, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Hovatta, Iiris, Varilo, Teppo, Suvisaari, Jaana, Terwilliger, Joseph D., Ollikainen, Vesa, Arajärvi, Ritva, ...
Schizophrenia is a severe mental disorder affecting ∼1% of the world's population. Here, we report the results from a three-stage genomewide screen performed in a study sample from an internal...
Transition into daylight saving time influences the fragmentation of the rest-activity cycle
Lahti, Tuuli A, Leppämäki, Sami, Ojanen, Sanna-Maria, Haukka, Jari, Tuulio-Henriksson, Annamari, Lönnqvist, Jouko, ...
Psychosis among "healthy" siblings of schizophrenia patients
Arajärvi, Ritva, Ukkola, Jonna, Haukka, Jari, Suvisaari, Jaana, Hintikka, Jukka, Partonen, Timo, ...
Tiihonen, Jari, Walhbeck, Kristian, Lönnqvist, Jouko, Klaukka, Timo, Ioannidis, John P A, Volavka, Jan, ...
Objective To study the association between prescribed antipsychotic drugs and outcome in schizophrenia or schizoaffective disorder in the community.
Seasonal Changes in Mood and Behavior Are Linked to Metabolic Syndrome
Rintamäki, Reeta, Grimaldi, Sharon, Englund, Ani, Haukka, Jari, Partonen, Timo, Reunanen, Antti, ...
Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles
Lahti, Tuuli A, Leppämäki, Sami, Lönnqvist, Jouko, Partonen, Timo
Daylight saving time transitions and hospital treatments due to accidents or manic episodes
Lahti, Tuuli A, Haukka, Jari, Lönnqvist, Jouko, Partonen, Timo
Li, Weidong, Zhou, Yu, Jentsch, J. David, Brown, Robert A. M., Tian, Xiaoli, Ehninger, Dan, ...
Disrupted-in-schizophrenia 1 (DISC1) was initially discovered through a balanced translocation (1;11)(q42.1;q14.3) that results in loss of the C terminus of the DISC1 protein, a region that is...
Validation of the Finnish version of the SCOFF questionnaire among young adults aged 20 to 35 years
Lähteenmäki, Sini, Aalto-Setälä, Terhi, Suokas, Jaana T, Saarni, Suoma E, Perälä, Jonna, Saarni, Samuli I, ...
NPAS2 and PER2 are linked to risk factors of the metabolic syndrome
Englund, Ani, Kovanen, Leena, Saarikoski, Sirkku T, Haukka, Jari, Reunanen, Antti, Aromaa, Arpo, ...
Grimaldi, Sharon, Englund, Ani, Partonen, Timo, Haukka, Jari, Pirkola, Sami, Reunanen, Antti, ...
We tested which environmental, social, lifestyle, and health related factors of the individual contribute to the seasonal variations in mood and behavior and whether these influence the risks of the...