Jue Zeng

Active Learning of informative p53 cancer rescue mutants (2008)

Samuel A. Danziger, Jue Zeng, Ying Wang, Rainer K. Brachmann, Richard H. Lathrop

where to look next in a mutation sequence space:

Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins (2008)

Zeng, Jue, Yan, Jizhou, Wang, Ting, Mosbrook-Davis, Deborah, Dolan, Kyle T., Christensen, Ryan, ...

Knowledge of all binding sites for transcriptional activators and repressors is essential for computationally aided identification of transcriptional networks. The techniques developed for defining...

Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants (2007)

Danziger, Samuel A., Zeng, Jue, Wang, Ying, Brachmann, Rainer K., Lathrop, Richard H.

Motivation: Many biomedical projects would benefit from reducing the time and expense of in vitro experimentation by using computer models for in silico predictions. These models may help determine...

Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants. (2007)

Danziger, Samuel A, Zeng, Jue, Wang, Ying, Brachmann, Rainer K, Lathrop, Richard H

MOTIVATION: Many biomedical projects would benefit from reducing the time and expense of in vitro experimentation by using computer models for in silico predictions. These models may help determine...

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers (2007)

Dearth, Lawrence R., Qian, Hua, Wang, Ting, Baroni, Timothy E., Zeng, Jue, Chen, Stephanie W., ...

Over 1000 different mutants of the tumor suppressor protein p53 with one amino acid change in the core domain have been reported in human cancers. In mouse knock-in models, two frequent mutants...

Functional census of mutation sequence spaces: The example of p53 cancer rescue mutants (2006)

Samuel A. Danziger, S. Joshua Swamidass, Jue Zeng, Lawrence R. Dearth, Qiang Lu, Rainer K. Brachmann, ...

Abstract—Many biomedical problems relate to mutant functional properties across a sequence space of interest, e.g., flu, cancer, and HIV. Detailed knowledge of mutant properties and function...

Functional census of mutation sequence spaces: The example of p53 cancer rescue mutants (2006)

Samuel A. Danziger, S. Joshua Swamidass, Jue Zeng, Lawrence R. Dearth, Qiang Lu, Rainer K. Brachmann, ...

Abstract — Many biomedical problems relate to mutant functional properties across a sequence space of interest, e.g., flu, cancer, and HIV. Detailed knowledge of mutant properties and function...

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss-of-heterozygosity as an important aspect of p53 status in human cancers (2006)

Dearth, Lawrence R., Qian, Hua, Wang, Ting, Baroni, Timothy E., Zeng, Jue, Chen, Stephanie W., ...

Over one thousand different mutants of the tumor suppressor protein p53 with one amino acid change in the core domain have been reported in human cancers. In mouse knock-in models, two frequent...

A global suppressor motif for p53 cancer mutants

Baroni, Timothy E., Wang, Ting, Qian, Hua, Dearth, Lawrence R., Truong, Lan N., Zeng, Jue, ...

The transcription factor and tumor suppressor protein p53 is frequently inactivated in human cancers. In many cases, p53 gene mutations result in high levels of inactive, full-length p53 protein with...

A Genetic Suppressor of Two Dominant Temperature-Sensitive Lethal Proteasome Mutants of Drosophila melanogaster Is Itself a Mutated Proteasome Subunit Gene

Neuburger, Peter J., Saville, Kenneth J., Zeng, Jue, Smyth, Kerrie-Ann, Belote, John M.

Two dominant temperature-sensitive (DTS) lethal mutants of Drosophila melanogaster are Pros261 and Prosβ21, previously known as DTS5 and DTS7. Heterozygotes for either mutant die as pupae when...

A global suppressor motif for p53 cancer mutants

Baroni, Timothy E., Wang, Ting, Qian, Hua, Dearth, Lawrence R., Truong, Lan N., Zeng, Jue, ...

The transcription factor and tumor suppressor protein p53 is frequently inactivated in human cancers. In many cases, p53 gene mutations result in high levels of inactive, full-length p53 protein with...

A Genetic Suppressor of Two Dominant Temperature-Sensitive Lethal Proteasome Mutants of Drosophila melanogaster Is Itself a Mutated Proteasome Subunit Gene

Neuburger, Peter J., Saville, Kenneth J., Zeng, Jue, Smyth, Kerrie-Ann, Belote, John M.

Two dominant temperature-sensitive (DTS) lethal mutants of Drosophila melanogaster are Pros261 and Prosβ21, previously known as DTS5 and DTS7. Heterozygotes for either mutant die as pupae when...

Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins

Zeng, Jue, Yan, Jizhou, Wang, Ting, Mosbrook-Davis, Deborah, Dolan, Kyle T., Christensen, Ryan, ...

Knowledge of all binding sites for transcriptional activators and repressors is essential for computationally aided identification of transcriptional networks. The techniques developed for defining...

Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53

Wang, Ting, Zeng, Jue, Lowe, Craig B., Sellers, Robert G., Salama, Sofie R., Yang, Min, ...

The evolutionary forces that establish and hone target gene networks of transcription factors are largely unknown. Transposition of retroelements may play a role, but its global importance, beyond a...