Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients (2008)
Ruosaari, Salla, Hienonen-Kempas, Tuija, Puustinen, Anne, Sarhadi, Virinder K, Hollmén, Jaakko, Knuutila, Sakari, ...
Abstract Background Studies on asbestos-induced tumourigenesis have indicated the role of, e.g., reactive oxygen/nitrogen species, mitochondria, as well as NF-κB and MAPK signalling pathways. The...
Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients (2008)
Ruosaari, Salla, Hienonen-Kempas, Tuija, Puustinen, Anne, Sarhadi, Virinder K., Hollmen, Jaakko, Knuutila, Sakari, ...
Studies on asbestos-induced tumourigenesis have indicated the role of, e.g., reactive oxygen/nitrogen species, mitochondria, as well as NF-кB and MAPK signalling pathways. The exact molecular...
Unregulated smooth-muscle myosin in human intestinal neoplasia (2008)
Alhopuro, Pia, Phichith, Denis, Tuupanen, Sari, Sammalkorpi, Heli, Nybondas, Miranda, Saharinen, Juha, ...
A recent study described a recessive ATPase activating germ-line mutation in smooth-muscle myosin (smmhc/myh11) underlying the zebrafish meltdown (mlt) phenotype. The mlt zebrafish develops...
Von Schantz, Carina, Saharinen, Juha, Kopra, Outi, Cooper, Jonathan D, Gentile, Massimiliano, Hovatta, Iiris, ...
Abstract Background The neuronal ceroid lipofuscinoses (NCL) are a group of children's inherited neurodegenerative disorders, characterized by blindness, early dementia and pronounced cortical...
Kirsi H. Pietiläinen, Jussi Naukkarinen, Aila Rissanen, Juha Saharinen, Pekka Ellonen, Heli Keränen, ...
BackgroundThe acquired component of complex traits is difficult to dissect in humans. Obesity represents such a trait, in which the metabolic and molecular consequences emerge from complex...
Unregulated smooth-muscle myosin in human intestinal neoplasia. (2008)
Alhopuro, Pia, Phichith, Denis, Tuupanen, Sari, Sammalkorpi, Heli, Nybondas, Miranda, Saharinen, Juha, ...
A recent study described a recessive ATPase activating germ-line mutation in smooth-muscle myosin (smmhc/myh11) underlying the zebrafish meltdown (mlt) phenotype. The mlt zebrafish develops...
BMC Medical Genomics BioMed Central (2008)
Salla Ruosaari, Tuija Hienonen-kempas, Anne Puustinen, Virinder K Sarhadi, Jaakko Hollmén, Sakari Knuutila, ...
Research article Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients
CanGEM: mining gene copy number changes in cancer (2008)
Scheinin, Ilari, Myllykangas, Samuel, Borze, Ioana, Böhling, Tom, Knuutila, Sakari, Saharinen, Juha
The use of genome-wide and high-throughput screening methods on large sample sizes is a well-grounded approach when studying a process as complex and heterogeneous as tumorigenesis. Gene copy number...
CanGEM: mining gene copy number changes (2007)
Ilari Scheinin, Samuel Myllykangas, Ioana Borze, Tom Böhling, Sakari Knuutila, Juha Saharinen
in cancer
CanGEM: mining gene copy number changes (2007)
Ilari Scheinin, Samuel Myllykangas, Ioana Borze, Tom Böhling, Sakari Knuutila, Juha Saharinen
in cancer
Mononen, Nina, Seppälä, Eija H., Duggal, Priya, Autio, Ville, Ikonen, Tarja, Ellonen, Pekka, ...
Cancer Research Vol.66 Nr.2, 743 - 747
Nikali, Kaisu, Suomalainen, Anu, Saharinen, Juha, Kuokkanen, Mikko, Spelbrink, Johannes N., Lönnqvist, Tuula, ...
Infantile onset spinocerebellar ataxia (IOSCA) (MIM 271245) is a severe autosomal recessively inherited neurodegenerative disorder characterized by progressive atrophy of the cerebellum, brain stem...
Nikali, Kaisu, Suomalainen, Anu, Saharinen, Juha, Kuokkanen, Mikko, Spelbrink, Johannes N., Lönnqvist, Tuula, ...
Infantile onset spinocerebellar ataxia (IOSCA; MIM271245) is a severe autosomal recessively inherited neurodegenerative disorder characterized by progressive atrophy of the cerebellum, brain stem and...
Diss. -- Helsingin yliopisto.
Saharinen, Juha, Keski-Oja, Jorma
Transforming growth factor (TGF)-βs are secreted in large latent complexes consisting of TGF-β, its N-terminal latency-associated peptide (LAP) propeptide, and latent TGF-β binding protein (LTBP)....
Saharinen, Juha, Keski-Oja, Jorma
Transforming growth factor (TGF)-βs are secreted in large latent complexes consisting of TGF-β, its N-terminal latency-associated peptide (LAP) propeptide, and latent TGF-β binding protein (LTBP)....
CanGEM: mining gene copy number changes in cancer
Scheinin, Ilari, Myllykangas, Samuel, Borze, Ioana, Böhling, Tom, Knuutila, Sakari, Saharinen, Juha
The use of genome-wide and high-throughput screening methods on large sample sizes is a well-grounded approach when studying a process as complex and heterogeneous as tumorigenesis. Gene copy number...
Pietiläinen, Kirsi H, Naukkarinen, Jussi, Rissanen, Aila, Saharinen, Juha, Ellonen, Pekka, Keränen, Heli, ...
Leena Peltonen and colleagues uncover the metabolic changes that result from obesity through an analysis of genetically identical twin pairs in which one was obese and the other was not.
Von Schantz, Carina, Saharinen, Juha, Kopra, Outi, Cooper, Jonathan D, Gentile, Massimiliano, Hovatta, Iiris, ...
Unregulated smooth-muscle myosin in human intestinal neoplasia
Alhopuro, Pia, Phichith, Denis, Tuupanen, Sari, Sammalkorpi, Heli, Nybondas, Miranda, Saharinen, Juha, ...
A recent study described a recessive ATPase activating germ-line mutation in smooth-muscle myosin (smmhc/myh11) underlying the zebrafish meltdown (mlt) phenotype. The mlt zebrafish develops...
Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients
Ruosaari, Salla, Hienonen-Kempas, Tuija, Puustinen, Anne, Sarhadi, Virinder K, Hollmén, Jaakko, Knuutila, Sakari, ...
The Genome-wide Patterns of Variation Expose Significant Substructure in a Founder Population
Jakkula, Eveliina, Rehnström, Karola, Varilo, Teppo, Pietiläinen, Olli P.H., Paunio, Tiina, Pedersen, Nancy L., ...
Although high-density SNP genotyping platforms generate a momentum for detailed genome-wide association (GWA) studies, an offshoot is a new insight into population genetics. Here, we present an...