Constraint-based network model of pathogen–immune system interactions (2009)
Juilee Thakar, Assieh Saadatpour-moghaddam, Eric T. Harvill, Réka Albert
Pathogenic bacteria such as Bordetella bronchiseptica modulate host immune responses to enable their establishment and persistence; however, the immune response is generally successful in clearing...
Modelling phagosomal lipid networks that regulate actin assembly (2008)
Kühnel, Mark, Mayorga, Luis S, Dandekar, Thomas, Thakar, Juilee, Schwarz, Roland, Anes, Elsa, ...
Abstract Background When purified phagosomes are incubated in the presence of actin under appropriate conditions, microfilaments start growing from the membrane in a process that is affected by ATP...
Boolean network simulations for life scientists (2008)
Albert, István, Thakar, Juilee, Li, Song, Zhang, Ranran, Albert, Réka
Abstract Modern life sciences research increasingly relies on computational solutions, from large scale data analyses to theoretical modeling. Within the theoretical models Boolean networks occupy an...
Modeling Systems-Level Regulation of Host Immune Responses (2007)
Juilee Thakar, Mylisa Pilione, Girish Kirimanjeswara, Eric T. Harvill, Réka Albert
Many pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of...
Modeling Systems-Level Regulation of Host Immune Responses (2007)
Juilee Thakar, Mylisa Pilione, Girish Kirimanjeswara, Eric T Harvill, Reka Albert
Many pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of...
Computational models for the study of responses to infections (2006)
In diesem Jahrhundert haben neue experimentelle Techniken und Computer-Verfahren enorme Mengen an Information erzeugt, die bereits viele biologische Rätsel enthüllt haben. Doch die Komplexität...
Modeling Systems-Level Regulation of Host Immune Responses
Thakar, Juilee, Pilione, Mylisa, Kirimanjeswara, Girish, Harvill, Eric T, Albert, Réka
Many pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of...
Boolean network simulations for life scientists
Albert, István, Thakar, Juilee, Li, Song, Zhang, Ranran, Albert, Réka
Modern life sciences research increasingly relies on computational solutions, from large scale data analyses to theoretical modeling. Within the theoretical models Boolean networks occupy an...