Khoury, Muin J., Bertram, Lars, Boffetta, Paolo, Butterworth, Adam S., Chanock, Stephen J., Dolan, Siobhan M., ...
Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to...
Burton, Paul R, Hansell, Anna L, Fortier, Isabel, Manolio, Teri A, Khoury, Muin J, Little, Julian, ...
Background Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible—both in theory and in practice—to identify and replicate genetic...
Terry, Mary Beth, Howe, Geoffrey R., Pogoda, Janice M., Zhang, Fang Fang, Ahlbom, Anders, Choi, Won N., ...
Mary Beth Terry, Geoffrey Howe, Janice M. Pogoda, Fang Fang Zhang, Anders Ahlbom, Won Choi, Graham G. Giles, Julian Little, Flora Lubin, Francoise Menegoz, Philip Ryan, Brigitte Schlehofer and Susan...
Terry, Mary Beth, Howe, Geoffrey R., Pogoda, Janice M., Zhang, Fang Fang, Ahlbom, Anders, Choi, Won N., ...
Mary Beth Terry, Geoffrey Howe, Janice M. Pogoda, Fang Fang Zhang, Anders Ahlbom, Won Choi, Graham G. Giles, Julian Little, Flora Lubin, Francoise Menegoz, Philip Ryan, Brigitte Schlehofer and Susan...
Assessment of cumulative evidence on genetic associations: interim guidelines (2008)
Ioannidis, John PA, Boffetta, Paolo, Little, Julian, OBrien, Thomas R, Uitterlinden, Andre G, Vineis, Paolo, ...
Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing...
Folate intake, markers of folate status and oral clefts: is the evidence converging? (2008)
Johnson, Candice Y, Little, Julian
Background The ability of folic acid in the periconceptional period to prevent the occurrence of neural tube defects has stimulated tremendous interest in its effects on other health outcomes. Its...
Higgins, Julian P. T., Little, Julian, Ioannidis, John P. A., Bray, Molly S., Manolio, Teri A., Smeeth, Liam, ...
Khoury, Muin J, Little, Julian, Gwinn, Marta, Ioannidis, John PA
Emerging technologies are allowing researchers to study hundreds of thousands of genetic variants simultaneously as risk factors for common complex diseases. Both theoretical considerations and...
Khoury, Muin J, Little, Julian, Gwinn, Marta, Ioannidis, John PA
Emerging technologies are allowing researchers to study hundreds of thousands of genetic variants simultaneously as risk factors for common complex diseases. Both theoretical considerations and...
CYP17and breast cancer: no overall effect, but what about interactions? (2005)
Little, Julian, Simard, Jacques
Abstract Three large studies published in recent issues of Breast Cancer Research reported no overall evidence of an association between the CYP17 5'-untranslated region Msp A1 polymorphism and...
Reply to: Occupational risk factors for low grade and high grade glioma by B. Hocking (2005)
Schlehofer, B, Hettinger, Iris, Blettner, Maria, Preston-Martin, Susan, Arslan, Annie, Ahlbom, Anders, ...
Copyright © 2005 Wiley-Liss, Inc.
Reply to: Occupational risk factors for low grade and high grade glioma by B. Hocking (2005)
Schlehofer, B, Hettinger, Iris, Blettner, Maria, Preston-Martin, Susan, Arslan, Annie, Ahlbom, Anders, ...
Copyright © 2005 Wiley-Liss, Inc.
How many genes underlie the occurrence of common complex diseases in the population? (2005)
Yang, Quanhe, Khoury, Muin J, Friedman, JM, Little, Julian, Flanders, W Dana
Background Most common human diseases are due to complex interactions among multiple genetic variants and environmental risk factors. There is debate over whether variants of a relatively small...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
How many genes underlie the occurrence of common complex diseases in the population? (2005)
Yang, Quanhe, Khoury, Muin J., Friedman, J. M., Little, Julian, Dana Flanders, W.
Background Most common human diseases are due to complex interactions among multiple genetic variants and environmental risk factors. There is debate over whether variants of a relatively small...
How many genes underlie the occurrence of common complex diseases in the population? (2005)
Yang, Quanhe, Khoury, Muin J., Friedman, J. M., Little, Julian, Dana Flanders, W.
Background Most common human diseases are due to complex interactions among multiple genetic variants and environmental risk factors. There is debate over whether variants of a relatively small...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
The emergence of epidemiology in the genomics age (2004)
Khoury, Muin J., Millikan, Robert, Little, Julian, Gwinn, Marta
The emergence of epidemiology in the genomics age (2004)
Khoury, Muin J, Millikan, Robert, Little, Julian, Gwinn, Marta
The Human Genome Project Is Complete. How Do We Develop a Handle for the Pump? (2003)
Little, Julian, Khoury, Muin J., Bradley, Linda, Clyne, Mindy, Gwinn, Marta, Lin, Bruce, ...
Little, Julian, Bradley, Linda, Bray, Molly S., Clyne, Mindy, Dorman, Janice, Ellsworth, Darrell L., ...
The recent completion of the first draft of the human genome sequence and advances in technologies for genomic analysis are generating tremendous opportunities for epidemiologic studies to evaluate...
Observational studies have provided leads regarding a number of micronutrients which may account for the apparent protective effects of high intakes of vegetables and fruit against many types of...
An international case-control study of adult glioma and meningioma: the role of head trauma (1998)
Preston-Martin, Susan, Pogoda, Janice M, Schlehofer, Brigitte, Blettner, Maria, Howe, Geoffrey R, Ryan, Philip, ...
Background Increased brain tumour risk after head trauma suggested by case reports and clinical series has been previously studied epidemiologicaily with mixed results. An international multicentre...
CYP17 and breast cancer: no overall effect, but what about interactions?
Little, Julian, Simard, Jacques
Three large studies published in recent issues of Breast Cancer Research reported no overall evidence of an association between the CYP17 5'-untranslated region MspA1 polymorphism and breast cancer....
CYP17 and breast cancer: no overall effect, but what about interactions?
Little, Julian, Simard, Jacques
Three large studies published in recent issues of Breast Cancer Research reported no overall evidence of an association between the CYP17 5'-untranslated region MspA1 polymorphism and breast cancer....
Reporting of Systematic Reviews: The Challenge of Genetic Association Studies
Khoury, Muin J, Little, Julian, Higgins, Julian, Ioannidis, John P. A, Gwinn, Marta
Little, Julian, Higgins, Julian P.T, Ioannidis, John P.A, Moher, David, Gagnon, France, Von Elm, Erik, ...
Julian Little and colleagues present the STREGA recommendations, which are aimed at improving the reporting of genetic association studies.
Burton, Paul R, Hansell, Anna L, Fortier, Isabel, Manolio, Teri A, Khoury, Muin J, Little, Julian, ...
Background Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible—both in theory and in practice—to identify and replicate genetic...
Systematic Reviews of Genetic Association Studies
Sagoo, Gurdeep S, Little, Julian, Higgins, Julian P. T
Gurdeep S. Sagoo and colleagues describe key components of the methodology for undertaking systematic reviews and meta-analyses of genetic association studies.
Tobacco smoking and oral clefts: a meta-analysis.
Little, Julian, Cardy, Amanda, Munger, Ronald G.
OBJECTIVE: To examine the association between maternal smoking and non-syndromic orofacial clefts in infants. METHODS: A meta-analysis of the association between maternal smoking during pregnancy was...
Khoury, Muin J., Bertram, Lars, Boffetta, Paolo, Butterworth, Adam S., Chanock, Stephen J., Dolan, Siobhan M., ...
Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to...
Little, Julian, Higgins, Julian PT, Ioannidis, John PA, Moher, David, Gagnon, France, Von Elm, Erik, ...
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine...
Little, Julian, Higgins, Julian P. T., Ioannidis, John P. A., Moher, David, Gagnon, France, Von Elm, Erik, ...
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine...