Khoury, Muin J., Bertram, Lars, Boffetta, Paolo, Butterworth, Adam S., Chanock, Stephen J., Dolan, Siobhan M., ...
Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to...
Sagoo, Gurdeep S., Tatt, Iain, Salanti, Georgia, Butterworth, Adam S., Sarwar, Nadeem, Van Maarle, Merel, ...
Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid...
Higgins, Julian P. T., Little, Julian, Ioannidis, John P. A., Bray, Molly S., Manolio, Teri A., Smeeth, Liam, ...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
Meta-analysis in occupational epidemiology: a review of practice (2004)
McElvenny, Damien M., Armstrong, Ben G., Järup, Lars, Higgins, Julian P. T.
Objectives To describe past practice in meta-analyses found in occupational epidemiology, identifying the major issues that should be considered by researchers planning a meta-analysis in this...
Relative efficacy of differential methods of dietary advice: a systematic review (2003)
Thompson, Rachel L., Summerbell, Carolyn D., Hooper, Lee, Higgins, Julian P.T., Little, Paul S., Talbot, Diane, ...
Background: Dietary advice to lower blood cholesterol may be given by a variety of means. The relative efficacy of the different methods is unknown. Objective: The objective was to assess the effects...
Higgins, Julian P. T., Thompson, Simon G., Deeks, Jonathan J., Altman, Douglas G.
Paper from the BMJ by Higgins J. P. T. et al Cochrane Reviews have recently started including the quantity I 2 to help readers assess the consistency of the results of studies in meta-analyses. What...
Meta-analysis of ordinal outcomes using individual patient data. (2001)
Whitehead, Anne, Higgins, Julian P. T., Omar, Rumana Z., Savaluny, Elly
Meta-analyses are being undertaken in an increasing diversity of diseases and conditions, some of which involve outcomes measured on an ordered categorical scale. We consider methodology for...
Dietary fat intake and prevention of cardiovascular disease: systematic review (2001)
Hooper, Lee, Summerbell, Carolyn D., Higgins, Julian P.T., Thompson, Rachel L., Capps, Nigel E., Smith, George Davey, ...
Objective: To assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity. Design: Systematic review. Data sources:...
Exploiting information in random effects meta-analysis. (1997)
Thesis (Ph. D.)--University of Reading, 1997.
Dietary fat intake and prevention of cardiovascular disease: systematic review
Hooper, Lee, Summerbell, Carolyn D, Higgins, Julian P T, Thompson, Rachel L, Capps, Nigel E, Smith, George Davey, ...
Measuring inconsistency in meta-analyses
Higgins, Julian P T, Thompson, Simon G, Deeks, Jonathan J, Altman, Douglas G
Cochrane Reviews have recently started including the quantity I2 to help readers assess the consistency of the results of studies in meta-analyses. What does this new quantity mean, and why is...
Hooper, Lee, Thompson, Rachel L, Harrison, Roger A, Summerbell, Carolyn D, Ness, Andy R, Moore, Helen J, ...
Objective To review systematically the evidence for an effect of long chain and shorter chain omega 3 fatty acids on total mortality, cardiovascular events, and cancer.
Ye, Zheng, Song, Honglin, Higgins, Julian P. T, Pharoah, Paul, Danesh, John
Large meta-analysis finds little evidence for a link between gene variants encoding inactive or less active variants of detoxifying enzymes and lung cancer risk.
Dietary fat intake and prevention of cardiovascular disease: systematic review
Hooper, Lee, Summerbell, Carolyn D, Higgins, Julian P T, Thompson, Rachel L, Capps, Nigel E, Smith, George Davey, ...
Measuring inconsistency in meta-analyses
Higgins, Julian P T, Thompson, Simon G, Deeks, Jonathan J, Altman, Douglas G
Cochrane Reviews have recently started including the quantity I2 to help readers assess the consistency of the results of studies in meta-analyses. What does this new quantity mean, and why is...
Ye, Zheng, Song, Honglin, Higgins, Julian P. T, Pharoah, Paul, Danesh, John
Large meta-analysis finds little evidence for a link between gene variants encoding inactive or less active variants of detoxifying enzymes and lung cancer risk.
Hooper, Lee, Thompson, Rachel L, Harrison, Roger A, Summerbell, Carolyn D, Ness, Andy R, Moore, Helen J, ...
Objective To review systematically the evidence for an effect of long chain and shorter chain omega 3 fatty acids on total mortality, cardiovascular events, and cancer.
Danesh, John, Kaptoge, Stephen, Mann, Andrea G, Sarwar, Nadeem, Wood, Angela, Angleman, Sara B, ...
John Danesh and colleagues show that long-term IL-6 levels are associated with coronary heart disease risk, thus highlighting the potential relevance of IL-6−mediated pathways to coronary heart...
Little, Julian, Higgins, Julian P.T, Ioannidis, John P.A, Moher, David, Gagnon, France, Von Elm, Erik, ...
Julian Little and colleagues present the STREGA recommendations, which are aimed at improving the reporting of genetic association studies.
Systematic Reviews of Genetic Association Studies
Sagoo, Gurdeep S, Little, Julian, Higgins, Julian P. T
Gurdeep S. Sagoo and colleagues describe key components of the methodology for undertaking systematic reviews and meta-analyses of genetic association studies.
A re-evaluation of random-effects meta-analysis
Higgins, Julian P T, Thompson, Simon G, Spiegelhalter, David J
Meta-analysis in the presence of unexplained heterogeneity is frequently undertaken by using a random-effects model, in which the effects underlying different studies are assumed to be drawn from a...
Khoury, Muin J., Bertram, Lars, Boffetta, Paolo, Butterworth, Adam S., Chanock, Stephen J., Dolan, Siobhan M., ...
Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to...
Tendal, Britta, Higgins, Julian P T, Jüni, Peter, Hróbjartsson, Asbjørn, Trelle, Sven, Nüesch, Eveline, ...
Objective To study the inter-observer variation related to extraction of continuous and numerical rating scale data from trial reports for use in meta-analyses.
Little, Julian, Higgins, Julian P. T., Ioannidis, John P. A., Moher, David, Gagnon, France, Von Elm, Erik, ...
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine...