Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth (2008)
Ahmed, Atique U., Schmidt, Rebecca L., Park, Cheol Hong, Reed, Nanette R., Hesse, Shayla E., Thomas, Charles F., ...
Background Hyperactivated epidermal growth factor receptor (EGFR) and/or RAS signaling drives cellular transformation and tumorigenesis in human lung cancers, but agents that block activated EGFR and...
Dai, Zunyan, Zhu, Wei-Guo, Morrison, Carl D., Brena, Romulo M., Smiraglia, Dominic J., Raval, Aparna, ...
Amplification of oncogenes is an important mechanism that can cause gene overexpression and contributes to tumor development. The identification of amplified regions might have both prognostic and...
Includes abstract.
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...