Julie A. Mangada

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice (2008)

Mangada, Julie A., Pearson, Todd, Brehm, Michael A., Wicker, Linda S., Peterson, Laurence B., Shultz, Leonard D., ...

OBJECTIVE: NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based...

Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice (2007)

Yamazaki, Masahiro, Pearson, Todd, Brehm, Michael A., Miller, David M., Mangada, Julie A., Markees, Thomas G., ...

Regulatory T cells (Treg) are important in peripheral tolerance, but their role in establishing and maintaining hematopoietic mixed chimerism and generating central tolerance is unclear. We now show...

Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice (2006)

Brehm, Michael A., Mangada, Julie A., Markees, Thomas G., Pearson, Todd, Daniels, Keith A., Thornley, Thomas B., ...

Allograft transplantation requires chronic immunosuppression, but there is no effective strategy to evaluate the long-term maintenance of immunosuppression other than assessment of graft function....