Julie Guignot

When Shigella Tells the Cell to Hang On (2009)

Tran Van Nhieu, Guy, Guignot, Julie

OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues...

Afa/Dr Diffusely Adhering Escherichia coli C1845 Infection Promotes Selective Injuries in the Junctional Domain of Polarized Human Intestinal Caco-2/TC7 Cells

Peiffer, Isabelle, Blanc-Potard, Anne-Béatrice, Bernet-Camard, Marie-Françoise, Guignot, Julie, Barbat, Alain, Servin, Alain L.

The Afa/Dr diffusely adhering Escherichia coli (DAEC) C1845 strain harboring the F1845 fimbrial adhesin interacts with the brush border-associated CD55 molecule and promotes elongation of brush...

Recruitment of CD55 and CD66e Brush Border-Associated Glycosylphosphatidylinositol-Anchored Proteins by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli That Infect the Human Polarized Intestinal Caco-2/TC7 Cells

Guignot, Julie, Peiffer, Isabelle, Bernet-Camard, Marie-Françoise, Lublin, Douglas M., Carnoy, Christophe, Moseley, Steve L., ...

The Afa/Dr family of diffusely adhering Escherichia coli (Afa/Dr DAEC) includes bacteria expressing afimbrial adhesins (AFA), Dr hemagglutinin, and fimbrial F1845 adhesin. We show that infection of...

Pyelonephritogenic Diffusely Adhering Escherichia coli EC7372 Harboring Dr-II Adhesin Carries Classical Uropathogenic Virulence Genes and Promotes Cell Lysis and Apoptosis in Polarized Epithelial Caco-2/TC7 Cells

Guignot, Julie, Breard, Jacqueline, Bernet-Camard, Marie-Françoise, Peiffer, Isabelle, Nowicki, Bogdan J., Servin, Alain L., ...

Diffusely adhering Escherichia coli (DAEC) strains expressing adhesins of the Afa/Dr family bind to epithelial cells in a diffuse adherence pattern by recognizing a common receptor, the...

Polarized Entry of Uropathogenic Afa/Dr Diffusely Adhering Escherichia coli Strain IH11128 into Human Epithelial Cells: Evidence for α5β1 Integrin Recognition and Subsequent Internalization through a Pathway Involving Caveolae and Dynamic Unstable Microtubules

Guignot, Julie, Bernet-Camard, Marie-Françoise, Poüs, Christian, Plançon, Laure, Le Bouguenec, Chantal, Servin, Alain L.

Afa/Dr diffusely adhering Escherichia coli strain IH11128 bacteria basolaterally entered polarized epithelial cells by a CD55- and CD66e-independent mechanism through interaction with the α5β1...

Structural and Functional Lesions in Brush Border of Human Polarized Intestinal Caco-2/TC7 Cells Infected by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli

Peiffer, Isabelle, Guignot, Julie, Barbat, Alain, Carnoy, Christophe, Moseley, Steve L., Nowicki, Bogdan J., ...

Diffusely adhering Escherichia coli (DAEC) strains expressing F1845 fimbrial adhesin or Dr hemagglutinin belonging to the Afa/Dr family of adhesins infect cultured polarized human intestinal cells...

Representational Difference Analysis between Afa/Dr Diffusely Adhering Escherichia coli and Nonpathogenic E. coli K-12

Blanc-Potard, Anne-Beatrice, Tinsley, Colin, Scaletsky, Isabel, Le Bouguenec, Chantal, Guignot, Julie, Servin, Alain L., ...

Diffusely adhering Escherichia coli strains harboring Afa/Dr adhesins (Afa/Dr DAEC) have been associated with diarrhea and urinary tract infections (UTIs). The present work is the first extensive...

The Afa/Dr Adhesins of Diffusely Adhering Escherichia coli Stimulate Interleukin-8 Secretion, Activate Mitogen-Activated Protein Kinases, and Promote Polymorphonuclear Transepithelial Migration in T84 Polarized Epithelial Cells

Bétis, Fréderic, Brest, Patrick, Hofman, Véronique, Guignot, Julie, Bernet-Camard, Marie-Françoise, Rossi, Bernard, ...

Afa/Dr diffusely adhering Escherichia coli (Afa/Dr DAEC) strains cause symptomatic urinary tract and intestinal infections. The proinflammatory effects of Afa/Dr DAEC strains in vitro have been not...

Afa/Dr Diffusely Adhering Escherichia coli Infection in T84 Cell Monolayers Induces Increased Neutrophil Transepithelial Migration, Which in Turn Promotes Cytokine-Dependent Upregulation of Decay-Accelerating Factor (CD55), the Receptor for Afa/Dr Adhesins

Bétis, Fréderic, Brest, Patrick, Hofman, Véronique, Guignot, Julie, Kansau, Imad, Rossi, Bernard, ...

Ulcerative colitis and Crohn's disease are inflammatory bowel diseases thought to involve strains of Escherichia coli. We report here that two wild-type Afa/Dr diffusely adhering E. coli (DAEC)...

Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection

Batchelor, Miranda, Guignot, Julie, Patel, Amit, Cummings, Nicola, Cleary, Jennifer, Knutton, Stuart, ...

While remaining extracellular, enteropathogenic Escherichia coli (EPEC) establish direct links with the cytoskeleton of the target epithelial cell leading to the formation of actin-rich pedestals...

Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection

Batchelor, Miranda, Guignot, Julie, Patel, Amit, Cummings, Nicola, Cleary, Jennifer, Knutton, Stuart, ...

Afa/Dr Diffusely Adhering Escherichia coli C1845 Infection Promotes Selective Injuries in the Junctional Domain of Polarized Human Intestinal Caco-2/TC7 Cells

Peiffer, Isabelle, Blanc-Potard, Anne-Béatrice, Bernet-Camard, Marie-Françoise, Guignot, Julie, Barbat, Alain, Servin, Alain L.

The Afa/Dr diffusely adhering Escherichia coli (DAEC) C1845 strain harboring the F1845 fimbrial adhesin interacts with the brush border-associated CD55 molecule and promotes elongation of brush...

Recruitment of CD55 and CD66e Brush Border-Associated Glycosylphosphatidylinositol-Anchored Proteins by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli That Infect the Human Polarized Intestinal Caco-2/TC7 Cells

Guignot, Julie, Peiffer, Isabelle, Bernet-Camard, Marie-Françoise, Lublin, Douglas M., Carnoy, Christophe, Moseley, Steve L., ...

The Afa/Dr family of diffusely adhering Escherichia coli (Afa/Dr DAEC) includes bacteria expressing afimbrial adhesins (AFA), Dr hemagglutinin, and fimbrial F1845 adhesin. We show that infection of...

Pyelonephritogenic Diffusely Adhering Escherichia coli EC7372 Harboring Dr-II Adhesin Carries Classical Uropathogenic Virulence Genes and Promotes Cell Lysis and Apoptosis in Polarized Epithelial Caco-2/TC7 Cells

Guignot, Julie, Breard, Jacqueline, Bernet-Camard, Marie-Françoise, Peiffer, Isabelle, Nowicki, Bogdan J., Servin, Alain L., ...

Diffusely adhering Escherichia coli (DAEC) strains expressing adhesins of the Afa/Dr family bind to epithelial cells in a diffuse adherence pattern by recognizing a common receptor, the...

Polarized Entry of Uropathogenic Afa/Dr Diffusely Adhering Escherichia coli Strain IH11128 into Human Epithelial Cells: Evidence for α5β1 Integrin Recognition and Subsequent Internalization through a Pathway Involving Caveolae and Dynamic Unstable Microtubules

Guignot, Julie, Bernet-Camard, Marie-Françoise, Poüs, Christian, Plançon, Laure, Le Bouguenec, Chantal, Servin, Alain L.

Afa/Dr diffusely adhering Escherichia coli strain IH11128 bacteria basolaterally entered polarized epithelial cells by a CD55- and CD66e-independent mechanism through interaction with the α5β1...

Structural and Functional Lesions in Brush Border of Human Polarized Intestinal Caco-2/TC7 Cells Infected by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli

Peiffer, Isabelle, Guignot, Julie, Barbat, Alain, Carnoy, Christophe, Moseley, Steve L., Nowicki, Bogdan J., ...

Diffusely adhering Escherichia coli (DAEC) strains expressing F1845 fimbrial adhesin or Dr hemagglutinin belonging to the Afa/Dr family of adhesins infect cultured polarized human intestinal cells...

Representational Difference Analysis between Afa/Dr Diffusely Adhering Escherichia coli and Nonpathogenic E. coli K-12

Blanc-Potard, Anne-Beatrice, Tinsley, Colin, Scaletsky, Isabel, Le Bouguenec, Chantal, Guignot, Julie, Servin, Alain L., ...

Diffusely adhering Escherichia coli strains harboring Afa/Dr adhesins (Afa/Dr DAEC) have been associated with diarrhea and urinary tract infections (UTIs). The present work is the first extensive...

The Afa/Dr Adhesins of Diffusely Adhering Escherichia coli Stimulate Interleukin-8 Secretion, Activate Mitogen-Activated Protein Kinases, and Promote Polymorphonuclear Transepithelial Migration in T84 Polarized Epithelial Cells

Bétis, Fréderic, Brest, Patrick, Hofman, Véronique, Guignot, Julie, Bernet-Camard, Marie-Françoise, Rossi, Bernard, ...

Afa/Dr diffusely adhering Escherichia coli (Afa/Dr DAEC) strains cause symptomatic urinary tract and intestinal infections. The proinflammatory effects of Afa/Dr DAEC strains in vitro have been not...

Afa/Dr Diffusely Adhering Escherichia coli Infection in T84 Cell Monolayers Induces Increased Neutrophil Transepithelial Migration, Which in Turn Promotes Cytokine-Dependent Upregulation of Decay-Accelerating Factor (CD55), the Receptor for Afa/Dr Adhesins

Bétis, Fréderic, Brest, Patrick, Hofman, Véronique, Guignot, Julie, Kansau, Imad, Rossi, Bernard, ...

Ulcerative colitis and Crohn's disease are inflammatory bowel diseases thought to involve strains of Escherichia coli. We report here that two wild-type Afa/Dr diffusely adhering E. coli (DAEC)...

Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection

Batchelor, Miranda, Guignot, Julie, Patel, Amit, Cummings, Nicola, Cleary, Jennifer, Knutton, Stuart, ...

While remaining extracellular, enteropathogenic Escherichia coli (EPEC) establish direct links with the cytoskeleton of the target epithelial cell leading to the formation of actin-rich pedestals...

Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection

Batchelor, Miranda, Guignot, Julie, Patel, Amit, Cummings, Nicola, Cleary, Jennifer, Knutton, Stuart, ...

Human Decay-Accelerating Factor and CEACAM Receptor-Mediated Internalization and Intracellular Lifestyle of Afa/Dr Diffusely Adhering Escherichia coli in Epithelial Cells▿

Guignot, Julie, Hudault, Sylvie, Kansau, Imad, Chau, Ingrid, Servin, Alain L.

We used transfected epithelial CHO-B2 cells as a model to identify the mechanism mediating internalization of Afa/Dr diffusely adhering Escherichia coli. We provide evidence that neither the α5 or...