Julie Lotharius

Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels (2007)

Vergo, Sandra, Johansen, Jens Leander, Leist, Marcel, Lotharius, Julie

An abnormal accumulation of cytosolic dopamine resulting in reactive oxygen species and dopamine–quinone productsmay play an important role in the rather selective degeneration of substantia nigra...

Progressive Degeneration of Human Mesencephalic Neuron Derived Cells Triggered by Dopamine-Dependent Oxidative Stress Is Dependent on the Mixed-Lineage Kinase Pathway (2005)

Lotharius, Julie, Falsig, Jeppe, Beek, Johan Van, Payne, Sarah, Dringen, Ralf, Brundin, Patrik, ...

Models of Parkinson's disease (PD) based on selective neuronal death have been used to study pathogenic mechanisms underlying nigral cell death and in some instances to develop symptomatic therapies....

Specific Modulation of Astrocyte Inflammation by Inhibition of Mixed Lineage Kinases with CEP-1347 (2004)

Falsig, Jeppe, Pörzgen, Peter, Lotharius, Julie, Leist, Marcel

Inflammatory conversion of murine astrocytes correlates with the activation of various MAPK, and inhibition of terminal MAPKs like JNK or p38 dampens the inflammatory reaction. Mixed lineage kinases...

Fria radikaler och sjuka proteiner - bovarna bakom Parkinsons sjukdom?[Free radicals and ailing proteins - the culprits behind Parkinson’s disease?] (2003)

Smith, Ruben, Lotharius, Julie, Brundin, Patrik

Abstract is not available

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. (2002)

Lotharius, Julie, Barg, Sebastian, Wiekop, Pia, Lundberg, Cecilia, Raymon, Heather K., Brundin, Patrik

Mutations in alpha-synuclein have been linked to rare, autosomal dominant forms of Parkinsons disease. Despite its ubiquitous expression, mutant alpha-synuclein primarily leads to the loss of...

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. (2002)

Lotharius, Julie, Brundin, Patrik

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the inability to initiate, execute and control movement. Neuropathologically, there is a striking loss of...

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. (2002)

Lotharius, Julie, Brundin, Patrik

Abstract is not available

Impaired dopamine storage resulting from {alpha}-synuclein mutations may contribute to the pathogenesis of Parkinson's disease (2002)

Lotharius, Julie, Brundin, Patrik

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the inability to initiate, execute and control movement. Neuropathologically, there is a striking loss of...