AIB1 Promotes DNA Replication by JNK Repression and AKT Activation during Cellular Stress (2006)
Horiguchi, Kikumi, Arai, Shigeki, Nishihara, Tsutomu, Nishikawa, Jun-ichi
Amplified in breast cancer 1 (AIB1) is a member of the p160 family of nuclear receptor coactivator protein. Recent studies have reported that high-level AIB1 production is involved in the...
Osada, Shigehiro, Kurita, Mitsumasa, Nishikawa, Jun-ichi, Nishihara, Tsutomu
Transcriptional repression of the silent mating-type loci HMLα and HMRa in Saccharomyces cerevisiae is regulated by chromatin structure. Sas2p is a catalytic subunit of the SAS histone...
Core promoter elements of eukaryotic genes have a highly distinctive mechanical property (2004)
Fukue, Yoshiro, Sumida, Noriyuki, Nishikawa, Jun-ichi, Ohyama, Takashi
In spite of the abundant data on DNA sequence, the mechanical aspects of promoter DNA remain poorly understood. We classified 1871 human and 196 mouse RNA polymerase II promoters and investigated...
Left-handedly curved DNA regulates accessibility to cis-DNA elements in chromatin (2003)
Nishikawa, Jun-ichi, Amano, Miho, Fukue, Yoshiro, Tanaka, Shigeo, Kishi, Haruka, Hirota, Yoshiko, ...
There is little information on chromatin structure that allows access of trans‐acting transcription factors. Logically, the target DNA elements become accessible by either exposing themselves...
Basis of a High-Throughput Method for Nuclear Receptor Ligands (2003)
Kanayama, Tomohiko, Mamiya, Satoru, Nishihara, Tsutomu, Nishikawa, Jun-ichi
Assessment of the risk of human exposure to man-made chemicals that bind to hormone receptors has emerged as a major public health issue. Among hormone receptors, nuclear receptors tend to be targets...
The transcriptional co-activator P/CAF potentiates TGF-{beta}/Smad signaling (2000)
Itoh, Susumu, Ericsson, Johan, Nishikawa, Jun-ichi, Heldin, Carl-Henrik, Dijke, Peter Ten
Smads perform pivotal functions in the intracellular signaling of transforming growth factor-&bgr; (TGF-&bgr;). TGF-&bgr;-mediated activation of TGF-&bgr; type I receptor stimulates the...
Identification of a Novel Vitamin D Response Element from the Rat Genome (1997)
Sakoda, Kenji, Suzuki, Asuka, Arai, Shigeki, Imagawa, Masayoshi, Nishikawa, Jun-ichi, Nishihara, Tsutomu
Iα25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the active form of vitamin D3, has been thought to be a multifunctional agent. In order to discover novel roles of 1,26-(OH)2D3, we have been looking for new...
Vitamin D receptor contains multiple dimerization interfaces that are functionally different (1995)
Nishikawa, Jun-ichi, Kitaura, Motoji, Imagawa, Masayoshi, Nishihara, Tsutomu
The vitamin D receptor medIates the signal of 1α,25-dihydroxyvitamin D3 by binding to vitamIn D responsive elements in DNA as a homodlmer or as a heterodlmer composed of one vitamin D receptor...
Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer (1994)
Nishikawa, Jun-ichi, Kitaura, Motoji, Matsumoto, Mayumi, Imagawa, Masayoshi, Nishihara, Tsutomu
Nuclear receptors for the thyroid hormone and vitamin A and D cooperate with the retinoid X receptor (RXR) in activating the transcription. Although the hormone response elements for these receptors...
Nishikawa, Jun-ichi, Kokubo, Tetsuro, Horikoshi, Masami, Roeder, Robert G., Nakatani, Yoshihiro
The transcription initiation factor TFIID, consisting of the TATA box-binding protein (TBP) and many TBP-associated factors (TAFs), plays a central role in both basal and activated transcription. An...
The Yeast TAF145 Inhibitory Domain and TFIIA Competitively Bind to TATA-Binding Protein
Kokubo, Tetsuro, Swanson, Mark J., Nishikawa, Jun-ichi, Hinnebusch, Alan G., Nakatani, Yoshihiro
The Drosophila 230-kDa TFIID subunit (dTAF230) interacts with the DNA binding domain of TATA box-binding protein (TBP) which exists in the same complex. Here, we characterize the inhibitory domain in...
The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling
Itoh, Susumu, Ericsson, Johan, Nishikawa, Jun-ichi, Heldin, Carl-Henrik, Ten Dijke, Peter
Smads perform pivotal functions in the intracellular signaling of transforming growth factor-β (TGF-β). TGF-β-mediated activation of TGF-β type I receptor stimulates the phosphorylation of Smad2...
Left-handedly curved DNA regulates accessibility to cis-DNA elements in chromatin
Nishikawa, Jun-ichi, Amano, Miho, Fukue, Yoshiro, Tanaka, Shigeo, Kishi, Haruka, Hirota, Yoshiko, ...
There is little information on chromatin structure that allows access of trans-acting transcription factors. Logically, the target DNA elements become accessible by either exposing themselves towards...
Core promoter elements of eukaryotic genes have a highly distinctive mechanical property
Fukue, Yoshiro, Sumida, Noriyuki, Nishikawa, Jun-ichi, Ohyama, Takashi
In spite of the abundant data on DNA sequence, the mechanical aspects of promoter DNA remain poorly understood. We classified 1871 human and 196 mouse RNA polymerase II promoters and investigated...
Osada, Shigehiro, Kurita, Mitsumasa, Nishikawa, Jun-ichi, Nishihara, Tsutomu
Transcriptional repression of the silent mating-type loci HMLα and HMRa in Saccharomyces cerevisiae is regulated by chromatin structure. Sas2p is a catalytic subunit of the SAS histone...
Nishikawa, Jun-ichi, Kokubo, Tetsuro, Horikoshi, Masami, Roeder, Robert G., Nakatani, Yoshihiro
The transcription initiation factor TFIID, consisting of the TATA box-binding protein (TBP) and many TBP-associated factors (TAFs), plays a central role in both basal and activated transcription. An...
The Yeast TAF145 Inhibitory Domain and TFIIA Competitively Bind to TATA-Binding Protein
Kokubo, Tetsuro, Swanson, Mark J., Nishikawa, Jun-ichi, Hinnebusch, Alan G., Nakatani, Yoshihiro
The Drosophila 230-kDa TFIID subunit (dTAF230) interacts with the DNA binding domain of TATA box-binding protein (TBP) which exists in the same complex. Here, we characterize the inhibitory domain in...
The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling
Itoh, Susumu, Ericsson, Johan, Nishikawa, Jun-ichi, Heldin, Carl-Henrik, Ten Dijke, Peter
Smads perform pivotal functions in the intracellular signaling of transforming growth factor-β (TGF-β). TGF-β-mediated activation of TGF-β type I receptor stimulates the phosphorylation of Smad2...
Left-handedly curved DNA regulates accessibility to cis-DNA elements in chromatin
Nishikawa, Jun-ichi, Amano, Miho, Fukue, Yoshiro, Tanaka, Shigeo, Kishi, Haruka, Hirota, Yoshiko, ...
There is little information on chromatin structure that allows access of trans-acting transcription factors. Logically, the target DNA elements become accessible by either exposing themselves towards...
Core promoter elements of eukaryotic genes have a highly distinctive mechanical property
Fukue, Yoshiro, Sumida, Noriyuki, Nishikawa, Jun-ichi, Ohyama, Takashi
In spite of the abundant data on DNA sequence, the mechanical aspects of promoter DNA remain poorly understood. We classified 1871 human and 196 mouse RNA polymerase II promoters and investigated...
Osada, Shigehiro, Kurita, Mitsumasa, Nishikawa, Jun-ichi, Nishihara, Tsutomu
Transcriptional repression of the silent mating-type loci HMLα and HMRa in Saccharomyces cerevisiae is regulated by chromatin structure. Sas2p is a catalytic subunit of the SAS histone...
Ohta, Kumiko, Ohigashi, Megumi, Naganawa, Ayako, Ikeda, Hiromi, Sakai, Masaharu, Nishikawa, Jun-ichi, ...
HATs (histone acetyltransferases) contribute to the regulation of gene expression, and loss or dysregulation of these activities may link to tumorigenesis. Here, we demonstrate that expression levels...