Jun Chen

Microwave-assisted synthesis of Pt/CNT nanocomposite electrocatalysts for PEM fuel cells (2009)

Zhang, Weimin, Chen, Jun, Swiegers, Gerhard F., Ma, Zi-Feng, Wallace, Gordon G.

Microwave-assisted heating of functionalized, single-wall carbon nanotubes (FCNTs) in ethylene glycol solution containing H2PtCl6, led to the reductive deposition of Pt nanoparticles (2.5–4 nm)...

Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording (2009)

Zhao, Xiao-Yan, Liu, Ming-Gang, Yuan, Dong-Liang, Wang, Yan, He, Ying, Wang, Dan-Dan, ...

Abstract Background Pain is known to be processed by a complex neural network (neuromatrix) in the brain. It is hypothesized that under pathological state, persistent or chronic pain can affect...

A Random Variable Substitution Lemma With Applications to Multiple Description Coding (2009)

Wang, Jia, Chen, Jun, Zhao, Lei, Cuff, Paul, Permuter, Haim

We establish a random variable substitution lemma and use it to investigate the role of refinement layer in multiple description coding, which clarifies the relationship among several existing...

Single-walled carbon nanotube/trititanate nanotube composite fibers (2009)

Dechakiatkrai, Chonlada, Lynam, Carol, Gilmore, Kerry J., Chen, Jun, Phanichphant, Sukon, Bavykin, Dmitry V., ...

For the first time, single-walled carbon nanotubes were dispersed with titanate nanotubes using bio-polymers. Direct injection (wet spinning) of the stable suspension of H2Ti3O7 and SWNTs into...

Mode expansion and Bragg filtering enable a high-fidelity fiber-based photon-pair source (2009)

Ling, Alexander, Chen, Jun, Fan, Jingyun, Migdall, Alan

We report the development of a fiber-based single spatial mode source of photon-pairs where the efficiency of extracting photon-pairs is improved over a previous source [18] through the use of...

Ni1−xPtx (x=0–0.08) films as the photocathode of dye-sensitized solar cells with high efficiency (2009)

Peng, Shengjie, Shi, Jifu, Pei, Juan, Liang, Yanliang, Cheng, Fangyi, Liang, Jing, ...

Films of Ni1−xPtx (x=0, 0.02, 0.04, 0.06, and 0.08) have been prepared on fluorine-doped tin oxide-coated (FTO) glass substrates by a chemical plating method and used as the photocathode for...

Resolution and sensitivity of a Fabry-Perot interferometer with a photon-number-resolving detector (2009)

Wildfeuer, Christoph F., Pearlman, Aaron J., Chen, Jun, Fan, Jingyun, Migdall, Alan, Dowling, Jonathan P.

With photon-number resolving detectors, we show compression of interference fringes with increasing photon numbers for a Fabry-Perot interferometer. This feature provides a higher precision in...

Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study (2009)

Shen, Wei, Punyanitya, Mark, Silva, Analiza M, Chen, Jun, Gallagher, Dympna, Sardinha, Luís B, ...

Abstract Background Despite increasing research and clinical significance, limited information is available on how the visceral and subcutaneous adipose tissue (VAT and SAT) compartments develop...

30S RI Beam Production and X-ray Bursts (2009)

Kahl, David, Chen, Alan A., Binh, Dam Nguyen, Chen, Jun, Hashimoto, Takashi, Hayakawa, Seiya, ...

The present work reports the results of 30S radioactive beam development for a future experiment directly measuring data to extrapolate the 30S(alpha,p) stellar reaction rate in Type I X-ray bursts,...

High resolution color reflectance and hematite and goethite record of ODP Hole 184-1143A in the South China Sea (2009)

Zhang, Yi Ge, Ji, Jungfeng, Balsam, William L, Liu, Lianwen, Chen, Jun

Precipitation has a larger variability than temperature in tropical monsoon regions, thus it is an important climate variable. However, reconstructions of long-term rainfall histories are scarce...

Mixing in stratified gravity currents: Prandtl mixing length (2009)

Odier, Philippe, Chen, Jun, Rivera, Michael K., Ecke, Robert E.

Shear-induced vertical mixing in a stratified flow is a key ingredient of thermohaline circulation. We experimentally determine the vertical flux of momentum and density of a forced gravity current...

Pore dilation occurs in TRPA1 but not in TRPM8 channels (2009)

Chen, Jun, Kim, Donghee, Bianchi, Bruce R, Cavanaugh, Eric J, Faltynek, Connie R, Kym, Philip R, ...

Abstract Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been...

Detection of IFN Response of Non-Specific Effects on RNAi (2009)

Yonggang LIANG, Hongyu LIU, Baoxing LIU, Yun BAI, Heng WU, Qinghua ZHOU, ...

Background and objective The RNA interference (RNAi) approach is an efficient and widely used method for silencing specific genes and exploring their functions. However, numerous studies have...

Construction, Expression and Purification of Wild and Mutant Type of nm23-H1 in Prokaryotic Expression System (2009)

Xueqin YANG, Yu FAN, Jun CHEN, Hongyu LIU, Li MA, Daxing ZHU, ...

Background and objective Nm23-H1 is a metastasis-suppressor gene. However, its molecular mechanism of suppressing metastasis is unknown until now. The aim of this study is to construct prokaryotic...

Meta Analysis of Association between Polymorphisms in Promoter Region of MMPs gene and Risk of Lung Cancer (2009)

Zhe LEI, Rengyun LIU, Jun CHEN, Qinghua ZHOU, Hongtao ZHANG

Background and objective Lung cancer is one of the most common cancers worldwide, especially in China. It has been proved that matrix metalloproteases (MMPs) play a key role in malignant cell...

Traction de fibre unitaire et mesure des déformations en champ complet. Application à la fibre de lin = Full field strain measurement of flax fibre during tensile test (2009)

Poilâne, Christophe, Vivet, Alexandre, Momayez, Ladan, Ben Doudou, Bessem, Ayachi, M'Hamed, Chen, Jun

Un banc d'essai de micro-traction est utilisé pour tester la traction de fibres élémentaires de lin. Les champs de déplacements de la fibre sont calculés en temps réel par une technique de...

Propriétés mécaniques de préimprégnés lin/époxyde = Mechanical properties of flax/epoxy industrial prepregs (2009)

Poilâne, Christophe, Vivet, Alexandre, Momayez, Ladan, Ben Doudou, Bessem, Ayachi, M'Hamed, Chen, Jun

La société Lineo NV produit des pré-imprégnés lin/époxyde destinés à un renfort unidirectionnel. Les fils de lin utilisés proviennent de l'industrie textile traditionnelle. Les propriétés...

Traction de fibre unitaire et mesure des déformations en champ complet. Application à la fibre de lin = Full field strain measurement of flax fibre during tensile test (2009)

Poilâne, Christophe, Vivet, Alexandre, Momayez, Ladan, Ben Doudou, Bessem, Ayachi, M'Hamed, Chen, Jun

Un banc d'essai de micro-traction est utilisé pour tester la traction de fibres élémentaires de lin. Les champs de déplacements de la fibre sont calculés en temps réel par une technique de...

Propriétés mécaniques de préimprégnés lin/époxyde = Mechanical properties of flax/epoxy industrial prepregs (2009)

Poilâne, Christophe, Vivet, Alexandre, Momayez, Ladan, Ben Doudou, Bessem, Ayachi, M'Hamed, Chen, Jun

La société Lineo NV produit des pré-imprégnés lin/époxyde destinés à un renfort unidirectionnel. Les fils de lin utilisés proviennent de l'industrie textile traditionnelle. Les propriétés...

Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer (2009)

Zuoqing SONG, Xiaohong XU, Sen WEI, Jun CHEN, Yi LIU, Xin LI, ...

Background and objective It has been proven that heparanase and Ki-67 had relationship with occurrence and metastasis in lung cancer. The aim of this work was to investigate the expressions of...

p53 isoform {Delta}113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish (2009)

Chen, Jun, Ng, Sok Meng, Chang, Changqing, Zhang, Zhenhai, Bourdon, Jean-Christophe, Lane, David P., ...

p53 is a well-known tumor suppressor and is also involved in processes of organismal aging and developmental control. A recent exciting development in the p53 field is the discovery of various p53...

First Identification of the Hepatotoxic Microcystins in the Serum of a Chronically Exposed Human Population Together with Indication of Hepatocellular Damage (2009)

Chen, Jun, Xie, Ping, Li, Li, Xu, Jun

Hepatotoxic microcystins (MCs) are the most commonly reported cyanotoxins in eutrophic freshwaters. In 1996, human intoxications by MCs caused deaths of 76 patients at Caruaru dialysis centers in...

Screening of Highly-expressed-HMGB1-Gene Human Lung Cancer Cell Lines (2009)

Yi LIU, Peng ZHANG, Zhihao WU, Jun CHEN, Qinghua ZHOU

Background and objective Lung cancer is a type of malignant tumor which threats human health and life. Its morbidity might increase dramatically in a long period. Lung cancer is the leading cause of...

EVENT-DRIVEN INCREMENTAL UPDATING: AN UPDATING APPROACFH OF SPATIO-TEMPORAL DATABASE (2008)

Xiaoguang Zhou, Jun Chen, Jie Jiang, Jianjun Zhu, Zhilin Li

Incremental updating of a Spatio-Temporal Data Base (STDB) means that master spatial data set is updated when any change (geometric or thematic) occurs, the changes can be recorded, updated and...

Summary (2008)

Mihaela Serpe, David Umulis, Amy Ralston, Jun Chen, David J. Olson, Hans Othmer, ...

cell-tethered BMP binding protein Crossveinless 2 is a short-range co-receptor that promotes or inhibits BMP signaling in a concentration dependant manner

An Experimental Prototype for Scalable Server Selection (2008)

Jun Chen, Gregor V. Bochmann, Johnny W. Wong

An experimental prototype for server selection using an independent brokerage service is described. This prototype is composed of four main components: instrumented Apache Web servers, monitoring...

Tracing the provenance of fine-grained dust deposited on the central Chinese Loess Plateau (2008)

Sun, Youbin, Tada, Ryuji, Chen, Jun, Liu, Qingsong, Toyoda, Shin, Tani, Atsushi, ...

Eolian dust deposits in north China provide an excellent means of determining past variations in continental paleoclimate and atmospheric circulation. However, debate still exists on which deserts in...

A MIX GLOBAL DATA STRUCTURE BASED ON QTM AND VORONOI (2008)

Xuesheng Zhao, Jun Chen, Zhilin Li

To efficiently store, retrieve and update the global spatial data, a hierarchical and dynamic data model on a global scale is urgently needed. The QTM (Quaternary Triangular Mesh) as a hierarchical...

Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia (2008)

Cui, Xiu-Yu, Dai, Yi, Wang, Sheng-Lan, Yamanaka, Hiroki, Kobayashi, Kimiko, Obata, Koichi, ...

Abstract Background Honeybee's sting on human skin can induce ongoing pain, hyperalgesia and inflammation. Injection of bee venom (BV) into the intraplantar surface of the rat hindpaw induces an...

Deterministically Executing Concurrent Programs for Testing and Debugging (2008)

Steve Macdonald, Jun Chen

Non-determinism is a serious problem in the testing and debugging of concurrent programs. Thread interleavings may be different on each run, changing the order of events. Testing a concurrent program...

Modeling and Synthesis of Multiport Transmission Line for Multichannel Communication (2008)

Jun Chen, Student Member

Abstract—To overcome the limitations of traditional interconnects, multichannel interconnects that transmit signals via highfrequency carriers have recently been proposed and realized for intrachip...

Exploiting Roles and Responsibilities to Generate Code in a Distributed Design-Pattern-Based Programming System (2008)

Jun Chen, Steve Macdonald

The implementation of a design pattern can be viewed as a process of selecting classes to play the roles needed by the pattern. To ensure that a class can play a role, each role has a set of...

Privacy Inspection and Monitoring Framework for Automated Business Processes (2008)

Yin Hua Li, Hye-young Paik, Jun Chen

Abstract. More and more personal data is exposed to automatic and programmatic access, making it more difficult to safeguard the personal information from unauthorised access at every step. We...

Multiuser Successive Refinement and Multiple Description Coding (2008)

Chao Tian, Jun Chen, Suhas N. Diggavi

We consider the multiuser successive refinement (MSR) problem, where the users are connected to a central server via links with different noiseless capacities, and each user wishes to reconstruct in...

Research Directions for Spatial Decision Support (2008)

Jun Chen

Spatial decision support has recently received more and more attention in many disciplines and organizations. In order to examine its research directions, the nature of spatial decision support and...

Approaching the Slepian-Wolf Limit with LDPC Coset Codes (2008)

Jun Chen, Dake He, Ashish Jagmohan

We consider the Slepian-Wolf code design based on LDPC (low-density parity-check) coset codes. We derive the density evolution formula for the Slepian-Wolf coding, equipped with a concentration...

ABSTRACT Noise Driven In-Package Decoupling Capacitor Optimization for Power Integrity ∗ (2008)

Jun Chen

The existing decoupling capacitance optimization approaches meet constraints on input impedance for package. In this paper, we show that using impedance as constraints leads to large overdesign and...

Plasmalemmal Vesicle Associated Protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models (2008)

Shue, Eveline H, Carson-Walter, Eleanor B, Liu, Yang, Winans, Bethany N, Ali, Zarina S, Chen, Jun, ...

Abstract Background Plasmalemmal vesicle associated protein-1 ( PV-1 ) is selectively expressed in human brain microvascular endothelial cells derived from clinical specimens of primary and secondary...

New Bounds for the Capacity Region of the Finite-State Multiple Access Channel (2008)

Permuter, Haim H., Weissman, Tsachy, Chen, Jun

The capacity region of the Finite-State Multiple Access Channel (FS-MAC) with feedback that may be an arbitrary time-invariant function of the channel output samples is considered. We provided a...

Demonstration of a Quantum Controlled-NOT Gate in the Telecom Band (2008)

Chen, Jun, Altepeter, Joseph B., Medic, Milja, Lee, Kim Fook, Gokden, Burc, Hadfield, Robert H., ...

We present the first quantum controlled-NOT (CNOT) gate realized using a fiber-based indistinguishable photon-pair source in the 1.55 $\mu$m telecommunications band. Using this free-space CNOT gate,...

The Inhibiting Effect and Its Molecular Mechanism of Tanshinone on Human Lung Cancer Cell Line in vitro (2008)

Yulin JI, Jintao HE, Qinghua ZHOU, Jun CHEN, Qiang LI, Jiang ZHU, ...

Background and objective To explore the inhibiting effect and its molecular mechanism of Tanshione on human lung carcinoma cell line. Methods Human lung adenocarcinoma cell line (SPC-A-1) was treated...

Construction and expression of eukaryotic expression vectors of full-length, amino-terminus and carboxyl-terminus Raf gene (2008)

Zhuomin WANG, Jun CHEN, Haisu WAN, Hongyu LIU, Wen ZHU, Wen XIAO, ...

Background and objective Raf is a key molecule in the Ras-Raf-MEK-ERK signal transduction pathway and is highly activated in different human carcinomas. However, its biological functions and...

The study of the tumorigenicity and metastasis ability in human lung cancer cell line L9981 using in vivo imaging (2008)

Yuanrong REN, Jun CHEN, Hongyu LIU, Huiqin YAN, Yuli WANG, Chengfei LIU, ...

Background and objective The aim of this work is to study the tumorigenicity and metastasis ability in human large cell lung caner cell line L9981 by in vivo imaging. Methods We firstly transfected...

Genome-wide detection of loss of heterozygosity and copy number variation in a human lung large cell carcinoma cell line by affymetrix single-nucleotide polymorphism array 500K (2008)

Bin HU, Jun CHEN, Hongyu LIU, Heng WU, Zhihao WU, Yuli WANG, ...

Background and objective Loss of heterozygosity (LOH) and Copy number copy number variation (CNV) of DNA sequences is a common feature of cancer genomes, which is thought to be linked to...

The mechanism and influence on the biological behavior of human high-metastatic large cell lung cancer cell lines with transfection of nm23-H1 gene (2008)

Qiang NIE, Wen ZHU, Lunxu LIU, Junke FU, Dingbiao LI, Yin LI, ...

Background and objective It has been confirmed that nm23-H1 gene is one of the tumor metastasis suppressor genes. Up to now, the exact mechanism of nm23-H1 gene is uncertian. The aim of this study is...

Selenium compounds induce ROS in human high-metastatic large cell lung cancer cell line L9981 (2008)

Chengfei LIU, Jun CHEN, Zhihao WU, Ying LI, Yu ZHU, Yuanrong REN, ...

Background and objective It has been proved that methylseleninic acid (MSA) is a kind of artificially developed selenium compound, which appeared to be the best candidate for cancer prevention and...

The variation of intracellular distribution and translocation of the protein kinase Cα among human lung cancer cell line with different metastasis potential (2008)

Qiang NIE, Wen ZHU, Lunxu LIU, Junke FU, Dingbiao LI, Yin LI, ...

Background and objective Protein Kinase C (PKC) is one of the key kinases in the cell signal transduction passway. There are more reports about it's ability on cell proliferation, but fewer on...

The expression of BAG-1 and its clinical significance in human lung cancer (2008)

Hongyu LIU, Yun BAI, Baoxing LIU, Zhuomin WANG, Min WANG, Qinghua ZHOU, ...

Background and objective BAG-1 is a multifunctional anti-apoptotic protein that binds to a variety of cellular proteins and affects their functions. It has been proven that overexpression of BAG-1...

The expression and clinical significance of heparanase in non-small cell lung cancer (2008)

Zuoqing SONG, Xiaohong XU, Sen WEI, Jun CHEN, Naikang ZHOU

Background and objective It has been proven that heparanase played an important role in tumorigenesis. The aim of this work is to investigate the level of expression of heparanase protein in...

Balancing the Paradox of Localization and Globalization : Research and Analyze the Levels of Market Involvement for Multinational Carmakers in China's Market (2008)

Chen, Jun, Jiao, Zhiqiang

Multinational Corporations (MNCs) are facing the paradox of globalization and localization in entering each new market. Generally, there are two perspectives which regard to how a MNC configure its...

Scanning the human genome at kilobase resolution (2008)

Chen, Jun, Kim, Yeong C., Jung, Yong-Chul, Xuan, Zhenyu, Dworkin, Geoff, Zhang, Yanming, ...

Normal genome variation and pathogenic genome alteration frequently affect small regions in the genome. Identifying those genomic changes remains a technical challenge. We report here the development...

Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability (2008)

Wang, Wenyan, Prosise, Winifred W., Chen, Jun, Taremi, S. Shane, Le, Hung V., Madison, Vincent, ...

The nuclear xenobiotic receptor PXR is a ligand-inducible transcription factor regulating drug-metabolizing enzymes and transporters and a master switch mediating potentially adverse drug–drug...

Balancing the Paradox of Localization and Globalization : Research and Analyze the Levels of Market Involvement for Multinational Carmakers in China's Market (2008)

Chen, Jun, Jiao, Zhiqiang

Multinational Corporations (MNCs) are facing the paradox of globalization and localization in entering each new market. Generally, there are two perspectives which regard to how a MNC configure its...

Detection and Correction of Con icting Concurrent Data Warehouse Updates (2007)

Songting Chen, Songting Chen, Jun Chen, Xin Zhang, Xin Zhang, Elke A. Rundensteiner, ...

A Data Warehouse Management System (DWMS) maintains materialized views derived from one or more information sources (ISs) under source changes. Given the dynamic nature of modern distributed...

Worst Case RLC Noise with Timing Window Constraints (2007)

Jun Chen

We study the problem of determining the switching patterns and switching times of multiple aggressors to generate the worst-case crosstalk noise (WCN) for a quiet victim in RLC interconnect...

A decoupling method for analysis of coupled RLC interconnects (2007)

Jun Chen Lei, Jun Chen

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Subsonic Flows for the Full Euler Equations in Half Plane (2007)

Chen, Jun

We study the subsonic flows governed by full Euler equations in the half plane bounded below by a piecewise smooth curve asymptotically approaching x1-axis. Nonconstant conditions in the far field...

Multiuser Successive Refinement and Multiple Description Coding (2007)

Tian, Chao, Chen, Jun, Diggavi, Suhas

We consider the multiuser successive refinement (MSR) problem, where the users are connected to a central server via links with different noiseless capacities, and each user wishes to reconstruct in...

Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naïve and pain-experiencing rats (2007)

Guo, She-Wei, Liu, Ming-Gang, Long, Ya-Li, Ren, Li-Ying, Lu, Zhuo-Min, Yu, Hou-You, ...

Abstract Background Extracellular signal-regulated kinase (ERK), one member of the mitogen-activated protein kinase (MAPK) family, has been suggested to regulate a diverse array of cellular...

Particular distribution and expression pattern of endoglin (CD105) in the liver of patients with hepatocellular carcinoma (2007)

Yu, Decai, Zhuang, Linyuan, Sun, Xitai, Chen, Jun, Yao, Yongzhong, Meng, Kui, ...

Abstract Background Endoglin (CD105) has been considered a prognostic marker for hepatocellular carcinoma (HCC), and widely used as an appropriate targeting for antiangenesis therapy in some cancers....

Partially coherent matter wave and its evolution (2007)

Chen, Jun, Lin, Qiang

The evolution and propagation of a partially coherent matter wave (PCMW) is investigated theoretically by the correlation function method. The ABCD matrix formalism previously used for a fully...

Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions (2007)

Chen, Jun, Huang, Shi-Wen, Lin, Wen-Hai, Zhuo, Ren-Xi

The controllable and sustained release of DNA from the surfaces of biomaterials or biomedical devices represents a new method for localized gene delivery. We report the synthesis of a novel...

Quantum theory of degenerate $\chi^{(3)}$ two-photon state (2007)

Chen, Jun, Lee, Kim Fook, Kumar, Prem

We developed a quantum theory for degenerate $\chi^{(3)}$ two-photon state generated from optical fiber, and compared the theory predictions with an experimental result which exhibits a...

Multiuser Successive Refinement and Multiple Description Coding (2007)

Tian, Chao, Chen, Jun, Diggavi, Suhas

We consider the multiuser successive refinement (MSR) problem, where the users are connected to a central server via links with different noiseless capacities, and each user wishes to reconstruct in...

An Accurate Approach of Large-Scale IP Traffic Matrix Estimation (2007)

JIANG, Dingde, CHEN, Jun, HE, Linbo

This letter proposes a novel method of large-scale IP traffic matrix estimation which is based on Partial Flow Measurement and Fratar Model (PFMFM). Firstly, we model OD flows as Fratar model and...

Slepian-Wolf Code Design via Source-Channel Correspondence (2006)

Chen, Jun, He, Da-ke, Jagmohan, Ashish

We consider Slepian-Wolf code design based on LDPC (low-density parity-check) coset codes for memoryless source-side information pairs. A density evolution formula, equipped with a concentration...

Capacity Results for Block-Stationary Gaussian Fading Channels with a Peak Power Constraint (2006)

Chen, Jun, Veeravalli, Venugopal V.

We consider a peak-power-limited single-antenna block-stationary Gaussian fading channel where neither the transmitter nor the receiver knows the channel state information, but both know the channel...

Robust Distributed Source Coding (2006)

Chen, Jun, Berger, Toby

We consider a distributed source coding system in which several observations are communicated to the decoder using limited transmission rate. The observations must be separately coded. We introduce a...

Successive Wyner-Ziv Coding Scheme and its Application to the Quadratic Gaussian CEO Problem (2006)

Chen, Jun, Berger, Toby

We introduce a distributed source coding scheme called successive Wyner-Ziv coding. We show that any point in the rate region of the quadratic Gaussian CEO problem can be achieved via the successive...

Brownian motion of a charged test particle near a reflecting boundary at finite temperature (2006)

Yu, Hongwei, Chen, Jun, Wu, Puxun

We discuss the random motion of charged test particles driven by quantum electromagnetic fluctuations at finite temperature in both the unbounded flat space and flat spacetime with a reflecting...

An integrable optical-fiber source of polarization entangled photon-pairs in the telecom band (2006)

Li, Xiaoying, Liang, Chuang, Lee, Kim Fook, Chen, Jun, Voss, Paul L., Kumar, Prem

We demonstrate an optical-fiber based source of polarization entangled photon-pairs with improved quality and efficiency, which has been integrated with off-the-shelf telecom components and is,...

Transactional XML database benchmark / (2006)

Chen, Jun.

"A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science, Department of Computing Science".

A large quantity of novel human antisense transcripts detected by LongSAGE (2006)

Xijin Ge, Qingfa Wu, Yong-chul Jung, Jun Chen, San Ming Wang, Nikolaus Rajewsky

Motivation: Taking advantage of the high sensitivity and specificity of LongSAGE tag for transcript detection and genome mapping, we analyzed the 632,813 unique human LongSAGE tags deposited in...

Multiuser Successive Refinement and Multiple Description Coding,” EPFL (2006)

Chao Tian, Jun Chen, Suhas N. Diggavi

Abstract—We consider the multiuser successive refinement (MSR) problem, where the users are connected to a central server via links with different noiseless capacities, and each user wishes to...

A large quantity of novel human antisense transcripts detected by LongSAGE (2006)

Ge, Xijin, Wu, Qingfa, Jung, Yong-Chul, Chen, Jun, Wang, San Ming

Motivation: Taking advantage of the high sensitivity and specificity of LongSAGE tag for transcript detection and genome mapping, we analyzed the 632 813 unique human LongSAGE tags deposited in...

Growth and field-emission property of tungsten oxide nanotip arrays (2005)

Zhou, Jun, Gong, Li, Deng, Shao Zhi, Chen, Jun, She, Jun Cong, Xu, Ning Sheng, ...

©2005 American Institute of Physics. The electronic version of this article is the complete one and can be found online at: http://link.aip.org/link/?APPLAB/87/223108/1

Study of the rutting resistance of asphalt surfacing mixtures (2005)

Yang, Jun, Zhao, Haibin, Chen, Jun, Qian, Guochao, Pan, Weiyu, Yang, Yiwen

This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document...

Study of the rutting resistance of asphalt surfacing mixtures (2005)

Yang, Jun, Zhao, Haibin, Chen, Jun, Qian, Guochao, Pan, Weiyu, Yang, Yiwen

This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document...

Osteoblasts response to anodized commercially pure titanium in vitro (2005)

Chen, Jun

In this study, the effect of anodized titanium surfaces on osteoblast-like cells behavior was investigated. Grade 2 commercially pure titanium specimens with 20x10x1 mm in size was anodized in two...

Multiple Description Quantization via Gram-Schmidt Orthogonalization (2005)

Chen, Jun, Tian, Chao, Berger, Toby, Hemami, Sheila

The multiple description (MD) problem has received considerable attention as a model of information transmission over unreliable channels. A general framework for designing efficient multiple...

The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO) (2005)

Chen, Jun, Small-Howard, Andrea, Yin, Amy, Berry, Marla J

Abstract Background glutathione (GSH) is the most abundant thiol antioxidant in mammalian cells. It directly reacts with reactive oxygen species (ROS), functions as a cofactor of antioxidant enzymes,...

Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model (2005)

Lin, Huimin, Hu, Ming, Chen, Jun

The purposes of this study were to determine the effect of structural change on the intestinal disposition of isoflavones and to elucidate the mechanisms responsible for transport of phase II...

Transonic shocks and gas dynamics [electronic resource]. (2005)

Chen, Jun.

We establish the existence and uniqueness of transonic shocks in the steady flows through a two-dimensional nozzle with varying cross-sections. The flow is governed by the steady full Euler...

Osteoblasts response to anodized commercially pure titanium in vitro / (2005)

Chen, Jun.

Tübingen, Univ., Diss., 2005 (Nicht für den Austausch).

When is bit allocation for predictive video coding easy (2005)

Yegnaswamy Sermadevi, Jun Chen, Sheila S. Hemami, Toby Berger

This paper addresses the problem of bit allocation among frames in a predictively encoded video sequence. Finding optimal solutions to this problem potentially requires making an exponential number...

The capacity of finite-state Markov channels with feedback (2005)

Jun Chen, Student Member, Toby Berger

We consider a class of finite-state Markov channels with feedback. After introducing a troduce a simplified equivalent channel model, we construct the optimal stationary and nonstationary input...

Choosing among alternative futures (2005)

Steve Macdonald, Jun Chen, Diego Novillo

Abstract. Non-determinism is a serious impediment to testing and debugging concurrent programs. Such programs do not execute the same way each time they are run, which can hide the presence of...

An introduction to micro-array data analysis / (2005)

Chen, Jun.

Thesis (M.S.)--Kansas State University, 2005.

Loss of function of def selectively up-regulates {Delta}113p53 expression to arrest expansion growth of digestive organs in zebrafish (2005)

Chen, Jun, Ruan, Hua, Ng, Sok Meng, Gao, Chuan, Soo, Hui Meng, Wu, Wei, ...

Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. However, there is currently no direct genetic evidence...

Brownian motion of a charged test particle in vacuum between two conducting plates (2004)

Yu, Hongwei, Chen, Jun

The Brownian motion of a charged test particle caused by quantum electromagnetic vacuum fluctuations between two perfectly conducting plates is examined and the mean squared fluctuations in the...

Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes (2004)

Jiang, Hongying, Deng, Youping, Chen, Huann-Sheng, Tao, Lin, Sha, Qiuying, Chen, Jun, ...

Abstract Background Due to the high cost and low reproducibility of many microarray experiments, it is not surprising to find a limited number of patient samples in each study, and very few common...

RMA: A Pattern Based J2EE Development Tool (2004)

Chen, Jun

The development process for creating J2EE web applications is complex and tedious, and is thus error prone. The quality of a J2EE web application depends on correctness of code as well as the...

RMA: A Pattern Based J2EE Development Tool (2004)

Chen, Jun

The development process for creating J2EE web applications is complex and tedious, and is thus error prone. The quality of a J2EE web application depends on correctness of code as well as the...

RMA: A Pattern Based J2EE Development Tool (2004)

Chen, Jun

The development process for creating J2EE web applications is complex and tedious, and is thus error prone. The quality of a J2EE web application depends on correctness of code as well as the...

RMA: A Pattern Based J2EE Development Tool (2004)

Chen, Jun

The development process for creating J2EE web applications is complex and tedious, and is thus error prone. The quality of a J2EE web application depends on correctness of code as well as the...

RMA a pattern based J2EE development tool / (2004)

Chen, Jun.

Thesis (MMath)--University of Waterloo, 2004.

Electrochemical deposition of biomaterials / (2004)

Chen, Jun.

Thesis (M.S.)--University of Nebraska--Lincoln, 2004.

RMA: A Pattern Based J2EE Development Tool (2004)

Jun Chen

any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. ii The development process for creating J2EE web...

RMA [electronic resource] : a pattern based J2EE development tool / (2004)

Chen, Jun.

The development process for creating J2EE web applications is complex and tedious, and is thus error prone. The quality of a J2EE web application depends on correctness of code as well as the...

RMA: A Pattern Based J2EE Development Tool (2004)

Chen, Jun

The development process for creating J2EE web applications is complex and tedious, and is thus error prone. The quality of a J2EE web application depends on correctness of code as well as the...

BMC Bioinformatics BioMed Central Methodology article (2004)

Hongying Jiang, Youping Deng, Huann-sheng Chen, Lin Tao, Qiuying Sha, Jun Chen, ...

Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes

Electrochemical preparation of chitosan/hydroxyapatite composite coatings on titanium substrates (2003)

Redepenning, J., Venkataraman, Guhanand, Chen, Jun, Stafford, Nathan

Composite coatings containing brushite (CaHPO4 2H2O) and chitosan were prepared by electrochemical deposition. The brushite/chitosan composites were converted to hydroxyapatite/chitosan composites in...

BTAudio (Bluetooth Audio Program) and quite talk profile / (2003)

Chen, Jun.

Thesis (M.S.)--Michigan State University. Dept. of Computer Science and Engineering, 2003.

BTAudio (Bluetooth Audio Program) and quite talk profile [microform] / (2003)

Chen, Jun.

Thesis (M.S.)--Michigan State University. Dept. of Computer Science and Engineering, 2003.

Modeling and synthesis of coplanar waveguide for buffered clock tree / (2003)

Chen, Jun.

"A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science Electrical and Computer Engineering at the University of Wisconsin-Madison."

An algorithm for the generation of Voronoi diagrams on the sphere based on QTM, Photogrammetric Engineering and Remote Sensing 69 (2003)

Xuesheng Zhao, Jun Chen, Zhilin Li

Table of contents Table des matières Authors index Index des auteurs To efficiently store and analyse spatial data at a global scale, the digital expression of the Earth’s data must be global,...

Improving 9-Intersection Model by Replacing the Complement with Voronoi Region (2003)

Jun Chen, Chengming Li, Zhilin Li, C. M. Gold

intersection model is the most popular framework used for formalizing the spatial relations between two spatial objects A and B. It transforms the topological relationships between two simple spatial...

Voronoi-based 9-Intersection Model for Topological Spatial Relations (2003)

Jun Chen, Chengming Li, Zhilin Li, Chris Gold

Spatial relations is a key component of Geographical information science (GIS). Efforts have been made on formal definition of spatial relations and the 9-intersection model developed by Egenhofer...

Detection and Correction of Conflicting Source Updates for Materialized View Maintenance (2003)

Songting Chen, Songting Chen, Jun Chen, Xin Zhang, Xin Zhang, Elke A. Rundensteiner, ...

Materialized views, often derived from several data sources, must be maintained under source changes. In a distributed context, autonomous source updates can be concurrent and thus cause erroneous...

Determination of Worst-Case Crosstalk Noise for Non-Switching Victims in GHz+ Interconnects (2003)

Jun Chen, Lei He

Considering RLC interconnect model and multiple switching aggressors, we study switching pattern generation and switching time alignment that leads to worst-case crosstalk noise for a quiet victim or...

Selenium Compounds and Antioxidant Capacity in Bovine Milk. Studies on Glutathione Peroxidase, Bioavailability and Electrochemical Techniques (2002)

Chen, Jun

The efficacy and function of antioxidants have been intensively studied in foods and other biological systems in recent decades. This thesis concerns different aspects of the antioxidant properties...

Multicode CDMA for high-speed mobile communications (2002)

Chen, Jun

(Uncorrected OCR) ABSTRACT Multicode CDMA for high-speed mobile communications Submitted by CHEN Jun for the degree of Doctor of Philosophy at the University of Hong Kong in April 2002 To meet the...

Multicode CDMA for high-speed mobile communications (2002)

Chen, Jun

(Uncorrected OCR) ABSTRACT Multicode CDMA for high-speed mobile communications Submitted by CHEN Jun for the degree of Doctor of Philosophy at the University of Hong Kong in April 2002 To meet the...

Multicode CDMA for high-speed mobile communications (2002)

Chen, Jun

(Uncorrected OCR) ABSTRACT Multicode CDMA for high-speed mobile communications Submitted by CHEN Jun for the degree of Doctor of Philosophy at the University of Hong Kong in April 2002 To meet the...

A Transactional Model for Data Warehouse Maintenance (2002)

Jun Chen, Songting Chen, Elke A. Rundensteiner

Abstract. A Data Warehouse Management System (DWMS) incremen-tally maintains materialized views by issuing maintenance queries to the data sources. To address erroneous query results caused by...

Determination of worst-case crosstalk noise for non-switching victims (2002)

Jun Chen

Considering RLC interconnect model and multiple switching aggressors, we study switching pattern generation and switching time alignment that leads to worst-case crosstalk noise for a quiet victim or...

Detection and Correction of Conflicting Concurrent Data Warehouse Updates (2002)

Songting Chen, Songting Chen, Jun Chen, Xin Zhang, Xin Zhang, Elke A. Rundensteiner, ...

A Data Warehouse Management System (DWMS) maintains materialized views derived from one or more data sources under source changes. Given the dynamic nature of modern distributed environments, both...

Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure (2002)

Chen, Jun, Zhang, Liang Ren, Min, Ji Mei, Zhang, Li He

The octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 (I), consisting of isonucleoside units 6′-O-allyl-4′-deoxy-4′-(nucleobase)-2′,5′-anhydro-l-mannitol, was synthesized by the phosphotriester...

A new reflective twisted nematic liquid crystal display mode with large cell gap for direct view applications (2001)

Chen, Jun, Kwok, Hoi-Sing

We propose a new reflective twisted nematic display mode, which is called the second minimum RTN mode. This mode has a larger d∆n value compared with the first minimum RTN mode which we proposed...

P-83: A New Reflective Twisted Nematic Liquid Crystal Display Mode with (2001)

Large Cell Gap, Jun Chen, Hoi-sing Kwok

We propose a new reflective twisted nematic display mode, which is called the second minimum RTN mode. This mode has a larger d#n value compared with the first minimum RTN mode which we proposed...

Hybrid characteristics of oligonucleotides consisting of isonucleoside 2',5'-anhydro-3'-deoxy-3'-(thymin-1-yl)-D-mannitol with different linkage modes (2001)

Lei, Zhen, Zhang, Ling, Zhang, Liang Ren, Chen, Jun, Min, Ji Mei, Zhang, Li He

Oligonucleotides consisting of the isonucleoside repeating unit 2′,5′-anhydro-3′-deoxy-3′-(thymin-1-yl)-d-mannitol (4) were synthesized with the monomeric unit 4 incorporated into...

Design and fabrication of reflective liquid crystal displays /--by Jun Chen. (2000)

Chen, Jun.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2000.

A variational method for recovering Lamé moduli /--by Jun Chen. (2000)

Chen, Jun.

Thesis (M.S.)--Michigan Technological University, 2000.

TxnWrap: A Transactional Approach to Data Warehouse Maintenance (2000)

Jun Chen, Jun Chen, Songting Chen, Songting Chen, Elke A. Rundensteiner, Elke A. Rundensteiner

A Data Warehouse Management System (DWMS) maintains materialized views derived from one or more information sources (ISs) under source changes. Much recent research has developed maintenance...

TxnWrap: A Transactional Approach to Data Warehouse Maintenance (2000)

Jun Chen, Jun Chen, Elke A. Rundensteiner, Elke A. Rundensteiner

A Data Warehouse Management System (DWMS) maintains materialized views derived from one or more information sources under source changes. Much recent research has developed maintenance algorithms to...

Research Article A Voronoi-based 9-intersection model for spatial relations (2000)

Jun Chen, Chengming Li, Zhilin Li, Christopher Gold

Abstract. Models of spatial relations are a key component of geographical information science (GIS). EŒorts have been made to formally de � ne spatial relations. The foundationmodel for such a...

Simultaneous shielding insertion and net ordering for capacitive and inductive coupling minimization (2000)

Kevin M. Lepak, Min Xu, Jun Chen, Lei He

In this article, we first show that existing net ordering formulations to minimize noise are no longer sufficient with the presence of inductive noise, and shield insertion is needed to minimize...

Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression (1999)

Hong, Frank D., Chen, Jun, Donovan, Scott, Schneider, Nancy, Nisen, Perry D.

In this report, we describe a novel lytic mechanism exploited by antimicrotubule drugs (AMDs) such as Taxol which are frequently used to treat multiple human cancers including breast and ovarian...

A Study on Fractal Dimension of Fracture Surface Created by Stress Corrosion Cracking in High Strength Steels. (1998)

Long, Q. Y., Chen, Jun, Chen, Jizhi, Mu, Z. Q., Lung, C. W.

Fractal dimension of the fracture surface(FS) created by stress corrosion cracking in high strength steels has been studied. SCC tests were carried out on 30CrMnSiNi2 steel (0.26 C, 1.02 Cr, 1.2Mn,...

Formation of Intermetallic Compounds With a High Flux Pulse Molybdenum Ion Beam in Steel and Aluminium. (1998)

Zhang, Tonghe, Ji, Chengzhou, Yang, Jianhua, Chen, Jun, Shen, Jinghua

Intermetallic compounds of molybdenum and tungsten implanted into H13 steel and aluminum were measured by transmission electron microscopy (TEM) and X-ray diffraction. Ions extracted from a metal...

A Study of Pulsed High Flux Ti, Mo, V and Y Ion Implantation for Surface Modification of Resistances in Wear, Corrosion and Oxidation. (1998)

Zhang, Tonghe, Ji, Chengzhou, Xie, Jindong, Chen, Jun, Wei, Fuzhong

This paper concerned metals in some important way and contained information about, utilized, or discussed these subjects: basic topics: experimental materials and material types: fe-5cr-1.5mo-1v, h13...

Derivation of membership functions for fuzzy variables using genetic algorithms (1998)

Jun Chen, Jun Chen, Susan Bridges, Julia Hodges

Candidate for Degree of Master of Computer Science This report explores the applicability of genetic algorithms (GAs) to derive fuzzy variable membership functions in the domain of radiological waste...

Superporous hydrogels: Synthesis and applications (1997)

Chen, Jun

The purpose of this study was to synthesize a new type of material, superporous hydrogel, and to explore its potential applications. Superporous hydrogels have numerous supersize pores inside them,...

Chromatic parameter space representation of LCD operating modes (1997)

Chen, Jun, Yu, F. H., Cheng, S. D., Kwok, Hoi-Sing

A chromatic parameter space (CPS) representation is proposed to represent the operation of LCDs. Both chrominance and luminance are visualized in the CPS diagrams. All the usual display modes, both...

Planning, coordination and control of multi-fingered robot hands / (1997)

Chen, Jun.

Thesis (M. Eng.)--Nanyang Technological University, School of Electrical and Electronic Engineering, 1997.

Sticking To The Point: A Friction And Adhesion Model For Simulated Surfaces (1997)

Jun Chen Christopher, Jun Chen, Christopher Dimattia

This paper describes the development and current status of our combined physics-based model to simulate friction, compliance and adhesion on surfaces using a haptic interface. We use points on the...

A comparison of interconnection topologies in virtual shared memory multiprocessors /--by Jun Chen. (1995)

Chen, Jun.

Thesis (M.S.)--University of Kansas, Electrical Engineering and Computer Science, 1995.

CTI: automatic construction of complex 3D surfaces from contours using the Delaunay triangulation (1994)

Gregg Tracton, Jun Chen, Edward Chaney

An automatic contour tiler (CTI) has been designed and implemented for use with planar, simple, possibly concave, non-intersecting "wireloop" contours which are typical in medical...

Observation of Single Magnetic-Domain Particles by Electron Holographic Microscopy (1994)

Hirayama, Tsukasa, Chen, Jun, Ru, Qingxin, Ishizuka, Kazuo, Tanji, Takayoshi, Tonomura, Akira

Single magnetic-domain particles of barium ferrite and iron are directly observed by electron holographic microscopy. Holograms of barium ferrite particles about 1 μm in size are formed without...

A structural basis for drug-induced long QT syndrome

Mitcheson, John S., Chen, Jun, Lin, Monica, Culberson, Chris, Sanguinetti, Michael C.

Mutations in the HERG K+ channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to lethal arrhythmias [Curran, M. E.,...

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

Nakayama, Masaki, Uchimura, Koichi, Zhu, Raymond Li, Nagayama, Tetsuya, Rose, Marie E., Stetler, R. Anne, ...

The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is not...

Hybrid characteristics of oligonucleotides consisting of isonucleoside 2′,5′-anhydro-3′-deoxy-3′-(thymin-1-yl)-d-mannitol with different linkage modes

Lei, Zhen, Zhang, Ling, Zhang, Liang Ren, Chen, Jun, Min, Ji Mei, Zhang, Li He

Oligonucleotides consisting of the isonucleoside repeating unit 2′,5′-anhydro-3′-deoxy-3′-(thymin-1-yl)-d-mannitol (4) were synthesized with the monomeric unit 4 incorporated into...

The S4–S5 linker couples voltage sensing and activation of pacemaker channels

Chen, Jun, Mitcheson, John S., Tristani-Firouzi, Martin, Lin, Monica, Sanguinetti, Michael C.

Voltage-gated channels are normally opened by depolarization and closed by repolarization of the membrane. Despite sharing significant sequence homology with voltage-gated K+ channels, the gating of...

Role of Agrobacterium VirB11 ATPase in T-Pilus Assembly and Substrate Selection

Sagulenko, Evgeniy, Sagulenko, Vitaliya, Chen, Jun, Christie, Peter J.

The VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells...

Self-Assembly of the Agrobacterium tumefaciens VirB11 Traffic ATPase

Rashkova, Svetlana, Zhou, Xue-Rong, Chen, Jun, Christie, Peter J.

The Agrobacterium tumefaciens VirB11 ATPase is a component of a type IV transporter dedicated to T-DNA delivery to plant cells. In this study, we tested a prediction from genetic findings that VirB11...

Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure

Chen, Jun, Zhang, Liang Ren, Min, Ji Mei, Zhang, Li He

The octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 (I), consisting of isonucleoside units 6′-O-allyl-4′-deoxy-4′-(nucleobase)-2′,5′-anhydro-l-mannitol, was synthesized by the phosphotriester...

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

Chen, Jun, Seebohm, Guiscard, Sanguinetti, Michael C.

Unintended block of HERG K+ channels is a side effect of many common medications and is the most common cause of acquired long QT syndrome associated with increased risk of life-threatening...

Molecular Cloning and Functional Analysis of a Novel Type of Bowman-Birk Inhibitor Gene Family in Rice1

Qu, Li-Jia, Chen, Jun, Liu, Meihua, Pan, Naisui, Okamoto, Haruko, Lin, Zhongzhuan, ...

Bowman-Birk inhibitor (BBI) genes encode serine protease inhibitors that have repetitive cysteine-rich domains with reactive sites for the trypsin or chymotrypsin family. We have identified seven BBI...

T Cell Integrin Overexpression as a Model of Murine Autoimmunity

Yung, Raymond L., Ray, Donna, Mo, Ru Ran, Chen, Jun

Integrin adhesion molecules have important adhesion and signaling functions. They also play a central role in the pathogenesis of many autoimmune diseases. Over the past few years we have described a...

Viral Virulence Protein Suppresses RNA Silencing–Mediated Defense but Upregulates the Role of MicroRNA in Host Gene ExpressionW⃞

Chen, Jun, Li, Wan Xiang, Xie, Daoxin, Peng, Jin Rong, Ding, Shou Wei

Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are processed by the ribonuclease Dicer from distinct precursors, double-stranded RNA (dsRNA) and hairpin RNAs, respectively, although either...

Bid-Cardiolipin Interaction at Mitochondrial Contact Site Contributes to Mitochondrial Cristae Reorganization and Cytochrome c Release

Kim, Tae-Hyoung, Zhao, Yongge, Ding, Wen-Xing, Shin, Jin Na, He, Xi, Seo, Young-Woo, ...

Release of cytochrome c from the mitochondrial intermembrane space is critical to apoptosis induced by a variety of death stimuli. Bid is a BH3-only prodeath Bcl-2 family protein that can potently...

Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

Chen, Jun, Ruan, Hua, Ng, Sok Meng, Gao, Chuan, Soo, Hui Meng, Wu, Wei, ...

Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. However, there is currently no direct genetic evidence...

Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth†

Chen, Jun, Wu, Wei, Tahir, Stephen K, Kroeger, Paul E, Rosenberg, Saul H, Cowsert, Lex M, ...

Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates...

A structural basis for drug-induced long QT syndrome

Mitcheson, John S., Chen, Jun, Lin, Monica, Culberson, Chris, Sanguinetti, Michael C.

Mutations in the HERG K+ channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to lethal arrhythmias [Curran, M. E.,...

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

Nakayama, Masaki, Uchimura, Koichi, Zhu, Raymond Li, Nagayama, Tetsuya, Rose, Marie E., Stetler, R. Anne, ...

The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is not...

Hybrid characteristics of oligonucleotides consisting of isonucleoside 2′,5′-anhydro-3′-deoxy-3′-(thymin-1-yl)-d-mannitol with different linkage modes

Lei, Zhen, Zhang, Ling, Zhang, Liang Ren, Chen, Jun, Min, Ji Mei, Zhang, Li He

Oligonucleotides consisting of the isonucleoside repeating unit 2′,5′-anhydro-3′-deoxy-3′-(thymin-1-yl)-d-mannitol (4) were synthesized with the monomeric unit 4 incorporated into...

The S4–S5 linker couples voltage sensing and activation of pacemaker channels

Chen, Jun, Mitcheson, John S., Tristani-Firouzi, Martin, Lin, Monica, Sanguinetti, Michael C.

Voltage-gated channels are normally opened by depolarization and closed by repolarization of the membrane. Despite sharing significant sequence homology with voltage-gated K+ channels, the gating of...

Role of Agrobacterium VirB11 ATPase in T-Pilus Assembly and Substrate Selection

Sagulenko, Evgeniy, Sagulenko, Vitaliya, Chen, Jun, Christie, Peter J.

The VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells...

Self-Assembly of the Agrobacterium tumefaciens VirB11 Traffic ATPase

Rashkova, Svetlana, Zhou, Xue-Rong, Chen, Jun, Christie, Peter J.

The Agrobacterium tumefaciens VirB11 ATPase is a component of a type IV transporter dedicated to T-DNA delivery to plant cells. In this study, we tested a prediction from genetic findings that VirB11...

Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure

Chen, Jun, Zhang, Liang Ren, Min, Ji Mei, Zhang, Li He

The octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 (I), consisting of isonucleoside units 6′-O-allyl-4′-deoxy-4′-(nucleobase)-2′,5′-anhydro-l-mannitol, was synthesized by the phosphotriester...

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

Chen, Jun, Seebohm, Guiscard, Sanguinetti, Michael C.

Unintended block of HERG K+ channels is a side effect of many common medications and is the most common cause of acquired long QT syndrome associated with increased risk of life-threatening...

Molecular Cloning and Functional Analysis of a Novel Type of Bowman-Birk Inhibitor Gene Family in Rice1

Qu, Li-Jia, Chen, Jun, Liu, Meihua, Pan, Naisui, Okamoto, Haruko, Lin, Zhongzhuan, ...

Bowman-Birk inhibitor (BBI) genes encode serine protease inhibitors that have repetitive cysteine-rich domains with reactive sites for the trypsin or chymotrypsin family. We have identified seven BBI...

T Cell Integrin Overexpression as a Model of Murine Autoimmunity

Yung, Raymond L., Ray, Donna, Mo, Ru Ran, Chen, Jun

Integrin adhesion molecules have important adhesion and signaling functions. They also play a central role in the pathogenesis of many autoimmune diseases. Over the past few years we have described a...

Viral Virulence Protein Suppresses RNA Silencing–Mediated Defense but Upregulates the Role of MicroRNA in Host Gene ExpressionW⃞

Chen, Jun, Li, Wan Xiang, Xie, Daoxin, Peng, Jin Rong, Ding, Shou Wei

Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are processed by the ribonuclease Dicer from distinct precursors, double-stranded RNA (dsRNA) and hairpin RNAs, respectively, although either...

Bid-Cardiolipin Interaction at Mitochondrial Contact Site Contributes to Mitochondrial Cristae Reorganization and Cytochrome c Release

Kim, Tae-Hyoung, Zhao, Yongge, Ding, Wen-Xing, Shin, Jin Na, He, Xi, Seo, Young-Woo, ...

Release of cytochrome c from the mitochondrial intermembrane space is critical to apoptosis induced by a variety of death stimuli. Bid is a BH3-only prodeath Bcl-2 family protein that can potently...

Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

Chen, Jun, Ruan, Hua, Ng, Sok Meng, Gao, Chuan, Soo, Hui Meng, Wu, Wei, ...

Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. However, there is currently no direct genetic evidence...

Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth†

Chen, Jun, Wu, Wei, Tahir, Stephen K, Kroeger, Paul E, Rosenberg, Saul H, Cowsert, Lex M, ...

Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates...

T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6▿

Lu, Xiaoqing, Chen, Jun, Sasmono, R. Tedjo, Hsi, Eric D., Sarosiek, Kristopher A., Tiganis, Tony, ...

Diffuse large B-cell lymphomas (DLBCLs) consist of clinically distinct subtypes: germinal center B-cell (GCB)-like and activated-B-cell (ABC)-like tumors, characterized by long and short survival,...

Hepatitis B Virus X Protein Stimulates the Mitochondrial Translocation of Raf-1 via Oxidative Stress▿

Chen, Jun, Siddiqui, Aleem

The human hepatitis B virus (HBV) X protein (HBx) plays a crucial role(s) in the viral life cycle and contributes to the onset of hepatocellular carcinoma (HCC). HBx caused the mitochondrial...

The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas

Natkunam, Yasodha, Zhao, Shuchun, Mason, David Y., Chen, Jun, Taidi, Behnaz, Jones, Margaret, ...

We previously developed a multivariate model based on the RNA expression of 6 genes (LMO2, BCL6, FN1, CCND2, SCYA3, and BCL2) that predicts survival in diffuse large B-cell lymphoma (DLBCL) patients....

Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate

Mitcheson, John S., Chen, Jun, Sanguinetti, Michael C.

Deactivation of voltage-gated potassium (K+) channels can slow or prevent the recovery from block by charged organic compounds, a phenomenon attributed to trapping of the compound within the inner...

Chemotherapeutic Drugs Induce PPAR-γ Expression and Show Sequence-Specific Synergy with PPAR-γ Ligands in Inhibition of Non-Small Cell Lung Cancer1

Reddy, Raju C, Srirangam, Anjaiah, Reddy, Kaunteya, Chen, Jun, Gangireddy, Srinivasareddy, Kalemkerian, Gregory P, ...

Preclinical studies have shown that peroxisome proliferator-activated receptor γ (PPAR-γ) ligands can exert antitumor effects against non-small cell lung cancer (NSCLC) and a variety of other...

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

Adimoolam, Shanthi, Sirisawad, Mint, Chen, Jun, Thiemann, Patti, Ford, James M., Buggy, Joseph J.

Histone deacetylase (HDAC) inhibitors such as the phenyl hydroxamic acid PCI-24781 have emerged recently as a class of therapeutic agents for the treatment of cancer. Recent data showing synergy of...

Molecular phenotypes of notochordal cells purified from immature nucleus pulposus

Chen, Jun, Yan, Wei, Setton, Lori A.

The immature nucleus pulposus (NP) is populated by cells of notochordal-origin that are larger and contain an extensive cytoskeletal network and numerous vacuoles. The disappearance of these cells...

Scanning the human genome at kilobase resolution

Chen, Jun, Kim, Yeong C., Jung, Yong-Chul, Xuan, Zhenyu, Dworkin, Geoff, Zhang, Yanming, ...

Normal genome variation and pathogenic genome alteration frequently affect small regions in the genome. Identifying those genomic changes remains a technical challenge. We report here the development...

Deleterious Effects of Plasminogen Activators in Neonatal Cerebral Hypoxia-Ischemia

Adhami, Faisal, Yu, Dan, Yin, Wei, Schloemer, Aryn, Burns, Kevin A., Liao, Guanghong, ...

The immature brains of newborns often respond differently from the brains of adults when exposed to similar insults. Previous studies have indicated that although hypoxia-ischemia (HI) induces...

HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration

Lu, Xiaoqing, Chen, Jun, Malumbres, Raquel, Cubedo Gil, Elena, Helfman, David M., Lossos, Izidore S.

HGAL is a newly identified germinal center (GC)–specific gene whose expression by the tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin...

The Quiet Life of a Monopolist: The Efficiency Losses of Monopoly Reconsidered

Jun Chen, Zhiqi Chen

In this paper we study the efficiency losses of monopoly by analyzing a model where a firm's total costs of production decrease with the manager's effort to control costs. We consider two separate...

Pore dilation occurs in TRPA1 but not in TRPM8 channels

Chen, Jun, Kim, Donghee, Bianchi, Bruce R, Cavanaugh, Eric J, Faltynek, Connie R, Kym, Philip R, ...

Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been attributed to...

Monocyte Chemotactic Protein 1 Promotes Lung Cancer-Induced Bone Resorptive Lesions In Vivo1

Cai, Zhong, Chen, Qiuyan, Chen, Jun, Lu, Yi, Xiao, Guozhi, Wu, Zhihao, ...

Lung cancer is the leading cause of cancer-related deaths. The morbidity and mortality of lung cancer have markedly increased in the past decade with at least 75% of patients with lung cancer having...

Impact of p27mt gene on transplantation model of human colorectal cancer in nude mice

Chen, Jun, Ding, Wu-Hua, Lu, Guang-Xin, Xu, Shao-Yong

AIM: To investigate the inhibitory and anti-metastatic effect of mutant p27 gene (p27mt) on the growth of colorectal cancer xenografts in nude mice and its underlying mechanism.

Genomic Analysis Reveals Age-Dependent Innate Immune Responses to Severe Acute Respiratory Syndrome Coronavirus▿ †

Baas, Tracey, Roberts, Anjeanette, Teal, Thomas H., Vogel, Leatrice, Chen, Jun, Tumpey, Terrence M., ...

The relationship between immunosenescence and the host response to virus infection is poorly understood at the molecular level. Two different patterns of pulmonary host responses to virus were...

Transonic shocks and gas dynamics.

Chen, Jun.

Thesis (Ph.D., Mathematics)--Northwestern University, 2005.

Effect of p27mt gene on apoptosis of the colorectal cancer cell line Lovo

Chen, Jun, Ding, Wu-Hua, Xu, Shao-Yong, Wang, Jia-Ning, Huang, Yong-Zhang, Deng, Chang-Sheng

AIM: To construct p27mt recombinant adenovirus, transfect the colorectal cell line Lovo and observe the effects of p27mt on Lovo cell apoptosis and cell cycle inhibition.

Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes : Selenoorganic Antioxidant Ebselen Restores Stem Cell Competence

Chen, Jun, Li, Houwei, Addabbo, Francesco, Zhang, Fung, Pelger, Edward, Patschan, Daniel, ...

There are conflicting data regarding the effects of transplantation of bone marrow-derived cells (BMDCs) on the severity of diabetes. We therefore inquired whether the competence of BMDCs is...

p53 isoform Δ113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish

Chen, Jun, Ng, Sok Meng, Chang, Changqing, Zhang, Zhenhai, Bourdon, Jean-Christophe, Lane, David P., ...

p53 is a well-known tumor suppressor and is also involved in processes of organismal aging and developmental control. A recent exciting development in the p53 field is the discovery of various p53...

The transcriptome of human CD34+ hematopoietic stem-progenitor cells

Kim, Yeong C., Wu, Qingfa, Chen, Jun, Xuan, Zhenyu, Jung, Yong-Chul, Zhang, Michael Q., ...

Studying gene expression at different hematopoietic stages provides insights for understanding the genetic basis of hematopoiesis. We analyzed gene expression in human CD34+ hematopoietic cells that...

Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone*S⃞

Sharlow, Elizabeth R., Giridhar, Karthik V., LaValle, Courtney R., Chen, Jun, Leimgruber, Stephanie, Barrett, Rebecca, ...

Protein kinase D (PKD) is a novel family of serine/threonine kinases targeted by the second messenger diacylglycerol. It has been implicated in many important cellular processes and pathological...