Jo, Junghyo, Choi, Moo Young, Koh, Duk-Su
Glucose homeostasis is controlled by the islets of Langerhans which are equipped with alpha-cells increasing the blood glucose level, beta-cells decreasing it, and delta-cells the precise role of...
How Noise and Coupling Induce Bursting Action Potentials in Pancreatic β-Cells
Jo, Junghyo, Kang, Hyuk, Choi, Moo Young, Koh, Duk-Su
Unlike isolated β-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled β-cells are apt to exhibit robust bursting action potentials. We consider the...
How Noise and Coupling Induce Bursting Action Potentials in Pancreatic β-Cells
Jo, Junghyo, Kang, Hyuk, Choi, Moo Young, Koh, Duk-Su
Unlike isolated β-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled β-cells are apt to exhibit robust bursting action potentials. We consider the...
Size Distribution of Mouse Langerhans Islets
Jo, Junghyo, Choi, Moo Young, Koh, Duk-Su
Pancreatic β-cells are clustered in islets of Langerhans, which are typically a few hundred micrometers in a variety of mammals. In this study, we propose a theoretical model for the growth of...
Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth
Jo, Junghyo, Gavrilova, Oksana, Pack, Stephanie, Jou, William, Mullen, Shawn, Sumner, Anne E., ...
Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the...
Islet Formation during the Neonatal Development in Mice
Miller, Kevin, Kim, Abraham, Kilimnik, German, Jo, Junghyo, Moka, Uchenna, Periwal, Vipul, ...
The islet of Langerhans is a unique micro-organ within the exocrine pancreas, which is composed of insulin-secreting beta-cells, glucagon-secreting alpha-cells, somatostatin-secreting delta-cells,...