MERIT40 facilitates BRCA1 localization and DNA damage repair (2009)
Feng, Lin, Huang, Jun, Chen, Junjie
The product of breast cancer susceptibility gene 1, BRCA1, plays pivotal roles in the maintenance of genomic integrity. Mounting evidence indicates that BRCA1 associates with many proteins or protein...
The annealing helicase HARP protects stalled replication forks (2009)
Yuan, Jingsong, Ghosal, Gargi, Chen, Junjie
Mutations in HepA-related protein (HARP) are the only identified causes of Schimke immunoosseous dysplasia (SIOD). HARP has a unique annealing helicase activity in vitro, but the in vivo functional...
110 Myofiber developmental plasticity in fetal hearts delineated with diffusion tensor MRI (2008)
Zhang, Lei, Chen, Junjie, Gibson, Allyson, Holland, Mark R, Lanza, Gregory M, Wickline, Samuel A
No abstract available.
Waters, Emily A, Chen, Junjie, Allen, John S, Zhang, Huiying, Lanza, Gregory M, Wickline, Samuel A
Abstract Background Angiogenesis is a critical early feature of atherosclerotic plaque development and may also feature prominently in the pathogenesis of aortic valve stenosis. It has been shown...
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP (2006)
Yu, Xiaochun, Fu, Shuang, Lai, Maoyi, Baer, Richard, Chen, Junjie
BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains...
Thesis (D. Sc.)--Washington University, 2005. Dept. of Biomedical Engineering.
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway (1999)
Chen, Junjie, Silver, Daniel P., Cantor, Sharon B., Livingston, David M., Scully, Ralph
The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode products that each interact with the product of...
Cellular Proteins Interacting with the Tumor Suppressor Protein p53. (1998)
The DNA replication factor RPA physically associates with the tumor suppressor protein p53, an interaction that could be important for the function of both these proteins in normal and cancer cells....
Cellular Proteins Interacting with the Tumor Suppressor Protein p53. (1998)
Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand DNA. We defined the domain of p53 that bound to RPA and constructed...
Functional Analysis of Interactions Between 53BP1, BRCA1 and p53 (1998)
53BP1 has been reported to interact with the central DNA-binding domain of the tumor suppressor p53 and to enhance p53-dependent transcription. The C-terminus of 53BP1 contains a tandem BRCT motif....
Chen, Junjie, Silver, Daniel P., Walpita, Deepika, Cantor, Sharon B., Gazdar, Adi F., Tomlinson, Gail, ...
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2...
The synthesis and reactions of some Acridone, Pyrazoloacridine and Quinolizine derivatives (1998)
Includes bibliographical references. The research reported in this thesis is concerned with the development of a new and versatile synthesis of acridine and benzo[c]quinolizine derivatives, with...
Cellular Proteins Interacting with the Tumor Suppressor Protein p53. (1997)
Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand-DNA. We defined the domain of p53 that bound to RPA and constructed...
Chromatin structure and regulation of the HSP26 gene in yeast SACCHAROMYCES CEREVISIAE / (1994)
Thesis (Ph. D.)--University of Vermont, 1994.
Joukov, Vladimir, Chen, Junjie, Fox, Edward A., Green, Jeremy B. A., Livingston, David M.
The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in...
Saha, Partha, Chen, Junjie, Thome, Kelly C., Lawlis, Stephanie J., Hou, Zhi-hui, Hendricks, Marvin, ...
In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid...
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
Yamane, Kazuhiko, Wu, Xianglin, Chen, Junjie
BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair and/or DNA damage-signaling pathways. Human DNA topoisomerase II binding protein 1 (TopBP1) contains...
p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
Ward, Irene M., Minn, Kay, Van Deursen, Jan, Chen, Junjie
53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative...
The BRCA1 C-terminal (BRCT) domain has recently been implicated as a phospho-protein binding domain. We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a...
Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, ...
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Lai, Maoyi, Zimmerman, Erik S., Planelles, Vicente, Chen, Junjie
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR (ataxia-telangiectasia and...
Human TopBP1 Ensures Genome Integrity during Normal S Phase
Kim, Ja-Eun, McAvoy, Sarah A., Smith, David I., Chen, Junjie
Cell cycle checkpoints are essential for maintaining genomic integrity. Human topoisomerase II binding protein 1 (TopBP1) shares sequence similarity with budding yeast Dpb11, fission yeast Rad4/Cut5,...
Joukov, Vladimir, Chen, Junjie, Fox, Edward A., Green, Jeremy B. A., Livingston, David M.
The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in...
Saha, Partha, Chen, Junjie, Thome, Kelly C., Lawlis, Stephanie J., Hou, Zhi-hui, Hendricks, Marvin, ...
In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid...
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
Yamane, Kazuhiko, Wu, Xianglin, Chen, Junjie
BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair and/or DNA damage-signaling pathways. Human DNA topoisomerase II binding protein 1 (TopBP1) contains...
p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
Ward, Irene M., Minn, Kay, Van Deursen, Jan, Chen, Junjie
53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative...
The BRCA1 C-terminal (BRCT) domain has recently been implicated as a phospho-protein binding domain. We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a...
Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, ...
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Lai, Maoyi, Zimmerman, Erik S., Planelles, Vicente, Chen, Junjie
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR (ataxia-telangiectasia and...
Human TopBP1 Ensures Genome Integrity during Normal S Phase
Kim, Ja-Eun, McAvoy, Sarah A., Smith, David I., Chen, Junjie
Cell cycle checkpoints are essential for maintaining genomic integrity. Human topoisomerase II binding protein 1 (TopBP1) shares sequence similarity with budding yeast Dpb11, fission yeast Rad4/Cut5,...
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP
Yu, Xiaochun, Fu, Shuang, Lai, Maoyi, Baer, Richard, Chen, Junjie
BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains...
Sengupta, Sagar, Robles, Ana I., Linke, Steven P., Sinogeeva, Natasha I., Zhang, Ran, Pedeux, Remy, ...
Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormal...
53BP1 is required for class switch recombination
Ward, Irene M., Olaru, Alexandru, Minn, Kay, Tamada, Koji, Lau, Julie S., ...
53BP1 participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of mice and cells deficient in 53BP1 suggests a defect in DNA repair...
Based on ethnographic fieldwork, this paper explores the gender dimensions of population control and land tenure policies in a rural village in Northeast China. Gender bias was explicit in the...
Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways
Rappold, Irene, Iwabuchi, Kuniyoshi, Date, Takayasu, Chen, Junjie
The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast cancer susceptibility gene 1...
Steger, David J., Lefterova, Martina I., Ying, Lei, Stonestrom, Aaron J., Schupp, Michael, Zhuo, David, ...
The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia. However, the normal...
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
Minter-Dykhouse, Katherine, Ward, Irene, Huen, Michael S.Y., Chen, Junjie, Lou, Zhenkun
The importance of the DNA damage response (DDR) pathway in development, genomic stability, and tumor suppression is well recognized. Although 53BP1 and MDC1 have been recently identified as critical...
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
Wu, Liming, Luo, Kuntian, Lou, Zhenkun, Chen, Junjie
The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50. However, it remains to be...
Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly▿ †
Huen, Michael S. Y., Huang, Jun, Yuan, Jingsong, Yamamoto, Masahiro, Akira, Shizuo, Ashley, Carolyn, ...
The E2 ubiquitin-conjugating enzyme UBC13 plays pivotal roles in diverse biological processes. Recent studies have elucidated that UBC13, in concert with the E3 ubiquitin ligase RNF8, propagates the...
Huen, Michael S. Y., Sy, Shirley M.-H., Van Deursen, Jan M., Chen, Junjie
Chromatin endowed by histone modifications governs chromatin structure, which in turn represents a means to regulate cellular processes, including transcription and heterochromatin formation. Recent...
Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression▿ ‡
Lu, Lin-Yu, Wood, Jamie L., Minter-Dykhouse, Katherine, Ye, Lin, Saunders, Thomas L., Yu, Xiaochun, ...
Polo-like kinases (Plks) are serine/threonine kinases that are highly conserved in organisms from yeasts to humans. Previous reports have shown that Plk1 is critical for all stages of mitosis and may...
Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response▿ †
Wu, Jiaxue, Huen, Michael S. Y., Lu, Lin-Yu, Ye, Lin, Dou, Yali, Ljungman, Mats, ...
Histone ubiquitination participates in multiple cellular processes, including the DNA damage response. However, the molecular mechanisms involved are not clear. Here, we have identified that...
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice
Fu, Zheng, Regan, Kevin, Zhang, Lizhi, Muders, Michael H., Thibodeau, Stephen N., French, Amy, ...
Genetic instability, which leads to an accumulation of various genetic abnormalities, has been considered an essential component of the human neoplasic transformation process. However, the molecular...
MERIT40 facilitates BRCA1 localization and DNA damage repair
Feng, Lin, Huang, Jun, Chen, Junjie
The product of breast cancer susceptibility gene 1, BRCA1, plays pivotal roles in the maintenance of genomic integrity. Mounting evidence indicates that BRCA1 associates with many proteins or protein...
Wood, Jamie L., Liang, Yulong, Li, Kaiyi, Chen, Junjie
Microcephalin/MCPH1 is one of the causative genes responsible for the autosomal recessive disorder primary microcephaly. Patients with this disease present with mental retardation and dramatic...
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Sy, Shirley M. H., Huen, Michael S. Y., Chen, Junjie
Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer development. We previously reported an in vivo interaction between BRCA1...
Aurora A Is Essential for Early Embryonic Development and Tumor Suppression*S⃞
Lu, Lin-Yu, Wood, Jamie L., Ye, Lin, Minter-Dykhouse, Katherine, Saunders, Thomas L., Yu, Xiaochun, ...
Aurora A is a serine/threonine kinase that functions in various stages of mitosis. Accumulating evidence has demonstrated that gene amplification and overexpression of Aurora A are linked to...