Jyoti Misra Sen

ICAT expression disrupts {beta}-catenin-TCF interactions and impairs survival of thymocytes and activated mature T cells (2008)

Hossain, M. Zulfiquer, Yu, Qing, Xu, Mai, Sen, Jyoti Misra

T cell factor (TCF) family of transcription factors and β-catenin critically regulate T cell development as demonstrated by the deletion of the tcf gene, which results in a block early in...

{beta}-Catenin expression enhances generation of mature thymocytes (2003)

Mulroy, Thomas, Xu, Youyuan, Sen, Jyoti Misra

T cell factor (TCF)‐1 is a T‐cell‐specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF‐1 gene leads to an early block in...

β-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo▿ †

Xu, Mai, Yu, Qing, Subrahmanyam, Ramesh, Difilippantonio, Michael J., Ried, Thomas, Sen, Jyoti Misra

The expression of β-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of oncogenic β-catenin in thymocytes resulted in...