Bartizal, K, Scott, T, Abruzzo, G K, Gill, C J, Pacholok, C, Lynch, L, ...
Lipopeptide L-733560 is a hybrid analog of L-731373 and L-705589. All are water-soluble semisynthetic pneumocandin Bo derivatives. In vitro susceptibility testing of L-705589, L-731373, and L-733560...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...
Bartizal, K, Abruzzo, G, Trainor, C, Krupa, D, Nollstadt, K, Schmatz, D, ...
The in vivo anti-Candida activities of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991 (cilofungin), L-687,901 (tetrahydroechinocandin B), and L-687,781 (a papulacandin analog) were...
Collaborative comparison of broth macrodilution and microdilution antifungal susceptibility tests.
Espinel-Ingroff, A, Kish, C W, Kerkering, T M, Fromtling, R A, Bartizal, K, Galgiani, J N, ...
A collaborative comparison of macro- and microdilution antifungal susceptibility tests was performed in five laboratories. MICs of amphotericin B, fluconazole, flucytosine, and ketoconazole were...
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.
McFadden, D C, Powles, M A, Smith, J G, Flattery, A M, Bartizal, K, Schmatz, D M
A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been...
Anthrax lethal factor inhibition
Shoop, W. L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J. V., ...
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways,...
Bartizal, K, Scott, T, Abruzzo, G K, Gill, C J, Pacholok, C, Lynch, L, ...
Lipopeptide L-733560 is a hybrid analog of L-731373 and L-705589. All are water-soluble semisynthetic pneumocandin Bo derivatives. In vitro susceptibility testing of L-705589, L-731373, and L-733560...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...
Bartizal, K, Abruzzo, G, Trainor, C, Krupa, D, Nollstadt, K, Schmatz, D, ...
The in vivo anti-Candida activities of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991 (cilofungin), L-687,901 (tetrahydroechinocandin B), and L-687,781 (a papulacandin analog) were...
Collaborative comparison of broth macrodilution and microdilution antifungal susceptibility tests.
Espinel-Ingroff, A, Kish, C W, Kerkering, T M, Fromtling, R A, Bartizal, K, Galgiani, J N, ...
A collaborative comparison of macro- and microdilution antifungal susceptibility tests was performed in five laboratories. MICs of amphotericin B, fluconazole, flucytosine, and ketoconazole were...
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.
McFadden, D C, Powles, M A, Smith, J G, Flattery, A M, Bartizal, K, Schmatz, D M
A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been...
Anthrax lethal factor inhibition
Shoop, W. L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J. V., ...
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways,...