Pharmacological profile of a potent, efficacious fentanyl derivative in rhesus monkeys (1992)
Rice, K. C., Seggel, M. R., Woods, J. H., France, C. P., Winger, G.
The recent synthesis of fentanyl derivatives, some of which appear to have novel profiles of pharmacological effects, has provided compelling evidence that μ opioid efficacy might be altered...
Koek, W., Woods, J. H., Jacobson, A. E., Rice, K. C.
Pigeons were trained to discriminate either a fixed dose of PCP (1 mg/kg; n =3) or a progressively decreasing dose (1-0.56–0.32 mg/kg; n =4) from saline. Lowering of the training dose shifted the...
Cannabinoid receptor localization in brain.
Herkenham, M, Lynn, A B, Little, M D, Johnson, M R, Melvin, L S, De Costa, B R, ...
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor...
Wang, Y, Palmer, M, Freedman, R, Hoffer, B, Mattson, M V, Lessor, R A, ...
Metaphit (1-[1-(3-isothiocyanatophenyl)-cyclohexyl]piperidine), a derivative of the psychotomimetic drug phencyclidine (PCP), is postulated to bind irreversibly to PCP receptors. We examined here the...
Presence and formation of codeine and morphine in the rat.
Donnerer, J, Oka, K, Brossi, A, Rice, K C, Spector, S
Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that...
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
Simonds, W F, Burke, T R, Rice, K C, Jacobson, A E, Klee, W A
Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand...
Jamieson, G A, Agrawal, A K, Greco, N J, Tenner, T E, Jones, G D, Rice, K C, ...
The ion channel probe phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] selectively inhibited aggregation, secretion and ultrastructural changes in platelets induced by adrenaline, but did not...
Winter, J. C., Eckler, J. R., Rice, K. C., Rabin, R. A.
Previous investigations in our laboratory have found that the stimulus effects of the hallucinogenic serotonergic agonists DOM and LSD are potentiated by phencyclidine [PCP], a non-competitive NMDA...
Jutkiewicz, E. M., Wood, S. K., Woods, J. H., Houshyar, H., Hsin, L.-W., Rice, K. C.
The Stimulus Properties of LSD in C57BL/6 Mice1
Winter, J. C., Kiers, A. K., Zimmerman, M. D., Reissig, C. J, Eckler, J.R., Ullrich, T., ...
Cannabinoid receptor localization in brain.
Herkenham, M, Lynn, A B, Little, M D, Johnson, M R, Melvin, L S, De Costa, B R, ...
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor...
Wang, Y, Palmer, M, Freedman, R, Hoffer, B, Mattson, M V, Lessor, R A, ...
Metaphit (1-[1-(3-isothiocyanatophenyl)-cyclohexyl]piperidine), a derivative of the psychotomimetic drug phencyclidine (PCP), is postulated to bind irreversibly to PCP receptors. We examined here the...
Presence and formation of codeine and morphine in the rat.
Donnerer, J, Oka, K, Brossi, A, Rice, K C, Spector, S
Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that...
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
Simonds, W F, Burke, T R, Rice, K C, Jacobson, A E, Klee, W A
Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand...
Jamieson, G A, Agrawal, A K, Greco, N J, Tenner, T E, Jones, G D, Rice, K C, ...
The ion channel probe phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] selectively inhibited aggregation, secretion and ultrastructural changes in platelets induced by adrenaline, but did not...
Ko, M C H, Naughton, N N, Traynor, J R, Song, M S, Woods, J H, Rice, K C, ...
Orphanin FQ (OFQ), an endogenous peptide for ORL1 receptors, has been identified. Although the actions of OFQ have much in common with those of opioid peptides at the cellular level, behavioral...