Derakhshan, M.H., Liptrot, S., Paul, J, Brown, I.L., Morrison, D.J., McColl, K.E.L.
Background and aims: Upper gastrointestinal adenocarcinomas show an unexplained male predominance that is more apparent in oesophagus than stomach and in intestinal than diffuse histological subtype....
Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation (2007)
Combet, E.J.M., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., ...
Background: The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in...
Derakhshan, M.H., Malekzadeh, R., Watabe, H., Yazdanbod, A., Fyfe, V., Kazemi, A., ...
INTRODUCTION Atrophic gastritis is a risk factor for non-cardia gastric cancer, and gastro-oesophageal reflux disease (GORD) for oesophageal adenocarcinoma. The role of atrophic gastritis and GORD in...
Hansen, S., Vollset, S.E., Derakhshan, M.H., Fyfe, V., Melby, K.K., Aase, S., ...
Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia...
Iijima, K., Grant, J., McElroy, K., Fyfe, V., Preston, T., McColl, K.E.L.
High luminal concentrations of nitric oxide are generated at the human gastro-oesophaegal junction and within Barrett's oesophagus due to the reduction of salivary nitrite to nitric oxide by acidic...
Moriya, A., Grant, J., Mowat, C., Williams, C., Carswell, A., Preston, T., ...
Background: Dietary nitrate increases saliva nitrite levels and swallowed saliva is the main source of nitrite entering the acidic stomach. In acidic gastric juice, this nitrite can generate...
Interleukin-1 polymorphisms associated with increased risk of gastric cancer (2000)
El Omar, E.M., Carrington, M., Chow, W-H., McColl, K.E.L., Bream, J.H., Young, H.A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Mowat, C., Williams, C., Gillen, D., Hossack, M., Gilmour, D., Carswell, A., ...
Background and Aims: Omeprazole produces greater acid inhibition in Helicobacter pylori-positive than -negative subjects. We investigated whether this is accompanied by more profound changes in the...
Helicobacter pylori in the faeces? (1999)
Weaver, L.T., Shepherd, A.J., Doherty, C.P., McColl, K.E.L., Williams, C.L.
Interactions between H. pylori infection, gastric acid secretion and anti-secretory therapy (1998)
McColl, K E L, El-Omar, E, Gillen, D
There is evidence of a two-way interaction between gastric acid secretion and H. pylori-associated gastritis. Gastric acid secretion influences the density of H. pylori colonisation, its distribution...
Birnie, D.H., Holme, E.R., McKay, I.C., Hood, S., McColl, K.E.L., Hillis, W.S.
Introduction There is growing evidence that the immune response is involved in atherosclerosis. Antibodies to heat shock protein 60/65 have been shown to be a risk factor for carotid atherosclerosis...
McDonagh, T. A., Woodward, M., Morrison, C. E., McMurray, J. J. V., Tunstall-Pedoe, H., Lowe, G. D. O., ...
Aim Recent evidence suggests that Helicobacter pylori infection is associated with coronary heart disease. We investigated whether H. Pylori infection is related to prevalent coronary heart disease,...
LHRH Analogue Treatment for the Prevention of Premenstrual Attacks of Acute Porphyria (1990)
HERRICK, A. L., MCCOLL, K. E. L., WALLACE, A. M., MOORE, M. R., GOLDBERG, A.
We have assessed the value of suppressing ovulation with the luteinizing hormone releasing hormone (LHRH) analogue buserelin in seven patients experiencing crises of acute intermittent porphyria...
Renal Transplantation for Chronic Renal Failure in Acute Porphyria (1987)
Nunez, D. J., Williams, P. F., Herrick, A. L., Evans, D. B., McColl, K. E. L.
A woman with acute intermittent porphyria and a man with variegate porphyria developed chronic renal failure in middle age. After periods on haemodialysis, both received successful cadaveric renal...
Treatment with Haematin in Acute Hepatic Porphyria (1981)
MCCOLL, K. E. L., MOORE, M. R., THOMPSON, G. G., GOLDBERG, A.
We report our experience with intravenous haematin in the treatment of 13 attacks of acute porphyria In eight patients. Seven patients had acute intermittent porphyria and one variegate porphyria....
Iijima, K., Grant, J., McElroy, K., Fyfe, V., Preston, T., McColl, K.E.L.
High luminal concentrations of nitric oxide are generated at the human gastro-oesophaegal junction and within Barrett's oesophagus due to the reduction of salivary nitrite to nitric oxide by acidic...
Moriya, A., Grant, J., Mowat, C., Williams, C., Carswell, A., Preston, T., ...
Background: Dietary nitrate increases saliva nitrite levels and swallowed saliva is the main source of nitrite entering the acidic stomach. In acidic gastric juice, this nitrite can generate...
Mowat, C., Williams, C., Gillen, D., Hossack, M., Gilmour, D., Carswell, A., ...
Background and Aims: Omeprazole produces greater acid inhibition in Helicobacter pylori-positive than -negative subjects. We investigated whether this is accompanied by more profound changes in the...
McColl, K E L, Murray, L S, Gillen, D, Walker, A, Wirz, A, Fletcher, J, ...
McColl, K E L, Murray, L S, Gillen, D, Walker, A, Wirz, A, Fletcher, J, ...
Iijima, K., Grant, J., McElroy, K., Fyfe, V., Preston, T., McColl, K.E.L.
High luminal concentrations of nitric oxide are generated at the human gastro-oesophaegal junction and within Barrett's oesophagus due to the reduction of salivary nitrite to nitric oxide by acidic...
Moriya, A., Grant, J., Mowat, C., Williams, C., Carswell, A., Preston, T., ...
Background: Dietary nitrate increases saliva nitrite levels and swallowed saliva is the main source of nitrite entering the acidic stomach. In acidic gastric juice, this nitrite can generate...
Mowat, C., Williams, C., Gillen, D., Hossack, M., Gilmour, D., Carswell, A., ...
Background and Aims: Omeprazole produces greater acid inhibition in Helicobacter pylori-positive than -negative subjects. We investigated whether this is accompanied by more profound changes in the...
Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia
Suzuki, H, Iijima, K, Moriya, A, McElroy, K, Scobie, G, Fyfe, V, ...
Background: Saliva has a high nitrite concentration, derived from the enterosalivary recirculation of dietary nitrate, and is the main source of nitrite entering the acidic stomach. Acidification of...
Fletcher, J, Wirz, A, Henry, E, McColl, K E L
Background and aims: Oesophageal pH is conventionally recorded from a point 5 cm above the lower oesophageal sphincter. However, the mucosal changes of reflux oesophagitis and intestinal metaplasia...
High incidence of adenocarcinoma arising from the right side of the gastric cardia in NW Iran
Derakhshan, M H, Yazdanbod, A, Sadjadi, A R, Shokoohi, B, McColl, K E L, Malekzadeh, R
Background: In the West, the subsite incidence of gastric cancer has changed in recent decades, with cancer of the cardia increasing in incidence and that of the more distal stomach decreasing. NW...
Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation
Combet, E.J.M., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., ...
Background: The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in...
Hansen, S., Vollset, S.E., Derakhshan, M.H., Fyfe, V., Melby, K.K., Aase, S., ...
Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia...
When saliva meets acid: chemical warfare at the oesophagogastric junction
In the Western world at least, most upper gastrointestinal cancers now arise from the mucosa near to the oesophagogastric junction. Research into the mechanism of the development of adenocarcinoma at...
Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation
Combet, E.J.M., Paterson, S., Iijima, K., Winter, J., Mullen, W., Crozier, A., ...
Background: The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in...
Hansen, S., Vollset, S.E., Derakhshan, M.H., Fyfe, V., Melby, K.K., Aase, S., ...
Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia...
Derakhshan, M.H., Malekzadeh, R., Watabe, H., Yazdanbod, A., Fyfe, V., Kazemi, A., ...
INTRODUCTION Atrophic gastritis is a risk factor for non-cardia gastric cancer, and gastro-oesophageal reflux disease (GORD) for oesophageal adenocarcinoma. The role of atrophic gastritis and GORD in...
Nitrate and nitrosative chemistry within Barrett’s oesophagus during acid reflux
Suzuki, H, Iijima, K, Scobie, G, Fyfe, V, McColl, K E L
Background and aims: When saliva, with its high nitrite content derived from the enterosalivary recirculation of dietary nitrate, meets acidic gastric juice, the nitrite is converted to nitrous acid,...
Acid inhibitory medication and risk of gastric and oesophageal cancer
What are the long term effects of acid suppressive medication on the risk of gastric and oesophageal cancer?