K. Erb

The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine (2006)

Hermann, R., Borlak, J., Munzel, U., Niebch, G., Fuhr, U., Maus, J.E.K., ...

Retigabine (RGB) is an investigational antiepileptic drug, which undergoes extensive UGT1A1, 1A9 and 1A4-mediated N-glucuronidation and N-acetylation. The mono-acetylated metabolite of RGB has some...

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure (2004)

Jetter, A., Kinzig-Schippers, M., Illauer, M., Hermann, R., Erb, K., Borlak, J., ...

BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after...

A rapid and simple CYP2D6 genotyping assay - Case study with the analgetic tramadol (2003)

Borlak, J., Hermann, R., Erb, K., Thum, T.

There is substantial evidence for a causal relationship between genetic variability of the CYP2D6 gene and changes in the pharmacokinetics of drugs. Therefore, knowledge of single-nucleotide...

Retigabine: Progress report on new antieliptic drugs: A summary of the Sixth Eilat Conference (EILAT VI) (2002)

Hermann, R., Schneider, E., Menth, M., Knebel, N., Ferron, G., Borlak, J., ...

The Sixth Eilat Conference on New Antieliptic Drugs (AEDs) took place in Taormina, Sicily, Italy from 7th to 11th April, 2002. Basic scientists, clinical pharmacologists and neurologists from 27...

Molecular diagnosis of a familial non heamolytic hyperbilirubinemia (Gilbert's Syndrome) in healthy subjects (2000)

Borlak, J., Thum, T., Landt, O., Erb, K., Hermann, R.

Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects (2000)

Borlak, J., Thum, T., Landt, O., Erb, K., Hermann, R.

Recent research has shown that congenital nonhemolytic low grade hyperbilirubinemias in patients with Gilbert's syndrome (GS) are linked to mutations in the TATA box upstream of the uridine...

Immune complex formation analysed by high-performance size exclusion chromatography (HPLC-SEC) using either 125I-labelled antigen or enzyme-linked immunosorbent assay (ELISA) for detection.

Holmskov-Nielsen, U, Jensenius, J C, Erb, K, Husby, S

A physical/immunochemical method has been developed for the analysis of soluble immune complexes. Human serum with high amount of antibody against bovine serum albumin (BSA) was incubated at 37...

Haemodynamic and hormonal effects of cilazapril in comparison with propranolol in healthy subjects and in hypertensive patients

Kleinbloesem, C. H., Erb, K., Essig, J., Breithaupt, K., Belz, G. G.

1 The purpose of the present studies was to compare the pharmacodynamic profile of the new ACE inhibitor cilazapril with the β-adrenoceptor antagonist propranolol in healthy subjects and in...

Pharmacokinetic and pharmacodynamic interactions between the ACE inhibitor cilazapril and β-adrenoceptor antagonist propranolol in healthy subjects and in hypertensive patients

Belz, G. G., Essig, J., Erb, K., Breithaupt, K., Hoogkamer, J. F. W., Kneer, J., ...

1 Six healthy subjects received cilazapril (2.5 mg once daily), propranolol (120 mg once daily), the combination of both and placebo for a period of 1 week each (wash-out phase 1 week).