K. G. Alberti

Publication List Details

Period

1991 - 2006

Number

128

Co-Authors

Validity of verbal autopsy procedures for determining cause of death in Tanzania (2006)

Setel, P. W., Whiting, D. R., Hemed, Y., Chandramohan, D., Wolfson, L. J., Alberti, K. G., ...

Objectives: To validate verbal autopsy (VA) procedures for use in sample vital registration. Verbal autopsy is an important method for deriving cause-specific mortality estimates where disease...

Core verbal autopsy procedures with comparative validation results from two countries (2006)

Setel, P. W., Rao, C., Hemed, Y., Whiting, D. R., Yang, G., Chandramohan, D., ...

BACKGROUND: Cause-specific mortality statistics remain scarce for the majority of low-income countries, where the highest disease burdens are experienced. Neither facility-based information systems...

Validity of verbal autopsy procedures for determining cause of death in Tanzania (2006)

Setel, P. W., Whiting, D. R., Hemed, Y., Chandramohan, D., Wolfson, L. J., Alberti, K. G., ...

Objectives: To validate verbal autopsy (VA) procedures for use in sample vital registration. Verbal autopsy is an important method for deriving cause-specific mortality estimates where disease...

Core verbal autopsy procedures with comparative validation results from two countries (2006)

Setel, P. W., Rao, C., Hemed, Y., Whiting, D. R., Yang, G., Chandramohan, D., ...

BACKGROUND: Cause-specific mortality statistics remain scarce for the majority of low-income countries, where the highest disease burdens are experienced. Neither facility-based information systems...

Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study (1999)

Bhopal, R., Unwin, N, White, M, Yallop, J, Walker, L, Alberti, K.G, ...

Objective: To compare coronary risk factors and disease prevalence among Indians, Pakistanis, and Bangladeshis, and in all South Asians (these three groups together) with Europeans. Design: Cross...

Prevalences of diabetes and cardiovascular disease risk factors in Hindu Indian subcommunities in Tanzania (1991)

Ramaiya, K.L, Swai, A.B, McLarty, D.G, Bhopal, Raj, Alberti, K.G

OBJECTIVES--To seek differences in the prevalence of diabetes mellitus and other coronary heart disease risk factors, and to identify factors associated with these differences within a Hindu Indian...

Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.

Ho, K Y, Veldhuis, J D, Johnson, M L, Furlanetto, R, Evans, W S, Alberti, K G, ...

Studies in man have shown that the episodic release of growth hormone (GH) is infrequent and erratic, and unlike that in the rat does not appear to have discernible ultradian periodicities. However,...

A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans.

Hartman, M L, Clayton, P E, Johnson, M L, Celniker, A, Perlman, A J, Alberti, K G, ...

To determine if insulin-like growth factor I (IGF-I) inhibits pulsatile growth hormone (GH) secretion in man, recombinant human IGF-I (rhIGF-I) was infused for 6 h at 10 micrograms.kg-1.h-1 during a...

Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes.

Agius, L, Peak, M, Alberti, K G

Glycogen synthesis in hepatocyte cultures is dependent on: (1) the nutritional state of the donor rat, (2) the acinar origin of the hepatocytes, (3) the concentrations of glucose and gluconeogenic...

Regulation of fatty acid and carbohydrate metabolism by insulin, growth hormone and tri-iodothyronine in hepatocyte cultures from normal and hypophysectomized rats.

Betley, S, Alberti, K G, Agius, L

The interactions of insulin, growth hormone (somatotropin) and tri-iodothyronine (T3) in the long-term (24 h) regulation of fatty acid and carbohydrate metabolism were studied in hepatocyte primary...

Hypophysectomy does not alter the acinar zonation of gluconeogenesis or the mitochondrial redox state in rat liver.

Tosh, D, Alberti, K G, Agius, L

The biochemical and functional heterogeneity of hepatocytes in different zones of the liver acinus may be related to the concentrations of hormones within the liver acinus. We examined the effects of...

Effects of monensin on insulin interactions with isolated hepatocytes. Evidence for inhibition of receptor recycling and insulin degradation.

Whittaker, J, Hammond, V A, Taylor, R, Alberti, K G

Recent evidence suggests that, during endocytosis, receptors for many polypeptide ligands are spared degradation and are recycled to the plasma membrane for re-utilization. The univalent ionophore...

Regulation of ketogenesis, gluconeogenesis and the mitochondrial redox state by dexamethasone in hepatocyte monolayer cultures.

Agius, L, Chowdhury, M H, Alberti, K G

The effects of the glucocorticoid dexamethasone on fatty acid and pyruvate metabolism were studied in rat hepatocyte cultures. Parenchymal hepatocytes were cultured for 24 h with nanomolar...

Fatty acid metabolism in hepatocytes cultured with hypolipidaemic drugs. Role of carnitine.

Gerondaes, P, Alberti, K G, Agius, L

The direct effects of clofibrate analogues on carnitine acyltransferase activities and fatty acid metabolism were studied in cultured hepatocytes. Rat hepatocytes cultured with bezafibrate or...

Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes.

Gerondaes, P, Alberti, K G, Agius, L

Culture of rat hepatocytes with etomoxir, an inhibitor of carnitine palmitoyltransferase I (CPT I), for 48 h, resulted in increased carnitine acetyltransferase (CAT) activity (74%), a marked decrease...

Metabolic effects of bacitracin in isolated rat hepatocytes.

Agius, L, Wilding, C, Alberti, K G

Bacitracin is a proteolytic inhibitor which interacts with the intracellular processing of insulin. Its effects on pyruvate, fatty acid and amino acid metabolism were examined in rat hepatocyte...

Conversion of pyruvate into ketone bodies in rat hepatocyte suspensions.

Battersby, C M, Alberti, K G, Agius, L

The contribution of pyruvate to ketogenesis was determined in rat hepatocyte suspensions by using [14C]pyruvate. The rates of conversion of pyruvate into ketone bodies in hepatocytes from fed and 24...

Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis.

Backshear, P J, Holloway, P A, Alberti, K G

1. The infusion of sodium dichloroacetate into rats with severe diabetic ketoacidosis over 4h caused a 2mM decrease in blood glucose, and small falls in blood lactate and pyruvate concentrations....

Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.

Blackshear, P J, Holloway, P A, Alberti, K G

1. Factors regulating the release of alanine and glutamine in vivo were investigated in starved rats by removing the liver from the circulation and monitoring blood metabolite changes for 30 min. 2....

The biochemical consequences of hypoxia.

Alberti, K G

The various phases of energy production have been described. These include glycolysis which is unique in its ability to produce ATP anaerobically, the tricarboxylic acid cycle with its major...

Metabolic abnormalities in children of non-insulin dependent diabetics.

Leslie, R D, Volkmann, H P, Poncher, M, Hanning, I, Orskov, H, Alberti, K G

Non-insulin dependent diabetes appears to be an inherited condition. A study of young offspring of non-insulin dependent diabetics was conducted to determine whether metabolic abnormalities could be...

Intensive attention improves glycaemic control in insulin-dependent diabetes without further advantage from home blood glucose monitoring: results of a controlled trial.

Worth, R, Home, P D, Johnston, D G, Anderson, J, Ashworth, L, Burrin, J M, ...

Forty-six diabetics treated with twice-daily insulin were seen every two weeks for six months in an intensive education programme aided by regular home urine glucose testing. Control was improved...

Management of severely brittle diabetes by continuous subcutaneous and intramuscular insulin infusions: evidence for a defect in subcutaneous insulin absorption.

Pickup, J C, Home, P D, Bilous, R W, Keen, H, Alberti, K G

Severely brittle diabetes is defined as a rare subtype of insulin-dependent diabetes with wide, fast, unpredictable, and inexplicable swings in blood glucose concentration, often culminating in...

Human insulin: study of safety and efficacy in man.

Owens, D R, Jones, M K, Hayes, T M, Heding, L G, Alberti, K G, Home, P D, ...

The safety and efficacy of a new highly purified neutral soluble human insulin produced by conversion of porcine insulin was compared with a highly purified neutral soluble porcine insulin in six...

Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics.

Barnett, A H, Spiliopoulos, A J, Pyke, D A, Stubbs, W A, Burrin, J, Alberti, K G

Forty-eight out of 53 non-insulin-dependent diabetic identical twin pairs were concordant for diabetes. In the five discordant pairs the diabetic twin had only recently been diagnosed. Oral glucose...

Intermediate acting insulin given at bedtime: effect on blood glucose concentrations before and after breakfast.

Francis, A J, Home, P D, Hanning, I, Alberti, K G, Tunbridge, W M

Six C-peptide deficient diabetics receiving twice daily mixtures of short and intermediate acting insulins were selected for study because of persistently raised blood glucose concentrations before...

Role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes.

Madsbad, S, Alberti, K G, Binder, C, Burrin, J M, Faber, O K, Krarup, T, ...

The role of preserved beta-cell function in preventing ketoacidosis in type I insulin-dependent diabetes was assessed in eight patients with and seven patients without residual beta-cell function as...

Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor.

Walton, R J, Sherif, I T, Noy, G A, Alberti, K G

An alpha-glucosidehydrolase inhibitor (acarbose; BAY g 5421) taken with food was compared with dummy tablets in seven insulin-treated diabetic patients over eight-hour periods that included...

Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.

Pickup, J C, Keen, H, Parsons, J A, Alberti, K G

A study was performed to examine the feasibility of achieving long periods of near-normoglycaemia in patients with diabetes mellitus by giving a continuous subcutaneous infusion of insulin solution...

Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.

Jenkins, D J, Wolever, T M, Leeds, A R, Gassull, M A, Haisman, P, Dilawari, J, ...

To define the type of dietary fibre of fibre analogue with the greatest potential use in diabetic treatment, groups of four to six volunteers underwent 50-g glucose tolerance tests (GTT) with and...

A glucose-controlled insulin infusion system for diabetic women during labour.

Nattrass, M, Alberti, K G, Dennis, K J, Gillibrand, P N, Letchworth, A T, Buckle, A L

A glucose-controlled insulin infusion system was used to control blood glucose concentration during labour or caesarean section in six insulin-dependent diabetics. The mean blood glucose...

Renal replacement treatment for diabetic patients in Newcastle upon Tyne and the Northern region, 1964-88.

Catalano, C, Goodship, T H, Tapson, J S, Venning, M K, Taylor, R M, Proud, G, ...

OBJECTIVES--To review the experience of renal replacement treatment in diabetic patients treated in Newcastle upon Tyne and the Northern region from 1964 to 1988, and to compare the morbidity and...

Comparison of non-mydriatic retinal photography with ophthalmoscopy in 2159 patients: mobile retinal camera study.

Taylor, R, Lovelock, L, Tunbridge, W M, Alberti, K G, Brackenridge, R G, Stephenson, P, ...

OBJECTIVE--To determine whether non-mydriatic Polaroid retinal photography was comparable to ophthalmoscopy with mydriasis in routine clinic screening for early, treatable diabetic retinopathy....

Insulin dependent diabetes in childhood and material deprivation in northern England, 1977-86.

Crow, Y J, Alberti, K G, Parkin, J M

OBJECTIVE--To determine the incidence of insulin dependent diabetes in the Northern region of England in children less than 16 years old in the period 1977 to 1986 and to relate the incidence data to...

Prevalences of diabetes and cardiovascular disease risk factors in Hindu Indian subcommunities in Tanzania.

Ramaiya, K L, Swai, A B, McLarty, D G, Bhopal, R S, Alberti, K G

OBJECTIVES--To seek differences in the prevalence of diabetes mellitus and other coronary heart disease risk factors, and to identify factors associated with these differences within a Hindu Indian...

Association between impaired glucose tolerance and circulating concentration of Lp(a) lipoprotein in relation to coronary heart disease.

Farrer, M, Game, F L, Albers, C J, Neil, H A, Winocour, P H, Laker, M F, ...

OBJECTIVE--To examine whether impaired glucose tolerance and raised Lp(a) lipoprotein concentrations are associated in subjects with coronary artery disease. DESIGN--Study of two subject populations,...

Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.

Ho, K Y, Veldhuis, J D, Johnson, M L, Furlanetto, R, Evans, W S, Alberti, K G, ...

Studies in man have shown that the episodic release of growth hormone (GH) is infrequent and erratic, and unlike that in the rat does not appear to have discernible ultradian periodicities. However,...

A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans.

Hartman, M L, Clayton, P E, Johnson, M L, Celniker, A, Perlman, A J, Alberti, K G, ...

To determine if insulin-like growth factor I (IGF-I) inhibits pulsatile growth hormone (GH) secretion in man, recombinant human IGF-I (rhIGF-I) was infused for 6 h at 10 micrograms.kg-1.h-1 during a...

Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes.

Agius, L, Peak, M, Alberti, K G

Glycogen synthesis in hepatocyte cultures is dependent on: (1) the nutritional state of the donor rat, (2) the acinar origin of the hepatocytes, (3) the concentrations of glucose and gluconeogenic...

Regulation of fatty acid and carbohydrate metabolism by insulin, growth hormone and tri-iodothyronine in hepatocyte cultures from normal and hypophysectomized rats.

Betley, S, Alberti, K G, Agius, L

The interactions of insulin, growth hormone (somatotropin) and tri-iodothyronine (T3) in the long-term (24 h) regulation of fatty acid and carbohydrate metabolism were studied in hepatocyte primary...

Hypophysectomy does not alter the acinar zonation of gluconeogenesis or the mitochondrial redox state in rat liver.

Tosh, D, Alberti, K G, Agius, L

The biochemical and functional heterogeneity of hepatocytes in different zones of the liver acinus may be related to the concentrations of hormones within the liver acinus. We examined the effects of...

Effects of monensin on insulin interactions with isolated hepatocytes. Evidence for inhibition of receptor recycling and insulin degradation.

Whittaker, J, Hammond, V A, Taylor, R, Alberti, K G

Recent evidence suggests that, during endocytosis, receptors for many polypeptide ligands are spared degradation and are recycled to the plasma membrane for re-utilization. The univalent ionophore...

Regulation of ketogenesis, gluconeogenesis and the mitochondrial redox state by dexamethasone in hepatocyte monolayer cultures.

Agius, L, Chowdhury, M H, Alberti, K G

The effects of the glucocorticoid dexamethasone on fatty acid and pyruvate metabolism were studied in rat hepatocyte cultures. Parenchymal hepatocytes were cultured for 24 h with nanomolar...

Fatty acid metabolism in hepatocytes cultured with hypolipidaemic drugs. Role of carnitine.

Gerondaes, P, Alberti, K G, Agius, L

The direct effects of clofibrate analogues on carnitine acyltransferase activities and fatty acid metabolism were studied in cultured hepatocytes. Rat hepatocytes cultured with bezafibrate or...

Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes.

Gerondaes, P, Alberti, K G, Agius, L

Culture of rat hepatocytes with etomoxir, an inhibitor of carnitine palmitoyltransferase I (CPT I), for 48 h, resulted in increased carnitine acetyltransferase (CAT) activity (74%), a marked decrease...

Metabolic effects of bacitracin in isolated rat hepatocytes.

Agius, L, Wilding, C, Alberti, K G

Bacitracin is a proteolytic inhibitor which interacts with the intracellular processing of insulin. Its effects on pyruvate, fatty acid and amino acid metabolism were examined in rat hepatocyte...

Conversion of pyruvate into ketone bodies in rat hepatocyte suspensions.

Battersby, C M, Alberti, K G, Agius, L

The contribution of pyruvate to ketogenesis was determined in rat hepatocyte suspensions by using [14C]pyruvate. The rates of conversion of pyruvate into ketone bodies in hepatocytes from fed and 24...

Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis.

Backshear, P J, Holloway, P A, Alberti, K G

1. The infusion of sodium dichloroacetate into rats with severe diabetic ketoacidosis over 4h caused a 2mM decrease in blood glucose, and small falls in blood lactate and pyruvate concentrations....

Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.

Blackshear, P J, Holloway, P A, Alberti, K G

1. Factors regulating the release of alanine and glutamine in vivo were investigated in starved rats by removing the liver from the circulation and monitoring blood metabolite changes for 30 min. 2....

Metabolic abnormalities in children of non-insulin dependent diabetics.

Leslie, R D, Volkmann, H P, Poncher, M, Hanning, I, Orskov, H, Alberti, K G

Non-insulin dependent diabetes appears to be an inherited condition. A study of young offspring of non-insulin dependent diabetics was conducted to determine whether metabolic abnormalities could be...

Intensive attention improves glycaemic control in insulin-dependent diabetes without further advantage from home blood glucose monitoring: results of a controlled trial.

Worth, R, Home, P D, Johnston, D G, Anderson, J, Ashworth, L, Burrin, J M, ...

Forty-six diabetics treated with twice-daily insulin were seen every two weeks for six months in an intensive education programme aided by regular home urine glucose testing. Control was improved...

Management of severely brittle diabetes by continuous subcutaneous and intramuscular insulin infusions: evidence for a defect in subcutaneous insulin absorption.

Pickup, J C, Home, P D, Bilous, R W, Keen, H, Alberti, K G

Severely brittle diabetes is defined as a rare subtype of insulin-dependent diabetes with wide, fast, unpredictable, and inexplicable swings in blood glucose concentration, often culminating in...

Human insulin: study of safety and efficacy in man.

Owens, D R, Jones, M K, Hayes, T M, Heding, L G, Alberti, K G, Home, P D, ...

The safety and efficacy of a new highly purified neutral soluble human insulin produced by conversion of porcine insulin was compared with a highly purified neutral soluble porcine insulin in six...

Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics.

Barnett, A H, Spiliopoulos, A J, Pyke, D A, Stubbs, W A, Burrin, J, Alberti, K G

Forty-eight out of 53 non-insulin-dependent diabetic identical twin pairs were concordant for diabetes. In the five discordant pairs the diabetic twin had only recently been diagnosed. Oral glucose...

The biochemical consequences of hypoxia.

Alberti, K G

The various phases of energy production have been described. These include glycolysis which is unique in its ability to produce ATP anaerobically, the tricarboxylic acid cycle with its major...

Intermediate acting insulin given at bedtime: effect on blood glucose concentrations before and after breakfast.

Francis, A J, Home, P D, Hanning, I, Alberti, K G, Tunbridge, W M

Six C-peptide deficient diabetics receiving twice daily mixtures of short and intermediate acting insulins were selected for study because of persistently raised blood glucose concentrations before...

Role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes.

Madsbad, S, Alberti, K G, Binder, C, Burrin, J M, Faber, O K, Krarup, T, ...

The role of preserved beta-cell function in preventing ketoacidosis in type I insulin-dependent diabetes was assessed in eight patients with and seven patients without residual beta-cell function as...

Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor.

Walton, R J, Sherif, I T, Noy, G A, Alberti, K G

An alpha-glucosidehydrolase inhibitor (acarbose; BAY g 5421) taken with food was compared with dummy tablets in seven insulin-treated diabetic patients over eight-hour periods that included...

Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.

Pickup, J C, Keen, H, Parsons, J A, Alberti, K G

A study was performed to examine the feasibility of achieving long periods of near-normoglycaemia in patients with diabetes mellitus by giving a continuous subcutaneous infusion of insulin solution...

Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.

Jenkins, D J, Wolever, T M, Leeds, A R, Gassull, M A, Haisman, P, Dilawari, J, ...

To define the type of dietary fibre of fibre analogue with the greatest potential use in diabetic treatment, groups of four to six volunteers underwent 50-g glucose tolerance tests (GTT) with and...

A glucose-controlled insulin infusion system for diabetic women during labour.

Nattrass, M, Alberti, K G, Dennis, K J, Gillibrand, P N, Letchworth, A T, Buckle, A L

A glucose-controlled insulin infusion system was used to control blood glucose concentration during labour or caesarean section in six insulin-dependent diabetics. The mean blood glucose...

Renal replacement treatment for diabetic patients in Newcastle upon Tyne and the Northern region, 1964-88.

Catalano, C, Goodship, T H, Tapson, J S, Venning, M K, Taylor, R M, Proud, G, ...

OBJECTIVES--To review the experience of renal replacement treatment in diabetic patients treated in Newcastle upon Tyne and the Northern region from 1964 to 1988, and to compare the morbidity and...

Comparison of non-mydriatic retinal photography with ophthalmoscopy in 2159 patients: mobile retinal camera study.

Taylor, R, Lovelock, L, Tunbridge, W M, Alberti, K G, Brackenridge, R G, Stephenson, P, ...

OBJECTIVE--To determine whether non-mydriatic Polaroid retinal photography was comparable to ophthalmoscopy with mydriasis in routine clinic screening for early, treatable diabetic retinopathy....

Insulin dependent diabetes in childhood and material deprivation in northern England, 1977-86.

Crow, Y J, Alberti, K G, Parkin, J M

OBJECTIVE--To determine the incidence of insulin dependent diabetes in the Northern region of England in children less than 16 years old in the period 1977 to 1986 and to relate the incidence data to...

Prevalences of diabetes and cardiovascular disease risk factors in Hindu Indian subcommunities in Tanzania.

Ramaiya, K L, Swai, A B, McLarty, D G, Bhopal, R S, Alberti, K G

OBJECTIVES--To seek differences in the prevalence of diabetes mellitus and other coronary heart disease risk factors, and to identify factors associated with these differences within a Hindu Indian...

Association between impaired glucose tolerance and circulating concentration of Lp(a) lipoprotein in relation to coronary heart disease.

Farrer, M, Game, F L, Albers, C J, Neil, H A, Winocour, P H, Laker, M F, ...

OBJECTIVE--To examine whether impaired glucose tolerance and raised Lp(a) lipoprotein concentrations are associated in subjects with coronary artery disease. DESIGN--Study of two subject populations,...

Glycerol clearance in alcoholic liver disease.

Johnston, D G, Alberti, K G, Wright, R, Blain, P G

Glycerol clearance was studied by a primed dose-constant infusion technique in 14 patients with alcoholic liver disease and six normal control subjects. Fasting blood glycerol concentrations were...

Pectin and complications after gastric surgery: normalisation of postprandial glucose and endocrine responses.

Jenkins, D J, Bloom, S R, Albuquerque, R H, Leeds, A R, Sarson, D L, Metz, G L, ...

Pectin has been shown to minimise the fall in blood glucose seen in patients who are troubled by hypoglycaemia attacks after gastric surgery. We therefore performed 50 g glucose tolerance tests with...

Electrocardiographic abnormalities and associated factors in Chinese living in Beijing and in Mauritius. The Mauritius Non-Communicable Disease Study Group.

Li, N., Tuomilehto, J., Dowse, G., Alberti, K. G., Zimmet, P., Min, Z., ...

OBJECTIVE--To compare the prevalence of electrocardiographic abnormalities and to evaluate the association between these abnormalities and the levels of coronary heart disease among Chinese living in...

Is diabetes mellitus related to undernutrition in rural Tanzania?

Swai, A. B., Kitange, H. M., Masuki, G., Kilima, P. M., Alberti, K. G., McLarty, D. G.

OBJECTIVE--To investigate the relation between undernutrition and diabetes. DESIGN--Survey of glucose tolerance in rural Tanzania. SETTING--Eight villages in three widely separated regions of...

Valproate causes metabolic disturbance in normal man.

Turnbull, D M, Dick, D J, Wilson, L, Sherratt, H S, Alberti, K G

Valproate is an important anticonvulsant which is rarely associated with fatal hepatotoxicity. Previous experiments have shown that valproate inhibits several metabolic processes in isolated rat...

Circulating lipids and glycaemic control in insulin dependent diabetic children.

Azad, K, Parkin, J M, Court, S, Laker, M F, Alberti, K G

The prevalence of dyslipidaemia in children with insulin dependent diabetes mellitus (IDDM) and its relation to glycaemic control was studied in a group of 51 diabetic children and a control...

Coronary heart disease risk factors in sub-Saharan Africa: studies in Tanzanian adolescents.

Kitange, H M, Swai, A B, Masuki, G, Kilima, P M, Alberti, K G, McLarty, D G

STUDY OBJECTIVE--To assess the level of cardiovascular risk factors in young people in sub-Saharan Africa living in rural and urban settings. DESIGN--Cross sectional survey of the population aged 15...

Body mass index, waist circumference, waist-hip ratio, and glucose intolerance in Chinese and Europid adults in Newcastle, UK.

Unwin, N, Harland, J, White, M, Bhopal, R, Winocour, P, Stephenson, P, ...

OBJECTIVE: To compare the prevalence of glucose intolerance (impaired glucose tolerance and diabetes), and its relationship to body mass index (BMI) and waist-hip ratio in Chinese and Europid adults....

Low levels of cardiovascular risk factors and coronary heart disease in a UK Chinese population.

Harland, J O, Unwin, N, Bhopal, R S, White, M, Watson, B, Laker, M, ...

OBJECTIVE: To compare the prevalence of cardiovascular risk factors and coronary heart disease in Chinese and Europid adults. DESIGN: Population based, cross sectional survey. SETTING: Newcastle upon...

The role of pancreatic insulin secretion in neonatal glucoregulation. I. Healthy term and preterm infants.

Hawdon, J M, Aynsley-Green, A, Alberti, K G, Ward Platt, M P

The glucoregulatory role of insulin in adult subjects is undisputed. However, less is known about the secretion of insulin and its actions in the neonatal period, either for healthy subjects, or for...

The metabolic load of stored blood. Implications for major transfusions in infants.

Ratcliffe, J M, Elliott, M J, Wyse, R K, Hunter, S, Alberti, K G

Plasma electrolyte, intermediary metabolite, and hormone concentrations were measured in samples of 110 units of citrate phosphate dextrose blood being used for clinical transfusions. The most...

Outlook for survivors of childhood in sub-Saharan Africa: adult mortality in Tanzania. Adult Morbidity and Mortality Project.

Kitange, H. M., Machibya, H., Black, J., Mtasiwa, D. M., Masuki, G., Whiting, D., ...

OBJECTIVE--To measure age and sex specific mortality in adults (15-59 years) in one urban and two rural areas of Tanzania. DESIGN--Reporting of all deaths occurring between 1 June 1992 and 31 May...

Fall in total cholesterol concentration over five years in association with changes in fatty acid composition of cooking oil in Mauritius: cross sectional survey.

Uusitalo, U., Feskens, E. J., Tuomilehto, J., Dowse, G., Haw, U., Fareed, D., ...

OBJECTIVE: To determine the extent to which reducing the saturated fatty acid composition of a ubiquitously used cooking oil influenced changes in cholesterol concentration in the population during a...

Lipid and lipoprotein metabolism in familial combined hyperlipidaemia during treatment of sporadic phaeochromocytoma: a case study.

Winocour, P. H., Masud, T., Clark, F., Cooper, B. G., Laker, M. F., Alberti, K. G.

Lipid metabolism was evaluated during management of phaeochromocytoma in a 41 year old non-obese post-menopausal women with familial combined hyperlipidaemia. The main effect of the excess...

The metabolic effects of moderately severe upper gastrointestinal haemorrhage in man.

Foster, K. J., Alberti, K. G., Binder, C., Holdstock, G., Karran, S. J., Smith, C. L., ...

The metabolic effects of moderately severe gastrointestinal haemorrhage were investigated in man. Before resuscitation, patients had raised circulating concentrations of glucose, lactate, alanine,...

Reversible lactic acidosis associated with repeated intravenous infusions of sorbitol and ethanol.

Batstone, G. F., Alberti, K. G., Dewar, A. K.

Infusions of fructose or sorbitol are used commonly in parenteral nutrition and may cause lactic acidosis. A case is reported in whom blood lactate concentration was monitored frequently over a 5-day...

Resting energy expenditure, substrate use, and video tapes.

Cooper, B. G., Matthews, J. N., Alberti, K. G.

OBJECTIVE--To investigate the effect of watching different types of video on energy expenditure. DESIGN--Randomised study assessing a "pleasant," an "amusing," an "exciting," and no video film clips....

Changes in population cholesterol concentrations and other cardiovascular risk factor levels after five years of the non-communicable disease intervention programme in Mauritius. Mauritius Non-communicable Disease Study Group.

Dowse, G. K., Gareeboo, H., Alberti, K. G., Zimmet, P., Tuomilehto, J., Purran, A., ...

OBJECTIVE--To study changes in the prevalence of risk factors for cardiovascular disease after a five year population-wide intervention programme promoting a healthy lifestyle in a developing...

Noncommunicable diseases in sub-Saharan Africa: where do they feature in the health research agenda?

Unwin, N., Setel, P., Rashid, S., Mugusi, F., Mbanya, J. C., Kitange, H., ...

There is no doubt that communicable diseases will remain the predominant health problem for the populations in sub-Saharan Africa, including adults, for the next 10-20 years. Concern has been...