Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
The end of a telomeric DNA sequence isolated from a polytene chromosome of a hypotrichous ciliate folds back and hybridizes with downstream telomeric sequence to form a t loop that is stable in the...
Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.
Murti, K G, Takimoto, T, Laver, W G, Portner, A
When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle...
Murti, K G, Brown, P S, Ratner, L, Garcia, J V
A human T-cell line constitutively expressing the nef gene from the human immunodeficiency virus type 1 SF2 isolate was used to examine the distribution of the Nef protein in the nucleus....
Murti, K G, Bondurant, M, Tereba, A
The secondary structural features in the 70S RNAs of the Prague strain of avian Rous sarcoma virus, subgroup A (PR-RSV-A), and Moloney murine leukemia virus (M-MuLV) were compared by electron...
Mitnaul, L J, Castrucci, M R, Murti, K G, Kawaoka, Y
In this study, we investigated the role of the conserved neuraminidase (NA) cytoplasmic tail residues in influenza virus replication. Mutants of influenza A virus (A/WSN/33 [H1N1]) with deletions of...
Gubareva, L V, Bethell, R, Hart, G J, Murti, K G, Penn, C R, Webster, R G
The development of viral resistance to the neuraminidase (NA) inhibitor, 4-guanidino-Neu5Ac2en, of influenza viruses was studied by serial passage of A/Turkey/Minnesota/833/80 (H4N2) in Madin-Darby...
Hou, S, Fishman, M, Murti, K G, Doherty, P C
Sendai virus pneumonia in beta 2-microglobulin-deficient [beta 2-m(-/-)] mice lacking CD8+ T cells is characterized by the development of CD4+ cytotoxic T lymphocytes that can be recovered directly...
Takimoto, T, Laver, W G, Murti, K G, Portner, A
We isolated, purified, and characterized the hemagglutinin-neuraminidase (HN) of human parainfluenza virus type 1, with the ultimate goal of producing crystals suitable for three-dimensional X-ray...
Thompson, S D, Laver, W G, Murti, K G, Portner, A
As a first step in establishing the three-dimensional structure of the Sendai virus hemagglutinin-neuraminidase (HN), we have isolated and characterized a potentially crystallizable form of the...
Ubiquitin is a component of the microtubule network.
Murti, K G, Smith, H T, Fried, V A
Immunofluorescence microscopy was used to study the intracellular localization of ubiquitin. Baby hamster kidney cells (BHK cells) and several other cell lines were probed with a well characterized...
In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum.
Hendershot, L M, Wei, J Y, Gaut, J R, Lawson, B, Freiden, P J, Murti, K G
BiP possesses ATP binding/hydrolysis activities that are thought to be essential for its ability to chaperone protein folding and assembly in the endoplasmic reticulum (ER). We have produced a series...
The genome of frog virus 3, an animal DNA virus, is circularly permuted and terminally redundant.
We examined the structure of the frog virus 3 (FV 3) genome by using electron microscopic and biochemical techniques. The linear FV 3 DNA molecules (Mr approximately 100 x 10(6) formed circles when...
Assembly of vesicular stomatitis virus nucleocapsids in vivo: a kinetic analysis.
Hsu, C H, Kingsbury, D W, Murti, K G
Pulse-chase labeling and cell fractionation were used to examine the pathways taken by the three nucleocapsid polypeptide species of vesicular stomatitis virus into nucleocapsids and then into...
Replication forms of the gene-sized DNA molecules of hypotrichous ciliates.
Using a method for obtaining DNA from 10 to 40 macronuclei for electron microscopy, we analyzed the structure of gene-sized, linear DNA molecules from S-phase macronuclei of two hypotrichous...
Chromosome 1 contains the endogenous RAV-0 retrovirus sequences in chicken cells.
Tereba, A, Lai, M M, Murti, K G
We have developed a structurally unique probe which can be used to determine the chromosomal location of nonreiterated genes in vertebrate organisms by the method of in situ hybridization. The probe...
Fornerod, M, Van Deursen, J, Van Baal, S, Reynolds, A, Davis, D, Murti, K G, ...
The oncogenic nucleoporin CAN/Nup214 is essential in vertebrate cells. Its depletion results in defective nuclear protein import, inhibition of messenger RNA export and cell cycle arrest. We recently...
Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
The end of a telomeric DNA sequence isolated from a polytene chromosome of a hypotrichous ciliate folds back and hybridizes with downstream telomeric sequence to form a t loop that is stable in the...
Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.
Murti, K G, Takimoto, T, Laver, W G, Portner, A
When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle...
Murti, K G, Brown, P S, Ratner, L, Garcia, J V
A human T-cell line constitutively expressing the nef gene from the human immunodeficiency virus type 1 SF2 isolate was used to examine the distribution of the Nef protein in the nucleus....
Murti, K G, Bondurant, M, Tereba, A
The secondary structural features in the 70S RNAs of the Prague strain of avian Rous sarcoma virus, subgroup A (PR-RSV-A), and Moloney murine leukemia virus (M-MuLV) were compared by electron...
Mitnaul, L J, Castrucci, M R, Murti, K G, Kawaoka, Y
In this study, we investigated the role of the conserved neuraminidase (NA) cytoplasmic tail residues in influenza virus replication. Mutants of influenza A virus (A/WSN/33 [H1N1]) with deletions of...
Gubareva, L V, Bethell, R, Hart, G J, Murti, K G, Penn, C R, Webster, R G
The development of viral resistance to the neuraminidase (NA) inhibitor, 4-guanidino-Neu5Ac2en, of influenza viruses was studied by serial passage of A/Turkey/Minnesota/833/80 (H4N2) in Madin-Darby...
Hou, S, Fishman, M, Murti, K G, Doherty, P C
Sendai virus pneumonia in beta 2-microglobulin-deficient [beta 2-m(-/-)] mice lacking CD8+ T cells is characterized by the development of CD4+ cytotoxic T lymphocytes that can be recovered directly...
Takimoto, T, Laver, W G, Murti, K G, Portner, A
We isolated, purified, and characterized the hemagglutinin-neuraminidase (HN) of human parainfluenza virus type 1, with the ultimate goal of producing crystals suitable for three-dimensional X-ray...
Thompson, S D, Laver, W G, Murti, K G, Portner, A
As a first step in establishing the three-dimensional structure of the Sendai virus hemagglutinin-neuraminidase (HN), we have isolated and characterized a potentially crystallizable form of the...
Ubiquitin is a component of the microtubule network.
Murti, K G, Smith, H T, Fried, V A
Immunofluorescence microscopy was used to study the intracellular localization of ubiquitin. Baby hamster kidney cells (BHK cells) and several other cell lines were probed with a well characterized...
In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum.
Hendershot, L M, Wei, J Y, Gaut, J R, Lawson, B, Freiden, P J, Murti, K G
BiP possesses ATP binding/hydrolysis activities that are thought to be essential for its ability to chaperone protein folding and assembly in the endoplasmic reticulum (ER). We have produced a series...
The genome of frog virus 3, an animal DNA virus, is circularly permuted and terminally redundant.
We examined the structure of the frog virus 3 (FV 3) genome by using electron microscopic and biochemical techniques. The linear FV 3 DNA molecules (Mr approximately 100 x 10(6) formed circles when...
Assembly of vesicular stomatitis virus nucleocapsids in vivo: a kinetic analysis.
Hsu, C H, Kingsbury, D W, Murti, K G
Pulse-chase labeling and cell fractionation were used to examine the pathways taken by the three nucleocapsid polypeptide species of vesicular stomatitis virus into nucleocapsids and then into...
Replication forms of the gene-sized DNA molecules of hypotrichous ciliates.
Using a method for obtaining DNA from 10 to 40 macronuclei for electron microscopy, we analyzed the structure of gene-sized, linear DNA molecules from S-phase macronuclei of two hypotrichous...
Chromosome 1 contains the endogenous RAV-0 retrovirus sequences in chicken cells.
Tereba, A, Lai, M M, Murti, K G
We have developed a structurally unique probe which can be used to determine the chromosomal location of nonreiterated genes in vertebrate organisms by the method of in situ hybridization. The probe...
Fornerod, M, Van Deursen, J, Van Baal, S, Reynolds, A, Davis, D, Murti, K G, ...
The oncogenic nucleoporin CAN/Nup214 is essential in vertebrate cells. Its depletion results in defective nuclear protein import, inhibition of messenger RNA export and cell cycle arrest. We recently...