Zhao, H. B., Smith, K. J., Fan, Y., Lüpke, G., Bhattacharya, A., Bader, S. D., ...
Photoinduced magnetization dynamics is investigated in chemically ordered $(\mathrm{LaMnO}_3)_{2n}/(\mathrm{SrMnO}_3)_n$ superlattices using the time-resolved magneto-optic Kerr effect. A monotonic...
Black, J.A., Waxman, S.G., Smith, K.J.
Demyelination of CNS axons occurs in a number of pathological conditions, including multiple sclerosis and contusion-type spinal cord injury. The demyelination can be repaired by remyelination in...
FEASIBILITY DEMONSTRATION OF A TRANSPIRATION COOLED NOZZLE SYSTEM (2006)
Smith, K. J., Poulos, E. N., Steigerwald, E. A., Lally, F., Peck, J. V., Pappas, C.
The use of transpiration cooling for advanced solid propellant application is described. The mechanism used for demonstration purposes consisted of a porous tungsten insert cooled by anhydrous...
Szmuk, P., Rabb, M. F., Curry, B., Smith, K. J., Lantin-Hermoso, M. R., Ezri, T.
We describe the anaesthetic management of a pair of thoracopagus twins of 14 months of age undergoing complex cardiac evaluation. Synchronous ventilation of the twins, needed for the ECG-gated...
THRUST CHAMBER MATERIALS AND DESIGN CONCEPTS EVALUATION (2005)
Crump, D. N., Poulos, E. N., Pearson, J. B., Smith, K. J.
A program was conducted to investigate and evaluate new and unique designs of non-regenerative combustion chambers and nozzles using new materials or new techniques for applying the best materials....
EVALUATION OF THE BIOCHEMICAL AND PHYSIOLOGICAL EFFECTS OF CONFINEMENT ON HUMAN SUBJECTS. (2005)
Homer,G. M., Blanchard,W. W., Dunco,D. W., Smith,K. J., George,Marilyn E.
A series of experiments has been designed to determine the water, energy, and protein requirements of man under various simulated aerospace conditions. The reported 42-day experiment was designed to...
NUTRITIONAL ACCEPTABILITY OF A DEHYDRATED DIET. (2005)
SPECKMANN,E. W., Smith,K. J., Vanderveen,J. E., Homer,G. M., Dunco,D. Wiltsie
Precooked, dehydrated and bite size compressed foods were arranged into a nutritionally balanced four-day cycle experimental menu with four meals per day. A control menu composed of frozen, fresh and...
Smith,K. J., Speckmann,E. W., George,Marilyn E., Homer,G. M., Dunco,D. Wiltsie
A series of experiments has been designed to determine the water, energy, and protein requirements of man under various simulated aerospace conditions. The experiment described measured the effects...
PHYSIOLOGICAL STATUS OF MEN SUBJECTED TO PROLONGED CONFINEMENT. (2005)
Speckmann,E. W., Smith,K. J., Offner,K. M., Day,J. L.
To determine if confinement of men resulted in physiological changes, 12 men in groups of 4 each were confined for 28 consecutive days. During this time, daily measurements of ECG, EEG, blood...
Interactions among smoking, obesity, and symptoms of acid reflux in Barrett's esophagus (2005)
Smith, K.J., O'Brien, S.M., Smithers, B.M., Gotley, D.C., Webb, PM, Green, A.C., ...
Background: Barrett's esophagus, a metaplastic precursor to esophageal adenocarcinoma, is becoming increasingly prevalent in many populations. Clinical studies suggest acid reflux causes Barrett's...
Axonal protection using flecainide in experimental autoimmune encephalomyelitis (2004)
Bechtold, D.A., Kapoor, R., Smith, K.J.
Axonal degeneration is a major cause of permanent neurological deficit in multiple sclerosis (MS), but no current therapies for the disease are known to be effective at axonal protection. Here, we...
Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration (2003)
Kapoor, R., Davies, M., Blaker, P.A., Hall, S.M., Smith, K.J.
Axonal degeneration can be an important cause of permanent disability in neurological disorders in which inflammation is prominent, including multiple sclerosis and Guillain-Barré syndrome. The...
Emsley, J.W., Merlet, D., Smith, K.J., Suryaprakash, N.
It is shown that the proton NMR spectra of molecules containing rare spins at natural abundance dissolved in a liquid crystalline solvent can be obtained free from the strong lines from the spectrum...
Anney, R. J., Rees, Mark Ian, Bryan, E., Spurlock, Gillian, Williams, N., Norton, Nadine, ...
The dopamine D3 receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported...
Anney, R. J., Rees, Mark Ian, Bryan, E., Spurlock, Gillian, Williams, Nigel Melville, Norton, Nadine, ...
The dopamine D3 receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported...
Kubota, Y., Temelcos, C., Bathgate, R.A.D., Smith, K.J., Scott, D., Zhao, C., ...
Transabdominal testicular descent is influenced by various anatomical and hormonal factors and is mediated by gubernacular enlargement and regression of the cranial suspensory ligament, but its...
Electrically active axons degenerate when exposed to nitric oxide (2001)
Smith, K.J., Kapoor, R., Hall, S.M., Davies, M.
Axonal degeneration is a major cause of permanent deficit in inflammatory neurological diseases such as multiple sclerosis. Axons undergo degeneration specifically at the site of the inflammatory...
Redford, E. J., Hall, S.M., Smith, K. J.
Several observations suggest that tumour necrosis factor (TNF) plays a role in demyelination, although direct evidence for this is lacking. We have examined ultrastructurally rat sciatic nerves...
Central demyelination induced in vivoby the calcium ionophore ionomycin (1994)
The effects of injecting the calcium-selective ionophore, ionomycin, into myelinated tracts in the dorsal columns of adult rat spinal cords were examined electron microscopically. In vivo, ionomycin...
Studies directed towards the synthesis of FK506. (1993)
Smith, K.J, Southampton Univ. (GB).
Thesis (Ph.D.)
Zhong, D, Smith, K J, Birktoft, J J, Bajaj, S P
Factor IX consists of a gamma-carboxyglutamic acid-rich domain followed by two epidermal growth factor (EGF)-like domains and the C-terminal protease domain. To delineate the function of EGF1 domain...
The APC gene product in normal and tumor cells.
Smith, K J, Johnson, K A, Bryan, T M, Hill, D E, Markowitz, S, Willson, J K, ...
The APC gene has been found to be mutated during the development of sporadic colorectal tumors as well as in the germ line of familial adenomatous polyposis patients. To facilitate the...
Elgh, F, Lundkvist, A, Alexeyev, O A, Stenlund, H, Avsic-Zupanc, T, Hjelle, B, ...
Worldwide, hantaviruses cause more than 100,000 human infections annually. Rapid and accurate methods are important both in monitoring acute infections and for epidemiological studies. We and others...
Rees, D J, Jones, I M, Handford, P A, Walter, S J, Esnouf, M P, Smith, K J, ...
beta-Hydroxyaspartic acid is a post-translationally modified amino acid found in a number of plasma proteins in a domain homologous to epidermal growth factor. Its presence can be correlated with a...
Smith, K J, Ashley, C R, Darville, J M, Harbour, J, Roome, A
Isolates of herpes simplex virus which had previously been typed by restriction enzyme analysis were typed again with a commercial ELISA system using polyclonal antibodies. There was complete...
Comparison of ELISA with virus isolation for the diagnosis of genital herpes.
Alexander, I, Ashley, C R, Smith, K J, Harbour, J, Roome, A P, Darville, J M
An enzyme linked immunosorbent assay (ELISA) system which detects and simultaneously types herpes simplex virus antigens in clinical specimens from patients with genital herpes has been compared with...
Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.
1. Internal gallamine triethiodide (Flaxedil) modifies Na+ channel kinetics in Myxicola axons but does not alter K+ conductance. The drug has no effect externally. 2. Gallamine initially increases...
The number and topographic distribution of the profiles of degenerating primary afferent fibres were determined within the rat dorsal column 3-4 weeks after division of the lumbar and S2 dorsal...
Monoclonal antibodies to coagulation factor IX define a high-frequency polymorphism by immunoassays.
Monoclonal antibodies have been used to demonstrate a polymorphism of human plasma coagulation factor IX antigen in double antibody solid-phase immunoradiometric assays. This polymorphism is detected...
Zhong, D, Smith, K J, Birktoft, J J, Bajaj, S P
Factor IX consists of a gamma-carboxyglutamic acid-rich domain followed by two epidermal growth factor (EGF)-like domains and the C-terminal protease domain. To delineate the function of EGF1 domain...
The APC gene product in normal and tumor cells.
Smith, K J, Johnson, K A, Bryan, T M, Hill, D E, Markowitz, S, Willson, J K, ...
The APC gene has been found to be mutated during the development of sporadic colorectal tumors as well as in the germ line of familial adenomatous polyposis patients. To facilitate the...
Elgh, F, Lundkvist, A, Alexeyev, O A, Stenlund, H, Avsic-Zupanc, T, Hjelle, B, ...
Worldwide, hantaviruses cause more than 100,000 human infections annually. Rapid and accurate methods are important both in monitoring acute infections and for epidemiological studies. We and others...
Rees, D J, Jones, I M, Handford, P A, Walter, S J, Esnouf, M P, Smith, K J, ...
beta-Hydroxyaspartic acid is a post-translationally modified amino acid found in a number of plasma proteins in a domain homologous to epidermal growth factor. Its presence can be correlated with a...
Smith, K J, Ashley, C R, Darville, J M, Harbour, J, Roome, A
Isolates of herpes simplex virus which had previously been typed by restriction enzyme analysis were typed again with a commercial ELISA system using polyclonal antibodies. There was complete...
Comparison of ELISA with virus isolation for the diagnosis of genital herpes.
Alexander, I, Ashley, C R, Smith, K J, Harbour, J, Roome, A P, Darville, J M
An enzyme linked immunosorbent assay (ELISA) system which detects and simultaneously types herpes simplex virus antigens in clinical specimens from patients with genital herpes has been compared with...
Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.
1. Internal gallamine triethiodide (Flaxedil) modifies Na+ channel kinetics in Myxicola axons but does not alter K+ conductance. The drug has no effect externally. 2. Gallamine initially increases...
The number and topographic distribution of the profiles of degenerating primary afferent fibres were determined within the rat dorsal column 3-4 weeks after division of the lumbar and S2 dorsal...
Monoclonal antibodies to coagulation factor IX define a high-frequency polymorphism by immunoassays.
Monoclonal antibodies have been used to demonstrate a polymorphism of human plasma coagulation factor IX antigen in double antibody solid-phase immunoradiometric assays. This polymorphism is detected...
The pathophysiology of multiple sclerosis is reviewed, with emphasis on the axonal conduction properties underlying the production of symptoms, and the course of the disease. The major cause of the...
The effect of metoclopramide and atropine on the absorption of orally administered mexiletine.
Wing, L M, Meffin, P J, Grygiel, J J, Smith, K J, Birkett, D J
The effect of pretreatment with intravenous metoclopramide (10 mg) and atropine (0.6 mg), both separately and combined, on the absorption rate and relative oral bioavailability of the antiarrhythmic...
Miners, J O, Wing, L M, Lillywhite, K J, Smith, K J
The effects of separate 1 week pre-treatments with each of the beta-adrenoceptor antagonists, propranolol (80 mg every 12 h), metoprolol (100 mg every 12 h) and atenolol (50 mg once daily), on the...
Insights into post‐infectious bronchiolitis obliterans in children
New information contributing to our understanding of risk factors predisposing to bronchiolitis obliterans in children