Disposition and Elimination of BIOLF-143, an Antiviral Agent, in the Rabbit (1990)
ECOBICHON, D. J., BONDZI-SlMPSON, F., COMEAU, A. M., MEKHAEL, K. M., MAJOR, P., OGILVIE, K. K.
Disposition and Elimination of BIOLF-143, an Antiviral Agent, in the Rabbit. ECOBICHON, D. J., BONDZI-SIMPSON, F., COMEAU, A. M., MEKHAEL, K. M., MAJOR, P., AND OGJLVIE, K. K. (1990). Fundam. Appl....
The Acute Toxicity of BIOLF-143 in the Rat (1988)
ECOBICHON, D. J., MEKHAEL, K. M., MAJORS, P., OGILVIE, K.K.
The Acute Toxicity of BIOLF-143 in the Rat. ECOBICHON, D. J., MEKHAEL, K. M., MAJOR, P., AND OGILVIE, K. K. (1988). Fundam. Appl. Toxicol. 10, 313-320. BIOLF-143, an experimental, purine-based...
Antimyocarditic activity of the guanine derivative BIOLF-70 in a coxsackievirus B3 murine model.
Gauntt, C J, Arizpe, H M, Kung, J T, Ogilvie, K K, Cheriyan, U O
Prophylactic administration of a nontoxic dose of 9-[[2-benzyloxyl-1-(benzyloxymethyl)ethoxy]methyl]-6-chlo roguanine (BIOLF-70) to mice reduced the number of myocarditic lesions induced by...
Smith, K O, Galloway, K S, Kennell, W L, Ogilvie, K K, Radatus, B K
A novel nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-guanine (BIOLF-62), was found to have potent antiviral activity against herpes simplex virus types 1 and 2 at concentrations...
Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds.
Smith, K O, Galloway, K S, Ogilvie, K K, Cheriyan, U O
9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1...
Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activity.
Ogilvie, K K, Usman, N, Nicoghosian, K, Cedergren, R J
Chemical synthesis is described of a 77-nucleotide-long RNA molecule that has the sequence of an Escherichia coli Ado-47-containing tRNA(fMet) species in which the modified nucleosides have been...
Pon, R T, Usman, N, Damha, M J, Ogilvie, K K
Phosphoramidite reagents can phosphitylate guanine bases at the O6-position during solid phase synthesis and serious chain cleavage occurs if the base phosphitylation is not eliminated before the...
Prevention of chain cleavage in the chemical synthesis of 2'-silylated oligoribonucleotides.
Strong aqueous ammonium hydroxide used to remove N-acyl protecting groups from synthetic oligoribonucleotides causes removal of some alkylsilyl protecting groups from 2'-hydroxyls and leads to chain...
Pon, R T, Damha, M J, Ogilvie, K K
Nucleoside 3'-phosphoramidite and chlorophosphite reagents have been found to react with the lactam function of guanine. This reaction caused unsatisfactory results when oligodeoxyribonucleotides...
The t-butyldimethylsilyl group is shown to be an ideal protecting group for the 2T-hydroxyl function of ribonucleosides during the synthesis of ribonucleotides using any of nine commonly used...
Ogilvie, K K, Beaucage, S L, Gillen, M F, Entwistle, D, Quilliam, M
Alkyl halides react rapidly with purines and pyrimidines in the presence of fluoride ion. Alkylation of thymidine leads to novel dimeric nucleoside derivatives bridged through N3. Alkylation of...
Ogilvie, K K, Beaucage, S L, Gillen, M F, Entwistle, D W
Trimethyl phosphate, dimethyl and diethyl sulfate and methyl and ethyl methanesulfonate all give high yields of alkylation on purines and pyrimidines in the presence of tetrabutylammonium fluoride....
Fluoride ion promoted deprotection and transesterification in nucleotide triesters.
Tetrabutylammonium fluoride will remove phenyl, trichloroethyl and cyanoethyl groups from nucleotides. In addition to the desired nucleotide products other results including chain cleavage,...
Synthesis of hexanucleotide analogues containing diisopropylsilyl internucleotide linkages.
The synthesis of two silyl-linked hexanucleotide analogues is described. Hypochromicity and CD measurements indicate that the thymidine hexanucleotide analogue bears a strong resemblance to its...
Antimyocarditic activity of the guanine derivative BIOLF-70 in a coxsackievirus B3 murine model.
Gauntt, C J, Arizpe, H M, Kung, J T, Ogilvie, K K, Cheriyan, U O
Prophylactic administration of a nontoxic dose of 9-[[2-benzyloxyl-1-(benzyloxymethyl)ethoxy]methyl]-6-chlo roguanine (BIOLF-70) to mice reduced the number of myocarditic lesions induced by...
Smith, K O, Galloway, K S, Kennell, W L, Ogilvie, K K, Radatus, B K
A novel nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-guanine (BIOLF-62), was found to have potent antiviral activity against herpes simplex virus types 1 and 2 at concentrations...
Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds.
Smith, K O, Galloway, K S, Ogilvie, K K, Cheriyan, U O
9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1...
Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activity.
Ogilvie, K K, Usman, N, Nicoghosian, K, Cedergren, R J
Chemical synthesis is described of a 77-nucleotide-long RNA molecule that has the sequence of an Escherichia coli Ado-47-containing tRNA(fMet) species in which the modified nucleosides have been...
Pon, R T, Usman, N, Damha, M J, Ogilvie, K K
Phosphoramidite reagents can phosphitylate guanine bases at the O6-position during solid phase synthesis and serious chain cleavage occurs if the base phosphitylation is not eliminated before the...
Prevention of chain cleavage in the chemical synthesis of 2'-silylated oligoribonucleotides.
Strong aqueous ammonium hydroxide used to remove N-acyl protecting groups from synthetic oligoribonucleotides causes removal of some alkylsilyl protecting groups from 2'-hydroxyls and leads to chain...
Pon, R T, Damha, M J, Ogilvie, K K
Nucleoside 3'-phosphoramidite and chlorophosphite reagents have been found to react with the lactam function of guanine. This reaction caused unsatisfactory results when oligodeoxyribonucleotides...
The t-butyldimethylsilyl group is shown to be an ideal protecting group for the 2T-hydroxyl function of ribonucleosides during the synthesis of ribonucleotides using any of nine commonly used...
Ogilvie, K K, Beaucage, S L, Gillen, M F, Entwistle, D, Quilliam, M
Alkyl halides react rapidly with purines and pyrimidines in the presence of fluoride ion. Alkylation of thymidine leads to novel dimeric nucleoside derivatives bridged through N3. Alkylation of...
Ogilvie, K K, Beaucage, S L, Gillen, M F, Entwistle, D W
Trimethyl phosphate, dimethyl and diethyl sulfate and methyl and ethyl methanesulfonate all give high yields of alkylation on purines and pyrimidines in the presence of tetrabutylammonium fluoride....
Fluoride ion promoted deprotection and transesterification in nucleotide triesters.
Tetrabutylammonium fluoride will remove phenyl, trichloroethyl and cyanoethyl groups from nucleotides. In addition to the desired nucleotide products other results including chain cleavage,...
Synthesis of hexanucleotide analogues containing diisopropylsilyl internucleotide linkages.
The synthesis of two silyl-linked hexanucleotide analogues is described. Hypochromicity and CD measurements indicate that the thymidine hexanucleotide analogue bears a strong resemblance to its...