K. Kasahara

Publication List Details

Period

1990 - 2009

Number

78

Co-Authors

Large-scale sidereal anisotropy of multi-TeV galactic cosmic rays and the heliosphere (2009)

Amenomori, M., Bi, X. J., Chen, D., Cui, S. W., Ding, L. K., ...

We develop a model anisotropy best-fitting to the two-dimensional sky-map of multi-TeV galactic cosmic ray (GCR) intensity observed with the Tibet III air shower (AS) array. By incorporating a pair...

Electrical injection and detection of spin-polarized electrons in silicon through an Fe_3Si/Si Schottky tunnel barrier (2009)

Ando, Y., Hamaya, K., Kasahara, K., Kishi, Y., Ueda, K., Sawano, K., ...

We demonstrate electrical injection and detection of spin-polarized electrons in silicon (Si) using epitaxially grown Fe_3Si/Si Schottky-tunnel-barrier contacts. By an insertion of a delta-doped...

High-energy electron observations by PPB-BETS flight in Antarctica (2008)

Torii, S., Yamagami, T., Tamura, T., Yoshida, K., Kitamura, H., Anraku, K., ...

We have observed cosmic-ray electrons from 10 GeV to 800 GeV by a long duration balloon flight using Polar Patrol Balloon (PPB) in Antarctica. The observation was carried out for 13 days at an...

New estimation of the spectral index of high-energy cosmic rays as determined by the Compton-Getting anisotropy (2007)

Amenomori, M., Bi, X. J., Chen, D., Cui, S. W., Ding, L. K., ...

The amplitude of the Compton-Getting (CG) anisotropy contains the power-law index of the cosmic-ray energy spectrum. Based on this relation and using the Tibet air-shower array data, we measure the...

Future plan for observation of cosmic gamma rays in the 100 TeV energy region with the Tibet air shower array : simulation and sensitivity (2007)

Amenomori, M., Bi, X. J., Chen, D., Cui, S. W., Ding, L. K., ...

The Tibet air shower array, which has an effective area of 37,000 square meters and is located at 4300 m in altitude, has been observing air showers induced by cosmic rays with energies above a few...

Future plan for observation of cosmic gamma rays in the 100 TeV energy region with the Tibet air shower array : physics goal and overview (2007)

Amenomori, M., Bi, X. J., Chen, D., Cui, S. W., Ding, L. K., ...

The Tibet air shower array, which has an effective area of 37,000 square meters and is located at 4300 m in altitude, has been observing air showers induced by cosmic rays with energies above a few...

Performance of the prototype detector for the LHCf experiment (2007)

Sako, T., Adriani, O., Bonechi, L., Bongi, M., Faus, Ángeles, Haguenauer, M., ...

14 pages, 11 figures.-- PACS nrs.: 13.85.Tp; 95.30.Cq; 95.55.Vj; 95.85.Ry.-- ISI Article Identifier: 000248784500012

LHCf: A LHC detector for astroparticle physics (2007)

D'Alessandro, Raffaello, Adriani, O., Bonechi, L., Bongi, M., Papini, P., Castellini, G., ...

10 pages, 10 figures.-- PACS nrs.: 13.85.Tp, 13.85.Ni, 13.85.Qk.-- ISI Article Identifier: 000245672900017.-- Presented at the "Physics at LHC" Conference, Kraków, Poland, July 3–8, 2006.

Calculation of atmospheric neutrino flux using the interaction model calibrated with atmospheric muon data (2006)

Honda, M., Kajita, T., Kasahara, K., Midorikawa, S., Sanuki, T.

Using the ``modified DPMJET-III'' model explained in the previous paper, we calculate the atmospheric neutrino flux. The calculation scheme is almost the same as HKKM04 \cite{HKKM2004}, but the usage...

Study of cosmic ray interaction model based on atmospheric muons for the neutrino flux calculation (2006)

Sanuki, T., Honda, M., Kajita, T., Kasahara, K., Midorikawa, S.

We have studied the hadronic interaction for the calculation of the atmospheric neutrino flux by summarizing the accurately measured atmospheric muon flux data and comparing with simulations. We find...

Joint LIGO and TAMA300 search for gravitational waves from inspiralling neutron star binaries (2006)

Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Agresti, J., Ajith, P., ...

We search for coincident gravitational wave signals from inspiralling neutron star binaries using LIGO and TAMA300 data taken during early 2003. Using a simple trigger exchange method, we perform an...

Joint LIGO and TAMA300 search for gravitational waves from inspiralling neutron star binaries (2006)

Abbott, B., Abbott, R., Adhikari, R., Ageev, A., Agresti, Juri, Ajith, P., ...

We search for coincident gravitational wave signals from inspiralling neutron star binaries using LIGO and TAMA300 data taken during early 2003. Using a simple trigger exchange method, we perform an...

Results of the search for inspiraling compact star binaries from TAMA300's observation in 2000-2004 (2006)

Akutsu, Tomomi, Akutsu, Tomotadu, Ando, Masaki, Arai, Koji, Araya, Akito, Asada, H., ...

We analyze the data of the TAMA300 detector to search for gravitational waves from inspiraling compact star binaries with masses of the component stars in the range 1M[sun]–3M[sun]. In this...

The Current Status and Prospect of the Ta Experiment (2005)

Kasahara, K.

The Telescope Array (TA) experiment is designed to observe cosmic-ray-induced air showers at extremely high energies. It is being deployed in a desert of Utah, USA; an array of 3 m^2 scintillation...

A New calculation of the atmospheric neutrino flux in a 3-dimensional scheme (2004)

Honda, M., Kajita, T., Kasahara, K., Midorikawa, S.

We have revised the calculation of the flux of atmospheric neutrinos based on a 3-dimensional scheme with the realistic IGRF geomagnetic model. The primary flux model has been revised, based on the...

Calculation of Muon Fluxes at the Small Atmospheric Depths (2003)

Abe, K., Honda, M., Kasahara, K., Kajita, T., Midorikawa, S., Sanuki, T.

Precise knowledge of the hadronic interaction between primary cosmic rays and atmospheric nuclei is very important and fundamental to study atmospheric neutrinos and their oscillations. We studied...

Atmospheric gamma-ray observation with the BETS detectorfor calibrating atmospheric neutrino flux calculations (2002)

Kasahara, K., Mochizuki, E., Torii, S., Tamura, T., Tateyama, N., Yoshida, K., ...

We observed atmospheric gamma-rays around 10 GeV at balloon altitudes (15~25 km) and at a mountain (2770 m a.s.l). The observed results were compared with Monte Carlo calculations to find that an...

Comparison of 3-Dimensional and 1-Dimensional Schemes in the calculation of Atmospheric Neutrinos (2001)

Honda, M., Kajita, T., Kasahara, K., Midorikawa, S.

A 3-dimensional calculation of atmospheric neutrinos flux is presented, and the results are compared with those of a 1-dimensional one. In this study, interaction and propagation of particles is...

Test by JANZOS of the Standard Model of Cosmic Ray Acceleration in the COMPTEL/ROSAT Supernova Renmant (1999)

Abe, F., Bond, I., Budding, E., Daniel, A., Dobcsanyi, P., Fujii, H., ...

A search for ultra-high energy gamma-rays emitted by the young, nearby supernova remnant that was discovered recently by the COMPTEL and ROSAT satellites was made using the JANZOS database for the...

High Temperature Oxidation Behavior of TiAl-Base Alloys with Additions of Third Elements. (1998)

Kasahara, K., Hashimoto, K., Doi, H., Tsujimoto, T.

Oxidation behavior of the intermetallic compound TiAl with additions of Cr, Y, Mn and Si as the third elements has been investigated from 1123-1223 K under ambient condition; small additions of Cr or...

Comparison of Atmospheric Neutrino Flux Calculations at Low Energies (1996)

Gaisser, T. K., Honda, M., Kasahara, K., Lee, H., Midorikawa, S., Naumov, V., ...

We compare several different calculations of the atmospheric neutrino flux in the energy range relevant for contained neutrino interactions, and we identify the major sources of difference among the...

Atmospheric Neutrinos (1995)

Honda, M., Kajita, T., Kasahara, K., Midorikawa, S.

The atmospheric neutrino-flux is calculated over the wide energy range from 1 GeV to 3,000 GeV for the study of neutrino-physics using the data from underground neutrino-detectors. The uncertainty of...

Calculation of the Flux of Atmospheric Neutrinos (1995)

Honda, M., Kajita, T., Midorikawa, S., Kasahara, K.

Atmospheric neutrino-fluxes are calculated over the wide energy range from 30 MeV to 3,000 GeV for the study of neutrino-physics using the data from underground neutrino-detectors. The atmospheric...

Photonic Packet Switch Based on a VSTEP Two-Dimensional Arrays, (1992)

Suzuki, S., Kasahara, K.

Photonic ATM switches, using two dimensional arrays as buffer memories and routing fabrics are discussed. Possible switch performance is estimated based on a vertical-to surface transmission...

Surface-Emitting-Laser Operation and Optical Switching Characteristics in Vertical to Surface Transmission Electro-Photonic Devices with a Vertical Cavity (VC-VSTEP), (1992)

Ogura, I., Numai, T., Kosaka, H., Sugimoto, M., Kasahara, K.

The advantage of optical interconnections over electronic interconnections is that they are free of mutual interference and require no capacitive charging. The development of low power consumption...

Progress in Arrays of Opto-Electronic Bistable Devices and Sources, (1992)

Kasahara, K., Ogura, I., Yamanaka, Y.

With recent progress in semiconductor arrays of opto-electronic bistable devices and sources, highly parallel optical interconnections and information processing has gradually become a reality. The...

Human neutrophils exhibit disparate chemotactic factor gene expression (1990)

Strieter, Robert M., Kasahara, K., Allen, R., Showell, H.J., Standiford, T.J., Kunkel, Steven L.

The evolution of acute inflammation from initiation through resolution is associated with the changing character of the infiltrating leukocytes. Recruitment of these leukocytes is dependent upon the...

Disparate regulation of interleukin 8 gene expression from blood monocytes, endothelial cells, and fibroblasts by interleukin 4 (1990)

Standiford, T. J., Strieter, Robert M., Kasahara, K., Kunkel, Steven L.

The role(s) of novel chemotactic cytokines as mediators in the pathogenesis of many acute and chronic disease states is becoming increasingly apparent. One of these cytokines, interleukin 8, is a...

Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.

Nara, K, Watanabe, Y, Maruyama, K, Kasahara, K, Nagai, Y, Sanai, Y

Using an expression cloning approach, we have isolated a cDNA encoding GD3 synthase (CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase, EC 2.4.99.8), which is a key...

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

Matsumura, H, Nakajima, T, Osaka, T, Satoh, S, Kawase, K, Kubo, E, ...

The site of action for the sleep-promoting effect of prostaglandin (PG) D2 was extensively examined in the brain of adult male rats (n = 231). PGD2 was administered at 100 pmol/0.2 microliter per min...

Isolation of a Suppressor-mutator/Enhancer-like transposable element, Tpn1, from Japanese morning glory bearing variegated flowers.

Inagaki, Y, Hisatomi, Y, Suzuki, T, Kasahara, K, Iida, S

The Japanese morning glory has an extensive history of genetic studies. Many mutants in the colors and shapes of its flowers and leaves have been isolated since the 17th century, and more than 200...

Regulation of Mycobacterium bovis BCG and foreign body granulomas in mice by the Bcg gene.

Sato, I Y, Kobayashi, K, Kasama, T, Kaga, S, Kasahara, K, Kanemitsu, H, ...

Natural bactericidal resistance to Mycobacterium bovis BCG is under the control of a single gene, designated Bcg. Lung granuloma formation in susceptible (Bcgs) and resistant (Bcgr) mice was studied...

Molecular basis of selective IgG2 deficiency. The mutated membrane-bound form of gamma2 heavy chain caused complete IGG2 deficiency in two Japanese siblings.

Tashita, H, Fukao, T, Kaneko, H, Teramoto, T, Inoue, R, Kasahara, K, ...

Patients with IgG2 deficiency have recurrent sinopulmonary infections caused by Pneumococcus and Hemophilus. Hereditary and selective IgG2 deficiency was suspected in two Japanese siblings whose...

Pancreatoduodenectomy with preservation of the pylorus and gastroduodenal artery.

Nagai, H, Ohki, J, Kondo, Y, Yasuda, T, Kasahara, K, Kanazawa, K

OBJECTIVE: The authors evaluated the rationale for and feasibility of gastroduodenal artery preservation in pylorus-preserving pancreatoduodenectomy (PPPD) for periampullary cancer in which the...

Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.

Nara, K, Watanabe, Y, Maruyama, K, Kasahara, K, Nagai, Y, Sanai, Y

Using an expression cloning approach, we have isolated a cDNA encoding GD3 synthase (CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase, EC 2.4.99.8), which is a key...

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

Matsumura, H, Nakajima, T, Osaka, T, Satoh, S, Kawase, K, Kubo, E, ...

The site of action for the sleep-promoting effect of prostaglandin (PG) D2 was extensively examined in the brain of adult male rats (n = 231). PGD2 was administered at 100 pmol/0.2 microliter per min...

Isolation of a Suppressor-mutator/Enhancer-like transposable element, Tpn1, from Japanese morning glory bearing variegated flowers.

Inagaki, Y, Hisatomi, Y, Suzuki, T, Kasahara, K, Iida, S

The Japanese morning glory has an extensive history of genetic studies. Many mutants in the colors and shapes of its flowers and leaves have been isolated since the 17th century, and more than 200...

Regulation of Mycobacterium bovis BCG and foreign body granulomas in mice by the Bcg gene.

Sato, I Y, Kobayashi, K, Kasama, T, Kaga, S, Kasahara, K, Kanemitsu, H, ...

Natural bactericidal resistance to Mycobacterium bovis BCG is under the control of a single gene, designated Bcg. Lung granuloma formation in susceptible (Bcgs) and resistant (Bcgr) mice was studied...

Molecular basis of selective IgG2 deficiency. The mutated membrane-bound form of gamma2 heavy chain caused complete IGG2 deficiency in two Japanese siblings.

Tashita, H, Fukao, T, Kaneko, H, Teramoto, T, Inoue, R, Kasahara, K, ...

Patients with IgG2 deficiency have recurrent sinopulmonary infections caused by Pneumococcus and Hemophilus. Hereditary and selective IgG2 deficiency was suspected in two Japanese siblings whose...

Pancreatoduodenectomy with preservation of the pylorus and gastroduodenal artery.

Nagai, H, Ohki, J, Kondo, Y, Yasuda, T, Kasahara, K, Kanazawa, K

OBJECTIVE: The authors evaluated the rationale for and feasibility of gastroduodenal artery preservation in pylorus-preserving pancreatoduodenectomy (PPPD) for periampullary cancer in which the...

Granuloma formation by artificial microparticles in vitro. Macrophages and monokines play a critical role in granuloma formation.

Shikama, Y., Kobayashi, K., Kasahara, K., Kaga, S., Hashimoto, M., Yoneya, I., ...

To investigate the basic mechanisms of granuloma formation, in vitro granulomas were induced by culturing murine spleen cells in the presence of artificial microparticles. Large granulomas developed...

Direct evidence for granuloma-inducing activity of interleukin-1. Induction of experimental pulmonary granuloma formation in mice by interleukin-1-coupled beads.

Kasahara, K., Kobayashi, K., Shikama, Y., Yoneya, I., Soezima, K., Ide, H., ...

Pulmonary granulomas were induced in BALB/c mice by the intratracheal injection of Sephadex G-50 and latex beads. Very large granulomas developed around Sephadex G-50 beads. Minimal inflammation was...

Cytokine-induced neutrophil-derived interleukin-8.

Strieter, R. M., Kasahara, K., Allen, R. M., Standiford, T. J., Rolfe, M. W., Becker, F. S., ...

During acute inflammation, the first line of cellular response for host defense is the neutrophil. In addition to the historic role of the neutrophil as a phagocyte, recent studies have identified...

Failure of IgG production due to a defect in the opening of the chromatin structure of I gamma 1 region in a patient with IgG and IgA deficiency.

Kondo, N, Inoue, R, Kasahara, K, Kaneko, H, Kameyama, T, Orii, T

Patients with common variable immunodeficiency (CVID) display reduced levels of two or all three of the major immunoglobulin isotypes, and the deficiency is characterized by failure of B cells to...

Reduced secreted mu mRNA synthesis in selective IgM deficiency of Bloom's syndrome.

Kondo, N, Ozawa, T, Kato, Y, Motoyoshi, F, Kasahara, K, Kameyama, T, ...

Serum IgM concentrations were low although serum IgG and IgA concentrations were normal in both our patients with Bloom's syndrome. Although the percentages of surface IgM-bearing cells were not...

Molecular analysis of B-cell differentiation in selective or partial IgA deficiency

ASANO, T, KANEKO, H, TERADA, T, KASAHARA, Y, FUKAO, T, KASAHARA, K, ...

Selective IgA deficiency is the most common form of primary immunodeficiency, the molecular basis of which is unknown. To investigate the cause of selective IgA deficiency, we examined what stage of...

Leaky phenotype of X-linked agammaglobulinaemia in a Japanese family

Kaneko, H, Kawamoto, N, Asano, T, Mabuchi, Y, Horikoshi, H, Teramoto, T, ...

X-linked agammaglobulinaemia (XLA) is an inherited immunodeficiency that is caused by a block in early B-cell differentiation. Whereas early B precursors in the bone marrow are present in substantial...

Expression of Pax5 gene in human haematopoietic cells and tissues: comparison with immunodeficient donors

Kaneko, H, Ariyasu, T, Inoue, R, Fukao, T, Kasahara, K, Teramoto, T, ...

In mice, Pax5 gene is indispensable for B cell development. Pax5-deficient mice fail to produce mature B cells owing to complete arrest of B cell development at a precursor stage. However, the...

Expression of the BLM gene in human haematopoietic cells

Kaneko, H, Matsui, E, Fukao, T, Kasahara, K, Morimoto, W, Kondo, N

Bloom's syndrome (BS) is a rare autosomal recessive disorder characterized by stunted growth, sun-sensitive erythema and immunodeficiency. Chromosomal abnormalities are often observed. Patients with...

Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma

Kasahara, K, Shiba, K, Ozawa, T, Okuda, K, Adachi, M

Background: The epithelial reticular basement membrane (Rbm) of the airway wall thickens in patients with asthma. However, whether the thickening parallels whole airway wall thickening, which limits...

Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders.

Kondo, N, Kobayashi, Y, Shinoda, S, Kasahara, K, Kameyama, T, Iwasa, S, ...

Proliferative responses of cord blood lymphocytes (CBLs) to food antigens and cord blood IgE concentrations were measured in 37 full term newborn infants for the prediction of allergic disorders. In...

Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin.

Nishio, K., Sugimoto, Y., Nakagawa, K., Niimi, S., Fujiwara, Y., Bungo, M., ...

The growth inhibitory effect of tumour promoters on human leukaemia and lung cancer cell lines was examined using the [3-(4,5 dimethylthiazol)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. The four...

Giant-cell tumour of bone: cytological studies.

Kasahara, K., Yamamuro, T., Kasahara, A.

Cell-surface markers were investigated in 7 patients with giant-cell tumours and 30 patients with other tumours as controls. 25--55% of mononuclear cells in giant-cell tumours showed...

Modulation of sensitivity to cis-diamminedichloroplatinum (II) by thromboxane A2 receptor antagonists in non-small-cell lung cancer cell lines.

Kasahara, K., Fujimura, M., Bando, T., Shibata, K., Shirasaki, H., Matsuda, T.

We examined the effect of selective thromboxane A2 (TXA2) receptor antagonists, calcium 5(Z)-1R, 2S, 3S, 4S-7-[3-phenylsulphonylaminobicyclo [2.2.1] hept-2-yl]-5-heptonoate hydrate (S-1452) and +/-...

Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA)

Kimura, H, Suminoe, M, Kasahara, K, Sone, T, Araya, T, Tamori, S, ...

The aim of this study was to evaluate the usefulness of EGFR mutation status in serum DNA as a means of predicting a benefit from gefitinib (IRESSA) therapy in Japanese patients with non-small cell...

EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib

Kimura, H, Fujiwara, Y, Sone, T, Kunitoh, H, Tamura, T, Kasahara, K, ...

Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common...