Mutational spectrometry without phenotypic selection: human mitochondrial DNA (1997)
Khrapko, K, Coller, H, Andre, P, Li, XC, Foret, F, Belenky, A, ...
Khrapko, K., Hanekamp, J.S., Thilly, W.G., Belenkii, A., Foret, F., Karger, B.L.
Using a zone of constant temperature and denaturant concentration in capillary electrophoresis, we have devised a simple, rapid, and reproducible system for separating mutant from wild type DNA...
Mutational spectrometry without phenotypic selection: human mitochondrial DNA.
Khrapko, K, Coller, H, André, P, Li, X C, Foret, F, Belenky, A, ...
By first separating mutant from nonmutant DNA sequences on the basis of their melting temperatures and then increasing the number of copies by high-fidelity DNA amplification, we have developed a...
Identification of point mutations in mixtures by capillary electrophoresis hybridization.
Khrapko, K, Coller, H A, Hanekamp, J S, Thilly, W G
We have developed a rapid method for unambiguous identification and mutant fraction determination of individual mutants in mixtures of DNA sequence variants each differing by one or a few...
Khrapko, K, Bodyak, N, Thilly, W G, Van Orsouw, N J, Zhang, X, Coller, H A, ...
Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the...
Khrapko, K, Hanekamp, J S, Thilly, W G, Belenkii, A, Foret, F, Karger, B L
Using a zone of constant temperature and denaturant concentration in capillary electrophoresis, we have devised a simple, rapid, and reproducible system for separating mutant from wild type DNA...
Mutational spectrometry without phenotypic selection: human mitochondrial DNA.
Khrapko, K, Coller, H, André, P, Li, X C, Foret, F, Belenky, A, ...
By first separating mutant from nonmutant DNA sequences on the basis of their melting temperatures and then increasing the number of copies by high-fidelity DNA amplification, we have developed a...
Identification of point mutations in mixtures by capillary electrophoresis hybridization.
Khrapko, K, Coller, H A, Hanekamp, J S, Thilly, W G
We have developed a rapid method for unambiguous identification and mutant fraction determination of individual mutants in mixtures of DNA sequence variants each differing by one or a few...
Khrapko, K, Bodyak, N, Thilly, W G, Van Orsouw, N J, Zhang, X, Coller, H A, ...
Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the...
Khrapko, K, Hanekamp, J S, Thilly, W G, Belenkii, A, Foret, F, Karger, B L
Using a zone of constant temperature and denaturant concentration in capillary electrophoresis, we have devised a simple, rapid, and reproducible system for separating mutant from wild type DNA...