K. Kiyosawa

Publication List Details

Period

1985 - 2009

Number

54

Co-Authors

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress (2009)

Okiyama, W, Tanaka, N, Nakajima, T, Tanaka, E, Kiyosawa, K, Gonzalez, FJ, ...

Background/Aims: Alcoholic liver disease (ALD) is one of the leading causes of cirrhosis and yet efficient therapeutic strategies are lacking. Polyenephosphatidylcholine (PPC), a major component of...

Epidemiology of hepatocellular carcinoma in Japan (2009)

Umemura, T, Ichijo, T, Yoshizawa, K, Tanaka, E, Kiyosawa, K

The original publication is available at www.springerlink.com

Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase (2008)

Tanaka, N, Nagaya, T, Komatsu, M, Horiuchi, A, Tsuruta, G, Shirakawa, H, ...

Author Posting. © The Authors 2008 This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in Liver International,...

Pancreatic exocrine insufficiency: a rare cause of nonalcoholic steatohepatitis (2008)

Tanaka, N, Horiuchi, A, Yokoyama, T, Kawa, S, Kiyosawa, K

This is an electronic version of an Article published in the American Journal of Gastroenterology 2008; 103(1): 245-246.

Epidemiology of hepatocellular carcinoma in Japan (2007)

Umemura, T, Kiyosawa, K

The definitive version is available at www.blackwell-synergy.com.

Diurnal Rb+ Transport from Roots to the Laminar Pulvinus in Phaseolus vulgaris L. (1985)

HOSOKAWA, Y., KIYOSAWA, K.

The primary leaves of kidney bean (Phaseolus vulgaris L.) open under light and close in the dark by the deformation of the pulvinus resulting from diurnal distribution changes of K+, Cl−,...

Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.

Imai, H, Chan, E K, Kiyosawa, K, Fu, X D, Tan, E M

A patient with liver cirrhosis who progressed to hepatocellular carcinoma was found to develop novel antinuclear antibodies. The serum was used to isolate full-length cDNA clones encoding related...

Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.

Imai, H, Chan, E K, Kiyosawa, K, Fu, X D, Tan, E M

A patient with liver cirrhosis who progressed to hepatocellular carcinoma was found to develop novel antinuclear antibodies. The serum was used to isolate full-length cDNA clones encoding related...

High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis

Sobajima, J, Ozaki, S, Uesugi, H, Osakada, F, Inoue, M, Fukuda, Y, ...

BACKGROUND—High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 have been identified as novel antigens of perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCAs), and the...

Association between severity of type A hepatitis and nucleotide variations in the 5` non-translated region of hepatitis A virus RNA: strains from fulminant hepatitis have fewer nucleotide substitutions

Fujiwara, K, Yokosuka, O, Ehata, T, Saisho, H, Saotome, N, Suzuki, K, ...

Background: Type A hepatitis is still a considerable problem in both underdeveloped and developed countries. Why some patients progress to fulminant type A hepatitis and others do not is unclear.

A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus

Hosaka, S, Nakamura, N, Akamatsu, T, Fujisawa, T, Ogiwara, Y, Kiyosawa, K, ...

We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in June 1999 for further...

Nucleolar antigens and autoantibodies in hepatocellular carcinoma and other malignancies.

Imai, H., Ochs, R. L., Kiyosawa, K., Furuta, S., Nakamura, R. M., Tan, E. M.

Patients with hepatocellular carcinoma (HCC), gastrointestinal, lung, and ovarian cancers were shown to have autoantibodies to nuclear and nucleolar antigens as detected by immunofluorescence on cell...

Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.

Von Mühlen, C A, Chan, E K, Peebles, C L, Imai, H, Kiyosawa, K, Tan, E M

Three patients with hepatitis C virus (HCV)-related chronic liver disease were shown to have autoantibodies strongly reacting with cytoskeletal fibres of non-muscle cells. The heavy chain of...

Analysis of T cell repertoire in the liver of patients with chronic hepatitis C

Umemura, T, Yoshizawa, K, Ota, M, Katsuyama, Y, Inada, H, Tanaka, E, ...

Many T cells infiltrate into the liver of patients with chronic hepatitis C (CH-C). They are believed to play a crucial role in the immunopathogenesis of hepatic inflammation, but their clonality and...

De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma

Zhang, J Y, Zhu, W, Imai, H, Kiyosawa, K, Chan, E K L, Tan, E M

A feature of hepatocellular carcinoma (HCC) is that antecedent liver cirrhosis and chronic hepatitis are common precursor conditions and during transition to malignancy some patients develop...

Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour.

Yoshida, J, Wakabayashi, T, Okamoto, S, Kimura, S, Washizu, K, Kiyosawa, K, ...

Tenascin, an extracellular matrix glycoprotein, has been reported to be expressed predominantly on glioma tissue in the CNS, both in a cell associated and an excreted form. Recently, a highly...

Bronchoalveolar lavage fluid findings in patients with chronic hepatitis C virus infection.

Kubo, K, Yamaguchi, S, Fujimoto, K, Hanaoka, M, Hayasaka, M, Honda, T, ...

BACKGROUND: Hepatitis C virus (HCV) infection has recently been incriminated as an aetiological agent in idiopathic pulmonary fibrosis. This study was performed to determine the cellularity and...

Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer.

Kawa, S., Tokoo, M., Hasebe, O., Hayashi, K., Imai, H., Oguchi, H., ...

A comparative study of a new tumour marker, CA242, and CA19-9 was conducted with special reference to their diagnostic usefulness in pancreatic cancer. CA242 showed sensitivity similar to that of...

Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines.

Kawa, S., Nikaido, T., Aoki, Y., Zhai, Y., Kumagai, T., Furihata, K., ...

To obtain information regarding the growth-inhibitory effect of 1,25-dihydroxyvitamin D3 and its non-calcaemic analogue 22-oxa-1,25-dihydroxyvitamin D3 on pancreatic cancer cell lines, differences in...

Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

Ueno, H, Kiyosawa, K, Kaniwa, N

Gemcitabine is a deoxycytidine analogue that has a broad spectrum of antitumour activity in many solid tumours including pancreatic cancer. We have recently carried out a pharmacogenomic study in...