K. M. Coggeshall

Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

Coggeshall, K M, McHugh, J C, Altman, A

The triggering of T- or B-cell antigen-specific receptors is accompanied by rapid tyrosine phosphorylation of distinct cellular substrates, one of which is the gamma 1 isoform of inositol...

Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2

Alcorn, M. J., Booth, J. L., Coggeshall, K. M., Metcalf, J. P.

Infection with adenovirus serotype 7 (Ad7) frequently causes lower respiratory pneumonia and is associated with severe lung inflammation and neutrophil infiltration. Earlier studies indicated release...

Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif.

Tridandapani, S, Kelley, T, Pradhan, M, Cooney, D, Justement, L B, Coggeshall, K M

Recently, we and others have demonstrated that negative signaling in B cells selectively induces the tyrosine phosphorylation of a novel inositol polyphosphate phosphatase, p145SHIP. In this study,...

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

Mustelin, T, Coggeshall, K M, Altman, A

T lymphocytes express a tyrosine protein kinase (TPK; protein-tyrosine kinase; ATP:protein-tyrosine O-phosphotransferase, EC 2.7.1.112), pp56lck that is encoded by the lck protooncogene. This TPK was...

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

Gulbins, E, Coggeshall, K M, Langlet, C, Baier, G, Bonnefoy-Berard, N, Burn, P, ...

We recently identified Vav, the product of the vav proto-oncogene, as a guanine nucleotide exchange factor (GEF) for Ras. Vav is enzymatically activated by lymphocyte antigen receptor-coupled protein...

Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.

Gulbins, E, Coggeshall, K M, Baier, G, Telford, D, Langlet, C, Baier-Bitterlich, G, ...

We recently identified Vav as a Ras-activating guanine nucleotide exchange factor (GEF) stimulated by a T-cell antigen receptor-coupled protein tyrosine kinase (PTK). Here, we describe a novel,...

Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

Pleiman, C M, Clark, M R, Gauen, L K, Winitz, S, Coggeshall, K M, Johnson, G L, ...

Engagement of the B-cell antigen receptor complex induces immediate activation of receptor-associated Src family tyrosine kinases including p55blk, p59fyn, p53/56lyn, and perhaps p56lck, and this...

Adenovirus Type 7 Induces Interleukin-8 in a Lung Slice Model and Requires Activation of Erk

Booth, J. L., Coggeshall, K. M., Gordon, B. E., Metcalf, J. P.

Adenovirus (Ad), particularly Ad type 7 (Ad7), causes severe lung infection and pneumonia. Initially, Ad causes neutrophilic inflammation of the distal airways and alveoli. Interleukin-8 (IL-8) is...

Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

Coggeshall, K M, McHugh, J C, Altman, A

The triggering of T- or B-cell antigen-specific receptors is accompanied by rapid tyrosine phosphorylation of distinct cellular substrates, one of which is the gamma 1 isoform of inositol...

Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2

Alcorn, M. J., Booth, J. L., Coggeshall, K. M., Metcalf, J. P.

Infection with adenovirus serotype 7 (Ad7) frequently causes lower respiratory pneumonia and is associated with severe lung inflammation and neutrophil infiltration. Earlier studies indicated release...

Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif.

Tridandapani, S, Kelley, T, Pradhan, M, Cooney, D, Justement, L B, Coggeshall, K M

Recently, we and others have demonstrated that negative signaling in B cells selectively induces the tyrosine phosphorylation of a novel inositol polyphosphate phosphatase, p145SHIP. In this study,...

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

Mustelin, T, Coggeshall, K M, Altman, A

T lymphocytes express a tyrosine protein kinase (TPK; protein-tyrosine kinase; ATP:protein-tyrosine O-phosphotransferase, EC 2.7.1.112), pp56lck that is encoded by the lck protooncogene. This TPK was...

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

Gulbins, E, Coggeshall, K M, Langlet, C, Baier, G, Bonnefoy-Berard, N, Burn, P, ...

We recently identified Vav, the product of the vav proto-oncogene, as a guanine nucleotide exchange factor (GEF) for Ras. Vav is enzymatically activated by lymphocyte antigen receptor-coupled protein...

Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.

Gulbins, E, Coggeshall, K M, Baier, G, Telford, D, Langlet, C, Baier-Bitterlich, G, ...

We recently identified Vav as a Ras-activating guanine nucleotide exchange factor (GEF) stimulated by a T-cell antigen receptor-coupled protein tyrosine kinase (PTK). Here, we describe a novel,...

Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

Pleiman, C M, Clark, M R, Gauen, L K, Winitz, S, Coggeshall, K M, Johnson, G L, ...

Engagement of the B-cell antigen receptor complex induces immediate activation of receptor-associated Src family tyrosine kinases including p55blk, p59fyn, p53/56lyn, and perhaps p56lck, and this...

Adenovirus Type 7 Induces Interleukin-8 in a Lung Slice Model and Requires Activation of Erk

Booth, J. L., Coggeshall, K. M., Gordon, B. E., Metcalf, J. P.

Adenovirus (Ad), particularly Ad type 7 (Ad7), causes severe lung infection and pneumonia. Initially, Ad causes neutrophilic inflammation of the distal airways and alveoli. Interleukin-8 (IL-8) is...

Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis.

Gulbins, E, Brenner, B, Schlottmann, K, Welsch, J, Heinle, H, Koppenhoefer, U, ...

Fas induces apoptosis in lymphocytes via a poorly defined intracellular signalling cascade. Previously, we have demonstrated the involvement and significance of a signalling cascade from the Fas...