K. M. Kazemier

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia (2005)

Holleman, A., Boer, M.L. Den, Kazemier, K.M., Beverloo, H.B., Von Bergh, A.R., Janka-Schaub, G.E., ...

Drug resistance in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) is associated with impaired ability to induce apoptosis. To elucidate causes of apoptotic defects, we...

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment (2004)

Holleman, A., Cheng, C., Pui, C.H., Evans, W.E., Relling, M.V., Pieters, R., ...

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of...

Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia (2003)

Holleman, A., Boer, M.L. Den, Kazemier, K.M., Janka-Schaub, G.E., Pieters, R.

Resistance of leukemic cells to chemotherapeutic agents is associated with an unfavorable outcome in pediatric acute lymphoblastic leukemia (ALL). To investigate the underlying mechanisms of cellular...

Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assay.

Kaspers, G. J., Veerman, A. J., Pieters, R., Broekema, G. J., Huismans, D. R., Kazemier, K. M., ...

The methyl-thiazol-tetrazolium (MTT) assay is a drug resistance assay which cannot discriminate between malignant and non-malignant cells. We previously reported that samples with > or = 80%...