Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side Chain to Selectivity (vol 371, pg 989, 2007) (2009)
Tochowicz, A.,
Maskos, K.,
Huber, R.,
Oltenfreiter, R.,
Dive, V.,
Yiotakis, A.,
...
Phosphorylation of the human full-length protein kinase C iota (2008)
Macek, B.,
Benda, C.,
Jestel, A.,
Maskos, K.,
Mann, M.,
Messerschmidt, A.
Structural determinants of the ADAM inhibition by TIMP-3: Crystal structure of the TACE-N-TIMP-3 complex (2008)
Wisniewska, M.,
Goettig, P.,
Maskos, K.,
Belouski, E.,
Winters, D.,
Hecht, R.,
...
X-ray structures of Sap 1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans (2008)
Borelli, C.,
Ruge, E.,
Lee, J. H.,
Schaller, M.,
Vogelsang, A.,
Monod, M.,
...
Crystal structures of MMP-9 complexes with five inhibitors: Contribution of the flexible arg424 side-chain to selectivity (2007)
Tochowicz, A.,
Maskos, K.,
Huber, R.,
Oltenfreiter, R.,
Dive, V.,
Yiotakis, A.,
...
The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A (2007)
Borelli, C.,
Ruge, E.,
Schaller, M.,
Monod, M.,
Korting, H. C.,
Huber, R.,
...
Crystal structures of MMP-9 complexes with five inhibitors: Contribution of the flexible arg424 side-chain to selectivity (2007)
Tochowicz, A.,
Maskos, K.,
Huber, R.,
Oltenfreiter, R.,
Dive, V.,
Yiotakis, A.,
...
The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A (2007)
Borelli, C.,
Ruge, E.,
Schaller, M.,
Monod, M.,
Korting, H. C.,
Huber, R.,
...
Crystal Structure of the Human Carboxypeptidase N (Kininase I) Catalytic Domain (2007)
Keil, C.,
Maskos, K.,
Than, M.,
Hoopes, J.T.,
Huber, R.,
Tan, F.,
...
Crystal structures of MMP-9 complexes with five inhibitors: Contribution of the flexible arg424 side-chain to selectivity (2007)
TOCHOWICZ, A,
MASKOS, K,
HUBER, R,
OLTENFREITER, RUTH,
DIVE, V,
YIOTAKIS, A,
...
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria (2006)
Van Den Steen, P. E.,
Van Aelst, I.,
Starckx, S.,
Maskos, K.,
Opdenakker, G.,
Pagenstecher, A.
Eukaryotic expression: developments for structural proteomics (2006)
Aricescu, A. R.,
Assenberg, R.,
Bill, R. M.,
Busso, D.,
Chang, V. T.,
Davis, S. J.,
...
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value (2006)
Banci, L.,
Bertini, I.,
Cusack, S.,
De Jong, R. N.,
Heinemann, U.,
Jones, E. Y.,
...
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors (2005)
Bayes,A.,
Comellas-Bigler,M.,
De La Vega,M. R.,
Maskos,K.,
Bode,W.,
Aviles,F. X.,
...
X-ray structure of human proMMP-1 - New insights into procollagenase activation and collagen binding (2005)
Jozic,D.,
Bourenkov,G.,
Lim,N. H.,
Visse,R.,
Nagase,H.,
Bode,W.,
...
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors (2005)
Bayés, A.,
Comellas-Bigler, M.,
Maskos, K.,
Bode, W.,
Aviles, F.X.,
...
Corn earworm (Helicoverpa zea), also called tomato fruitworm, is a common pest of many Solanaceous plants. This insect is known to adapt to the ingestion of plant serine protease inhibitors by using...
X-ray structure of human proMMP-1 - New insights into procollagenase activation and collagen binding (2005)
Jozic, D.,
Bourenkov, G.,
Lim, N. H.,
Visse, R.,
Nagase, H.,
Bode, W.,
...
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors (2005)
Bayes, A.,
Comellas-Bigler, M.,
De La Vega, M. R.,
Maskos, K.,
Bode, W.,
Aviles, F. X.,
...
Xray structure of human proMMP1: new insights into procollagenase activation and collagen binding. (2005)
Jozic, D.,
Bourenkov, G.,
Lim, N. H.,
Visse, R.,
Nagase, H.,
Bode, W.,
...
1.2 angstrom crystal structure of the serine carboxyl proteinase pro-kumamolisin: Structure of an intact pro-subtilase (2004)
Comellas-Bigler,M.,
Maskos,K.,
Huber,R.,
Oyama,H.,
Oda,K.,
Bode,W.
Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity (2004)
Reverter,D.,
Maskos,K.,
Tan,F. L.,
Skidgel,R. A.,
Bode,W.
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features (2004)
Lang,R.,
Braun,M.,
Sounni,N. E.,
Noel,A.,
Frankenne,F.,
Foidart,J. M.,
...
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features (2004)
Lang, R,
Braun, M,
Sounni, Nor Eddine,
Noël, Agnès,
Frankenne, Francis,
Foidart, Jean-Michel,
...
Membrane-type matrix metalloproteinases (MT-MMPs) have attracted strong attention, because four of them can activate a key player in the tumor scenario, proMMP-2/progelatinase A. In addition to this...
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features (2004)
Lang, R.,
Braun, M.,
Sounni, N. E.,
Noel, A.,
Frankenne, F.,
Foidart, J. M.,
...
Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity (2004)
Reverter, D.,
Maskos, K.,
Tan, F. L.,
Skidgel, R. A.,
Bode, W.
1.2 angstrom crystal structure of the serine carboxyl proteinase pro-kumamolisin: Structure of an intact pro-subtilase (2004)
Comellas-Bigler, M.,
Maskos, K.,
Huber, R.,
Oyama, H.,
Oda, K.,
Bode, W.
Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme (2003)
Lee,M. H.,
Dodds,P.,
Verma,V.,
Maskos,K.,
Knauper,V.,
Murphy,G.
Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme (2003)
Lee, M. H.,
Dodds, P.,
Verma, V.,
Maskos, K.,
Knauper, V.,
Murphy, G.
Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: A new frontier in TIMP engineering (2002)
Lee,M. H.,
Maskos,K.,
Knäuper,V.,
Dodds,P.,
Murphy,G.
Tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE/ADAM-17) is responsible for the release of TNF-u, a potent proinflammatory cytokine associated with many chronic debilitating diseases...
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides (2002)
Jozic,D.,
Bourenkow,G.,
Bartunik,H.,
Scholze,H.,
Dive,V.,
Henrich,B.,
...
PepV from Lactobacillus delbrueckii, a dinuclear zinc peptidase, has been characterized as an unspecific amino dipeptidase. The crystal structure of PepV in complex with the phosphinic inhibitor...
The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3 (2002)
Lee,M. H.,
Verma,V.,
Maskos,K.,
Becherer,J. D.,
Knäuper,V.,
Dodds,P.,
...
Tumor necrosis factor-alpha converting enzyme (TACE) is an ADAM (a disintegrin and metalloproteinases) that comprises an active catalytic domain and several C-terminal domains. We compare the binding...
The 1.4 angstrom crystal structure of kumamolysin: A thermostable serine-carboxyl-type proteinase (2002)
Comellas-Bigler,M.,
Fuentes-Prior,P.,
Maskos,K.,
Huber,R.,
Oyama,H.,
Uchida,K.,
...
Kumamolysin is a thermostable endopeptidase from Bacillus novosp. MN-32, exhibiting maximal proteolytic activity around pH 3. It belongs to the newly identified family of serine- carboxyl...
Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme (2002)
Lee,M. H.,
Verma,V.,
Maskos,K.,
Nath,D.,
Knäuper,V.,
Dodds,P.,
...
We previously reported that full-length tissue inhibitor of metallo-proteinase-3 (TIMP-3) and its N-terminal domain form (N-TIMP-3) displayed equal binding affinity for tissue necrosis factor-alpha...
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides. (2002)
Jozic, D.,
Bourenkow, G.,
Bartunik, H. D.,
Scholze, H.,
Dive, V.,
Henrich, B.,
...
The 1.4 angstrom crystal structure of kumamolysin: A thermostable serine-carboxyl-type proteinase (2002)
Comellas-Bigler, M.,
Fuentes-Prior, P.,
Maskos, K.,
Huber, R.,
Oyama, H.,
Uchida, K.,
...
Kumamolysin is a thermostable endopeptidase from Bacillus novosp. MN-32, exhibiting maximal proteolytic activity around pH 3. It belongs to the newly identified family of serine- carboxyl...
The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3 (2002)
Lee, M. H.,
Verma, V.,
Maskos, K.,
Becherer, J. D.,
Knäuper, V.,
Dodds, P.,
...
Tumor necrosis factor-alpha converting enzyme (TACE) is an ADAM (a disintegrin and metalloproteinases) that comprises an active catalytic domain and several C-terminal domains. We compare the binding...
Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme (2002)
Lee, M. H.,
Verma, V.,
Maskos, K.,
Nath, D.,
Knäuper, V.,
Dodds, P.,
...
We previously reported that full-length tissue inhibitor of metallo-proteinase-3 (TIMP-3) and its N-terminal domain form (N-TIMP-3) displayed equal binding affinity for tissue necrosis factor-alpha...
Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: A new frontier in TIMP engineering (2002)
Lee, M. H.,
Maskos, K.,
Knäuper, V.,
Dodds, P.,
Murphy, G.
Tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE/ADAM-17) is responsible for the release of TNF-u, a potent proinflammatory cytokine associated with many chronic debilitating diseases...
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides (2002)
Jozic, D.,
Bourenkow, G.,
Bartunik, H.,
Scholze, H.,
Dive, V.,
Henrich, B.,
...
PepV from Lactobacillus delbrueckii, a dinuclear zinc peptidase, has been characterized as an unspecific amino dipeptidase. The crystal structure of PepV in complex with the phosphinic inhibitor...
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
Fernandez-Catalan, C,
Bode, W,
Huber, R,
Turk, D,
Calvete, J J,
Lichte, A,
...
The proteolytic activity of matrix metalloproteinases (MMPs) towards extracellular matrix components is held in check by the tissue inhibitors of metalloproteinases (TIMPs). The binary complex of...
Time-resolved fluorescence studies of tomaymycin bonding to synthetic DNAs.
Barkley, M D,
Chen, Q,
Walczak, W J,
Maskos, K
Tomaymycin reacts covalently with guanine in the DNA minor groove, exhibiting considerable specificity for the flanking bases. The sequence dependence of tomaymycin bonding to DNA was investigated in...
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
Fernandez-Catalan, C,
Bode, W,
Huber, R,
Turk, D,
Calvete, J J,
Lichte, A,
...
The proteolytic activity of matrix metalloproteinases (MMPs) towards extracellular matrix components is held in check by the tissue inhibitors of metalloproteinases (TIMPs). The binary complex of...
Time-resolved fluorescence studies of tomaymycin bonding to synthetic DNAs.
Barkley, M D,
Chen, Q,
Walczak, W J,
Maskos, K
Tomaymycin reacts covalently with guanine in the DNA minor groove, exhibiting considerable specificity for the flanking bases. The sequence dependence of tomaymycin bonding to DNA was investigated in...