Toxicological Evaluation And Antinociceptive Effects Of Wrightia tomentosa In Mice (2008)
Nagarajan, K, Mazumder, A, Ghosh, L K
Acute toxicity testing and the antinociceptive activity in mice of ethanolic extract of Wrightia tomentosa leaves and bark were carried out. The bark extract (400mg/kg) exhibited maximum...
5-Benzyl-1-(4-fluorophenyl)-2-phenyl-4,5,6,7- tetrahydro-1H-pyrrolo[3,2-c]pyridine (2006)
Chopra, Deepak, Nagarajan, K, Row, Guru TN
In the title compound, $C_2_6H_2_3FN_2$, the dihedral angle between the 4-fluorophenyl ring and the adjacent phenyl ring is 62.3 (1)°. The crystal structure is stabilized by...
1-(4-Chlorobenzyl)-6,6-dimethyl-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one (2005)
Chopra, D, Nagarajan, K, Row, Guru TN
In the title compound, $C_2_3H_2_2ClNO$, there are two independent molecules showing similar conformations, the tetrahydroindole ring system being approximately planar except for the...
1-(4-chlorophenyl)-2,6,6-trimethyl-1,5,6,7-tetra-hydro-4H-indol-4-one (2005)
Chopra, Deepak, Nagarajan, K, Row, Guru TN
In the title compound, $C_{17}H_{18}ClNO$, the tetrahydroindole ring system is nearly planar, except for the dimethyl- substituted C atom. Molecules are linked via $C-H\cdot\cdot\cdotO$ and...
Chopra, Deepak, Nagarajan, K, Row, Tayur Guru N
An understanding of structural features associated with polymorphism in an anti-implantation agent has been made in terms of morphology, single-crystal structure, powder X-ray diffraction, and...
N-(3-Fluorophenyl)-9H-xanthen-9-ylideneamine. (2004)
Chopra, Deepak, Nagarajan, K, Row, Guru TN
In the title compound, $C_1_9H_1_2FNO_,$ the dihedral angle between the mean planes of the 9H-xanthene moiety and the 3-fluorophenyl group is 82.5(1)°. An intramolecular. $C-H\cdot\cdot\cdot\p$$\pi$...
4-(2-Methylprop-2-enyl)-1-[3-(trifluoromethyl)phenyl]thiosemicarbazide (2004)
Chopra, Deepak, Choudhury, AR, Nagarajan, K, Row, Guru TN
The title compound, $C_1_2H_1_4F_3N_3S,$ is a biologically active antiimplantation agent. Its crystal structure is stabilized by intermolecular $N-H\cdot\cdot\cdot\cdot S $ hydrogen bonds, which form...
N-Phenylethyl-N'-[3-(trifluoromethyl)phenyl]- thiourea (2004)
Chopra, Deepak, Choudhury, AR, Nagarajan, K, Row, Guru TN
The title compound, $C_1_6H_1_5F_3N_2S,$ is a biologically active antiimplantation agent. The dihedral angle between the phenyl and triØuoromethylphenyl rings is $15.9 (2)^o.$ The crystal structure...
N-[(9E)-2-Chloro-9-thia-9H-xanthen-9-ylidene]-N-(4-fluorophenyl)amine. (2004)
Chopra, Deepak, Nagarajan, K, Row, Guru TN
In the title compound, $C_1_9H_1_1ClFNS_,$the central 4H-thiapyran ring of the 9H-thiaxanthene moiety shows a roof-shaped structure, with a dihedral angle of $34.3 (2)^o.$ The molecules pack in the...
Crystal engineering via C-H...F and C-H...\pi interactions in two substi-tuted indoles (2004)
Choudhury, AR, Nagarajan, K, Row, Guru TN
The crystal structures of 1-(4-fluorophenyl)-2-phenyl-4,5,6,7- tetrahydro-1H-indole, $C_{20}H_{18}FN$, and 1-(4-fluorophenyl)-6,6- dimethyl-2-phenyl-4,5,6,7-tetrahydro-1H-indole,$C_{22}H_{22}FN$,...
Choudhury, AR, Nagarajan, K, Row, Guru TN
The crystal and molecular structures of the three 4-ketotetrahydroindoles 2-(4-chlorophenyl)-1-(4-Øuorophenyl)-6,6-dimethyl- 4,5,6,7-tetrahydro-1H-indol-4-one$(C_{22}H_{19}ClFNO),$(I),...
Ananda, K, Aravinda, S, Vasudev, Prema G, Raja, Muruga Poopathi K, Sivaramakrishnan, H, Nagarajan, K, ...
Gabapentin (1-(aminomethyl)cycloheaxaneacetic acid; Gpn) is a widely used anti-epileptic drug. The target site of action of Gpn remains controversial. Gpn can exist in two isomeric chair forms. The...
Choudhury, AR, Nagarajan, K, Row, Guru TN
The compounds 1-(2-fluorophenyl)-6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (1) and 5-(2- fluorophenyl)-6-phenyl-5,6,7,8-tetrahydro dioxolo[4,5-g]isoquinoline (2) have been studied via...
Choudhury, AR, Nagarajan, K, Row, Guru TN
Comparison of conformational features on halogen substitution in 1, 2-diaryl-6-methoxy-1, 2, 3, 4-tetrahydroisoquinolines based on crystal structures indicate that the derivatives with fluorine...
Choudhury, AR, Urs, UK, Row, Guru TN, Nagarajan, K
Weak interactions involving fluorine have been analyzed in the structure of 6-methoxy-1,2-diphenyl-1,2,3,4-tetrahydroisoquinoline with fluorine substitution at para-, meta- and ortho- positions,...
Whitesides, George M., Kaplan, Fred, Nagarajan, K., Roberts, John D.
The protons of a methylene group removed by one or more bonds from a center of molecular asymmetry may be magnetically nonequivalent and display AB-type nuclear magnetic resonance (n.m.r.) spectra...
Shafer, Paul R., Davis, Donald R., Vogel, Martin, Nagarajan, K., Roberts, John D.
Nuclear magnetic resonance (n.m.r.) spectroscopy provides an excellent means for qualitative identification of ethyl groups by use of the familiar three-four pattern of spin-spin splitting (1). It...