$\pi N$ and $\pi\pi N$ Couplings of the $\Delta(1232)$ and its Chiral Partners (2008)
Nagata, K., Hosaka, A., Dmitrasinovic, V.
We investigate the interactions and chiral properties of the four spin-$\thalf$-baryons : $N^-(D_{13})$, $N^+(P_{13})$, $\Delta^+(P_{33})$ and $\Delta^-(D_{33})$ together with the nucleon. We...
Structure of the Nucleon and Roper Resonance with Diquark Correlations (2008)
We investigate the electric form factors of the nucleon and Roper resonance using a quark-diquark model. We find that the charge radii of the nucleon and Roper resonance are almost the same in size.
Twisted supersymmetric invariant formulation of Chern-Simons gauge theory on a lattice (2008)
We propose a twisted supersymmetric (SUSY) invariant formulation of the Chern-Simons theory on a Euclidean three-dimensional lattice. The SUSY algebra to be realized on the lattice is the N ¼ 4 D ¼...
NAGATA, K., WONG, H., HUNT, J. C. R., SAJJADI, S. G., DAVIDSON, P. A.
Journal of Fluid Mechanics. v.556, 2006, p.329-360
Morioka, A., Oya, H., Obara, T., Miyoshi, Y. S., Nagata, K., ...
LHR band emissions observed at mid-latitude were investigated using data from the EXOS-C (Ohzora) satellite. A typical feature of the LHR band emissions is a continuous banded structure without...
Morioka, A., Oya, H., Obara, T., Miyoshi, Y. S., Nagata, K., ...
LHR band emissions observed at mid-latitude were investigated using data from the EXOS-C (Ohzora) satellite. A typical feature of the LHR band emissions is a continuous banded structure without...
The mass of the nucleon in a chiral quark-diquark model (2004)
Nagata, K., Hosaka, A., Abu-Raddad, L. J.
The mass of the nucleon is studied in a chiral quark-diquark model. Both scalar and axial-vector diquarks are taken into account for the construction of the nucleon state. After the hadronization...
Iwata, M., Imamura, H., Stambouli, E., Ikeda, C., Tamakoshi, M., Nagata, K., ...
The vacuole-type ATPases (V-ATPases) exist in various intracellular compartments of eukaryotic cells to regulate physiological processes by controlling the acidic environment. The crystal structure...
Watanabe, T., Kukita, T., Kukita, A., Wada, Naohisa, Toh, K., Nagata, K., ...
Copyright © 2004 by Society for Endocrinology
RANKL-induced DC-STAMP is essential for osteoclastogenesis (2004)
Kukita, T., Wada, Naohisa, Kukita, A., Kakimoto, T., Sandra, F., Toh, K., ...
Copyright © The Rockefeller University Press
Watanabe, T., Kukita, T., Kukita, A., Wada, Naohisa, Toh, K., Nagata, K., ...
Copyright © 2004 by Society for Endocrinology
RANKL-induced DC-STAMP is essential for osteoclastogenesis (2004)
Kukita, T., Wada, Naohisa, Kukita, A., Kakimoto, T., Sandra, F., Toh, K., ...
Copyright © The Rockefeller University Press
Iwata, M., Imamura, H., Stambouli, E., Ikeda, C., Tamakoshi, M., Nagata, K., ...
The vacuole-type ATPases (V-ATPases) exist in various intracellular compartments of eukaryotic cells to regulate physiological processes by controlling the acidic environment. The crystal structure...
Structure of the nuclear force in a chiral quark-diquark model (2003)
We discuss the structure of the nuclear force using a lagrangian derived from hadronization of a chiral quark and diquark model. A generalized trace log formula including meson and nucleon fields is...
Goto,H., Yasui,Y., Kawajiri,A., Nigg,E. A., Terada,Y., Tatsuka,M., ...
Aurora-B is an evolutionally conserved protein kinase that regulates several mitotic events including cytokinesis. We previously demonstrated the possible existence of a protein kinase that...
Goto, H., Yasui, Y., Kawajiri, A., Nigg, E. A., Terada, Y., Tatsuka, M., ...
Aurora-B is an evolutionally conserved protein kinase that regulates several mitotic events including cytokinesis. We previously demonstrated the possible existence of a protein kinase that...
Michimata, T., Sakai, M., Miyazaki, S., Ogasawara, M.S., Suzumori, K., Aoki, K., ...
BACKGROUND: In normal pregnancy, predominant type 2 cytokines help maintain pregnancy, and a T‐helper (Th)1 type response is associated with unexplained recurrent spontaneous abortion (RSA)....
Ihara,A., Doke,T., Hasebe,N., Kikuchi,J., Kobayashi,M. N., Maezawa,K., ...
Susceptibility, Magnetization Process and ESR Studies on the Helical Spin System RbCuCl$_{3}$ (2000)
Maruyama, S., Tanaka, H., Narumi, Y., Kindo, K., Nojiri, H., Motokawa, M., ...
The static and dynamic magnetic properties of an $S=1/2$ stacked triangular antiferromagnet RbCuCl$_{3}$ with a helical spin structure due to lattice distortion were investigated by susceptibility,...
Knowledge and attitudes toward AIDS among female college students in Nagasaki, Japan (2000)
Maswanya, E., Moji, K., Aoyagi, K., Yahata, Y., Kusano, Y., Nagata, K., ...
This study assesses knowledge and attitudes concerning HIV infection and individuals with AIDS among 383 female students attending colleges in Nagasaki, Japan. A structured questionnaire containing...
Yamamoto, K, Hamaguchi, H, Nagata, K, Hara, M, Tone, O, Tomita, H, ...
Maswanya, E. S., Moji, K., Horiguchi, I., Nagata, K., Aoyagi, K., Honda, S., ...
A questionnaire survey was carried out among 1041 students in secondary schools and colleges in Dar-es-Salaam, Tanzania to evaluate the relationship between HIV-risky sexual behaviour and anti-condom...
Effect of Rhenium Addition on Fracture Toughness of Tungsten at Elevated Temperatures. (1998)
Mutoh, Y., Ichikawa, K., Nagata, K., Takeuchi, M.
Fracture toughness tests of tungsten and tungsten-rhenium alloy specimens were carried out at elevated temperatures. temperature dependence of fracture toughness and effect of rhenium content on...
A Comment on the Geometric Entropy and Conical Space (1996)
Hotta, M., Kato, T., Nagata, K.
It has been recently pointed out that a definition of the geometric entropy using the partition function in a conical space does not in general lead to a positive definite quantity. For a scalar...
Development of the pulse-shape discrimination LSI for Astro-E hard X-ray detector (1996)
Ezawa, H, Hirayama, M, Kamae, T, Kubo, H, Matsuzaki, K, Nagata, K, ...
ESR MODES IN HEXAGONAL ABX3-TYPE ANTIFERROMAGNETS (1988)
Tanaka, H., Teraoka, S., Kakehashi, E., Iio, K., Nagata, K.
ESR modes in the ground state of hexagonal ABX3-type antiferromagnets are discussed by taking a sixsublattice model for the spin structure. Results of ESR measurements performed on CsNiCl3, RbNiCl3...
ESR MODES IN HEXAGONAL ABX3-TYPE ANTIFERROMAGNETS (1988)
Tanaka, H., Teraoka, S., Kakehashi, E., Iio, K., Nagata, K.
ESR modes in the ground state of hexagonal ABX3-type antiferromagnets are discussed by taking a sixsublattice model for the spin structure. Results of ESR measurements performed on CsNiCl3, RbNiCl3...
ESR MODES IN HEXAGONAL ABX3-TYPE ANTIFERROMAGNETS (1988)
Tanaka, H., Teraoka, S., Kakehashi, E., Iio, K., Nagata, K.
ESR modes in the ground state of hexagonal ABX3-type antiferromagnets are discussed by taking a sixsublattice model for the spin structure. Results of ESR measurements performed on CsNiCl3, RbNiCl3...
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.
Nagata, K, Kawase, H, Handa, H, Yano, K, Yamasaki, M, Ishimi, Y, ...
DNA replication of the adenovirus genome complexed with viral core proteins is dependent on the host factor designated template activating factor I (TAF-I) in addition to factors required for...
Yamanaka, K, Ogasawara, N, Yoshikawa, H, Ishihama, A, Nagata, K
A system for the expression of a foreign gene derived from negative polarity RNA was developed using influenza virus, a negative-stranded RNA virus. From cDNA for the influenza virus RNA genome...
Aoyama, T, Nagata, K, Yamazoe, Y, Kato, R, Matsunaga, E, Gelboin, H V, ...
A cDNA containing the full coding region of human cytochrome b5 was inserted into a vaccinia virus cDNA expression vector. Infection of human thymidine kinase-minus (TK-) 143 cells in culture with...
Nagata, K, Takagi, E, Tsuda, M, Nakazawa, T, Satoh, H, Nakao, M, ...
The proton pump inhibitors omeprazole and lansoprazole and its acid-activated derivative AG-2000, which are potent and specific inhibitors of urease of Helicobacter pylori (K. Nagata, H. Satoh, T....
Nagata, K, Takagi, E, Satoh, H, Okamura, H, Tamura, T
The proton pump inhibitors (PPIs) omeprazole and lansoprazole and the acid-activated analog of lansoprazole AG-2000, which potently inhibit the urease of Helicobacter pylori (K. Nagata, H. Satoh, T....
Nishihara, T, Ueda, N, Amano, K, Ishihara, Y, Hayakawa, H, Kuroyanagi, T, ...
The mechanism of osteoclast-like cell formation induced by periodontopathic bacterium Actinobacillus actinomycetemcomitans Y4 (serotype b) capsular-polysaccharide-like polysaccharide (capsular-like...
Okamura, H, Nagata, K, Komatsu, T, Tanimoto, T, Nukata, Y, Tanabe, F, ...
Administration of monoclonal anti-CD3 antibody to mice treated with Propionibacterium acnes induced secretion of a high level of gamma interferon (IFN-gamma) into the circulation system, while it...
Nagata, K, Satoh, H, Iwahi, T, Shimoyama, T, Tamura, T
The gastric proton pump inhibitor lansoprazole, its active analog AG-2000, and omeprazole dose dependently inhibited urease activity extracted with distilled water from Helicobacter pylori cells; the...
Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein.
Watanabe, K, Handa, H, Mizumoto, K, Nagata, K
Influenza virus M1 protein has been shown to inhibit the transcription catalyzed by viral ribonucleoprotein complexes isolated from virions. Here, this inhibition mechanism was studied with the...
Nakai, A, Kawazoe, Y, Tanabe, M, Nagata, K, Morimoto, R I
Avian cells express three heat shock transcription factor (HSF) genes corresponding to a novel factor, HSF3, and homologs of mouse and human HSF1 and HSF2. Analysis of the biochemical and cell...
Nakai, A, Tanabe, M, Kawazoe, Y, Inazawa, J, Morimoto, R I, Nagata, K
Heat shock transcription factors (HSFs) mediate the inducible transcriptional response of genes that encode heat shock proteins and molecular chaperones. In vertebrates, three related HSF genes (HSF1...
Nagata, K, Ide, Y, Takagi, T, Ohtani, K, Aoshima, M, Tozawa, H, ...
We examined cellular components which associate with p40tax, the viral transactivation molecule of human T-cell leukemia virus type I. Such molecules were searched by immunoprecipitation with...
Nagata, K, Ohtani, K, Nakamura, M, Sugamura, K
We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate...
Nagata, K, Mizuta, T, Tonokatu, Y, Fukuda, Y, Okamura, H, Hayashi, T, ...
Monoclonal antibodies (MAbs) against the native urease of Helicobacter pylori NCTC 11637 were found to clearly inhibit the urease activity. Interestingly, synergistic inhibition by two MAbs...
Okamura, H, Wada, M, Nagata, K, Tamura, T, Shoji, K
Lipopolysaccharide (LPS) induces high levels of gamma interferon (IFN-gamma) in the circulation of mice pretreated with heat-killed Propionibacterium acnes. The following results were obtained in the...
Purification of a factor which provides a costimulatory signal for gamma interferon production.
Nakamura, K, Okamura, H, Nagata, K, Komatsu, T, Tamura, T
A protein factor which induces high levels of gamma interferon (IFN-gamma) in resting splenic nonadherent cells was isolated from the sera of mice with generalized inflammation caused by endotoxic...
Undermethylation of interferon-gamma gene in human T cell lines and normal T lymphocytes.
Fukunaga, R, Matsuyama, M, Okamura, H, Nagata, K, Nagata, S, Sokawa, Y
The relative levels of DNA methylation at CCGG sequences within and around the interferon-gamma (IFN-gamma) gene in normal human tissues and cell lines were examined by Southern blot analysis using...
Endotoxin-induced serum factor that stimulates gamma interferon production.
Nakamura, K, Okamura, H, Wada, M, Nagata, K, Tamura, T
Serum from Mycobacterium bovis BCG-infected mice that had been challenged with lipopolysaccharide (LPS) exhibited a marked ability to induce gamma interferon (IFN-gamma) in cultures of spleen cells...
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).
Yamano, S, Nagata, K, Yamazoe, Y, Kato, R, Gelboin, H V, Gonzalez, F J
Masuda, H, Fukumoto, M, Hirayoshi, K, Nagata, K
HSP47 is a collagen-binding stress protein and is assumed to act as a collagen-specific molecular chaperone during the biosynthesis and secretion of procollagen in the living cell. The synthesis of...
Ohtani, K, Nakamura, M, Saito, S, Nagata, K, Sugamura, K, Hinuma, Y
Conditions were developed for stable introduction of foreign DNA into human lymphoid cell lines by electroporation. To introduce stably the p40 gene of human T-cell leukemia virus type I (HTLV-I)...
cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats.
Nagata, K, Sasamura, H, Miyata, M, Shimada, M, Yamazoe, Y, Kato, R
Kobayashi, M, Nagata, K, Ishihama, A
A set of 18 variant lac UV5 promoters was constructed, each carrying a single base substitution within the -35 region (nucleotide positions from -36 to -31 relative to the transcription start site)....
DNA sequences required for the in vitro replication of adenovirus DNA.
Guggenheimer, R A, Stillman, B W, Nagata, K, Tamanoi, F, Hurwitz, J
Initiation of adenovirus (Ad) DNA replication occurs on viral DNA containing a 55-kilodalton (kDa) protein at the 5' terminus of each viral DNA strand and on plasmid DNAs containing the origin of Ad...
Gronostajski, R M, Nagata, K, Hurwitz, J
Nuclear factor I is a 47,000-dalton protein isolated from human HeLa cells that is required for the in vitro replication of adenovirus DNA. This protein was previously shown to bind specifically to...
Nagata, K, Guggenheimer, R A, Enomoto, T, Lichy, J H, Hurwitz, J
A protein factor that participates in the formation of a covalent complex between the 80,000-dalton precursor of the adenovirus (Ad) terminal protein (pTP) and 5'-dCMP has been isolated and...
Hinuma, Y, Nagata, K, Hanaoka, M, Nakai, M, Matsumoto, T, Kinoshita, K I, ...
Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm of 1--5% of the cells of a T-cell line, MT-1, from a patient with adult T-cell leukemia (ATL), which is...
Alternative 5' splice site selection induced by heat shock.
Takechi, H, Hosokawa, N, Hirayoshi, K, Nagata, K
The mouse HSP47 gene consists of six exons separated by five introns. Three HSP47 cDNAs differing only in their 5' noncoding regions have been reported. One of these alternatively spliced mRNAs was...
Ohta, S, Shimekake, Y, Nagata, K
The promoter function of the human C-type natriuretic peptide (CNP) gene in various cultured cells was examined by transient transfection assays. The CNP promoter functioned very effectively in GH3...
Hirayoshi, K, Kudo, H, Takechi, H, Nakai, A, Iwamatsu, A, Yamada, K M, ...
We report the isolation and characterization of a cDNA clone encoding HSP47, a transformation-sensitive heat shock protein that binds to collagen. A cDNA library was prepared from total RNA isolated...
Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids.
Hosokawa, N, Hirayoshi, K, Kudo, H, Takechi, H, Aoike, A, Kawai, K, ...
Transcriptional activation of human heat shock protein (HSP) genes by heat shock or other stresses is regulated by the activation of a heat shock factor (HSF). Activated HSF posttranslationally...
Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites.
Gronostajski, R M, Adhya, S, Nagata, K, Guggenheimer, R A, Hurwitz, J
Nuclear factor I is a cellular site-specific DNA-binding protein required for the efficient in vitro replication of adenovirus DNA. We have characterized human DNA sequences to which nuclear factor I...
Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins.
Nagata, K, Guggenheimer, R A, Hurwitz, J
A protein required for the elongation of replicating intermediates of adenovirus (Ad) DNA to full length has been isolated and characterized. This factor, isolated from nuclear extracts of uninfected...
Nagata, K, Guggenheimer, R A, Hurwitz, J
Nuclear factor I, a 47-kilodalton protein, purified from nuclear extracts of uninfected HeLa cells, is involved in the initiation and possibly the elongation of replicating adenovirus (Ad) DNA in...
Nagata, K, Kohda, D, Hatanaka, H, Ichikawa, S, Matsuda, S, Yamamoto, T, ...
p185erbB-2 and p180erbB-4 are epidermal growth factor (EGF) receptor-like tyrosine kinases, whose co-expression is observed in many breast carcinomas. Heregulins (HRGs), which contain an...
Terasawa, H, Kohda, D, Hatanaka, H, Nagata, K, Higashihashi, N, Fujiwara, H, ...
The three-dimensional structure of human insulin-like growth factor II was determined at high resolution in aqueous solution by NMR and simulated annealing based calculations. The structure is quite...
Regulation of influenza virus RNA polymerase activity by cellular and viral factors.
Shimizu, K, Handa, H, Nakada, S, Nagata, K
An in vitro RNA synthesis system mimicking replication of genomic influenza virus RNA was developed with nuclear extracts prepared from influenza virus-infected HeLa cells using exogenously added RNA...
Waxman, D J, Lapenson, D P, Nagata, K, Conlon, H D
Rat hepatic cytochrome P-450 form 3 (testosterone 7 alpha-hydroxylase; P-450 gene IIA1) and P-450 form RLM2 (testosterone 15 alpha-hydroxylase; P-450 gene IIA2) are 88% identical in primary...
Sagara, J, Nagata, K, Ichikawa, Y
Myosin purified from a murine myeloid leukaemia cell line (M1) that had been incubated with [32P]orthophosphate incorporated 32P into the heavy, but not the light, chain. When the heavy chain was...
Solution structure of midkine, a new heparin-binding growth factor.
Iwasaki, W, Nagata, K, Hatanaka, H, Inui, T, Kimura, T, Muramatsu, T, ...
Midkine (MK) is a 13 kDa heparin-binding polypeptide which enhances neurite outgrowth, neuronal cell survival and plasminogen activator activity. MK is structurally divided into two domains, and most...
Nagata, K, Puls, A, Futter, C, Aspenstrom, P, Schaefer, E, Nakata, T, ...
The MLK (mixed lineage) ser/thr kinases are most closely related to the MAP kinase kinase kinase family. In addition to a kinase domain, MLK1, MLK2 and MLK3 each contain an SH3 domain, a leucine...
Tapon, N, Nagata, K, Lamarche, N, Hall, A
The Rho, Rac and Cdc42 GTPases coordinately regulate the organization of the actin cytoskeleton and the JNK MAP kinase pathway. Mutational analysis of Rac has previously shown that these two...
Tanabe, M, Kawazoe, Y, Takeda, S, Morimoto, R I, Nagata, K, Nakai, A
The vertebrate genome encodes a family of heat shock factors (HSFs 1-4) of which the DNA-binding and transcriptional activities of HSF1 and HSF3 are activated upon heat shock. HSF1 has the properties...
Dexamethasone and nitric oxide synthase gene expression in brain.
Suzuki, E, Shintani, F, Nakaki, T, Nagata, K, Yamazoe, Y, Fujita, N, ...
Systemic administration of lipopolysaccharide (LPS), which causes endotoxemia and systemic inflammation, has been reported to induce expression of the gene for type II inducible nitric oxide synthase...
Ohta, S, Yanagihara, K, Nagata, K
Human gastric carcinoma cell line HSC-39 has been shown to undergo apoptotic cell death in response to treatment with transforming growth factor beta1 (TGF-beta1). To understand better the cell death...
The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1.
Nagata, K, Ohashi, K, Yang, N, Mizuno, K
LIM-kinase 1 (LIMK1, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3) is a serine/threonine kinase that phosphorylates cofilin and regulates actin cytoskeletal...
Ohta, S, Takeuchi, M, Deguchi, M, Tsuji, T, Gahara, Y, Nagata, K
Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Recently some factors such as Smads (Sma and Mad proteins) and TGF-beta activating...
Yamazoe, Y, Ozawa, S, Nagata, K, Gong, D W, Kato, R
An aryl sulfotransferase, whose cDNA was isolated from the rat liver library, was found to catalyze bioactivation of minoxidil through N-O-sulfation and N-sulfation of a carcinogenic heterocyclic...
Inductive effect on hepatic enzymes and toxicity of congeners of PCBs and PCDFs.
Yoshimura, H, Yoshihara, S, Koga, N, Nagata, K, Wada, I, Kuroki, J, ...
The present paper describes a marked induction of liver microsomal cytochrome P-450 and cytosolic DT-diaphorase to cause possible disorder of steroid homeostasis and promotion of carcinogenicity of...
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.
Nagata, K, Kawase, H, Handa, H, Yano, K, Yamasaki, M, Ishimi, Y, ...
DNA replication of the adenovirus genome complexed with viral core proteins is dependent on the host factor designated template activating factor I (TAF-I) in addition to factors required for...
Yamanaka, K, Ogasawara, N, Yoshikawa, H, Ishihama, A, Nagata, K
A system for the expression of a foreign gene derived from negative polarity RNA was developed using influenza virus, a negative-stranded RNA virus. From cDNA for the influenza virus RNA genome...
Aoyama, T, Nagata, K, Yamazoe, Y, Kato, R, Matsunaga, E, Gelboin, H V, ...
A cDNA containing the full coding region of human cytochrome b5 was inserted into a vaccinia virus cDNA expression vector. Infection of human thymidine kinase-minus (TK-) 143 cells in culture with...
Nagata, K, Takagi, E, Tsuda, M, Nakazawa, T, Satoh, H, Nakao, M, ...
The proton pump inhibitors omeprazole and lansoprazole and its acid-activated derivative AG-2000, which are potent and specific inhibitors of urease of Helicobacter pylori (K. Nagata, H. Satoh, T....
Nagata, K, Takagi, E, Satoh, H, Okamura, H, Tamura, T
The proton pump inhibitors (PPIs) omeprazole and lansoprazole and the acid-activated analog of lansoprazole AG-2000, which potently inhibit the urease of Helicobacter pylori (K. Nagata, H. Satoh, T....
Nishihara, T, Ueda, N, Amano, K, Ishihara, Y, Hayakawa, H, Kuroyanagi, T, ...
The mechanism of osteoclast-like cell formation induced by periodontopathic bacterium Actinobacillus actinomycetemcomitans Y4 (serotype b) capsular-polysaccharide-like polysaccharide (capsular-like...
Okamura, H, Nagata, K, Komatsu, T, Tanimoto, T, Nukata, Y, Tanabe, F, ...
Administration of monoclonal anti-CD3 antibody to mice treated with Propionibacterium acnes induced secretion of a high level of gamma interferon (IFN-gamma) into the circulation system, while it...
Nagata, K, Satoh, H, Iwahi, T, Shimoyama, T, Tamura, T
The gastric proton pump inhibitor lansoprazole, its active analog AG-2000, and omeprazole dose dependently inhibited urease activity extracted with distilled water from Helicobacter pylori cells; the...
Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein.
Watanabe, K, Handa, H, Mizumoto, K, Nagata, K
Influenza virus M1 protein has been shown to inhibit the transcription catalyzed by viral ribonucleoprotein complexes isolated from virions. Here, this inhibition mechanism was studied with the...
Nakai, A, Kawazoe, Y, Tanabe, M, Nagata, K, Morimoto, R I
Avian cells express three heat shock transcription factor (HSF) genes corresponding to a novel factor, HSF3, and homologs of mouse and human HSF1 and HSF2. Analysis of the biochemical and cell...
Nakai, A, Tanabe, M, Kawazoe, Y, Inazawa, J, Morimoto, R I, Nagata, K
Heat shock transcription factors (HSFs) mediate the inducible transcriptional response of genes that encode heat shock proteins and molecular chaperones. In vertebrates, three related HSF genes (HSF1...
Nagata, K, Ide, Y, Takagi, T, Ohtani, K, Aoshima, M, Tozawa, H, ...
We examined cellular components which associate with p40tax, the viral transactivation molecule of human T-cell leukemia virus type I. Such molecules were searched by immunoprecipitation with...
Nagata, K, Ohtani, K, Nakamura, M, Sugamura, K
We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate...
Nagata, K, Mizuta, T, Tonokatu, Y, Fukuda, Y, Okamura, H, Hayashi, T, ...
Monoclonal antibodies (MAbs) against the native urease of Helicobacter pylori NCTC 11637 were found to clearly inhibit the urease activity. Interestingly, synergistic inhibition by two MAbs...
Okamura, H, Wada, M, Nagata, K, Tamura, T, Shoji, K
Lipopolysaccharide (LPS) induces high levels of gamma interferon (IFN-gamma) in the circulation of mice pretreated with heat-killed Propionibacterium acnes. The following results were obtained in the...
Purification of a factor which provides a costimulatory signal for gamma interferon production.
Nakamura, K, Okamura, H, Nagata, K, Komatsu, T, Tamura, T
A protein factor which induces high levels of gamma interferon (IFN-gamma) in resting splenic nonadherent cells was isolated from the sera of mice with generalized inflammation caused by endotoxic...
Undermethylation of interferon-gamma gene in human T cell lines and normal T lymphocytes.
Fukunaga, R, Matsuyama, M, Okamura, H, Nagata, K, Nagata, S, Sokawa, Y
The relative levels of DNA methylation at CCGG sequences within and around the interferon-gamma (IFN-gamma) gene in normal human tissues and cell lines were examined by Southern blot analysis using...
Endotoxin-induced serum factor that stimulates gamma interferon production.
Nakamura, K, Okamura, H, Wada, M, Nagata, K, Tamura, T
Serum from Mycobacterium bovis BCG-infected mice that had been challenged with lipopolysaccharide (LPS) exhibited a marked ability to induce gamma interferon (IFN-gamma) in cultures of spleen cells...
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).
Yamano, S, Nagata, K, Yamazoe, Y, Kato, R, Gelboin, H V, Gonzalez, F J
Masuda, H, Fukumoto, M, Hirayoshi, K, Nagata, K
HSP47 is a collagen-binding stress protein and is assumed to act as a collagen-specific molecular chaperone during the biosynthesis and secretion of procollagen in the living cell. The synthesis of...
Ohtani, K, Nakamura, M, Saito, S, Nagata, K, Sugamura, K, Hinuma, Y
Conditions were developed for stable introduction of foreign DNA into human lymphoid cell lines by electroporation. To introduce stably the p40 gene of human T-cell leukemia virus type I (HTLV-I)...
cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats.
Nagata, K, Sasamura, H, Miyata, M, Shimada, M, Yamazoe, Y, Kato, R
Kobayashi, M, Nagata, K, Ishihama, A
A set of 18 variant lac UV5 promoters was constructed, each carrying a single base substitution within the -35 region (nucleotide positions from -36 to -31 relative to the transcription start site)....
DNA sequences required for the in vitro replication of adenovirus DNA.
Guggenheimer, R A, Stillman, B W, Nagata, K, Tamanoi, F, Hurwitz, J
Initiation of adenovirus (Ad) DNA replication occurs on viral DNA containing a 55-kilodalton (kDa) protein at the 5' terminus of each viral DNA strand and on plasmid DNAs containing the origin of Ad...
Gronostajski, R M, Nagata, K, Hurwitz, J
Nuclear factor I is a 47,000-dalton protein isolated from human HeLa cells that is required for the in vitro replication of adenovirus DNA. This protein was previously shown to bind specifically to...
Nagata, K, Guggenheimer, R A, Enomoto, T, Lichy, J H, Hurwitz, J
A protein factor that participates in the formation of a covalent complex between the 80,000-dalton precursor of the adenovirus (Ad) terminal protein (pTP) and 5'-dCMP has been isolated and...
Hinuma, Y, Nagata, K, Hanaoka, M, Nakai, M, Matsumoto, T, Kinoshita, K I, ...
Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm of 1--5% of the cells of a T-cell line, MT-1, from a patient with adult T-cell leukemia (ATL), which is...
Alternative 5' splice site selection induced by heat shock.
Takechi, H, Hosokawa, N, Hirayoshi, K, Nagata, K
The mouse HSP47 gene consists of six exons separated by five introns. Three HSP47 cDNAs differing only in their 5' noncoding regions have been reported. One of these alternatively spliced mRNAs was...
Ohta, S, Shimekake, Y, Nagata, K
The promoter function of the human C-type natriuretic peptide (CNP) gene in various cultured cells was examined by transient transfection assays. The CNP promoter functioned very effectively in GH3...
Hirayoshi, K, Kudo, H, Takechi, H, Nakai, A, Iwamatsu, A, Yamada, K M, ...
We report the isolation and characterization of a cDNA clone encoding HSP47, a transformation-sensitive heat shock protein that binds to collagen. A cDNA library was prepared from total RNA isolated...
Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids.
Hosokawa, N, Hirayoshi, K, Kudo, H, Takechi, H, Aoike, A, Kawai, K, ...
Transcriptional activation of human heat shock protein (HSP) genes by heat shock or other stresses is regulated by the activation of a heat shock factor (HSF). Activated HSF posttranslationally...
Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites.
Gronostajski, R M, Adhya, S, Nagata, K, Guggenheimer, R A, Hurwitz, J
Nuclear factor I is a cellular site-specific DNA-binding protein required for the efficient in vitro replication of adenovirus DNA. We have characterized human DNA sequences to which nuclear factor I...
Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins.
Nagata, K, Guggenheimer, R A, Hurwitz, J
A protein required for the elongation of replicating intermediates of adenovirus (Ad) DNA to full length has been isolated and characterized. This factor, isolated from nuclear extracts of uninfected...
Nagata, K, Guggenheimer, R A, Hurwitz, J
Nuclear factor I, a 47-kilodalton protein, purified from nuclear extracts of uninfected HeLa cells, is involved in the initiation and possibly the elongation of replicating adenovirus (Ad) DNA in...
Nagata, K, Kohda, D, Hatanaka, H, Ichikawa, S, Matsuda, S, Yamamoto, T, ...
p185erbB-2 and p180erbB-4 are epidermal growth factor (EGF) receptor-like tyrosine kinases, whose co-expression is observed in many breast carcinomas. Heregulins (HRGs), which contain an...
Terasawa, H, Kohda, D, Hatanaka, H, Nagata, K, Higashihashi, N, Fujiwara, H, ...
The three-dimensional structure of human insulin-like growth factor II was determined at high resolution in aqueous solution by NMR and simulated annealing based calculations. The structure is quite...
Regulation of influenza virus RNA polymerase activity by cellular and viral factors.
Shimizu, K, Handa, H, Nakada, S, Nagata, K
An in vitro RNA synthesis system mimicking replication of genomic influenza virus RNA was developed with nuclear extracts prepared from influenza virus-infected HeLa cells using exogenously added RNA...
Waxman, D J, Lapenson, D P, Nagata, K, Conlon, H D
Rat hepatic cytochrome P-450 form 3 (testosterone 7 alpha-hydroxylase; P-450 gene IIA1) and P-450 form RLM2 (testosterone 15 alpha-hydroxylase; P-450 gene IIA2) are 88% identical in primary...
Sagara, J, Nagata, K, Ichikawa, Y
Myosin purified from a murine myeloid leukaemia cell line (M1) that had been incubated with [32P]orthophosphate incorporated 32P into the heavy, but not the light, chain. When the heavy chain was...
Solution structure of midkine, a new heparin-binding growth factor.
Iwasaki, W, Nagata, K, Hatanaka, H, Inui, T, Kimura, T, Muramatsu, T, ...
Midkine (MK) is a 13 kDa heparin-binding polypeptide which enhances neurite outgrowth, neuronal cell survival and plasminogen activator activity. MK is structurally divided into two domains, and most...
Nagata, K, Puls, A, Futter, C, Aspenstrom, P, Schaefer, E, Nakata, T, ...
The MLK (mixed lineage) ser/thr kinases are most closely related to the MAP kinase kinase kinase family. In addition to a kinase domain, MLK1, MLK2 and MLK3 each contain an SH3 domain, a leucine...
Tapon, N, Nagata, K, Lamarche, N, Hall, A
The Rho, Rac and Cdc42 GTPases coordinately regulate the organization of the actin cytoskeleton and the JNK MAP kinase pathway. Mutational analysis of Rac has previously shown that these two...
Tanabe, M, Kawazoe, Y, Takeda, S, Morimoto, R I, Nagata, K, Nakai, A
The vertebrate genome encodes a family of heat shock factors (HSFs 1-4) of which the DNA-binding and transcriptional activities of HSF1 and HSF3 are activated upon heat shock. HSF1 has the properties...
Dexamethasone and nitric oxide synthase gene expression in brain.
Suzuki, E, Shintani, F, Nakaki, T, Nagata, K, Yamazoe, Y, Fujita, N, ...
Systemic administration of lipopolysaccharide (LPS), which causes endotoxemia and systemic inflammation, has been reported to induce expression of the gene for type II inducible nitric oxide synthase...
Ohta, S, Yanagihara, K, Nagata, K
Human gastric carcinoma cell line HSC-39 has been shown to undergo apoptotic cell death in response to treatment with transforming growth factor beta1 (TGF-beta1). To understand better the cell death...
The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1.
Nagata, K, Ohashi, K, Yang, N, Mizuno, K
LIM-kinase 1 (LIMK1, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3) is a serine/threonine kinase that phosphorylates cofilin and regulates actin cytoskeletal...
Ohta, S, Takeuchi, M, Deguchi, M, Tsuji, T, Gahara, Y, Nagata, K
Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Recently some factors such as Smads (Sma and Mad proteins) and TGF-beta activating...
Yamazoe, Y, Ozawa, S, Nagata, K, Gong, D W, Kato, R
An aryl sulfotransferase, whose cDNA was isolated from the rat liver library, was found to catalyze bioactivation of minoxidil through N-O-sulfation and N-sulfation of a carcinogenic heterocyclic...
Inductive effect on hepatic enzymes and toxicity of congeners of PCBs and PCDFs.
Yoshimura, H, Yoshihara, S, Koga, N, Nagata, K, Wada, I, Kuroki, J, ...
The present paper describes a marked induction of liver microsomal cytochrome P-450 and cytosolic DT-diaphorase to cause possible disorder of steroid homeostasis and promotion of carcinogenicity of...
Shimizu, W., Tsuchioka, Y., Karakawa, S., Nagata, K., Mukai, J., Yamagata, T., ...
OBJECTIVE--This study investigated the dominance of each limb of the autonomic nervous system and tested sympathetic-vagal interactions in the human ventricle and atrium after administration of...
Serum granulysin is a marker for Th1 type immunity in pre-eclampsia
SAKAI, M, OGAWA, K, SHIOZAKI, A, YONEDA, S, SASAKI, Y, NAGATA, K, ...
Recent studies suggest that pre-eclampsia is associated with a Th1 predominant state and may be considered a failure of tolerance. Granulysin is a cytotoxic granule protein of natural killer (NK)...
Increase in Ksp37-positive peripheral blood lymphocytes in mild extrinsic asthma
Kuepper, M, Koester, K, Bratke, K, Myrtek, D, Ogawa, K, Nagata, K, ...
Killer-specific secretory protein of 37 kDa (Ksp37), identified as a Th1/Tc1 specific secretory protein is expressed preferentially in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells and...
Tsuda, H, Michimata, T, Sakai, M, Nagata, K, Nakamura, M, Saito, S
It has been demonstrated that pregnancy induces the immunomodulation of cytokine responses away from the Th1 paradigm and towards the Th2 paradigm. In this study, we examined the expression of CRTH2...
Orihara, K, Nagata, K, Hamasaki, S, Oba, R, Hirai, H, Ishida, S, ...
The clinical course of bacterial infectious diseases is often variable, especially in elderly patients. Thus, new biological markers have been sought to predict the disease outcome. Recent studies...
Nagata, K, Sagara, J, Ichikawa, Y
A myeloid leukemia cell line, M1, differentiates to macrophage and gains locomotive and phagocytic activity when incubated with conditioned medium (CM) from a fibroblast culture and bacterial...
Saitou, M, Goto, M, Horinouchi, M, Tamada, S, Nagata, K, Hamada, T, ...
Background: Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are...
Scoliosis after termination of vertebral growth.
Risser, J. C., Iqbal, Q. M., Nagata, K.
A follow-up study of 34 cases shows that scoliosis after termination of vertebral growth is commonly a progressive condition. In the increase of scoliosis disc degeneration is the most important...