K. Nishioka

Publication List Details

Period

1998 - 2007

Number

77

Co-Authors

COST-PERFORMANCE TRADEOFFS OF ADVANCED MATERIALS AND CONSTRUCTION FOR LARGE LAUNCH VEHICLE STRUCTURE. (1998)

NISHIOKA,K., MUNCH,N. E., POSTELNEK,W.

PAPER PRESENTED AT THE BERYLLIUM CONFERENCE, ARLINGTON, VIRGINIA, 23-25 MAR 70. SEE ALSO: GENERAL ELECTRIC COMPANY, PHILADELPHIA, PENNSYLVANIA, (389118).

Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.

Oda, H, Taketomi, A, Maruyama, R, Itoh, R, Nishioka, K, Yakushiji, H, ...

The human MTH1 gene for 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, produces seven types (types 1, 2A, 2B, 3A, 3B, 4A and 4B) of mRNAs. The B-type mRNAs with exon 2b-2c segments have three...

Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1.

Sasaki, S, Tsuji, T, Hamajima, K, Fukushima, J, Ishii, N, Kaneko, T, ...

To enhance immunity induced by DNA vaccination against human immunodeficiency virus type 1 (HIV-1), we evaluated the efficacy of monophosphoryl lipid A (MPL), an adjuvant of bacterial origin. BALB/c...

Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test.

Imai, M, Hayashi, T, Kondo, M, Saito, T, Ito, A, Hayami, M, ...

The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from...

Detection of human T-cell leukemia virus type I (HTLV-I) provirus in an infected cell line and in peripheral mononuclear cells of blood donors by the nested double polymerase chain reaction method: comparison with HTLV-I antibody tests.

Matsumoto, C, Mitsunaga, S, Oguchi, T, Mitomi, Y, Shimada, T, Ichikawa, A, ...

Human T-cell leukemia virus type I (HTLV-I) provirus DNA from the cultured cell line HUT 102 and from peripheral mononuclear cells (PBMC) of anti-HTLV-I antibody-positive Japanese blood donors was...

Detection of circulating antigens in sera of rabbits infected with Toxoplasma gondii.

Ise, Y, Iida, T, Sato, K, Suzuki, T, Shimada, K, Nishioka, K

Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood....

Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.

Nakajima, T, Aono, H, Hasunuma, T, Yamamoto, K, Maruyama, I, Nosaka, T, ...

One of the salient pathological features of rheumatoid arthritis is synovial cell proliferation with bone erosion. Despite extensive investigation, the factors essential for synovial cell...

Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy.

Kitajima, I, Yamamoto, K, Sato, K, Nakajima, Y, Nakajima, T, Maruyama, I, ...

To investigate the pathogenesis of human T cell lymphotropic virus type I (HTLV-I)-associated chronic inflammatory arthropathy (HAAP), we sought to detect proviral DNA in the articular lesions. For...

Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein.

Kohsaka, H, Yamamoto, K, Fujii, H, Miura, H, Miyasaka, N, Nishioka, K, ...

To analyze the autoepitopes on the SS-B/La protein, a cDNA covering the entire region coding the protein was isolated from a human cDNA library. The cDNA was subcloned into an expression plasmid...

The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw.

Ono, Y, Onda, H, Sasada, R, Igarashi, K, Sugino, Y, Nishioka, K

The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188...

Level of complement activity and components C1, C4, C2, and C3 in complement response to bacterial challenge in malnourished rats.

Sakamoto, M, Ishii, S, Nishioka, K, Shimada, K

In experimentally induced malnutrition in rats, there was no significant difference between the measured level of complement activity of the classical pathway (50% hemolytic complement [CH50]) and...

Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture.

Goto, M, Sasano, M, Yamanaka, H, Miyasaka, N, Kamatani, N, Inoue, K, ...

We have cloned adherent synovial cells from rheumatoid synovitis. These can be generally divided into three types, including cells that have the characteristic features of dendritic cells (DCs),...

Common T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjögren's syndrome.

Matsumoto, I, Tsubota, K, Satake, Y, Kita, Y, Matsumura, R, Murata, H, ...

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration into lacrimal and salivary glands leading to symptomatic dry eyes and mouth. Immunohistological studies have...

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

Fujisawa, K, Asahara, H, Okamoto, K, Aono, H, Hasunuma, T, Kobata, T, ...

We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To...

Enhancement of interleukin-2 immunotherapy with L-arginine.

Lieberman, M D, Nishioka, K, Redmond, H P, Daly, J M

Nutrient substrates have been shown to enhance cell-mediated immunity, but their role as adjuvants to immunotherapy has not been previously determined. This study evaluated L-arginine as an essential...

Detection of an amino acid substitution in the mutant enzyme for a special type of adenine phosphoribosyltransferase (APRT) deficiency by sequence-specific protein cleavage.

Kamatani, N, Kuroshima, S, Terai, C, Hidaka, Y, Palella, T D, Nishioka, K

Generally, if mutant and normal proteins have similar molecular weights and electric charges, they cannot easily be distinguished from one another. We have developed a unique method by which a mutant...

Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.

Oda, H, Taketomi, A, Maruyama, R, Itoh, R, Nishioka, K, Yakushiji, H, ...

The human MTH1 gene for 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, produces seven types (types 1, 2A, 2B, 3A, 3B, 4A and 4B) of mRNAs. The B-type mRNAs with exon 2b-2c segments have three...

Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1.

Sasaki, S, Tsuji, T, Hamajima, K, Fukushima, J, Ishii, N, Kaneko, T, ...

To enhance immunity induced by DNA vaccination against human immunodeficiency virus type 1 (HIV-1), we evaluated the efficacy of monophosphoryl lipid A (MPL), an adjuvant of bacterial origin. BALB/c...

Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test.

Imai, M, Hayashi, T, Kondo, M, Saito, T, Ito, A, Hayami, M, ...

The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from...

Detection of human T-cell leukemia virus type I (HTLV-I) provirus in an infected cell line and in peripheral mononuclear cells of blood donors by the nested double polymerase chain reaction method: comparison with HTLV-I antibody tests.

Matsumoto, C, Mitsunaga, S, Oguchi, T, Mitomi, Y, Shimada, T, Ichikawa, A, ...

Human T-cell leukemia virus type I (HTLV-I) provirus DNA from the cultured cell line HUT 102 and from peripheral mononuclear cells (PBMC) of anti-HTLV-I antibody-positive Japanese blood donors was...

Detection of circulating antigens in sera of rabbits infected with Toxoplasma gondii.

Ise, Y, Iida, T, Sato, K, Suzuki, T, Shimada, K, Nishioka, K

Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood....

Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.

Nakajima, T, Aono, H, Hasunuma, T, Yamamoto, K, Maruyama, I, Nosaka, T, ...

One of the salient pathological features of rheumatoid arthritis is synovial cell proliferation with bone erosion. Despite extensive investigation, the factors essential for synovial cell...

Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy.

Kitajima, I, Yamamoto, K, Sato, K, Nakajima, Y, Nakajima, T, Maruyama, I, ...

To investigate the pathogenesis of human T cell lymphotropic virus type I (HTLV-I)-associated chronic inflammatory arthropathy (HAAP), we sought to detect proviral DNA in the articular lesions. For...

Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein.

Kohsaka, H, Yamamoto, K, Fujii, H, Miura, H, Miyasaka, N, Nishioka, K, ...

To analyze the autoepitopes on the SS-B/La protein, a cDNA covering the entire region coding the protein was isolated from a human cDNA library. The cDNA was subcloned into an expression plasmid...

The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw.

Ono, Y, Onda, H, Sasada, R, Igarashi, K, Sugino, Y, Nishioka, K

The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188...

Level of complement activity and components C1, C4, C2, and C3 in complement response to bacterial challenge in malnourished rats.

Sakamoto, M, Ishii, S, Nishioka, K, Shimada, K

In experimentally induced malnutrition in rats, there was no significant difference between the measured level of complement activity of the classical pathway (50% hemolytic complement [CH50]) and...

Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture.

Goto, M, Sasano, M, Yamanaka, H, Miyasaka, N, Kamatani, N, Inoue, K, ...

We have cloned adherent synovial cells from rheumatoid synovitis. These can be generally divided into three types, including cells that have the characteristic features of dendritic cells (DCs),...

Common T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjögren's syndrome.

Matsumoto, I, Tsubota, K, Satake, Y, Kita, Y, Matsumura, R, Murata, H, ...

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration into lacrimal and salivary glands leading to symptomatic dry eyes and mouth. Immunohistological studies have...

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

Fujisawa, K, Asahara, H, Okamoto, K, Aono, H, Hasunuma, T, Kobata, T, ...

We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To...

Enhancement of interleukin-2 immunotherapy with L-arginine.

Lieberman, M D, Nishioka, K, Redmond, H P, Daly, J M

Nutrient substrates have been shown to enhance cell-mediated immunity, but their role as adjuvants to immunotherapy has not been previously determined. This study evaluated L-arginine as an essential...

Detection of an amino acid substitution in the mutant enzyme for a special type of adenine phosphoribosyltransferase (APRT) deficiency by sequence-specific protein cleavage.

Kamatani, N, Kuroshima, S, Terai, C, Hidaka, Y, Palella, T D, Nishioka, K

Generally, if mutant and normal proteins have similar molecular weights and electric charges, they cannot easily be distinguished from one another. We have developed a unique method by which a mutant...

HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody.

Toda, S, Ishii, N, Okada, E, Kusakabe, K I, Arai, H, Hamajima, K, ...

The adjuvant effect of mannan-coated liposomes on human immunodeficiency virus type-1 (HIV-1) DNA vaccine and the mechanism of this enhancement were studied. Coating of cationic liposomes with mannan...

Apoptosis with FasL+ cell infiltration in the periphery and thymus of corrected autoimmune mice.

Kobata, T, Takasaki, K, Asahara, H, Hong, N M, Masuko-Hongo, K, Kato, T, ...

Fas (CD95) ligand (L) is a death factor that binds to its receptor, Fas, and induces apoptotic cell death, a crucial process in immunological tolerance. gld (generalized lymphoproliferative disorder)...

The effects of Cu-chlorophyllin on the active site formation of each component of guinea-pig complement

Okada, H., Nishioka, K., Sindo, T.

The effects of Cu-chlorophyllin on the formation of intermediate complexes (site formation) by each component of guinea-pig complement on sensitized sheep erythrocytes were examined. When the Z value...

Contact sensitivity in vitro: The production of macrophage inhibition factors from DNCB sensitized lymphocytes by subcellular organelles obtained from DNCB epidermal tissue

Nishioka, K., Amos, H. E.

Actively allergized cells from guinea-pigs with contact sensitivity to DNCB were specifically triggered to produce the macrophage inhibition factors—antigen-dependent and non-antigen-dependent MIF...

Effect of malnutritional rehabilitation on tuberculin reactivity and complement level in rats

Sakamoto, Motoko, Nishioka, K., Shimada, K.

The purpose of this study was to clarify the effect of differing nutritional states on various components of the immune system, especially on the interplay of the complement system and cell-mediated...

Complement response after experimental bacterial infection in various nutritional states.

Sakamoto, M, Ishii, S, Nishioka, K, Shimada, K

In malnourished rats, nutritionally rehabilitated rats at various stages, and in well nourished rats, levels of serum complement after bacterial infection caused by Staphylococcus aureus, as well as...

Allopurinol metabolism in a patient with xanthine oxidase deficiency.

Yamanaka, H, Nishioka, K, Suzuki, T, Kohno, K

A patient with complete deficiency of xanthine oxidase would not be expected to oxidase allopurinol to oxipurinol if allopurinol did not have any alternative metabolic pathway. 400 mg of allopurinol...

Immunological and immunohistochemical analysis of rheumatoid nodules.

Miyasaka, N, Sato, K, Yamamoto, K, Goto, M, Nishioka, K

An attempt was made to examine the pathophysiology of the rheumatoid nodule. Significant amounts of interleukin 1-like activity and prostaglandin E2 were detected in the supernatants from in vitro...

Spontaneous release of angiotensin converting enzyme and interleukin 1 beta from peripheral blood monocytes from patients with rheumatoid arthritis under a serum free condition.

Goto, M, Fujisawa, M, Yamada, A, Okabe, T, Takaku, F, Sasano, M, ...

Angiotensin converting enzyme (ACE) and interleukin 1 activities were assayed simultaneously in the serum free medium from the unstimulated peripheral blood monocytes from 32 patients with rheumatoid...

Production of prostaglandin E2 induced by histamine by cloned rheumatoid synovial cells.

Sasano, M, Goto, M, Nishioka, K

Production of prostaglandin E2, with or without histamine stimulation, by three different types of cloned rheumatoid synovial cells (macrophage like, dendritic, and fibroblast like) was evaluated....

Aberrant cytokine production from tenosynovium in dialysis associated amyloidosis.

Miyasaka, N, Sato, K, Kitano, Y, Higaki, M, Nishioka, K, Ohta, K

Culture supernatants of tenosynovial tissues from patients with carpal tunnel syndrome undergoing chronic haemodialysis contained interleukin (IL) 1-like and IL6-like activity. These culture...

High prevalence of arthropathy in HTLV-I carriers on a Japanese island.

Motokawa, S, Hasunuma, T, Tajima, K, Krieg, A M, Ito, S, Iwasaki, K, ...

OBJECTIVE: To determine the aetiological relationship between human T cell leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological study of the inhabitants of Tsushima, an...

Prospective study of the clinical value of determining circulating IgA-alpha 1-antitrypsin complex using a prototype ELISA kit in patients with rheumatoid arthritis.

Iwana, K, Aotsuka, S, Nishioka, K

OBJECTIVE: To evaluate the clinical value of determining circulating IgA-alpha 1-antitrypsin (IgA-AT) complex in rheumatoid arthritis. METHODS: The IgA-AT complex was assayed by a prototype ELISA kit...

Long term persistent accumulation of CD8+ T cells in synovial fluid of rheumatoid arthritis

Masuko-Hongo, K., Sekine, T., Ueda, S., Kobata, T., Yamamoto, K., Nishioka, K., ...

OBJECTIVE—To characterise the type and kinetics of T cell clones in synovial lesions of patients with rheumatoid arthritis (RA).
METHODS—Mononuclear cells from serial samples of synovial fluid...

Characterisation of fibroblast-like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes

Xue, C., Takahashi, M., Hasunuma, T., Aono, H., Yamamoto, K., Yoshino, S., ...

OBJECTIVE—To better understand the characteristics of synoviocytes located in the rheumatoid arthritis (RA) pannus.
METHODS—One cell line, termed PSC, was cloned from RA pannus lesions....