Trpsl regulates proliferation and apoptosis of chondrocytes through Stat3 signaling (2007)
Suemoto, H., Muragaki, Y., Nishioka, K., Sato, M., Ooshima, A., Itoh, S., ...
Hyper-ERAD: a novel pathomechanism for rheumatoid arthritis (2004)
Nakajima, T, Yagishita, N, Yamasaki, S, Tsuchimochi, K, Amano, T, Fukamizu, A, ...
No abstract available.
Clinical classification of fibromyalgia according to disease progression (2004)
No abstract available.
Nagaya, N, Horio, T, Miyatake, K, Chiba, Y, Kangawa, K, Kanda, M, ...
Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., Kobata, T.
Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the...
Proteomic surveillance of autoimmunity in osteoarthritis (2003)
Kato, T, Xiang, Y, Sekine, T, Nakamura, H, Imajoh-Ohmi, S, Fukuda, H, ...
No abstract available.
15-deoxy-delta12,14-prostaglandin J2induces apoptosis in human articular chondrocytes (2003)
Masuko-Hongo, K, Shang, Z-Z, Kato, T, Nakamura, H, Nishioka, K
No abstract available.
Matsuno, H, Yudoh, K, Nishioka, K
No abstract available.
Pathogenetic roles of Synoviolin in synovial hyperplasia of rheumatoid arthritis (2003)
Yamasaki, S, Yagishita, N, Amano, T, Tsuchimochi, K, Maruyama, I, Nishioka, K, ...
No abstract available.
Tsuchimochi, K, Yamasaki, S, Yagishita, N, Amano, T, Komiya, S, Maruyama, I, ...
No abstract available.
The importance of Synoviolin in embryogenesis (2003)
Yagishita, N, Amano, T, Yamasaki, S, Tsuchimochi, T, Nishioka, K, Maruyama, I, ...
No abstract available.
Synoviolin as a novel pathogenic factor for arthropathy (2003)
Amano, T, Yamasaki, S, Yagishita, N, Tsuchimochi, K, Fukamizu, A, Maruyama, I, ...
No abstract available.
Yudoh, K, Trieu, N Van, Matsuno, H, Nishioka, K
No abstract available.
T cell–chondrocyte interaction in the pathogenesis of osteoarthritis (2003)
Nakamura, H, Kato, T, Masuko-Hongo, K, Tanaka, M, Shibakawa, A, Nishioka, K
No abstract available.
Nakamura, H, Hoshi, K, Kato, T, Ozaki, S, Nishioka, M, Nishioka, K
No abstract available.
Nagaya, N, Kangawa, K, Kanda, M, Uematsu, M, Horio, T, Fukuyama, N, ...
Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., Kobata, T.
Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the...
Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., Kobata, T.
Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the...
Fas-associated death domain protein is a Fas-mediated apoptosis modulator in synoviocytes (2000)
Okamoto, K., Kobayashi, T., Kobata, T., Hasunuma, T., Kato, T., Sumida, T., ...
Objective. To understand the intracellular regulatory mechanisms in Fas‐mediated apoptosis of synoviocytes, we examined the involvement of caspases [caspase‐1/ICE...
Oda, H, Taketomi, A, Maruyama, R, Itoh, R, Nishioka, K, Yakushiji, H, ...
Decreased TCR AV24AJ18+ double-negative T cells in rheumatoid synovium (1999)
Maeda, T, Keino, H, Asahara, H, Taniguchi, M, Nishioka, K, Sumida, T
NISHIOKA,K., MUNCH,N. E., POSTELNEK,W.
PAPER PRESENTED AT THE BERYLLIUM CONFERENCE, ARLINGTON, VIRGINIA, 23-25 MAR 70. SEE ALSO: GENERAL ELECTRIC COMPANY, PHILADELPHIA, PENNSYLVANIA, (389118).
Correlation of clonal T cell expansion with disease activity in systemic lupus erythematosus (1997)
Mato, T, Masuko, K, Misaki, Y, Hirose, N, Ito, K, Takemoto, Y, ...
Oda, H, Taketomi, A, Maruyama, R, Itoh, R, Nishioka, K, Yakushiji, H, ...
The human MTH1 gene for 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, produces seven types (types 1, 2A, 2B, 3A, 3B, 4A and 4B) of mRNAs. The B-type mRNAs with exon 2b-2c segments have three...
Sasaki, S, Tsuji, T, Hamajima, K, Fukushima, J, Ishii, N, Kaneko, T, ...
To enhance immunity induced by DNA vaccination against human immunodeficiency virus type 1 (HIV-1), we evaluated the efficacy of monophosphoryl lipid A (MPL), an adjuvant of bacterial origin. BALB/c...
Imai, M, Hayashi, T, Kondo, M, Saito, T, Ito, A, Hayami, M, ...
The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from...
Matsumoto, C, Mitsunaga, S, Oguchi, T, Mitomi, Y, Shimada, T, Ichikawa, A, ...
Human T-cell leukemia virus type I (HTLV-I) provirus DNA from the cultured cell line HUT 102 and from peripheral mononuclear cells (PBMC) of anti-HTLV-I antibody-positive Japanese blood donors was...
Detection of circulating antigens in sera of rabbits infected with Toxoplasma gondii.
Ise, Y, Iida, T, Sato, K, Suzuki, T, Shimada, K, Nishioka, K
Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood....
Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.
Nakajima, T, Aono, H, Hasunuma, T, Yamamoto, K, Maruyama, I, Nosaka, T, ...
One of the salient pathological features of rheumatoid arthritis is synovial cell proliferation with bone erosion. Despite extensive investigation, the factors essential for synovial cell...
Kitajima, I, Yamamoto, K, Sato, K, Nakajima, Y, Nakajima, T, Maruyama, I, ...
To investigate the pathogenesis of human T cell lymphotropic virus type I (HTLV-I)-associated chronic inflammatory arthropathy (HAAP), we sought to detect proviral DNA in the articular lesions. For...
Kohsaka, H, Yamamoto, K, Fujii, H, Miura, H, Miyasaka, N, Nishioka, K, ...
To analyze the autoepitopes on the SS-B/La protein, a cDNA covering the entire region coding the protein was isolated from a human cDNA library. The cDNA was subcloned into an expression plasmid...
The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw.
Ono, Y, Onda, H, Sasada, R, Igarashi, K, Sugino, Y, Nishioka, K
The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188...
Sakamoto, M, Ishii, S, Nishioka, K, Shimada, K
In experimentally induced malnutrition in rats, there was no significant difference between the measured level of complement activity of the classical pathway (50% hemolytic complement [CH50]) and...
Goto, M, Sasano, M, Yamanaka, H, Miyasaka, N, Kamatani, N, Inoue, K, ...
We have cloned adherent synovial cells from rheumatoid synovitis. These can be generally divided into three types, including cells that have the characteristic features of dendritic cells (DCs),...
Matsumoto, I, Tsubota, K, Satake, Y, Kita, Y, Matsumura, R, Murata, H, ...
Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration into lacrimal and salivary glands leading to symptomatic dry eyes and mouth. Immunohistological studies have...
Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.
Fujisawa, K, Asahara, H, Okamoto, K, Aono, H, Hasunuma, T, Kobata, T, ...
We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To...
Enhancement of interleukin-2 immunotherapy with L-arginine.
Lieberman, M D, Nishioka, K, Redmond, H P, Daly, J M
Nutrient substrates have been shown to enhance cell-mediated immunity, but their role as adjuvants to immunotherapy has not been previously determined. This study evaluated L-arginine as an essential...
Kamatani, N, Kuroshima, S, Terai, C, Hidaka, Y, Palella, T D, Nishioka, K
Generally, if mutant and normal proteins have similar molecular weights and electric charges, they cannot easily be distinguished from one another. We have developed a unique method by which a mutant...
Oda, H, Taketomi, A, Maruyama, R, Itoh, R, Nishioka, K, Yakushiji, H, ...
The human MTH1 gene for 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, produces seven types (types 1, 2A, 2B, 3A, 3B, 4A and 4B) of mRNAs. The B-type mRNAs with exon 2b-2c segments have three...
Sasaki, S, Tsuji, T, Hamajima, K, Fukushima, J, Ishii, N, Kaneko, T, ...
To enhance immunity induced by DNA vaccination against human immunodeficiency virus type 1 (HIV-1), we evaluated the efficacy of monophosphoryl lipid A (MPL), an adjuvant of bacterial origin. BALB/c...
Imai, M, Hayashi, T, Kondo, M, Saito, T, Ito, A, Hayami, M, ...
The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from...
Matsumoto, C, Mitsunaga, S, Oguchi, T, Mitomi, Y, Shimada, T, Ichikawa, A, ...
Human T-cell leukemia virus type I (HTLV-I) provirus DNA from the cultured cell line HUT 102 and from peripheral mononuclear cells (PBMC) of anti-HTLV-I antibody-positive Japanese blood donors was...
Detection of circulating antigens in sera of rabbits infected with Toxoplasma gondii.
Ise, Y, Iida, T, Sato, K, Suzuki, T, Shimada, K, Nishioka, K
Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood....
Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.
Nakajima, T, Aono, H, Hasunuma, T, Yamamoto, K, Maruyama, I, Nosaka, T, ...
One of the salient pathological features of rheumatoid arthritis is synovial cell proliferation with bone erosion. Despite extensive investigation, the factors essential for synovial cell...
Kitajima, I, Yamamoto, K, Sato, K, Nakajima, Y, Nakajima, T, Maruyama, I, ...
To investigate the pathogenesis of human T cell lymphotropic virus type I (HTLV-I)-associated chronic inflammatory arthropathy (HAAP), we sought to detect proviral DNA in the articular lesions. For...
Kohsaka, H, Yamamoto, K, Fujii, H, Miura, H, Miyasaka, N, Nishioka, K, ...
To analyze the autoepitopes on the SS-B/La protein, a cDNA covering the entire region coding the protein was isolated from a human cDNA library. The cDNA was subcloned into an expression plasmid...
The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw.
Ono, Y, Onda, H, Sasada, R, Igarashi, K, Sugino, Y, Nishioka, K
The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188...
Sakamoto, M, Ishii, S, Nishioka, K, Shimada, K
In experimentally induced malnutrition in rats, there was no significant difference between the measured level of complement activity of the classical pathway (50% hemolytic complement [CH50]) and...
Goto, M, Sasano, M, Yamanaka, H, Miyasaka, N, Kamatani, N, Inoue, K, ...
We have cloned adherent synovial cells from rheumatoid synovitis. These can be generally divided into three types, including cells that have the characteristic features of dendritic cells (DCs),...
Matsumoto, I, Tsubota, K, Satake, Y, Kita, Y, Matsumura, R, Murata, H, ...
Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration into lacrimal and salivary glands leading to symptomatic dry eyes and mouth. Immunohistological studies have...
Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.
Fujisawa, K, Asahara, H, Okamoto, K, Aono, H, Hasunuma, T, Kobata, T, ...
We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To...
Enhancement of interleukin-2 immunotherapy with L-arginine.
Lieberman, M D, Nishioka, K, Redmond, H P, Daly, J M
Nutrient substrates have been shown to enhance cell-mediated immunity, but their role as adjuvants to immunotherapy has not been previously determined. This study evaluated L-arginine as an essential...
Kamatani, N, Kuroshima, S, Terai, C, Hidaka, Y, Palella, T D, Nishioka, K
Generally, if mutant and normal proteins have similar molecular weights and electric charges, they cannot easily be distinguished from one another. We have developed a unique method by which a mutant...
Toda, S, Ishii, N, Okada, E, Kusakabe, K I, Arai, H, Hamajima, K, ...
The adjuvant effect of mannan-coated liposomes on human immunodeficiency virus type-1 (HIV-1) DNA vaccine and the mechanism of this enhancement were studied. Coating of cationic liposomes with mannan...
Apoptosis with FasL+ cell infiltration in the periphery and thymus of corrected autoimmune mice.
Kobata, T, Takasaki, K, Asahara, H, Hong, N M, Masuko-Hongo, K, Kato, T, ...
Fas (CD95) ligand (L) is a death factor that binds to its receptor, Fas, and induces apoptotic cell death, a crucial process in immunological tolerance. gld (generalized lymphoproliferative disorder)...
Okada, H., Nishioka, K., Sindo, T.
The effects of Cu-chlorophyllin on the formation of intermediate complexes (site formation) by each component of guinea-pig complement on sensitized sheep erythrocytes were examined. When the Z value...
Actively allergized cells from guinea-pigs with contact sensitivity to DNCB were specifically triggered to produce the macrophage inhibition factors—antigen-dependent and non-antigen-dependent MIF...
Effect of malnutritional rehabilitation on tuberculin reactivity and complement level in rats
Sakamoto, Motoko, Nishioka, K., Shimada, K.
The purpose of this study was to clarify the effect of differing nutritional states on various components of the immune system, especially on the interplay of the complement system and cell-mediated...
Complement response after experimental bacterial infection in various nutritional states.
Sakamoto, M, Ishii, S, Nishioka, K, Shimada, K
In malnourished rats, nutritionally rehabilitated rats at various stages, and in well nourished rats, levels of serum complement after bacterial infection caused by Staphylococcus aureus, as well as...
Allopurinol metabolism in a patient with xanthine oxidase deficiency.
Yamanaka, H, Nishioka, K, Suzuki, T, Kohno, K
A patient with complete deficiency of xanthine oxidase would not be expected to oxidase allopurinol to oxipurinol if allopurinol did not have any alternative metabolic pathway. 400 mg of allopurinol...
Immunological and immunohistochemical analysis of rheumatoid nodules.
Miyasaka, N, Sato, K, Yamamoto, K, Goto, M, Nishioka, K
An attempt was made to examine the pathophysiology of the rheumatoid nodule. Significant amounts of interleukin 1-like activity and prostaglandin E2 were detected in the supernatants from in vitro...
Goto, M, Fujisawa, M, Yamada, A, Okabe, T, Takaku, F, Sasano, M, ...
Angiotensin converting enzyme (ACE) and interleukin 1 activities were assayed simultaneously in the serum free medium from the unstimulated peripheral blood monocytes from 32 patients with rheumatoid...
Production of prostaglandin E2 induced by histamine by cloned rheumatoid synovial cells.
Sasano, M, Goto, M, Nishioka, K
Production of prostaglandin E2, with or without histamine stimulation, by three different types of cloned rheumatoid synovial cells (macrophage like, dendritic, and fibroblast like) was evaluated....
Aberrant cytokine production from tenosynovium in dialysis associated amyloidosis.
Miyasaka, N, Sato, K, Kitano, Y, Higaki, M, Nishioka, K, Ohta, K
Culture supernatants of tenosynovial tissues from patients with carpal tunnel syndrome undergoing chronic haemodialysis contained interleukin (IL) 1-like and IL6-like activity. These culture...
High prevalence of arthropathy in HTLV-I carriers on a Japanese island.
Motokawa, S, Hasunuma, T, Tajima, K, Krieg, A M, Ito, S, Iwasaki, K, ...
OBJECTIVE: To determine the aetiological relationship between human T cell leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological study of the inhabitants of Tsushima, an...
Iwana, K, Aotsuka, S, Nishioka, K
OBJECTIVE: To evaluate the clinical value of determining circulating IgA-alpha 1-antitrypsin (IgA-AT) complex in rheumatoid arthritis. METHODS: The IgA-AT complex was assayed by a prototype ELISA kit...
Long term persistent accumulation of CD8+ T cells in synovial fluid of rheumatoid arthritis
Masuko-Hongo, K., Sekine, T., Ueda, S., Kobata, T., Yamamoto, K., Nishioka, K., ...
OBJECTIVE—To characterise the type and kinetics of T cell clones in synovial lesions of patients with rheumatoid arthritis (RA). METHODS—Mononuclear cells from serial samples of synovial fluid...
Xue, C., Takahashi, M., Hasunuma, T., Aono, H., Yamamoto, K., Yoshino, S., ...
OBJECTIVE—To better understand the characteristics of synoviocytes located in the rheumatoid arthritis (RA) pannus. METHODS—One cell line, termed PSC, was cloned from RA pannus lesions....
Sekine, T., Kato, T., Masuko-Hongo, K., Nakamura, H., Yoshino, S., Nishioka, K., ...
OBJECTIVE—To investigate whether type II collagen (CII) is recognised by oligoclonally expanded synovial T cells of patients with rheumatoid arthritis (RA). METHODS—Peripheral blood mononuclear...
Kurokawa, M., Kato, T., Masuko-Hongo, K., Ueda, S., Kobata, T., Okubo, M., ...
OBJECTIVE—To investigate whether identical T cell clonotypes accumulate in multiple rheumatoid joints, the clonality of T cells that had infiltrated into synovial tissue (ST) samples simultaneously...
Masuko-Hongo, K., Kurokawa, M., Kobata, T., Nishioka, K., Kato, T.
OBJECTIVE—Recent studies have suggested that interleukin (IL) 15 induces T cell accumulation in synovial lesions of rheumatoid arthritis (RA). This study aimed at determining whether this cytokine...
Sekine, T, Masuko-Hongo, K, Matsui, T, Asahara, H, Takigawa, M, Nishioka, K, ...
OBJECTIVE—To investigate whether autoimmunity to YKL-39, a recently cloned cartilage protein, occurs in patients with rheumatoid arthritis (RA). METHODS—Autoantibody to YKL-39 was assayed by...
Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice
Yao, Z, Nakamura, H, Masuko-Hongo, K, Suzuki-Kurokawa, M, Nishioka, K, Kato, T
Objectives: To characterise cartilage intermediate layer protein (CILP)-induced arthropathy in mice.
Ishihara, M, Sato, H, Kawagoe, T, Shimatani, Y, Kurisu, S, Nishioka, K, ...
OBJECTIVE—To assess the influence of diabetes on long term prognosis after reperfusion treatment and its interaction with multivessel disease. DESIGN—A retrospective observational...
YOKOZEKI, H, WU, M-H, SUMI, K, IGAWA, K, MIYAZAKI, Y, KATAYAMA, I, ...
We previously reported the establishment of a mouse model system of contact hypersensitivity (CHS) to paraphenylemediamine (PPD). In order to analyse the functional contribution of Th2 cytokines,...
Matsushita, M, Yamamoto, T, Nishioka, K
Accumulative data have demonstrated that plasminogen activator inhibitor-1 (PAI-1) plays an important role in the extracellular matrix metabolism; however, the involvement of PAI-1 in scleroderma has...
Satoh, T, Yokozeki, H, Nishioka, K
Eosinophils have a variety of functions. Although increasing evidence links the presence of eosinophils to airway damage, studies have not examined in detail if, and how, eosinophils affect skin...
Kurokawa, M, Tong, J, Matsui, T, Masuko-Hongo, K, Yabe, T, Nishioka, K, ...
T cell receptors, which recognize antigen peptides on MHC molecules, are essential probes for the analysis of T cell antigen specificity. The identification of paired T cell receptor (TCR) chains,...
Keino, H, Takeuchi, M, Suzuki, J, Kojo, S, Sakai, J, Nishioka, K, ...
Experimental autoimmune uveoretinitis (EAU), which is a T cell mediated organ specific autoimmune disease, is induced by immunization with interphotoreceptor retinoid binding protein (IRBP) in...
Yokozeki, H, Watanabe, K, Igawa, K, Miyazaki, Y, Katayama, I, Nishioka, K
Para-phenylenediamine (PPD) is known to be a common sensitizer of allergic contact dermatitis and contact urticaria. To clarify the mechanism of contact hypersensitivity (CHS) to PPD, we established...
Objective: To determine whether IL18 has any indirect effects on osteoclastogenesis mediated by T cells in RA synovium, and compare its effects with those of IL1ß and TNFα.
Dai, S, Shan, Z, Nishioka, K, Yudoh, K
Objective: To clarify the effect of interleukin (IL) 18 on cartilage degeneration by studying the profile of IL18 receptor (IL18R) on chondrocytes and the direct effect of IL18 on production of...
Nishioka, K., Levin, A. G., Simons, M. J.
The relative sensitivities of counterimmunoelectrophoresis (CIE) and haemagglutination assays for the detection of hepatitis B surface antigen (HBsAg) and antibodies (anti-HBs) were compared. Twelve...
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours
The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers...
Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus
Nishioka, K, Doki, Y, Shiozaki, H, Yamamoto, H, Tamura, S, Yasuda, T, ...
CDC25A, CDC25B and CDC25C belong to a family of protein phosphatases which activate the cyclin-dependent kinase at different points of the cell cycle. According to accumulating evidence, CDC25A and...