Tominaga, N., Blinnikov, S., Baklanov, P., Morokuma, T., Nomoto, K., Suzuki, T.
Shock breakout is the brightest radiative phenomenon in a Type II supernova (SN). Although it was predicted to be bright, the direct observation is difficult due to the short duration and...
Early phase observations of extremely luminous Type Ia Supernova 2009dc (2009)
Yamanaka, M., Kawabata, K. S., Kinugasa, K., Tanaka, M., Imada, A., Maeda, K., ...
We present early phase observations in optical and near-infrared wavelengths for the extremely luminous Type Ia supernova (SN Ia) 2009dc. The decline rate of the light curve is $\Delta...
A unique core-collapse supernova in an elliptical galaxy (2009)
Kawabata, K. S., Maeda, K., Nomoto, K., Taubenberger, S., Tanaka, M., Hattori, T., ...
We report on our discovery and observations of a very unique supernova, SN 2005cz, that exhibits previously unknown properties. The early-phase spectrum of this supernova (SN) is similar to those of...
Subaru high-resolution spectroscopy of Star G in the Tycho supernova remnant (2009)
Kerzendorf, W. E., Schmidt, B. P., Asplund, M., Nomoto, K., Podsiadlowski, Ph., Frebel, A., ...
It is widely believed that Type Ia supernovae (SN Ia) originate in binary systems where a white dwarf accretes material from a companion star until its mass approaches the Chandrasekhar mass and...
Type Ia supernova science 2010-2020 (2009)
Howell, D. A., Conley, A., Della Valle, M., Nugent, P. E., Perlmutter, S., Marion, G. H., ...
In the next decade Type Ia supernovae (SNe Ia) will be used to test theories predicting changes in the Dark Energy equation of state with time. Ultimately this requires a dedicated space mission like...
Anupama, GC, Sahu, DK, Gurugubelli, UK, Prabhu, TP, Tominaga, N, Tanaka, M, ...
We present optical UBVRI photometric and spectroscopic data of the Type Ibn supernova SN 2006jc, until the onset of the dust-forming phase. The optical spectrum shows a blue continuum and is...
Subaru and Keck observations of the peculiar type Ia supernova 2006GZ at late phases (2009)
Maeda, K., Kawabata, K., Li, W., Tanaka, M., Mazzali, P. A., Hattori, T., ...
Origin and Nature of Dust in the Early Universe (2008)
Nozawa, T., Kozasa, T., Umeda, H., Hirashita, H., Maeda, K., Nomoto, K., ...
We present recent advances in theoretical studies of the formation and evolution of dust in primordial supernovae (SNe) that are considered to be the main sources of dust in the early universe. Being...
Anupama, G. C., Sahu, D. K., Gurugubelli, U. K., Prabhu, T. P., Tominaga, N., Tanaka, M., ...
We present optical UBVRI photometric and spectroscopic data of the type Ibn supernova SN 2006jc, until the onset of the dust forming phase. The optical spectrum shows a blue continuum and is...
Nucleosynthesis in Electron Capture Supernovae of AGB Stars (2008)
Wanajo, S., Nomoto, K., Janka, H. -Th., Kitaura, F. S., Mueller, B.
We examine nucleosynthesis in the electron capture supernovae of progenitor AGB stars with an O-Ne-Mg core (with the initial stellar mass of 8.8 M_\odot). Thermodynamic trajectories for the first 810...
Gal-Yam, A., Bufano, F., Barlow, T. A., Baron, E., Benetti, S., Cappellaro, E., ...
We present the initial results from our GALEX program designed to obtain ultraviolet (UV) spectra of nearby core-collapse supernovae (SNe). Our first target, SN 2005ay in the nearby galaxy NGC 3938,...
Gal-Yam, A., Bufano, F., Barlow, T. A., Baron, E., Benetti, S., Cappellaro, E., ...
We present the initial results from our GALEX program designed to obtain ultraviolet (UV) spectra of nearby core-collapse supernovae (SNe). Our first target, SN 2005ay in the nearby galaxy NGC 3938,...
Takigawa, A., Miki, J., Tachibana, S., Huss, G. R., Tominaga, N., Umeda, H., ...
Several short-lived radionuclides (SLRs) were present in the early solar system, some of which should have formed just prior to or soon after the solar system formation. Stellar nucleosynthesis has...
GALEX Spectroscopy of SN 2005ay suggests a UV spectral uniformity among type II-P supernovae (2008)
Gal-Yam, A., Bufano, F., Barlow, T., Baron, E., Benetti, S., Cappellaro, E., ...
We present the first results from our GALEX program designed to obtain ultraviolet (UV) spectroscopy of nearby core-collapse supernovae (SNe). Our first target, SN 2005ay in the nearby galaxy NGC...
Nomoto, K., Tominaga, N., Tanaka, M., Maeda, K., Umeda, H.
The connection between the long GRBs and Type Ic Supernovae (SNe) has revealed the interesting diversity: (i) GRB-SNe, (ii) Non-GRB Hypernovae (HNe), (iii) X-Ray Flash (XRF)-SNe, and (iv) Non-SN GRBs...
ICRC 2001 c ○ Copernicus Gesellschaft 2002 (2008)
D. Argast, F. Brachwitz, G. Martinez-pinedo, R. Oechslin, T. Rauscher, ...
Abstract. With the exception of the Big Bang, responsible for 1,2 H, 3,4 He, and 7 Li, stars act as sources for the composition of the interstellar medium. Cosmic rays are related to the latter and...
The broad-lined type Ic supernova 2003jd (2008)
Valenti, S., Benetti, S., Cappellaro, E., Patat, F., Mazzali, P., Turatto, M., ...
The results of a worldwide coordinated observational campaign on the broad-lined Type Ic supernova (SN Ic) 2003jd are presented. In total, 74 photometric data points and 26 spectra were collected...
A Free Lagrange Method: adoption of a rectangle as a control volume (2008)
N. Nakasato, I. Hachisu, K. Nomoto
We present a simple way of solving the Euler equations. This method, which is based on a Godunov type Free Lagrange Method, can be implemented easily and requires small memory. It is easy to...
Supernova Nucleosynthesis As A Tool To Analyze The Explosion Mechanism (2008)
F. Brachwitz, C. Freiburghaus, T. Rauscher, K. Iwamoto, ...
Type II supernovae (SNe II) are linked to the gravitational collapse of massive stars (M?8M fi ) at the end of their hydrostatic evolution. The resulting central hot proto-neutron star cools via...
Nozawa, T., Kozasa, T., Tominaga, N., Sakon, I., Tanaka, M., Suzuki, T., ...
SN 2006jc is a peculiar supernova (SN), in which the formation of dust has been confirmed at an early epoch of ~50 days after the explosion. We investigate the possibility of such an earlier...
The broad-lined type Ic supernova 2003jd (2008)
Valenti, S., Benetti, S., Cappellaro, E., Patat, F., Mazzali, P., Turatto, M., ...
The peculiar type Ib supernova 2006jc: a WCO Wolf-Rayet star explosion (2008)
Tominaga, N., Limongi, M., Suzuki, T., Tanaka, M., Nomoto, K., Maeda, K., ...
Tycho Brahe's 1572 supernova as a standard type Ia as revealed by its light-echo spectrum (2008)
Krause, O., Tanaka, M., Usuda, T., Hattori, T., Goto, M., Birkmann, S., ...
Type Ia supernovae (SNe Ia) are thermonuclear explosions of white dwarf stars in close binary systems. They play an important role as cosmological distance indicators and have led to the discovery of...
The Peculiar Type Ib Supernova 2006jc: A WCO Wolf-Rayet Star Explosion (2007)
Tominaga, N., Limongi, M., Suzuki, T., Tanaka, M., Nomoto, K., Maeda, K., ...
We present a theoretical model for Type Ib supernova (SN) 2006jc. We calculate the evolution of the progenitor star, hydrodynamics and nucleosynthesis of the SN explosion, and the SN bolometric light...
Sakon, I., Wada, T., Ohyama, Y., Ishihara, D., Tanabé, T., Kaneda, H., ...
We present our latest results on near- to mid- infrared observation of SN2006jc at 200 days after the discovery using the Infrared Camera (IRC) on board $AKARI$. The near-infrared (2--5$\mu$m)...
Smoothed Particle Hydrodynamics with Parallel Virtual Machine (2007)
N. Nakasato, M. Mori, K. Nomoto
We have developed Remote-GRAPE, a subroutine library to use the special purpose computer GRAPE-3A. It allows us to run applications which use GRAPE-3A hardware on the significantly faster computers...
RXTE Observations of Cas A (2007)
Rothschild Lingenfelter, R. E. Rothschild, R. E. Lingenfelter, K. Jahoda, J. H. Swank, S. E. Woosley, ...
. The exciting detection by the COMPTEL instrument of the 1157 keV 44 Ti line from the supernova remnant Cas A sets important new constraints on supernova dynamics and nucleosynthesis. The 44 Ti...
The Broad-lined Type Ic SN 2003jd (2007)
Valenti, S., Benetti, S., Cappellaro, E., Patat, F., Mazzali, P., Turatto, M., ...
The results of a world-wide coordinated observational campaign on the broad-lined Type Ic SN 2003jd are presented. In total, 74 photometric data points and 26 spectra were collected using 11...
Detection of circumstellar material in a normal Type Ia Supernova (2007)
Patat, F., Chandra, P., Chevalier, R., Justham, S., Podsiadlowski, Ph., Wolf, C., ...
Type Ia supernovae are thought to be thermonuclear explosions of accreting white dwarfs that reach a critical mass limit. Despite their importance as cosmological distance indicators, the nature of...
Nucleosynthesis in Core-Collapse Supernovae and GRB--Metal-Poor Star Connection (2007)
Nomoto, K., Tominaga, N., Tanaka, M., Maeda, K., Umeda, H.
We review the nucleosynthesis yields of core-collapse supernovae (SNe) for various stellar masses, explosion energies, and metallicities. Comparison with the abundance patterns of metal-poor stars...
Maeda, K., Tanaka, M., Nomoto, K., Tominaga, N., Kawabata, K., Mazzali, P. A., ...
Late phase nebular spectra and photometry of Type Ib Supernova (SN) 2005bf taken by the Subaru telescope at ~ 270 and ~ 310 days since the explosion are presented. Emission lines ([OI]6300, 6363,...
Immler, S., Brown, P. J., Milne, P., Dessart, L., Mazzali, P. A., Landsman, W., ...
We present results on the X-ray and optical/UV emission from the type IIP SN 2006bp and the interaction of the SN shock with its environment, obtained with the X-Ray Telescope (XRT) and UV/Optical...
Diversity of the Supernova - Gamma-Ray Burst Connection (2007)
Nomoto, K., Tominaga, N., Tanaka, M., Maeda, K., Suzuki, T., Deng, J. S., ...
The connection between the long Gamma Ray Bursts (GRBs) and Type Ic Supernovae (SNe) has revealed interesting diversity. We review the following types of the GRB-SN connection. (1) GRB-SNe: The three...
Constraints on Type Ib/c and GRB Progenitors (2007)
Fryer, C. L., Mazzali, P. A., Prochaska, J., Cappellaro, E., Panaitescu, A., Berger, E., ...
Although there is strong support for the collapsar engine as the power source of long-duration gamma-ray bursts (GRBs), we still do not definitively know the progenitor of these explosions. Here we...
Detection of circumstellar material in a normal type Ia supernova (2007)
Patat, F., Chandra, P., Chevalier, R., Justham, S., Podsialkowski, P., Wolf, C., ...
Aoki, W., Honda, S., Beers, T.C., Takada-Hidai, M., Iwamoto, N., Tominaga, N., ...
Original article can be found at: http://www.iop.org/EJ/journal/apj Copyright American Astronomical Society. DOI: 10.1086/512601 [Full text of this article is not available in the UHRA]
Asymmetric Explosion of Type Ia Supernovae as Seen from Near Infrared Observations (2006)
Motohara, K., Maeda, K., Gerardy, C. L., Nomoto, K., Tanaka, M., Tominaga, N., ...
We present near-infrared spectra of late phase (>200 d) Type Ia supernovae (SNe Ia) taken at the Subaru telescope. The [Fe II] line of SN 2003hv shows a clear flat-topped feature, while that of SN...
Galactic chemical evolution: Carbon through Zinc (2006)
Kobayashi, C., Umeda, H., Nomoto, K., Tominaga, N., Ohkubo, T.
We calculate the evolution of heavy element abundances from C to Zn in the solar neighborhood adopting our new nucleosynthesis yields. Our yields are calculated for wide ranges of metallicity...
An optical supernova associated with the X-ray flash XRF 060218 (2006)
Pian, E., Mazzali, P. A., Masetti, N., Ferrero, P., Klose, S., Palazzi, E., ...
Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae(1) that are more luminous than average(2-5) and that eject material at very high velocities. Less-luminous supernovae were...
Immler, S., Brown, P. J., Milne, P., Petre, R., Gehrels, N., ...
We present a study of the early (days to weeks) X-ray and UV properties of eight Type Ia supernovae (SNe Ia) which have been extensively observed with the X-Ray Telescope (XRT) and UV/Optical...
SN 2005cs in M51 I. The first month of evolution of a subluminous SN II plateau (2006)
Pastorello, A., Sauer, D., Taubenberger, S., Mazzali, P. A., Nomoto, K., Kawabata, K. S., ...
Early time optical observations of supernova (SN) 2005cs in the Whirlpool Galaxy (M51), are reported. Photometric data suggest that SN 2005cs is a moderately under-luminous Type II plateau supernova...
The properties of the "standard" type Ic supernova 1994I from spectral models (2006)
Sauer, D. N., Mazzali, P. A., Deng, J., Valenti, S., Nomoto, K., Filippenko, A. V.
The properties of the type Ic supernova SN 1994I are re-investigated. This object is often referred to as a "standard SN Ic" although it exhibited an extremely fast light curve and unusually blue...
An optical supernova associated with the X-ray flash XRF 060218 (2006)
Pian, E., Mazzali, P. A., Masetti, N., Ferrero, P., Klose, S., Palazzi, E., ...
Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae that are more luminous than average and that eject material at very high velocities. Less-luminous supernovae were not...
The properties of the 'standard' type Ic supernova 1994I from spectral models (2006)
Sauer, D. N., Mazzali, P. A., Deng, J., Valenti, S., Nomoto, K., Filippenko, A. V.
SN 2005cs in M51 – I. The first month of evolution of a subluminous SN II plateau (2006)
Pastorello, A., Sauer, D., Taubenberger, S., Mazzali, P. A., Nomoto, K., Kawabata, K. S., ...
An optical supernova associated with the X-ray flash XRF 060218 (2006)
Pian, E., Mazzali, P. A., Masetti, N., Ferrero, P., Klose, S., Palazzi, E., ...
An optical supernova associated with the X-ray flash XRF 060218 (2006)
Pian, E., Mazzali, P.A., Masetti, N., Ferrero, P., Klose, S., Palazzi, E., ...
Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae that are more luminous than average and that eject material at very high velocities. Less-luminous supernovae were not...
Diversity of the supernova-gamma-ray burst connection (2006)
Nomoto, K., Tominaga, N., Tanaka, M., Maeda, K., Suzuki, T., Deng, J. S., ...
Afterglow spectrum of a gamma-ray burst with the highest known redshift z=6.295 (2005)
Kawai, N., Kosugi, G., Aoki, K., Yamada, T., Totani, T., Ohta, K., ...
Gamma-ray bursts (GRBs) and their afterglows have been proposed as an excellent probe to study the evolution of cosmic star formation, the reionization of the intergalactic medium, and the metal...
Optical Emission from Aspherical Supernovae and the Hypernova SN 1998bw (2005)
Maeda, K., Mazzali, P. A., Nomoto, K.
A fully 3D Monte Carlo scheme is applied to compute optical bolometric light curves for aspherical (jet-like) supernova explosion models. Density and abundance distributions are taken from...
Wanajo, S., Nomoto, K., Iwamoto, N., Ishimaru, Y., Beers, T. C.
Recent spectroscopic studies have revealed the presence of numerous carbon-enhanced, metal-poor stars with [Fe/H] < -2.0 that exhibit strong enhancements of s-process elements. These stars are...
Frebel, A., Aoki, W., Christlieb, N., Ando, H., Asplund, M., Barklem, P. S., ...
We describe the discovery of HE 1327-2326, a dwarf or subgiant with [Fe/H]}=-5.4. The star was found in a sample of bright metal-poor stars selected from the Hamburg/ESO survey. Its abundance pattern...
Anupama, G. C., Sahu, D. K., Deng, J., Nomoto, K., Tominaga, N., Tanaka, M., ...
We present BVRI photometry and optical spectroscopy of SN 2005bf near light maximum. The maximum phase is broad and occurred around 2005 May 7, about forty days after the shock breakout. SN 2005bf...
Tominaga, N., Tanaka, M., Nomoto, K., Mazzali, P. A., Deng, J., Maeda, K., ...
Observations and modeling for the light curve (LC) and spectra of supernova (SN) 2005bf are reported. This SN showed unique features: the LC had two maxima, and declined rapidly after the second...
HE1327-2326, an unevolved star with [Fe/H] (2005)
Aoki, W., Frebel, A., Christlieb, N., Norris, J. E., Beers, T. C., Minezaki, T., ...
We present the elemental abundances of HE1327-2326, the most iron-deficient star known, determined from a comprehensive analysis of spectra obtained with the Subaru Telescope High Dispersion...
Nebular Spectra of SN 1998bw Revisited: Detailed Study by One and Two Dimensional Models (2005)
Maeda, K., Nomoto, K., Mazzali, P. A., Deng, J.
Refined one- and two-dimensional models for the nebular spectra of the hyper-energetic Type Ic supernova (SN) 1998bw, associated with the gamma-ray burst GRB980425, from 125 to 376 days after B-band...
Ohkubo, T., Umeda, H., Maeda, K., Nomoto, K., Suzuki, T., Tsuruta, S., ...
We calculate evolution, collapse, explosion, and nucleosynthesis of Population III very-massive stars with 500$M_{\odot}$ and 1000$M_{\odot}$. Presupernova evolution is calculated in spherical...
Hypernovae, Black-Hole-Forming Supernovae, and First Stars (2005)
Nomoto, K., Tominaga, N., Umeda, H., Maeda, K., Ohkubo, T., Deng, J., ...
Recent studies of core-collapse supernovae have revealed the existence of two distinct classes of massive supernovae (SNe): 1) very energetic SNe (Hypernovae), whose kinetic energy (KE) exceeds...
An Asymmetric, Energetic Type Ic Supernova Viewed Off-Axis, and a Link to Gamma-Ray Bursts (2005)
Mazzali, P. A., Kawabata, K. S., Maeda, K., Nomoto, K., Filippenko, A. V., Ramirez-Ruiz, E., ...
Type Ic supernovae, the explosions following the core collapse of massive stars that have previously lost their hydrogen and helium envelopes, are particularly interesting because of the link with...
Nucleosynthetic signatures of the first stars (2005)
Frebel, A., Aoki, W., Christlieb, N., Ando, H., Asplund, M., Barklem, P.S., ...
Deng, J., Tominaga, N., Mazzali, P. A., Maeda, K., Nomoto, K.
The net optical light curves and spectra of the supernova (SN) 2003dh are obtained from the published spectra of GRB 030329, covering about 6 days before SN maximum to about 60 days after. The bulk...
Mattila, S., Lundqvist, P., Sollerman, J., Kozma, C., Baron, E., Fransson, C., ...
We present early time high-resolution (VLT/UVES) and late time low-resolution (VLT/FORS) optical spectra of the normal type Ia supernova, SN 2001el. The high-resolution spectra were obtained at -9...
Anupama, G. C, Sahu, D. K, Deng, J, Nomoto, K, Tominaga, N, Tanaka, M, ...
We present BVRI photometry and optical spectroscopy of SN 2005bf near maximum light. The maximum phase is broad and occurred around 2005 May 7, about 40 days after the shock breakout. SN 2005bf has a...
Mazzali, P. A., Benetti, S., Stehle, M., Branch, D., Deng, J., Maeda, K., ...
The near-maximum spectra of the Type Ia SN 1999ee are reviewed. Two narrow absorption features corresponding to the strongest component of the CaII IR triplet appear in the spectra from 7 days before...
Composition of the Innermost Core Collapse Supernova Ejecta (2004)
Frohlich, C., Hauser, P., Liebendoerfer, M., Martinez-Pinedo, G., Bravo, E., ...
With presently known input physics and computer simulations in 1D, a self-consistent treatment of core collapse supernovae does not yet lead to successful explosions, while 2D models show some...
Properties of Two Hypernovae Entering the Nebular Phase: SN 1997ef and SN 1997dq (2004)
Mazzali, P. A., Deng, J., Maeda, K., Nomoto, K., Filippenko, A. V., Matheson, T.
The two peculiar Type Ic supernovae (SNe) 1997ef and 1997dq are shown to have very similar photometric and spectral evolution in the epochs when both SNe are observed (i.e. beyond $\sim 80$ days...
Evidence for nucleosynthesis in supernova $\gamma$-process: Universal scaling on p-nuclei (2004)
Hayakawa, T., Iwamoto, N., Shizuma, T., Kajino, T., Umeda, H., Nomoto, K.
With analyzing the solar system abundance, we have found two universal scaling laws concerning the p- and s-nuclei. They indicate that the gamma-process in supernova (SN) explosions is the most...
SN 2003lw and GRB 031203: A Bright Supernova for a Faint Gamma-ray Burst (2004)
Malesani, D., Tagliaferri, G., Chincarini, G., Covino, S., Della Valle, M., Fugazza, D., ...
Optical and near-infrared observations of the gamma-ray burst GRB 031203, at z = 0.1055, are reported. A very faint afterglow is detected superimposed to the host galaxy in our first infrared JHK...
Supernova light curve models for the bump in the Optical Counterpart of X-Ray Flash 030723 (2004)
Tominaga, N., Deng, J., Mazzali, P. A., Maeda, K., Nomoto, K., Pian, E., ...
XRF 030723 is the first X-ray flash (XRF) to show in its optical light curve (LC) a bump that has been interpreted as the signature of a supernova (SN). After subtracting the afterglow component from...
The J-band Light Curve of SN 2003lw, Associated with GRB 031203 (2004)
Gal-Yam, A., Fox, D. B., Soderberg, A. M., Kulkarni, S. R., Berger, E., ...
At z=0.1055, the gamma-ray burst GRB 031203 is one of the two nearest GRBs known. Using observations from the Very Large Array (VLA) and Chandra X-ray Observatory, we derive sub-arcsecond...
The Rates of Hypernovae and Gamma-Ray Bursts: Implications for their Progenitors (2004)
Podsiadlowski, Ph., Mazzali, P. A., Nomoto, K., Lazzati, D., Cappellaro, E.
A critical comparison of estimates for the rates of hypernovae (HNe) and gamma-ray bursts (GRBs) is presented. Within the substantial uncertainties, the estimates are shown to be quite comparable and...
Direct Analysis of Spectra of the Peculiar Type Ia Supernova 2000cx (2004)
Branch, D., Thomas, R. C., Baron, E., Kasen, D., Hatano, K., Nomoto, K., ...
The Type Ia SN 2000cx exhibited multiple peculiarities, including a lopsided B-band light-curve peak that does not conform to current methods for using shapes of light curves to standardize SN Ia...
The rates of hypernovae and gamma-ray bursts : implications for their progenitors (2004)
Podsiadlowski, Ph., Mazzali, P. A., Nomoto, K., Lazzati, D., Cappellaro, E.
Deng, J., Kawabata, K. S., Ohyama, Y., Nomoto, K., Mazzali, P. A., Wang, L., ...
Optical spectroscopy of the Type Ia supernova SN 2002ic obtained on 2003 June 27.6 UT, i.e., about 222 rest-frame days after explosion, is presented. Strong H emission indicates an interaction...
SN 2003du: Signatures of the Circumstellar Environment in a Normal Type Ia Supernova? (2003)
Gerardy, C. L., Hoeflich, P., Fesen, R. A., Marion, G. H., Nomoto, K., Quimby, R., ...
We present observations of the Type Ia supernova 2003du and report the detectionof an unusual, high-velocity component in the Ca II infrared triplet, similar tofeatures previously observed in SN...
The Type Ic Hypernova SN 2003dh/GRB 030329 (2003)
Mazzali, P. A., Deng, J., Tominaga, N., Maeda, K., Nomoto, K., Matheson, T., ...
The spectra of SN 2003dh, identified in the afterglow of GRB030329, are modeled using radiation transport codes. It is shown that SN 2003dh had a high explosion kinetic energy ($\sim 4 \times...
Hypernovae and Other Black-Hole-Forming Supernovae (2003)
Nomoto, K., Maeda, K., Mazzali, P. A., Umeda, H., Deng, J., Iwamoto, K.
During the last few years, a number of exceptional core-collapse supernovae (SNe) have been discovered. Their kinetic energy of the explosions are larger by more than an order of magnitude than the...
Type Ia Supernovae: Progenitors and Diversities (2003)
Nomoto, K., Uenishi, T., Kobayashi, C., Umeda, H., Ohkubo, T., Hachisu, I., ...
A key question for supernova cosmology is whether the peak luminosities of Type Ia supernovae (SNe Ia) are sufficiently free from the effects of cosmic and galactic evolution. To answer this...
Nomoto, K., Maeda, K., Umeda, H., Tominaga, N., Ohkubo, T., Deng, J., ...
Stars more massive than $\sim$ 20 - 25 \ms form a black hole at the end of their evolution. Stars with non-rotating black holes are likely to collapse "quietly" ejecting a small amount of heavy...
On The Spectrum and Spectropolarimetry of Type Ic Hypernova SN 2003dh/GRB 030329 (2003)
Kawabata, K. S., Deng, J., Wang, L., Mazzali, P., Nomoto, K., Maeda, K., ...
Spectroscopic and spectropolarimetric observations of SN 2003dh/GRB 030329 obtained in 2003 May using the Subaru 8.2 m telescope are presented. The properties of the SN are investigated through a...
A Two-Component Model for the Light Curves of Hypernovae (2003)
Maeda, K., Mazzali, P. A., Deng, J., Nomoto, K., Yoshii, Y., Tomita, H., ...
The light curves of 'hypernovae', i.e. very energetic supernovae with $E_{51} \equiv E/10^{51}$ergs $\gsim 5-10$ are characterized at epochs of a few months by a phase of linear decline. Classical,...
Jets and Black Holes in Hypernova Explosions (2003)
Bipolar explosion models for hypernovae (very energetic supernovae), associated with the black hole formation, are presented. The model features are as follows: (1) Fe-peak elements are ejected at...
Hydrodynamics and explosive nucleosynthesis in bipolar supernova explosions are examined to account for some peculiar properties of hypernovae as well as peculiar abundance patterns of metal-poor...
The Optical/Near-Infrared Light Curves of SN 2002ap for the First 140 Days after Discovery (2003)
Yoshii, Y., Tomita, H., Kobayashi, Y., Deng, J., Maeda, K., Nomoto, K., ...
Supernova (SN) 2002ap in M74 was observed in the $UBVRIJHK$ bands for the first 40 days following its discovery (2002 January 29) until it disappeared because of solar conjunction, and then in June...
The r-process in supernova explosions from the collapse of O-Ne-Mg cores (2003)
Wanajo, S., Tamamura, M., Itoh, N., Nomoto, K., Ishimaru, Y., Beers, T. C., ...
We examine r-process nucleosynthesis in a "prompt supernova explosion" from an 8-10 Msun progenitor star, as an alternative scenario to the "neutrino wind" mechanism. In the present model, the...
Early-Phase Spectra of "Hypernova" SN 2002ap (2002)
Kinugasa, K., Kawakita, H., Ayani, K., Kawabata, T., Yamaoka, H., Deng, J. S., ...
The spectral evolution of the peculiar SN Ic 2002ap during the first 40 days is presented. The spectra display very broad absorption features, which are typical of "hypernovae". The maximum expansion...
Optical Spectropolarimetry of SN 2002ap: High Velocity Asymmetric Explosion (2002)
Kawabata, K. S., Jeffery, D. J., Iye, M., Ohyama, Y., Kosugi, G., Kashikawa, N., ...
We present spectropolarimetry of the Type Ic supernova SN 2002ap and give a preliminary analysis: the data were taken at two epochs, close to and one month later than the visual maximum (2002...
Extraordinary Late-Time Infrared Emission of Type IIn Supernovae (2002)
Gerardy, C. L., Fesen, R. A., Nomoto, K., Garnavich, P., Jha, S., Challis, P. M., ...
Near-Infrared (NIR) observations are presented for five Type IIn supernovae (SN 1995N, SN 1997ab, SN 1998S, SN 1999Z, and SN 1999el) that exhibit strong infrared excesses at late times (t >= 100 d)....
The Type Ic Hypernova SN 2002ap (2002)
Mazzali, P. A., Deng, J., Maeda, K., Nomoto, K., Umeda, H., Hatano, K., ...
Photometric and spectroscopic data of the energetic Type Ic supernova (SN) 2002ap are presented, and the properties of the SN are investigated through models of its spectral evolution and its light...
Stellar Sources of the Interstellar Medium (2002)
Argast, D., Brachwitz, F., Martinez-Pinedo, G., Oechslin, R., Rauscher, T., ...
With the exception of the Big Bang, responsible for 1,2H, 3,4He, and 7Li, stars act as sources for the composition of the interstellar medium. Cosmic rays are related to the latter and very probably...
Gamma-Ray Signatures of Supernovae and Hypernovae (2001)
Nomoto, K., Maeda, K., Mochizuki, Y., Kumagai, S., Umeda, H., Nakamura, T., ...
We review the characteristics of nucleosynthesis and radioactivities in 'Hypernovae', i.e., supernovae with very large explosion energies ($ \gsim 10^{52} $ ergs) and their $\gamma$-ray line...
Formation of the Black Hole in Nova Scorpii (2001)
Podsiadlowski, Ph., Nomoto, K., Maeda, K., Nakamura, T., Mazzali, P., Schmidt, B.
Israelian et al. (1999) showed that the stellar companion of the black-hole binary Nova Sco is polluted with material ejected in the supernova that accompanied the formation of the black-hole...
The nebular spectra of the hypernova SN 1998bw and evidence for asymmetry (2001)
Mazzali, P. A., Nomoto, K., Patat, F., Maeda, K.
The nebular spectra of the energetic Type Ic supernova SN1998bw (hypernova) are studied. The transition to the nebular phase occurred at an epoch of about 100 days after outburst, which is assumed to...
Hypernova Nucleosynthesis and Galactic Chemical Evolution (2001)
Nomoto, K., Maeda, K., Umeda, H., Nakamura, T.
We study nucleosynthesis in 'hypernovae', i.e., supernovae with very large explosion energies ($ \gsim 10^{52} $ ergs) for both spherical and aspherical explosions. The hypernova yields compared to...
X-ray, Optical, and Radio Observations of the Type II Supernovae 1999em and 1998S (2001)
Pooley, D., Lewin, W. H. G., Fox, D. W., Miller, J. M., Lacey, C. K., Van Dyk, S. D., ...
Observations of the Type II-P (plateau) Supernova (SN) 1999em and Type IIn (narrow emission line) SN 1998S have enabled estimation of the profile of the SN ejecta, the structure of the circumstellar...
Element Synthesis in Stars (2001)
Brachwitz, F., Freiburghaus, C., Kolbe, E., Martinez-Pinedo, G., Rauscher, T., ...
Except for 1H, 2H, 3He, 4He, and 7Li, originating from the Big Bang, all heavier elements are made in stellar evolution and stellar explosions. Nuclear physics, and in many cases nuclear structure...
The first year of optical-IR observations of SN1998bw (2001)
Danziger, I.J., Augusteijn, T., Brewer, J., Cappellaro, E., Doublier, V., Galama, T.J., ...
The Metamorphosis of SN 1998bw (2001)
Patat, F., Cappellaro, E., Danziger, I.J., Mazzali, P., Sollerman, J., Augusteijn, T., ...
Maeda, K., Nakamura, T., Nomoto, K., Mazzali, P. A., Patat, F., Hachisu, I.
Aspherical explosion models for the hypernova (hyper-energetic supernova) SN 1998bw are presented. Nucleosynthesis in aspherical explosions is examined with a two-dimensional hydrodynamical code and...
Benetti, S., Turatto, M., Balberg, S., Zampieri, L., Shapiro, S. L., Cappellaro, E., ...
We present a new set of spectroscopic and photometric data extending the observations of SN 1997D to over 400 days after the explosion. These observations confirm the peculiar properties of SN 1997D,...
The Properties of Hypernovae: SNe Ic 1998bw, 1997ef, and SN IIn 1997cy (2000)
Nomoto, K., Mazzali, P. A., Nakamura, T., Iwamoto, K., Maeda, K., Suzuki, T., ...
We discuss the properties of the hyper-energetic Type Ic supernovae (SNe Ic) 1998bw and 1997ef and Type IIn supernova (SN IIn) 1997cy. SNe Ic 1998bw and 1997ef are characterized by their large...
Iwamoto, K., Brachwitz, F., Nomoto, K., Kishimoto, N., Umeda, H., Hix, W. R., ...
We calculate explosive nucleosynthesis in Chandrasekhar mass models for Type Ia Supernovae(SNe Ia) to obtain new constraints on the rate of matter accretion onto the progenitor white dwarf and on the...
The first year of optical-IR observations of SNI 1998bw (2000)
Danziger, I.J., Augusteijn, T., Brewer, J., Cappellaro, E., Doublier, V., Galama, T.J., ...
The properties of Supernova 1997cy associated to GRB970514 (1999)
Turatto, M., Suzuki, T., Mazzali, P. A., Benetti, S., Cappellaro, E., Danziger, I. J., ...
The extraordinary SN 1997cy associated with GRB 970514 has been observed photometrically and spectroscopically for nearly 2 yr. At the time of discovery SN 1997cy was the brightest SN ever observed...
Impacts of the Detection of Cassiopeia A Point Source (1999)
Umeda, H., Nomoto, K., Tsuruta, S., Mineshige, S.
Very recently the Chandra First Light Observation discovered a point-like source in Cassiopeia A (Cas A) supernova remnant. This detection was subsequently confirmed by the analyses of the archival...
Höflich, P., Nomoto, K., Umeda, H., Wheeler, J. C.
The influence of the metallicity at the main sequence on the chemical structure of the exploding white dwarf, the nucleosynthesis during the explosion and the light curves of an individual Type Ia...
The Origin of Diversity of Type Ia Supernovae and Environmental Effects (1999)
Umeda, H., Nomoto, K., Kobayashi, C., Hachisu, I., Kato, M.
Observations suggest that the properties of Type Ia supernovae (SNe Ia) may depend on environmental characteristics, such as morphology, metallicity, and age of host galaxies. The influence of these...
Wanajo, S., Hashimoto, M., Nomoto, K.
Nucleosynthesis in ONeMg novae has been investigated with the wide ranges of three parameters, i.e., the white dwarf mass, the envelope mass at ignition, and the initial composition. A quasi-analytic...
The Peculiar Type Ic Supernova 1997ef: Another Hypernova (1998)
Iwamoto, K., Nakamura, T., Nomoto, K., Mazzali, P. A., Danziger, I. J., Garnavich, P., ...
SN 1997ef has been recognized as a peculiar supernova from its light curve and spectral properties. The object was classified as a Type Ic supernova (SN Ic) because its spectra are dominated by broad...
A `Hypernova' model for SN 1998bw associated with gamma-ray burst of 25 April 1998 (1998)
Iwamoto, K., Mazzali, P. A., Nomoto, K., Umeda, H., Nakamura, T., Patat, F., ...
The discovery of the peculiar supernova (SN) 1998bw and its possible association with the gamma-ray burst (GRB) 980425$^{1,2,3}$ provide new clues to the understanding of the explosion mechanism of...
Discovery of the peculiar supernova 1998bw in the error box of GRB980425 (1998)
Galama, T. J., Vreeswijk, P. M., Van Paradijs, J., Kouveliotou, C., Augusteijn, T., Hainaut, O. R., ...
The discovery of X-ray, optical and radio afterglows of gamma-ray bursts (GRBs) and the measurements of the distances to some of them have established that these events come from Gpc distances and...
The Peculiar Type II Supernova 1997 D: A Case for a Very Low 56Ni Mass (1998)
Turatto, M., Mazzali, P. A., Young, T. R., Nomoto, K., Iwamoto, K., Benetti, S., ...
SN 1997D in NGC 1536 is possibly the least luminous and energetic Type II supernova discovered to date. The entire light curve is subluminous, never reaching $M_V = -14.65$. The radioactive tail...
Nucleosynthesis Basics and Applications to Supernovae (1998)
Rauscher, T., Freiburghaus, C., Nomoto, K., Hashimoto, M., Pfeiffer, B., ...
This review concentrates on nucleosynthesis processes in general and their applications to massive stars and supernovae. A brief initial introduction is given to the physics in astrophysical plasmas...
Inward Propagation of Nuclear-Burning Shells in Merging C-O and He White Dwarfs (1998)
We have investigated the consequences of merging double white dwarf systems by calculating evolutionary models of accreting white dwarfs. We have considered two cases; a massive C-O white dwarf of...
A 'hypernova' model for the supernova associated with the gamma-ray burst of 25 April 1998 (1998)
Iwamoto, K., Mazzali, P., Nomoto, K., Umeda, H., Nakamura, T., Young, T.R., ...
An unusual supernova in the error box of the GRB of 25 April 1998 (1998)
Galama, T.J., Vreeswijk, P.M., Paradijs, J.A. Van, Kouveliotou, C., Augusteijn, T., Hainaut, O.R., ...
Nucleosynthesis in Type II Supernovae (1997)
Nomoto, K., Hashimoto, M., Tsujimoto, T., Kishimoto, N., Kubo, Y.
Presupernova evolution and explosive nucleosynthesis in massive stars for main-sequence masses from 13 $M_\odot$ to 70 $M_\odot$ are calculated. We examine the dependence of the supernova yields on...
Nucleosynthesis in Type Ia Supernovae (1997)
Nomoto, K., Iwamoto, K., Nakasato, N., Brachwitz, F., Tsujimoto, T., ...
Among the major uncertainties involved in the Chandrasekhar mass models for Type Ia supernovae are the companion star of the accreting white dwarf (or the accretion rate that determines the carbon...
Instabilities and Mixing in SN 1993J (1997)
Iwamoto, K., Young, T. R., Nakasato, N., Shigeyama, T., Nomoto, K., Hachisu, I., ...
Rayleigh-Taylor (R-T) instabilities in the explosion of SN 1993J are investigated by means of two-dimensional hydrodynamical simulations. It is found that the extent of mixing is sensitive to the...
Numerical Simulations of Formation of Globular Cluster (1997)
N. Nakasato, M. Mori, K. Nomoto
The globular clusters belong to the oldest populations in our galaxy. Then its formation is closely...
Explosion Models, Light Curves, Spectra and Ho (1996)
Hoeflich, P., Khokhlov, A., Wheeler, J. C., Nomoto, K., Thielemann, F. K.
From the spectra and light curves it is clear that SNIa are thermonuclear explosions of white dwarfs. However, details of the explosion are highly under debate. Here, we present detailed models which...
Grape-Sph Simulations Of The Globular Cluster Formation (1995)
Nakasato Mori, M. Mori, T. Tujimoto, G. Mathews, K. Nomoto
. We examine two globular cluster formation scenarios with SPH simulations, using GRAPE-3AF. First model is the spontaneous collapse, which is found to induce a disruption of the system. However, the...
A carbon-oxygen star as progenitor of the type Ic supernova 1994 (1994)
Nomoto, K., Yamaoka, H., Pols, O.R., Iwamoto, K., Kumagai, S., ...
Accreting white dwarf models for CAL 83, CAL 87 and other ultrasoft X-ray sources in the LMC (1992)
Bhattacharya, D., Nomoto, K., Rappaport, S.A.
The study demonstrates that the ultrasoft X-ray emission observed in the three strong LMC X-ray sources CAL 83, CAL 87, and RXJ 0527.8-6954 can be explained by steady nuclear burning of hydrogen...
ANAN, R., NAKAGAWA, M., HIGUCHI, I., NAKAO, S., NOMOTO, K., TANAKA, H.
A 15-year-old boy with Kearns-Sayre syndrome is reported. The deletion of mitochrondrial DNA in the endomyocardial biopsy sample from the patient was confirmed by the polymerase chain reaction...
Explosive nucleosynthesis in carbon deflagration models of Type I supernovae. (1986)
Thielemann, F.K., Nomoto, K., Yokoi, K.
Astronomy and Astrophysics, 158(1986) S.17-33
Internal Detoxification Mechanism of Al in Hydrangea (Identification of Al Form in the Leaves).
Ma, J. F., Hiradate, S., Nomoto, K., Iwashita, T., Matsumoto, H.
An internal detoxification mechanism for Al was investigated in an Al-accumulating plant, hydrangea (Hydrangea macrophylla), focusing on Al forms present in the cells. The leaves of hydrangea...
Two Related Biosynthetic Pathways of Mugineic Acids in Gramineous Plants.
The biosynthesis of mugineic acids was studied by feeding 2H- or 13C-labeled compounds to water-cultured roots in several gramineous plants. The fate of labeled compounds was monitored by using 2H-...
The biosynthetic pathway of 2[prime]-deoxymugineic acid, a key phytosiderophore, was investigated by feeding 13C-, 2H-, and 15N-labeled methionine, the first precursor, to the roots of hydroponically...
Inagaki, H, Suzuki, T, Nomoto, K, Yoshikai, Y
The host defense of germfree (GF) mice against primary infection with Listeria monocytogenes was compared with that of specific-pathogen-free (SPF) mice. In SPF mice, the numbers of bacteria in the...
Prevention of indigenous infection of mice with Escherichia coli by nonspecific immunostimulation.
Nomoto, K, Yokokura, T, Mitsuyama, M, Yoshikai, Y, Nomoto, K
We have previously reported that the lethal toxicity of 5-fluorouracil (5-FU) in specific-pathogen-free mice is due to an intestinal infection with indigenous Escherichia coli induced by the drug (K....
Induction of apoptosis of T cells by infecting mice with murine cytomegalovirus.
Yoshida, H, Sumichika, H, Hamano, S, He, X, Minamishima, Y, Kimura, G, ...
Cytomegalovirus (CMV) is associated with several lymphocyte dysfunctions, but the precise mechanisms of the dysfunctions are still unclear. To elucidate the mechanisms, a cell cycle-DNA content...
Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.
Lu, Y Y, Koga, Y, Tanaka, K, Sasaki, M, Kimura, G, Nomoto, K
In a previous study (Y. Koga, M. Sasaki, H. Yoshida, H. Wigzell, G. Kimura, and K. Nomoto, J. Immunol. 144:94-102, 1990), we demonstrated that the expression of gp160, a precursor form of envelope...
Priming of immature thymocytes to CD3-mediated apoptosis by infection with murine cytomegalovirus.
Koga, Y, Tanaka, K, Lu, Y Y, Oh-Tsu, M, Sasaki, M, Kimura, G, ...
Cytomegalovirus (CMV) causes severe clinical manifestations in immunocompromised hosts; however, it remains unclear whether the virus itself is a cause of immunosuppression or whether it is involved...
Koga, Y, Sasaki, M, Nakamura, K, Kimura, G, Nomoto, K
Human CD4+ and CD4- monocytoid cell lines were transfected with a constructed plasmid that has the envelope gene of human immunodeficiency virus under the transcriptional control of human...
Koga, Y, Sasaki, M, Yoshida, H, Oh-Tsu, M, Kimura, G, Nomoto, K
An extensive cytopathic effect occurred in the CD4+ cells expressing gp160 of human immunodeficiency virus. A protein capable of nuclear location that was microinjected into such cells was not...
Kawamura, I, Koga, Y, Oh-Hori, N, Onodera, K, Kimura, G, Nomoto, K
A CD4+ human monocytoid cell line, U937, was transfected with a constructed plasmid which has the envelope gene of human immunodeficiency virus under the transcriptional control of the human...
Yoshida, S, Goto, Y, Mizuguchi, Y, Nomoto, K, Skamene, E
It is known that Legionella pneumophila proliferates in peritoneal macrophage cultures derived from A/J mice but not in macrophage cultures derived from many other strains, including C57BL/6 mice. To...
Mitsuyama, M, Igarashi, K, Kawamura, I, Ohmori, T, Nomoto, K
T-cell-mediated immunity to Listeria monocytogenes in mice, as determined by delayed-type hypersensitivity and acquired resistance, was induced by immunization with viable bacteria but not with...
Tsukada, H, Kawamura, I, Arakawa, M, Nomoto, K, Mitsuyama, M
CD4+ T cells mediating both delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR) were generated in mice after immunization with viable Listeria monocytogenes. In contrast, CD4+...
Shinomiya, N, Tsuru, S, Katsura, Y, Kayashima, S, Nomoto, K
Phagocytosis, H2O2 production, Mac-1 expression, and in vivo elimination of Listeria monocytogenes were enhanced in granulocyte colony-stimulating factor (G-CSF)-treated mice. Transfer of...
Yoshikai, Y, Matsuzaki, G, Kishihara, K, Nomoto, K, Yokokura, T, Nomoto, K
To determine whether environmental antigens such as intestinal microflora contribute to expansion of the T-cell repertoire, age-related changes in the expression level of T-cell antigen receptor...
Yamada, A, Himeno, K, Nakamura, S, Kawamura, I, Nomoto, K
We found a new phenomenon which differs from previous reports on experimental listeriosis, that is, failure of passive transfer of serum from Listeria monocytogenes-infected mice to convey resistance...
Koga, T, Mitsuyama, M, Handa, T, Watanabe, Y, Nomoto, K
The role of gamma interferon (IFN-gamma) in an increase in Ia-bearing macrophages during Listeria monocytogenes infection was studied. The peritoneal macrophages from L. monocytogenes-infected mice...
Yoshida, S, Mizuguchi, Y, Nikaido, Y, Mitsuyama, M, Nomoto, K
Legionella pneumophila is known to grow intracellularly in resident peritoneal macrophages of guinea pigs. The present study was done to determine what kinds of macrophage stimulants are able to...
Tanaka, K, Koga, T, Konishi, F, Nakamura, M, Mitsuyama, M, Himeno, K, ...
Protection against Escherichia coli inoculated intraperitoneally into mice was enhanced by intraperitoneal, intravenous, or subcutaneous administration of a water-soluble, high-molecular-weight...
Watanabe, Y, Mitsuyama, M, Sano, M, Nakano, H, Nomoto, K
We investigated the pregnancy-induced changes in macrophage activity which are important in the expression of host defense against infections. Several macrophage functions were examined by using...
Ontogeny of macrophage-mediated protection against Listeria monocytogenes.
Ohara, R, Mitsuyama, M, Miyata, M, Nomoto, K
We investigated the ontogenic development of macrophage functions which are important in the expression of host defense against infection by Listeria monocytogenes. Macrophage functions, including...
Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice.
Miake, S, Nomoto, K, Yokokura, T, Yoshikai, Y, Mutai, M, Nomoto, K
The protective effect of heat-killed Lactobacillus casei YIT9018 (LC 9018) against Pseudomonas aeruginosa infection in mice was compared with that of Corynebacterium parvum. Survival of mice after...
Enhancement of hematopoietic response of mice by subcutaneous administration of Lactobacillus casei.
Yokokura, T, Nomoto, K, Shimizu, T, Nomoto, K
Mice that had received heat-killed Lactobacillus casei (LC 9018) subcutaneously (s.c.) showed enhanced resistance to systemic (i.e., intravenous) infection with Listeria monocytogenes, but the...
Ontogeny of macrophage function to release superoxide anion in conventional and germfree mice.
Mitsuyama, M, Ohara, R, Amako, K, Nomoto, K, Yokokura, T, Nomoto, K
To determine whether the presence of bacterial flora contributes to the ontogenic development of macrophage function, the ability of macrophages to release superoxide anion (O2-) in response to...
Hashimoto, S, Nomoto, K, Matsuzaki, T, Yokokura, T, Mutai, M
BALB/c mice were injected intraperitoneally (i.p.) or intravenously (i.v.) with Lactobacillus casei YIT9018 (LC 9018). The i.p. injected LC 9018 augmented oxygen radical (OR) production by peritoneal...
Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus.
Tanaka, K, Koga, Y, Lu, Y Y, Zhang, X Y, Wang, Y, Kimura, G, ...
At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a...
Kawamura, I, Yang, J, Takaesu, Y, Fujita, M, Nomoto, K, Mitsuyama, M
It has been shown that gamma interferon (IFN-gamma)-producing CD4+ T cells, which are generated only by immunization with viable bacteria, exert a significant role in protective immunity against...
Furuya, T, Kumazawa, Y, Takimoto, H, Nagumo, T, Watanabe, M, Aizawa, C, ...
The adjuvant activity of chemically synthesized 6-O-acylated muramyl dipeptides (MDP) was tested in aqueous form. The activity was assessed by determining immunoglobulin G (IgG) titers in sera of...
Igarashi, K, Mitsuyama, M, Muramori, K, Tsukada, H, Nomoto, K
We studied the effects of administration of recombinant interleukin-1 alpha (rIL-1 alpha) to mice after immunization with killed Listeria monocytogenes cells on the promotion of the functional...
Osada, Y, Mitsuyama, M, Une, T, Matsumoto, K, Otani, T, Satoh, M, ...
By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an...
Direct correlation between delayed footpad reaction and resistance to local bacterial infection.
Mitsuyama, M, Nomoto, K, Takeya, K
The resistance to bacteria was studied at the site of delayed footpad reaction in mice immunized with Listeria monocytogenes. When a challenge injection of listeria was given into the footpad of...
Enhanced elimination of Listeria monocytogenes at the site of delayed footpad reaction.
Mitsuyama, M, Nomoto, K, Akeda, H, Takeya, K
The protective activity against a challenge infection with Listeria monocytogenes was investigated at the site of a delayed footpad reaction in mice immunized with viable or killed listeria. Delayed...
Internal Detoxification Mechanism of Al in Hydrangea (Identification of Al Form in the Leaves).
Ma, J. F., Hiradate, S., Nomoto, K., Iwashita, T., Matsumoto, H.
An internal detoxification mechanism for Al was investigated in an Al-accumulating plant, hydrangea (Hydrangea macrophylla), focusing on Al forms present in the cells. The leaves of hydrangea...
Two Related Biosynthetic Pathways of Mugineic Acids in Gramineous Plants.
The biosynthesis of mugineic acids was studied by feeding 2H- or 13C-labeled compounds to water-cultured roots in several gramineous plants. The fate of labeled compounds was monitored by using 2H-...
The biosynthetic pathway of 2[prime]-deoxymugineic acid, a key phytosiderophore, was investigated by feeding 13C-, 2H-, and 15N-labeled methionine, the first precursor, to the roots of hydroponically...
Inagaki, H, Suzuki, T, Nomoto, K, Yoshikai, Y
The host defense of germfree (GF) mice against primary infection with Listeria monocytogenes was compared with that of specific-pathogen-free (SPF) mice. In SPF mice, the numbers of bacteria in the...
Prevention of indigenous infection of mice with Escherichia coli by nonspecific immunostimulation.
Nomoto, K, Yokokura, T, Mitsuyama, M, Yoshikai, Y, Nomoto, K
We have previously reported that the lethal toxicity of 5-fluorouracil (5-FU) in specific-pathogen-free mice is due to an intestinal infection with indigenous Escherichia coli induced by the drug (K....
Induction of apoptosis of T cells by infecting mice with murine cytomegalovirus.
Yoshida, H, Sumichika, H, Hamano, S, He, X, Minamishima, Y, Kimura, G, ...
Cytomegalovirus (CMV) is associated with several lymphocyte dysfunctions, but the precise mechanisms of the dysfunctions are still unclear. To elucidate the mechanisms, a cell cycle-DNA content...
Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.
Lu, Y Y, Koga, Y, Tanaka, K, Sasaki, M, Kimura, G, Nomoto, K
In a previous study (Y. Koga, M. Sasaki, H. Yoshida, H. Wigzell, G. Kimura, and K. Nomoto, J. Immunol. 144:94-102, 1990), we demonstrated that the expression of gp160, a precursor form of envelope...
Priming of immature thymocytes to CD3-mediated apoptosis by infection with murine cytomegalovirus.
Koga, Y, Tanaka, K, Lu, Y Y, Oh-Tsu, M, Sasaki, M, Kimura, G, ...
Cytomegalovirus (CMV) causes severe clinical manifestations in immunocompromised hosts; however, it remains unclear whether the virus itself is a cause of immunosuppression or whether it is involved...
Koga, Y, Sasaki, M, Nakamura, K, Kimura, G, Nomoto, K
Human CD4+ and CD4- monocytoid cell lines were transfected with a constructed plasmid that has the envelope gene of human immunodeficiency virus under the transcriptional control of human...
Koga, Y, Sasaki, M, Yoshida, H, Oh-Tsu, M, Kimura, G, Nomoto, K
An extensive cytopathic effect occurred in the CD4+ cells expressing gp160 of human immunodeficiency virus. A protein capable of nuclear location that was microinjected into such cells was not...
Kawamura, I, Koga, Y, Oh-Hori, N, Onodera, K, Kimura, G, Nomoto, K
A CD4+ human monocytoid cell line, U937, was transfected with a constructed plasmid which has the envelope gene of human immunodeficiency virus under the transcriptional control of the human...
Yoshida, S, Goto, Y, Mizuguchi, Y, Nomoto, K, Skamene, E
It is known that Legionella pneumophila proliferates in peritoneal macrophage cultures derived from A/J mice but not in macrophage cultures derived from many other strains, including C57BL/6 mice. To...
Mitsuyama, M, Igarashi, K, Kawamura, I, Ohmori, T, Nomoto, K
T-cell-mediated immunity to Listeria monocytogenes in mice, as determined by delayed-type hypersensitivity and acquired resistance, was induced by immunization with viable bacteria but not with...
Tsukada, H, Kawamura, I, Arakawa, M, Nomoto, K, Mitsuyama, M
CD4+ T cells mediating both delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR) were generated in mice after immunization with viable Listeria monocytogenes. In contrast, CD4+...
Shinomiya, N, Tsuru, S, Katsura, Y, Kayashima, S, Nomoto, K
Phagocytosis, H2O2 production, Mac-1 expression, and in vivo elimination of Listeria monocytogenes were enhanced in granulocyte colony-stimulating factor (G-CSF)-treated mice. Transfer of...
Yoshikai, Y, Matsuzaki, G, Kishihara, K, Nomoto, K, Yokokura, T, Nomoto, K
To determine whether environmental antigens such as intestinal microflora contribute to expansion of the T-cell repertoire, age-related changes in the expression level of T-cell antigen receptor...
Yamada, A, Himeno, K, Nakamura, S, Kawamura, I, Nomoto, K
We found a new phenomenon which differs from previous reports on experimental listeriosis, that is, failure of passive transfer of serum from Listeria monocytogenes-infected mice to convey resistance...
Koga, T, Mitsuyama, M, Handa, T, Watanabe, Y, Nomoto, K
The role of gamma interferon (IFN-gamma) in an increase in Ia-bearing macrophages during Listeria monocytogenes infection was studied. The peritoneal macrophages from L. monocytogenes-infected mice...
Yoshida, S, Mizuguchi, Y, Nikaido, Y, Mitsuyama, M, Nomoto, K
Legionella pneumophila is known to grow intracellularly in resident peritoneal macrophages of guinea pigs. The present study was done to determine what kinds of macrophage stimulants are able to...
Tanaka, K, Koga, T, Konishi, F, Nakamura, M, Mitsuyama, M, Himeno, K, ...
Protection against Escherichia coli inoculated intraperitoneally into mice was enhanced by intraperitoneal, intravenous, or subcutaneous administration of a water-soluble, high-molecular-weight...
Watanabe, Y, Mitsuyama, M, Sano, M, Nakano, H, Nomoto, K
We investigated the pregnancy-induced changes in macrophage activity which are important in the expression of host defense against infections. Several macrophage functions were examined by using...
Ontogeny of macrophage-mediated protection against Listeria monocytogenes.
Ohara, R, Mitsuyama, M, Miyata, M, Nomoto, K
We investigated the ontogenic development of macrophage functions which are important in the expression of host defense against infection by Listeria monocytogenes. Macrophage functions, including...
Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice.
Miake, S, Nomoto, K, Yokokura, T, Yoshikai, Y, Mutai, M, Nomoto, K
The protective effect of heat-killed Lactobacillus casei YIT9018 (LC 9018) against Pseudomonas aeruginosa infection in mice was compared with that of Corynebacterium parvum. Survival of mice after...
Enhancement of hematopoietic response of mice by subcutaneous administration of Lactobacillus casei.
Yokokura, T, Nomoto, K, Shimizu, T, Nomoto, K
Mice that had received heat-killed Lactobacillus casei (LC 9018) subcutaneously (s.c.) showed enhanced resistance to systemic (i.e., intravenous) infection with Listeria monocytogenes, but the...
Ontogeny of macrophage function to release superoxide anion in conventional and germfree mice.
Mitsuyama, M, Ohara, R, Amako, K, Nomoto, K, Yokokura, T, Nomoto, K
To determine whether the presence of bacterial flora contributes to the ontogenic development of macrophage function, the ability of macrophages to release superoxide anion (O2-) in response to...
Hashimoto, S, Nomoto, K, Matsuzaki, T, Yokokura, T, Mutai, M
BALB/c mice were injected intraperitoneally (i.p.) or intravenously (i.v.) with Lactobacillus casei YIT9018 (LC 9018). The i.p. injected LC 9018 augmented oxygen radical (OR) production by peritoneal...
Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus.
Tanaka, K, Koga, Y, Lu, Y Y, Zhang, X Y, Wang, Y, Kimura, G, ...
At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a...
Kawamura, I, Yang, J, Takaesu, Y, Fujita, M, Nomoto, K, Mitsuyama, M
It has been shown that gamma interferon (IFN-gamma)-producing CD4+ T cells, which are generated only by immunization with viable bacteria, exert a significant role in protective immunity against...
Furuya, T., Kumazawa, Y., Takimoto, H., Nagumo, T., Watanabe, M., Aizawa, C., ...
The adjuvant activity of chemically synthesized 6-O-acylated muramyl dipeptides (MDP) was tested in aqueous form. The activity was assessed by determining immunoglobulin G (IgG) titers in sera of...
Igarashi, K, Mitsuyama, M, Muramori, K, Tsukada, H, Nomoto, K
We studied the effects of administration of recombinant interleukin-1 alpha (rIL-1 alpha) to mice after immunization with killed Listeria monocytogenes cells on the promotion of the functional...
Osada, Y, Mitsuyama, M, Une, T, Matsumoto, K, Otani, T, Satoh, M, ...
By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an...
Direct correlation between delayed footpad reaction and resistance to local bacterial infection.
Mitsuyama, M, Nomoto, K, Takeya, K
The resistance to bacteria was studied at the site of delayed footpad reaction in mice immunized with Listeria monocytogenes. When a challenge injection of listeria was given into the footpad of...
Enhanced elimination of Listeria monocytogenes at the site of delayed footpad reaction.
Mitsuyama, M, Nomoto, K, Akeda, H, Takeya, K
The protective activity against a challenge infection with Listeria monocytogenes was investigated at the site of a delayed footpad reaction in mice immunized with viable or killed listeria. Delayed...
Kadena, T, Matsuzaki, G, Fujise, S, Kishihara, K, Takimoto, H, Sasaki, M, ...
T-cell receptor (TCR) alpha beta+ CD4- CD8- (double-negative; DN) T cells appear in the peritoneal cavity at an early stage of intraperitoneal (i.p.) infection with the intracellular pathogen...
Matsuzaki, G, Sonoda, K H, Mukasa, A, Yamada, H, Nakamura, T, Ikebe, H, ...
A unilateral infection of Listeria monocytogenes into the testis of mice induces not only Listeria-specific T cells but also autoreactive T cells that can transfer experimental autoimmune orchitis...
p56lck is not essential for the T-cell response to allo-MHC antigens.
Yamada, H, Kong, Y Y, Kishihara, K, Mak, T W, Nomoto, K
In mice lacking the src family protein tyrosine kinase, p 56lck (lck -/-), a greatly reduced number of peripheral T cells is observed due to a profound blockage of the thymocyte development. The...
Macrophages activated by Listeria monocytogenes induce organ-specific autoimmunity.
Sonoda, K H, Matsuzaki, G, Nomura, A, Yamada, H, Hamano, S, Nakamura, T, ...
We have previously reported an experimental autoimmune model induced by the local infection of Listeria monocytogenes. The unilateral inoculation of virulent Listeria into a testis of a normal mouse...
Nomura, A, Matsuzaki, G, Takada, H, Hiromatsu, K, Nabeshima, S, Nakamura, T, ...
The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found...
Onoe, Y, Harada, M, Tamada, K, Abe, K, Li, T, Tada, H, ...
It has been reported that a dramatic decrease in the number of thymocytes (thymic atrophy) in mice suffering from acute graft-versus-host disease (GVHD) is ascribed to glucocorticoids. In this study,...
Gamma delta T cells in infection-induced and autoimmune-induced testicular inflammation.
Mukasa, A, Yoshida, H, Kobayashi, N, Matsuzaki, G, Nomoto, K
In a previous report, we investigated inflammatory responses induced by injecting Listeria monocytogenes into one testis of a mouse. We demonstrated that the contralateral testis also developed an...
Kurosawa, S, Harada, M, Matsuzaki, G, Shinomiya, Y, Terao, H, Kobayashi, N, ...
Natural killer (NK) cells that infiltrated into the primary tumour site at an early stage of tumour development, were examined for their participation in the generation of anti-tumour cytotoxic T...
Matsuzaki, G, Song, F, Nomoto, K
Injection of goat anti-mouse IgD antibodies (GAM IgD) to mice has been shown to induce polyclonal IgG1 and IgE production by B cells and interleukin-4 (IL-4) production by goat Ig-specific T cells....
The induction of renal autoantigen-specific T cells by a local Listeria monocytogenes infection.
Sonoda, K, Mukasa, A, Matsuzaki, G, Nomoto, K
In order to examine the possibility that a local chronic infection can induce organ-specific autoimmune disease, we inoculated unilateral kidneys with viable Listeria monocytogenes (intrarenal...
Murakami, Y, Kong, Y Y, Nishimura, Y, Nomoto, K, Umesue, M, Omoto, K, ...
Anti-T-cell receptor (TCR)alpha beta monoclonal antibody (mAb; H57-597) injection in mice caused cytokine (tumour necrosis factor and interferon-gamma) release and clinical side-effects such as...
Yoshikai, Y, Matsuzaki, G, Inoue, T, Nomoto, K
It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T...
Harada, M, Okamoto, T, Omoto, K, Tamada, K, Takenoyama, M, Hirashima, C, ...
For providing costimulatory signals, we utilized anti-CD28 monoclonal antibody (mAb) for the in vitro culture of tumour-draining lymph node (LN) cells. The proliferation of B16 melanoma-draining LN...
Ohga, S, Yoshikai, Y, Kishihara, K, Matsuzaki, G, Ogimoto, M, Nomoto, K
In order to search for a possible role of abnormally proliferating T cells in developing autoimmune disease in lpr mice, and to define the difference of the T cells among various lpr-congeneic mice...
Two differential pathways from double-negative to double-positive thymocytes.
Matsumoto, K, Yoshikai, Y, Moroi, Y, Asano, T, Ando, T, Nomoto, K
Murine thymocytes are divided into four major populations on the basis of expression of CD4 and CD8 antigens. The bulk of evidence favours the view that CD4-CD8- cells can develop into CD4-CD8+ and...
Muramori, K, Mitsuyama, M, Handa, T, Serushago, B A, Nomoto, K
Using an in vitro primary culture system which we had previously established, the induction phase of Listeria monocytogenes-specific effector cells was analysed with respect to their abilities to...
Serushago, B A, Mitsuyama, M, Handa, T, Muramori, K, Koga, T, Nomoto, K
After subcutaneous immunization of mice with viable Listeria monocytogenes (LM), we evaluated the function of T cells induced in draining lymph nodes (LN) and spleen as determined by the local...
Serushago, B A, Yoshikai, Y, Handa, T, Mitsuyama, M, Muramori, K, Nomoto, K
Recombinant human granulocyte colony-stimulating factor (rh G-CSF) enhanced resistance of mice against Listeria monocytogenes (LM) as determined by survival and bacterial growth. Mice pretreated with...
Yoshikai, Y, Ishida, A, Murosaki, S, Ando, T, Nomoto, K
We have previously reported that T-cell receptor (TcR) gamma delta-bearing T cells precede TcR alpha beta-bearing T cells in appearance in the thymus after whole-body irradiation. In the present...
The stage of negative selection in tolerance induction in neonatal mice.
Ando, T, Yoshikai, Y, Matsuzaki, G, Takimoto, H, Nomoto, K
In flow microfluorometry analysis of thymus and lymph node cells of C57BL/6(I-E-,Mlsb) mice rendered neonatally tolerant to (C57BL/6 x AKR/J)F1 (I-E+,Mlsb/a) lymphoid cells, both CD4+ and CD8+ cells...
Taniguchi, K, Kawano, Y I, Nomoto, K
In vitro sensitization of (CBA x A)F1 spleen cells for 3 days with allogeneic C57BL cells raised the killer activity to the NK-sensitive YAC-1 target. When (A x C57BL)F1 spleen cells were cultured...
Yoshikai, Y, Takeda, Y, Ohga, S, Kishihara, K, Matsuzaki, G, Nomoto, K
We have previously shown that extrathymic rearrangements of T-cell receptor (TcR) gamma and delta chain genes occur in the peripheral lymphoid tissues of athymic nude mice. To further determine where...
Ohga, S, Yoshikai, Y, Matsumoto, K, Kishihara, K, Matsuzaki, G, Nomoto, K
To search the abnormality in prethymic T-cell precursors in lpr/lpr(lpr) mice, rearrangement and expression of T-cell receptor (TcR) genes were investigated in long-term cultured bone marrow (LTBM)...
Asensi, V, Kimeno, K, Kawamura, I, Sakumoto, M, Nomoto, K
The predominant accumulating cells in the lymphoid tissue of MRL/lpr mice have been shown to carry the B220 cell marker. This antigen is expressed on B cells and on T-cell precursors. In order to...
Handa, T, Mitsuyama, M, Serushago, B A, Muramori, K, Nomoto, K
The effects of macrophage chemotactic factor (MCF) and macrophage-activating factor (MAF) on protection to Listeria monocytogenes were analysed using 'MCF-rich fraction' and murine recombinant...
Ogimoto, M, Yoshikai, Y, Matsuzaki, G, Ohga, S, Matsumoto, K, Nomoto, K
Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible...
Takada, H, Matsuzaki, G, Hiromatsu, K, Nomoto, K
We have reported that T cells bearing T-cell receptors (TcR) of gamma delta type (gamma delta T cells) appear in the peritoneal cavity in a relatively early stage of primary intraperitoneal (i.p.)...
Nishimura, Y, Eto, M, Maeda, T, Hiromatsu, K, Kobayashi, N, Nomoto, K, ...
We compared the effects of in vivo administration of the anti-T-cell receptor (TCR) alpha beta monoclonal antibody (mAb) (H57-597) to those of the anti-CD3 mAb (145-2C11), with or without anti-NK1.1...
Nabeshima, S, Hiromatsu, K, Matsuzaki, G, Mukasa, A, Takada, H, Yoshida, S, ...
To evaluate the hypothesis that gamma delta T cells participate in protective immunity against mycobacterial infection, we depleted gamma delta T cells from mice by administration of anti-T-cell...
Li, X Y, Matsuzaki, G, Yoshikai, Y, Muramori, K, Nomoto, K
L-selectin, which was first reported as MEL-14 antigen in mice, is a type of animal lectin and expressed on lymphocytes, neutrophils and macrophages. L-selectin has been reported to be a homing...
Matsuzaki, G, Hiromatsu, K, Yoshikai, Y, Muramori, K, Nomoto, K
It has been shown that T-cell receptor (TcR) gamma delta + CD4- CD8- T cells increase in number and have an important role in early protection in murine Listeria monocytogenes infection. In this...
Maeda, T, Eto, M, Nishimura, Y, Nomoto, K, Kong, Y Y, Nomoto, K
It has previously been reported that a single i.p. injection of 200 mg/kg cyclophosphamide (CP) 2 days after priming with 10(8) donor spleen cells (SC) leads to donor-specific skin allograft...
Maeda, Y, Koga, Y, Tanaka, K, Zhang, X Y, Nomoto, K
It becomes increasingly clear that adhesion systems such as CD2/LFA-3 (lymphocyte function-associated antigen-3), LFA-1/ICAM-1 (intercellular adhesion molecule-1) and Thy-1/putative Thy-1 ligand...
Eto, M, Yoshikai, Y, Nishimura, Y, Hiromatsu, K, Maeda, T, Nomoto, K, ...
Anti-CD3 monoclonal antibody (mAb) has been administered in clinical organ transplantation to reverse acute allograft rejection; however, severe immunodeficiency can result from such mAb treatment...
Kobayashi, N, Matsuzaki, G, Yoshikai, Y, Seki, R, Ivanyi, J, Nomoto, K
The purpose of this paper was to study the gamma delta T-cell receptor repertoire and target specificity following stimulation of peripheral T cells of BALB/c mice with autologous or bacterial...
Ohmichi, Y, Nomoto, K, Yamada, H, Takeya, K
Relationships among tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper T cells were studied in AKR mice by means of footpad reaction, migration inhibition...
Nomoto, K., Ohmichi, Y., Yamada, H., Sato, M., Takeya, K.
Relationships among T-cell mediated cytotoxicity, tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper T cells were studied in AKR mice by means of target cell...
Kubo, C, Nomoto, K, Sato, M, Takeya, K
Immune responses were examined after immunization with chicken erythrocytes (CRBC) in mice. Cytotoxicity of spleen cells was assessed by the release of 51Cr from labelled target cells. (1) At early...
Shinomiya, N, Tsuru, S, Taniguchi, M, Fujisawa, H, Ikeda, M, Zinnaka, Y, ...
Characteristics of protective mechanisms during pregnancy were investigated using neonatally thymectomized (NTx) and/or pregnant mice infected with sublethal doses of Listeria monocytogenes, of which...
Cholera toxin-induced tolerance to allografts in mice.
Tsuru, S, Taniguchi, M, Shinomiya, N, Fujisawa, H, Zinnaka, Y, Nomoto, K
When C3H/HeN (C3H) mice were primed with viable C57BL/6 (B6) spleen cells and treated with cholera toxin (CT) on the same day, a profound tolerance to tumour allografts of B6 origin was induced. The...
Nakamura, S, Sanui, H, Nomoto, K
Guinea-pigs immunized with bovine gammaglobulin (BGG) in incomplete Freund's adjuvant (IFA) showed the typical Jones-Mote-type hypersensitivity (JMH) reaction when tested 5 days later. This is...
Tsuru, S, Aiso, S, Taniguchi, M, Zinnaka, Y, Nomoto, K
Mature cytotoxic T lymphocytes (CTL) were detected in the peritoneal cavity of syngeneic mice immunized intraperitoneally (i.p.) with mitomycin C (MC)-treated EL-4 or X5563 cells, but were not found...
Koga, T, Mitsuyama, M, Handa, T, Yayama, T, Muramori, K, Nomoto, K
Using a local passive transfer system, we found that effector T cells mediating delayed-type hypersensitivity (DTH) but not acquired cellular resistance (ACR) to Listeria monocytogenes (strain EGD)...
Sex difference in delayed footpad reaction to syngeneic testicular cells in C3H/He mice.
Yoshida, S, Ohhara, R, Sanui, H, Nomoto, K
Delayed footpad reaction against syngeneic testicular cells was compared between males and virgin females of C3H/He mice. Mice were immunized subcutaneously with 1 x 10(7) of syngeneic testicular...
Sanui, H, Yoshida, S, Himeno, K, Nomoto, K
Inoculation of 1 X 10(3) viable Listeria monocytogenes into unilateral testis induced pathological changes in the contralateral testis and epididymis in guinea-pigs. Because L. Monocytogenes was not...
The mechanism of reduction of cell-mediated cytotoxicity in neonatally thymectomized mice.
Kawauchi, H, Taniguchi, K, Kubo, C, Shimamoto, Y, Nomoto, K
The effect of neonatal thymectomy at various times after birth (Tx-1, Tx-7) on effector and suppressor T cells responsible for cell-mediated cytotoxicity (CMC) for allogenic antigens was determined....
Yokoyama, M, Koga, Y, Taniguchi, K, Nakano, H, Nomoto, K
We noted an increase of a splenic T-cell population in early postpartum normal mice, but not in thymectomized (Tx) postpartum mice. The T-cell population consisted mainly of Lyt-1+2- cells and...
Watanabe, Y, Mitsuyama, M, Koga, T, Handa, T, Yoshikai, Y, Nomoto, K
Neonatally thymectomized (NTx) mice, whose ability to mount antigen-specific cell-mediated immunity is reported to be generally defective, were found to be capable of mounting a normal level of...
Takada, H, Matsuzaki, G, Yoshida, H, Sumichika, H, Nomoto, K
There is an increase in number of gamma delta T cells in the peritoneal cavity after intraperitoneal (i.p.) inoculation with Escherichia coli. The E. coli-induced gamma delta T cells in C3H/He mice...
Omoto, K, Kong, Y Y, Nomoto, K, Umesue, M, Murakami, Y, Eto, M, ...
Although the survival of fully allogeneic skin grafts was prominently prolonged by adult thymectomy in anti-T-cell receptor-alpha beta monoclonal antibody (TCR-alpha beta mAb)-treated mice compared...
Tamada, K, Harada, M, Ito, O, Takenoyama, M, Mori, T, Matsuzaki, G, ...
The mechanism by which murine tumour-infiltrating lymphocytes (TIL) decreased their anti-tumour activity during an in vitro culture with interleukin-2 (IL-2) was investigated. A phenotype analysis...
Kubo, C, Nomoto, K, Taniguchi, K, Nanishi, F, Shimamoto, Y, Takeya, K
Exposure to 600 rad of X-irradiation 3 h after primary immunization with chicken erythrocytes (CRBC) abolished the production of antibodies and the generation of killer T cells, but scarcely affected...
Nomoto, K, Kubo, C, Taniguchi, K, Takeya, K
Direct cytotoxicity raised at an early interval after immunization with chicken erythrocytes (CRBC) has been ascribed to O-positive, immunoglobulin (Ig)-bearing lymphocytes. Cytotoxicity of such...
Nomoto, K, Taniguchi, K, Kubo, C, Takeya, K
Effects of whole body irradiation with 600 rad on delayed hypersensitivity, direct cytotoxicity and antibody production were examined in mice immunized with chicken erythrocytes (CRBC) or sheep...
Terasaka, R, Nomoto, K, Himeno, K, Takeya, T
Immune response in mice to xenogeneic cells was characterized by positive delayed footpad reaction and negative macrophage migration inhibition. Mice immunized with allogeneic cells exhibited...
Yoshikai, Y, Miake, S, Matsumoto, T, Nomoto, K, Takeya, K
The delayed footpad reaction to sheep erythrocytes (SRBC) was studied in mice whose mononuclear phagocyte system (MPS) was blocked or stimulated. Colloidal carbon or carrageenan was used for the...
Terasaka, R, Nomoto, K, Himeno, K
Rat tumours grew progressively in nu/nu mice but not in nu/+ mice, normal AKR mice or sublethally irradiated AKR mice after subcutaneous inoculation. Suppression of tumour growth appeared to depend...
Shiraishi, M, Nomoto, K, Himeno, K, Terasaka, R
Hamsters immunized with a murine tumour via the cheek pouch showed accelerated rejection following rechallenge with the same kind of tumour cells. Regional lymph node cells exhibited a suppressive...
Yoshikai, Y, Miake, S, Matsumoto, T, Nomoto, K, Takeya, K
Delayed footpad reactions and acquired cellular resistance to Listeria monocytogenes were studied in mice whose mononuclear phagocyte system (MPS) had been blocked or stimulated. Colloidal carbon was...
Effect of carrageenan on the induction of cell-mediated cytotoxic responses in vivo.
Sakemi, T, Kuroiwa, A, Nomoto, K
Carrageenan (CAR), a sulphated polygalactose having macrophage toxic properties, elicited a suppression of primary cytotoxic T lymphocyte (CTL) responses against allogeneic tumour cells in the spleen...
Nomoto, K, Yoshida, S, Himeno, K
Guinea-pigs were immunized via footpads with sheep red blood cells (SRBC) in saline. Histological examination of erythematous skin reaction was performed and effects of cyclophosphamide (CY) or BCG...
Differences in thymus-dependency among various T-cell functions.
Shimamoto, Y, Taniguchi, K, Kubo, C, Nomoto, K
Effects of thymectomy of various times after birth on cytotoxicity, delayed footpad reaction and antibody production were examined in 6 week old mice immunized intraperitoneally with chicken...
Delayed hypersensitivity to syngeneic or xenogeneic testicular cells in guinea-pigs.
Yoshida, S, Nomoto, K, Himeno, K, Sanui, H
Guinea-pigs of an inbred JY-l strain were immunized with syngeneic or xenogeneic testicular cells without added adjuvants. A delayed erythematous skin reaction accompanied by basophil infiltration...
Characteristics of resistance to Listeria monocytogenes enhanced by Corynebacterium parvum in mice.
Miyata, H, Nomoto, K, Takeya, K
In mice pre-treated with Corynebacterium parvum, Listeria monocytogenes was cleared rapidly from the blood and bacterial growth in the liver and spleen was inhibited effectively during the early...
Nanishi, F, Nomoto, K, Taniguchi, K, Kubo, C
While immunization with allogeneic spleen cells did not generate positive cytotoxic activity, it produced accelerated rejection of subsequent tumour grafts carrying the same H-2 antigen. No augmented...
Yoshikai, Y, Miake, S, Matsumoto, T, Nomoto, K, Takeya, K
The role of mononuclear phagocyte system (MPS) in the induction of suppressor T cells which depress the delayed footpad reaction to sheep erythrocytes (SRBC) was studied in mice in which MPS was...
Miyata, H, Himeno, K, Miake, S, Nomoto, K
In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was...
Sanui, H, Yoshida, S, Himeno, K, Nomoto, K
Guinea-pigs were inoculated into the testis with viable Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus and elicitation of skin reactions was carried out...
Miyata, M, Mitsuyama, M, Ogata, N, Nomoto, K, Takeya, K
Mice were immunized with 1 X 10(3) viable Listeria monocytogenes, and the mechanism of the acquired resistance against challenge infection with 5 X 10(4) L. monocytogenes was studied by the use of...
Ikebe, H, Yamada, H, Nomoto, M, Takimoto, H, Nakamura, T, Sonoda, K-H, ...
After intraperitoneal inoculation with Listeria monocytogenes, γδ T cells appear in the peritoneal cavity preceding the appearance of αβ T cells. Such γδ T cells predominantly express T-cell...
Winkles, J. A., Alberts, G. F., Peifley, K. A., Nomoto, K., Liau, G., Majesky, M. W.
Fibroblast growth factor (FGF)-1 and FGF-2 are potent angiogenic factors and vascular smooth muscle cell (SMC) mitogens in vivo. They function via binding to a family of structurally related cell...
Asano, T, Yoshikai, Y, Matsumoto, K, Matuzaki, G, Nomoto, K
CD4+ cells from autoimmune-prone C57BL/6 lpr/lpr mice contain two subpopulations, B220-CD4+ and B220+CD4+ cells. Highly purified B220-CD4+ cells from C57BL/6 +/+ and lpr/lpr mice were examined by...
In vivo treatment with anti B-220 monoclonal antibody affects T and B cell differentiation.
Asensi, V, Himeno, K, Kawamura, I, Sakumoto, M, Nomoto, K
The B220 cell marker is expressed on B cells and on T cell precursors. In order to determine the involvement of the B220 antigen on murine lymphoid differentiation, we treated 5-10-week-old mice...
Local passive transfer of delayed type hypersensitivity to syngeneic testicular cells in mice.
Sakamoto, Y, Sanui, H, Yoshida, S, Nomoto, K
A means for local passive transfer (LPT) of delayed footpad reaction (DFR) against syngeneic testicular cells (TC) was established in mice. Peritoneal exudate (PE) cells from immunized donors...
Kai, S, Tanaka, J, Nomoto, K, Torisu, M
The effects of the anti-tumour agent OK-432 on the immune response to hamster erythrocytes (HRBC) and nucleated chicken erythrocytes (CRBC) were studied in inbred SL mice. Mice were treated...
Yoshida, S, Nomoto, K, Himeno, K, Takeya, K
A delayed footpad reaction against syngeneic or autologous testicular cells was detected in mice of inbred C57BL/6, AKR and C3H/He strains. The reaction was only provoked to a measurable level if the...
Chronic mucocutaneous candidiasis accompanied by enhanced antibody production.
Takeya, K, Nomoto, K, Matsumoto, T, Miyake, T, Himeno, K
In four cases of chronic mucocutaneous candidiasis (CMCC) enhanced antibody production against candida antigen was detected in association iwth depressed cellular immunity. These patients showed...
Asano, T, Tomooka, S, Serushago, B A, Himeno, K, Nomoto, K
Autoimmune-prone mice homozygous for the lpr gene develop prominent lymphadenopathy composed mainly of Thy-1+ CD8- CD4- B220+ cells. Expression patterns of B220 vs CD4 on lymph node cells from lpr...
Ohga, S, Yoshikai, Y, Kishihara, K, Matsuzaki, G, Asano, T, Nomoto, K
An autosomal recessive gene, lpr, is responsible for lymphoproliferation and autoimmunity of lpr-mice, in which background genes are also known to influence the development of autoimmune disease. To...
Treatment of autoimmune MRL/Mp-lpr/lpr mice with cholera toxin.
Fan, J L, Himeno, K, Tsuru, S, Nomoto, K
The autoimmune manifestations of MRL/Mp-lpr/lpr(MRL/l), a murine model of systemic lupus erythematosus (SLE), were alleviated by administering 1 microgram cholera toxin (CT) every 14 days. The...
Enhanced release of reactive oxygen intermediates by immunologically activated rat Kupffer cells.
Matsuo, S, Nakagawara, A, Ikeda, K, Mitsuyama, M, Nomoto, K
Release of O2- and H2O2 from isolated rat liver Kupffer cells was studied by making use of the methods of SOD sensitive ferricytochrome c reduction and horseradish peroxidase catalysed scopoletin...
HARADA, M, TATSUGAMI, K, NOMOTO, M, NOMOTO, K
In order to elucidate the mechanisms by which tumour-specific CD4+ T-cell responses are impaired during tumour development, an attempt was made to identify factors which impair CD4+ T-cell responses...
Nakajima, T., Nomoto, K., Ohfune, Y., Shiratori, Y., Takemoto, T., Takeuchi, H., ...
The effects of the seven glutamic acid analogues, alpha-kainic acid, alpha-allo-kainic acid, domoic acid, erythro-L-tricholomic acid, DL-ibotenic acid, L-quisqualic acid and...
HARADA, M, SUMICHIKA, H, HAMANO, S, ITO, O, TAMADA, K, TAKENOYAMA, M, ...
A null cell line (SCM1) was established by a culture of spleen cells (SC) from normal adult C57Bl/6 mice with complete medium alone for 10 days and followed by weekly cultures with a 25% WEHI-3 cell...
The protective role of T-cell receptor Vγ1+ T cells in primary infection with Listeria monocytogenes
Nakamura, T, Matsuzaki, G, Nomoto, K
We have previously reported that the T-cell receptor (TCR) γδ+ T cells increase in mice infected with an intracellular bacteria Listeria monocytogenes, and the cells predominantly express Vδ6 and...
Eto, M, Kong, Y-Y, Uozumi, J, Naito, S, Nomoto, K
In B6 (H-2b) mice that had been given, neonatally, 1×108 B6AKF1 spleen cells intraperitoneally (i.p.), only a moderate prolongation of donor (AKR:H-2k) skin graft survival was observed. In such B6...
Approach to withdrawal from tacrolimus in a fully allogeneic murine skin graft model
Uchiyama, H, Kishihara, K, Sugimachi, K, Nomoto, K
With few exceptions, transplant patients must take immunosuppressants throughout their lives. In this study, we used anti-T-cell receptor (TCR/CD3) monoclonal antibodies (mAbs) to induce...
Characterization of CD4– CD8– CD3+ T-cell receptor-αβ+ T cells in murine cytomegalovirus infection
Hossain, M S, Takimoto, H, Ninomiya, T, Yoshida, H, Kishihara, K, Matsuzaki, G, ...
In this study, we have investigated that after the intraperitoneal infection with murine cytomegalovirus (MCMV), the CD3+ CD4– CD8–(double negative; DN) T-cell receptor (TCR)αβ+ T cells...
Ninomiya, T, Takimoto, H, Matsuzaki, G, Hamano, S, Yoshida, H, Yoshikai, Y, ...
Cytomegalovirus (CMV) causes severe opportunistic infection in immunocompromised hosts. The importance of conventional αβ T cells in protection against CMV infection has been well documented....
Zheng, H-C, Takahashi, H, Murai, Y, Cui, Z-G, Nomoto, K, Miwa, S, ...
Tumour growth depends on angiogenesis, which is closely associated with vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Extracellular MMP inducer (EMMPRIN) was...