K. Ogasawara

Publication List Details

Period

2000 - 2006

Number

49

Co-Authors

The murine c-fgr gene product associated with Ly6C and p70 integral membrane protein is expressed in cells of a monocyte/macrophage lineage.

Hatakeyama, S, Iwabuchi, K, Ogasawara, K, Good, R A, Onoé, K

The c-fgr gene is a member of the Src family of protooncogene tyrosine kinases. A monoclonal antibody (2H2) that recognizes the specific region of the N-terminal domain of the murine c-fgr gene...

A potential peptide vaccine against two different strains of influenza virus isolated at intervals of about 10 years.

Naruse, H, Ogasawara, K, Kaneda, R, Hatakeyama, S, Itoh, T, Kida, H, ...

We have developed a strategy for making synthetic peptide vaccines, in which a peptide, HA127-133, derived from the hemagglutinin (HA) of A/Aichi/2/68(H3N2) influenza virus (Aichi/68) is introduced...

An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.

Arase, H, Arase, N, Ogasawara, K, Good, R A, Onoé, K

In the present report we describe a CD4+8- heat stable antigen-negative (HSA-) thymocyte subpopulation that expresses a distinguishably low density of alpha beta T-cell antigen receptors (TCRlo) from...

A strategy for making synthetic peptide vaccines.

Ogasawara, K, Naruse, H, Itoh, Y, Gotohda, T, Arikawa, J, Kida, H, ...

We have determined the H-2 class II allele-specific amino acid motif of the agretope (the site of contact between the peptide antigen and the major histocompatibility complex) for a synthetic peptide...

Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.

Fukushi, N, Arase, H, Wang, B, Ogasawara, K, Gotohda, T, Good, R A, ...

Graft-versus-host reaction (GVHR) following allogeneic bone marrow (BM) transplantation was investigated by analyzing expression of antigen receptors on T cells specific for recipient antigens. GVHR...

Positive selection of a T-cell subpopulation in the thymus in which it develops.

Iwabuchi, K, Negishi, I, Arase, H, Iwabuchi, C, Ogasawara, K, Good, R A, ...

In SWR mice the expression with high-density V beta 17a (high V beta 17a) of the T-cell antigen receptors correlates with the CD4+8- subpopulation of thymocytes. By contrast, in thymocytes of SJL...

H-2-incompatible bone marrow chimeras produce donor-H-2-restricted Ly-2 suppressor T-cell factor(s).

Noguchi, M, Onoé, K, Ogasawara, M, Iwabuchi, K, Geng, L, Ogasawara, K, ...

To study adaptive-differentiation phenomena of T lymphocytes, suppressor T-cell factors (TsF) produced by Ly-2+ splenic T cells from fully allogeneic mouse bone marrow chimeras were analyzed. AKR...

Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations.

Fujii, H, Ogasawara, K, Otsuka, H, Suzuki, M, Yamamura, K, Yokochi, T, ...

The interleukin 2 (IL-2) receptor betac chain (IL-2Rbetac) is known to regulate the development and function of distinct lymphocyte populations. Thus far, the functions of the IL-2Rbetac cytoplasmic...

The murine c-fgr gene product associated with Ly6C and p70 integral membrane protein is expressed in cells of a monocyte/macrophage lineage.

Hatakeyama, S, Iwabuchi, K, Ogasawara, K, Good, R A, Onoé, K

The c-fgr gene is a member of the Src family of protooncogene tyrosine kinases. A monoclonal antibody (2H2) that recognizes the specific region of the N-terminal domain of the murine c-fgr gene...

A potential peptide vaccine against two different strains of influenza virus isolated at intervals of about 10 years.

Naruse, H, Ogasawara, K, Kaneda, R, Hatakeyama, S, Itoh, T, Kida, H, ...

We have developed a strategy for making synthetic peptide vaccines, in which a peptide, HA127-133, derived from the hemagglutinin (HA) of A/Aichi/2/68(H3N2) influenza virus (Aichi/68) is introduced...

An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.

Arase, H, Arase, N, Ogasawara, K, Good, R A, Onoé, K

In the present report we describe a CD4+8- heat stable antigen-negative (HSA-) thymocyte subpopulation that expresses a distinguishably low density of alpha beta T-cell antigen receptors (TCRlo) from...

A strategy for making synthetic peptide vaccines.

Ogasawara, K, Naruse, H, Itoh, Y, Gotohda, T, Arikawa, J, Kida, H, ...

We have determined the H-2 class II allele-specific amino acid motif of the agretope (the site of contact between the peptide antigen and the major histocompatibility complex) for a synthetic peptide...

Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.

Fukushi, N, Arase, H, Wang, B, Ogasawara, K, Gotohda, T, Good, R A, ...

Graft-versus-host reaction (GVHR) following allogeneic bone marrow (BM) transplantation was investigated by analyzing expression of antigen receptors on T cells specific for recipient antigens. GVHR...

Positive selection of a T-cell subpopulation in the thymus in which it develops.

Iwabuchi, K, Negishi, I, Arase, H, Iwabuchi, C, Ogasawara, K, Good, R A, ...

In SWR mice the expression with high-density V beta 17a (high V beta 17a) of the T-cell antigen receptors correlates with the CD4+8- subpopulation of thymocytes. By contrast, in thymocytes of SJL...

H-2-incompatible bone marrow chimeras produce donor-H-2-restricted Ly-2 suppressor T-cell factor(s).

Noguchi, M, Onoé, K, Ogasawara, M, Iwabuchi, K, Geng, L, Ogasawara, K, ...

To study adaptive-differentiation phenomena of T lymphocytes, suppressor T-cell factors (TsF) produced by Ly-2+ splenic T cells from fully allogeneic mouse bone marrow chimeras were analyzed. AKR...

Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations.

Fujii, H, Ogasawara, K, Otsuka, H, Suzuki, M, Yamamura, K, Yokochi, T, ...

The interleukin 2 (IL-2) receptor betac chain (IL-2Rbetac) is known to regulate the development and function of distinct lymphocyte populations. Thus far, the functions of the IL-2Rbetac cytoplasmic...

Antimetastatic effect of NK1+ T cells on experimental haematogenous tumour metastases in the liver and lungs of mice.

Seki, S, Hashimoto, W, Ogasawara, K, Satoh, M, Watanabe, H, Habu, Y, ...

Depletion of both natural killer 1.1+ (NK1+) intermediate alpha beta T-cell receptor (int T) cells and NK cells by in vivo treatment with anti-NK1 antibody greatly increased hepatic metastases of...

A study on type II collagen-induced arthritis in allogeneic bone marrow chimaeras.

Fujita, M, Mishima, M, Iwabuchi, K, Katsume, C, Gotohda, T, Ogasawara, K, ...

In the present investigation, the incidence, day of onset and severity of type II collagen (IIC)-induced polyarthritis (CA) in allogeneic bone marrow chimaeras were compared. These chimaeras were...

Analysis of synthetic sites of fourth and fifth components of serum complement system in allogeneic bone marrow chimaeras.

Geng, L, Iwabuchi, K, Sakai, S, Ogasawara, M, Fujita, M, Ogasawara, K, ...

Synthetic tissue sites for the fourth and fifth components of complement (C4 and C5) have been investigated using allogeneic bone marrow chimaeras in mice. One group of chimaeric mice was prepared by...

Inhibition of autologous mixed lymphocyte reaction by monoclonal antibodies specific for the β chain of HLA-DR antigens

Kasahara, M., Ikeda, H., Ogasawara, K., Ishikawa, N., Okuyama, T., Fukasawa, Y., ...

Recent studies using rabbit antisera to the separated HLA-DR α and β subunits have suggested that α chain-specific, but not β chain-specific, antisera inhibit T cell proliferative responses in...

Interleukin-12 induces cytotoxic NK1+ alpha beta T cells in the lungs of euthymic and athymic mice.

Anzai, R, Seki, S, Ogasawara, K, Hashimoto, W, Sugiura, K, Sato, M, ...

We recently reported that interleukin-12 (IL-12) stimulated hepatic NK1.1 Ag+ alpha beta T cells with intermediate T-cell receptor (TCR; NK1+ TCRint cells) and enhanced their NK1 expression (NK1high...

Regulation of experimental autoimmune uveitis in rats--separation of MHC and non-MHC gene effects.

Hirose, S, Ogasawara, K, Natori, T, Sasamoto, Y, Ohno, S, Matsuda, H, ...

Experimental autoimmune uveitis (EAU) is an organ-specific autoimmune disease and has served as a model of certain ocular inflammatory conditions in man. The present study was aimed at separating the...

Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice

Namba, K, Ogasawara, K, Kitaichi, N, Matsuki, N, Takahashi, A, Sasamoto, Y, ...

When certain strains of mice bearing H-2Ak are immunized with the interphotoreceptor retinoid-binding protein (IRBP), EAU is induced. Thus far uveitogenic determinant(s) has not been determined in...

Roles of tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 in the modulation of intercellular adhesion molecule-1 (ICAM-1) expression by macrophages during mycobacterial infection

Tomioka, H, Shimizu, T, Maw, W W, Ogasawara, K

Profiles of ICAM-1 expression on cultured murine peritoneal macrophages infected with Mycobacterium avium complex (MAC) were examined, with special reference to modulating roles of TNF-α, TGF-β,...

Profiles of cell-to-cell interaction of Mycobacterium intracellulare-induced immunosuppressive macrophages with target T cells in terms of suppressor signal transmission

OGASAWARA, K, TOMIOKA, H, SHIMIZU, T, SANO, C, KAWAUCHI, H, SATO, K

Previously, we have found that immunosuppressive macrophages (Mφs) induced by Mycobacterium intracellulare-infection (MI-Mφs) required cell contact with target T cells to express their suppressor...