K. P. Hanley

Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis (2008)

Hanley, K.P., Oakley, F., Sugden, S., Wilson, D.I., Mann, D.A., Hanley, N.A.

Appropriate temporospatial expression of the transcription factor SOX9 is important for normal development of a wide range of organs. Here, we show that when SOX9 is expressed ectopically, target...

The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development (2008)

Harries, L.W., Locke, J.M., Shields, B., Hanley, N.A., Hanley, K.P., Steele, A., ...

OBJECTIVE: Mutations in the alternatively spliced HNF4A gene cause maturity-onset diabetes of the young (MODY). We characterized the spatial and developmental expression patterns of HNF4A transcripts...

The long acting GLP-1 analogue, liraglutide, induces beta cell differentiation during normal human pancreas development (2006)

Hanley, K.P., Gray, S., Dijkstra, I.M.E., Hearn, T., Williams, L., Wilson, D.I., ...

Background and Aims: Glucagon-like peptide-1 (GLP-1) stimulates glucose-dependent insulin secretion; the primary reason long-acting analogues have been developed for use in Type 2 diabetes. In...

The long acting GLP-1 analogue, liraglutide, induces beta cell differentiation during normal human pancreas development (2006)

Hanley, K.P., Gray, S., Dijkstra, I.M.E., Hearn, T., Williams, L., Wilson, D.I., ...

The long-acting GLP-1 analogue, liraglutide, increases beta cell numbers during early human development (2005)

Hanley, K.P., Dijkstra, I.M.E., Dunleavey, L., Hanley, N.A.