K. Pfizenmaier

High affinity human IFN-gamma-binding capacity is encoded by a single receptor gene located in proximity to c-ros on human chromosome region 6q16 to 6q22 (2007)

Pfizenmaier, K., Wiegmann, K., Scheurich, P., Kronke, M., Merlin, G., Aguet, M., ...

We have used human-rodent somatic cell hybrids to investigate the regional localization of the IFN-gamma R gene on human chromosome 6 and studied functional and antigenic characteristics of the...

Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene (2007)

Fischer, T., Rehm, A., Aguet, M., Pfizenmaier, K.

The human interferon (IFN) gamma receptor cDNA has been stably expressed in human/mouse somatic cell hybrids, which differ in their content of human chromosome 21. Despite high affinity IFN gamma...

Tumor necrosis factor (TNF)-functionalized nanostructured particles for the stimulation of membrane TNF-specific cell responses (2005)

Bryde, S., Grunwald, I., Hammer, A., Krippner-Heidenreich, A., Schiestel, T., Brunner, H., ...

Nanopartikel mit daran immobilisiertem biologisch aktivem TNF (2003)

Tovar, G., Brunner, H., Schiestel, T., Pfizenmaier, K., Grell, M., Scheurich, P., ...

WO2003020320 A UPAB: 20030526 NOVELTY - Nanoparticles (NP) comprise a carrier having: (1) a surface with functional groups (1A) and (2) at least one monomer of a protein (I) of the tumor necrosis...

Protein kinase C (PKC)eta-mediated PKCmu activation modulates ERK and JNK signal pathways (2002)

Brändlin, I., Hübner, S., Eiseler, T., Martinez-Moya, M., Horschinek, A., Hausser, A., ...

Protein kinase C (PKC), a family of lipid-activated serine kinases, is involved in multiple functions in the regulation of growth control. The PKC-related isoform PKCmu/PKD has been implicated in...

Silica nanoparticle carrier system with special bioactivity (2002)

Schiestel, T., Hammer, A., Bryde, S., Zimmermann, G., Scheurich, P., Pfizenmaier, K., ...

PKCh-PKCµ interaction and mutual regulation: Modulation of ERK and JNK signal pathways in vivo (2001)

Brändlin, I., Eiseler, T., Hausser, A., Hübner, S., Rupp, S., Pfizenmaier, K., ...

Protein kinase C µ is regulated by the multifunctional chaperon protein p32 (2000)

Storz, P., Hausser, A., Link, G., Dedio, J., Ghebrehiwiet, B., Pfizenmaier, K., ...

Bruton's tyrosine kinase (Btk) associates with Protein Kinase Cµ (1999)

Hausser, A., Storz, P., Truckenmüller, L., Link, G., Kawakami, T., ...

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis (1976)

Starzinski-Powitz, A., Pfizenmaier, K., Koszinowski, Ulrich H., Röllinghoff, M., Wagner, H.

Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T...

Persistent NR2B expression in cerebellar granule cells interferes with cerebellar development and function

Pieri,I., Schlett,K., Metzger,F., Steigerwald,Frank, Dere,E., Marchetti,L., ...

Purification and Characterization of a Novel (R)-Mandelonitrile Lyase from the Fern Phlebodium aureum.

Wajant, H., Forster, S., Selmar, D., Effenberger, F., Pfizenmaier, K.

Using high-performance liquid chromatography and nuclear magnetic resonance we identified vicianin as the cyanogenic compound of Phlebodium aureum. The (R)-hydroxynitrile lyase involved during...

Short-term treatment with gamma interferon induces stable reversion of ras-transformed mouse fibroblasts.

Seliger, B, Pfizenmaier, K, Schäfer, R

Persistent revertants have been generated from NIH 3T3 cells transformed by an activated human Ha-ras gene after short-term gamma interferon treatment in the presence of the cardiac aminoglycoside...

Gamma interferon regulates long terminal repeat-controlled oncogene expression in transformed mouse fibroblasts at the level of mRNA transcription.

Seliger, B, Kruppa, G, Schäfer, R, Redmond, S M, Pfizenmaier, K

In transformed NIH 3T3 cells, murine gamma interferon reduces the expression of the long terminal repeat-controlled oncogenes v-mos, c-myc, and v-Ha-ras by a direct effect on the activity of...

Murine gamma interferon inhibits v-mos-induced fibroblast transformation via down regulation of retroviral gene expression.

Seliger, B, Kruppa, G, Pfizenmaier, K

Expression of the retroviral vector Neor myeloproliferative sarcoma virus (MPSV), which contains the v-mos oncogene and the neomycin resistance gene, leads to neoplastic transformation of mouse...

Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.

Hahn, G, Stuhlmüller, B, Hain, N, Kalden, J R, Pfizenmaier, K, Burmester, G R

One of the hallmarks in rheumatoid arthritis (RA) is the intense activation of the monocyte-macrophage system. In the present investigation, the modulation of blood monocyte activation was studied...

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

Beissert, S, Bergholz, M, Waase, I, Lepsien, G, Schauer, A, Pfizenmaier, K, ...

Tumor necrosis factor (TNF) produced by macrophages is thought to contribute to the host defense against development of cancer. However, since tumor cells themselves are able to produce TNF, it is...

Tumor necrosis factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription.

Krönke, M, Schlüter, C, Pfizenmaier, K

Highly purified, recombinant human tumor necrosis factor type alpha (rTNF-alpha) exerts cytostatic activity on the human promyelocytic leukemic cell line HL-60. Between 4 and 10 hr after treatment...

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

Stockinger, H, Pfizenmaier, K, Hardt, C, Rodt, H, Röllinghoff, M, Wagner, H

Fully allogeneic chimeras were able to develop in vitro alloantigen-specific, as well as H-2-restricted, Sendai virus-specific cytotoxic T-lymphocyte (CTL) response. Depending on the immunization...

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

Müller, G, Ayoub, M, Storz, P, Rennecke, J, Fabbro, D, Pfizenmaier, K

Tumor necrosis factor (TNF-alpha) stimulates a number of signal transduction pathways in which phospholipases produce lipid second messengers. However, the immediate molecular targets of these...

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling.

Müller, G, Storz, P, Bourteele, S, Döppler, H, Pfizenmaier, K, Mischak, H, ...

Raf-1 kinase is a central regulator of mitogenic signal pathways, whereas its general role in signal transduction of tumour necrosis factor (TNF) is less well defined. We have investigated mechanisms...

Fusion of the tissue factor extracellular domain to a tumour stroma specific single-chain fragment variable antibody results in an antigen-specific coagulation-promoting molecule.

Rippmann, J F, Pfizenmaier, K, Mattes, R, Rettig, W J, Moosmayer, D

Solid tumours growing beyond a size of 1-2 mm in diameter induce supporting connective tissue structures, the tumour stroma, comprising activated fibroblasts and newly formed blood vessels, embedded...

Purification and Characterization of a Novel (R)-Mandelonitrile Lyase from the Fern Phlebodium aureum.

Wajant, H., Forster, S., Selmar, D., Effenberger, F., Pfizenmaier, K.

Using high-performance liquid chromatography and nuclear magnetic resonance we identified vicianin as the cyanogenic compound of Phlebodium aureum. The (R)-hydroxynitrile lyase involved during...

Short-term treatment with gamma interferon induces stable reversion of ras-transformed mouse fibroblasts.

Seliger, B, Pfizenmaier, K, Schäfer, R

Persistent revertants have been generated from NIH 3T3 cells transformed by an activated human Ha-ras gene after short-term gamma interferon treatment in the presence of the cardiac aminoglycoside...

Gamma interferon regulates long terminal repeat-controlled oncogene expression in transformed mouse fibroblasts at the level of mRNA transcription.

Seliger, B, Kruppa, G, Schäfer, R, Redmond, S M, Pfizenmaier, K

In transformed NIH 3T3 cells, murine gamma interferon reduces the expression of the long terminal repeat-controlled oncogenes v-mos, c-myc, and v-Ha-ras by a direct effect on the activity of...

Murine gamma interferon inhibits v-mos-induced fibroblast transformation via down regulation of retroviral gene expression.

Seliger, B, Kruppa, G, Pfizenmaier, K

Expression of the retroviral vector Neor myeloproliferative sarcoma virus (MPSV), which contains the v-mos oncogene and the neomycin resistance gene, leads to neoplastic transformation of mouse...

Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.

Hahn, G, Stuhlmüller, B, Hain, N, Kalden, J R, Pfizenmaier, K, Burmester, G R

One of the hallmarks in rheumatoid arthritis (RA) is the intense activation of the monocyte-macrophage system. In the present investigation, the modulation of blood monocyte activation was studied...

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

Beissert, S, Bergholz, M, Waase, I, Lepsien, G, Schauer, A, Pfizenmaier, K, ...

Tumor necrosis factor (TNF) produced by macrophages is thought to contribute to the host defense against development of cancer. However, since tumor cells themselves are able to produce TNF, it is...

Tumor necrosis factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription.

Krönke, M, Schlüter, C, Pfizenmaier, K

Highly purified, recombinant human tumor necrosis factor type alpha (rTNF-alpha) exerts cytostatic activity on the human promyelocytic leukemic cell line HL-60. Between 4 and 10 hr after treatment...

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

Stockinger, H, Pfizenmaier, K, Hardt, C, Rodt, H, Röllinghoff, M, Wagner, H

Fully allogeneic chimeras were able to develop in vitro alloantigen-specific, as well as H-2-restricted, Sendai virus-specific cytotoxic T-lymphocyte (CTL) response. Depending on the immunization...

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

Müller, G, Ayoub, M, Storz, P, Rennecke, J, Fabbro, D, Pfizenmaier, K

Tumor necrosis factor (TNF-alpha) stimulates a number of signal transduction pathways in which phospholipases produce lipid second messengers. However, the immediate molecular targets of these...

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling.

Müller, G, Storz, P, Bourteele, S, Döppler, H, Pfizenmaier, K, Mischak, H, ...

Raf-1 kinase is a central regulator of mitogenic signal pathways, whereas its general role in signal transduction of tumour necrosis factor (TNF) is less well defined. We have investigated mechanisms...

Fusion of the tissue factor extracellular domain to a tumour stroma specific single-chain fragment variable antibody results in an antigen-specific coagulation-promoting molecule.

Rippmann, J F, Pfizenmaier, K, Mattes, R, Rettig, W J, Moosmayer, D

Solid tumours growing beyond a size of 1-2 mm in diameter induce supporting connective tissue structures, the tumour stroma, comprising activated fibroblasts and newly formed blood vessels, embedded...

Persistent NR2B expression in cerebellar granule cells interferes with cerebellar development and function

Pieri, I., Schlett, K., Metzger, F., Steigerwald, Frank, Dere, E., Marchetti, L., ...

Cell-mediated allograft responses in vitro. VI. Studies on macrophage-mediated cytotoxicity.

Pfizenmaier, K, Trostmann, H, Röllinghoff, M, Wagner, H

Normal murine peritoneal macrophages were rendered cytotoxic against 51Cr-labelled allogeneic and syngeneic target cells by incubation with supernatant of selected cell cultures.'Active' culture...

Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.

Jung, H, Pfizenmaier, K, Starzinski-Powitz, A, Röllinghoff, M, Wagner, H

CBA mouse-derived splenic lymphocytes treated with either beta-priopionlactone-inactivated or u.v. light-inactivated parainfluenza (sendai) virus stimulated in vitro unprimed syngeneic T-lymphocytes...

Species-crossreactive scFv against the tumor stroma marker "fibroblast activation protein" selected by phage display from an immunized FAP-/- knock-out mouse.

Brocks, B., Garin-Chesa, P., Behrle, E., Park, J. E., Rettig, W. J., Pfizenmaier, K., ...

BACKGROUND: Fibroblast activation protein (FAP) is a type II membrane protein expressed on tumor stroma fibroblasts in more than 90% of all carcinomas. FAP serves as a diagnostic marker and is...

Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes

Rollinghoff, M, Starzinski-Powitz, A, Pfizenmaier, K, Wagner, H

Murine T lymphocytes sensitized in vitro against either allogeneic lymphocytes or syngeneic hapten-conjugated lymphocytes do differentiate into highly effective cytotoxic T lymphocytes (CTL) (1-3)....