K. Pfleiderer

Amino acids determining operator binding specificity in the helix-turn-helix motif of Tn10 Tet repressor.

Wissmann, A, Baumeister, R, Müller, G, Hecht, B, Helbl, V, Pfleiderer, K, ...

Each of 22 amino acids in the proposed alpha-helix-turn-alpha-helix operator binding motif of the Tn10 encoded Tet repressor was replaced by alanine and one residue was replaced by valine to...

A threonine to alanine exchange at position 40 of Tet repressor alters the recognition of the sixth base pair of tet operator from GC to AT.

Altschmied, L, Baumeister, R, Pfleiderer, K, Hillen, W

The tet operators of two naturally evolved tetracycline resistance determinants differ by a G.C to A.T transition at the sixth base pair. This mutation prevents heterologous recognition of these tet...

Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor.

Schnappinger, D, Schubert, P, Pfleiderer, K, Hillen, W

Homo- and heterodimerization is essential for the activity of many proteins, particularly transcription factors. One widely distributed structural motif for protein recognition is the four helix...

Amino acids determining operator binding specificity in the helix-turn-helix motif of Tn10 Tet repressor.

Wissmann, A, Baumeister, R, Müller, G, Hecht, B, Helbl, V, Pfleiderer, K, ...

Each of 22 amino acids in the proposed alpha-helix-turn-alpha-helix operator binding motif of the Tn10 encoded Tet repressor was replaced by alanine and one residue was replaced by valine to...

A threonine to alanine exchange at position 40 of Tet repressor alters the recognition of the sixth base pair of tet operator from GC to AT.

Altschmied, L, Baumeister, R, Pfleiderer, K, Hillen, W

The tet operators of two naturally evolved tetracycline resistance determinants differ by a G.C to A.T transition at the sixth base pair. This mutation prevents heterologous recognition of these tet...

Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor.

Schnappinger, D, Schubert, P, Pfleiderer, K, Hillen, W

Homo- and heterodimerization is essential for the activity of many proteins, particularly transcription factors. One widely distributed structural motif for protein recognition is the four helix...