K. Q. Hu

Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.

Hu, K Q, Yu, C H, Vierling, J M

Intercellular adhesion molecule 1 (ICAM-1), a counter-receptor for lymphocyte function-associated antigen 1 on T cells, is critically important to a wide variety of adhesion-dependent leukocyte...

Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.

López-Cabrera, M, Letovsky, J, Hu, K Q, Siddiqui, A

The human hepatitis B virus (HBV) is a hepatotropic virus that replicates through an RNA intermediate referred to as the pregenome. The promoter that directs the synthesis of the pregenome and...

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

Hu, K Q, Vierling, J M, Siddiqui, A

Hepatocellular injury during hepatitis B virus (HBV) infection has been postulated to result from a human leukocyte antigen (HLA)-restricted T-lymphocyte host immune response against HBV antigens....

Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.

Foster, R, Hu, K Q, Lu, Y, Nolan, K M, Thissen, J, Settleman, J

We have identified a human Rho protein, RhoE, which has unusual structural and biochemical properties that suggest a novel mechanism of regulation. Within a region that is highly conserved among...

Direct detection of circulating hepatitis C virus RNA using probes from the 5' untranslated region.

Hu, K Q, Yu, C H, Vierling, J M

Diagnostic testing for hepatitis C virus (HCV) infection currently is based on the presence of anti-HCV antibodies or a positive HCV RNA polymerase chain reaction (PCR) test. Although HCV RNA PCR is...

Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.

Hariharan, I K, Hu, K Q, Asha, H, Quintanilla, A, Ezzell, R M, Settleman, J

The rho family of GTPases has been implicated in regulating changes in cell morphology in response to extracellular signals. We have cloned three widely expressed members of this family from...

Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.

Feener, E P, Shiba, T, Hu, K Q, Wilden, P A, White, M F, King, G L

Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial...

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation.

Hu, K Q, Settleman, J

Many cellular signaling proteins contain SH3 (Src homology 3) domains that mediate protein interactions via specific proline-containing peptides. Unlike SH2 domains, whose interactions with...

p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.

Foster, R, Hu, K Q, Shaywitz, D A, Settleman, J

In mitogenically stimulated cells, a specific complex forms between the Ras GTPase-activating protein (RasGAP) and the cellular protein p190. We have previously reported that p190 contains a...

Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.

Hu, K Q, Yu, C H, Vierling, J M

Intercellular adhesion molecule 1 (ICAM-1), a counter-receptor for lymphocyte function-associated antigen 1 on T cells, is critically important to a wide variety of adhesion-dependent leukocyte...

Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.

López-Cabrera, M, Letovsky, J, Hu, K Q, Siddiqui, A

The human hepatitis B virus (HBV) is a hepatotropic virus that replicates through an RNA intermediate referred to as the pregenome. The promoter that directs the synthesis of the pregenome and...

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

Hu, K Q, Vierling, J M, Siddiqui, A

Hepatocellular injury during hepatitis B virus (HBV) infection has been postulated to result from a human leukocyte antigen (HLA)-restricted T-lymphocyte host immune response against HBV antigens....

Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.

Foster, R, Hu, K Q, Lu, Y, Nolan, K M, Thissen, J, Settleman, J

We have identified a human Rho protein, RhoE, which has unusual structural and biochemical properties that suggest a novel mechanism of regulation. Within a region that is highly conserved among...

Direct detection of circulating hepatitis C virus RNA using probes from the 5' untranslated region.

Hu, K Q, Yu, C H, Vierling, J M

Diagnostic testing for hepatitis C virus (HCV) infection currently is based on the presence of anti-HCV antibodies or a positive HCV RNA polymerase chain reaction (PCR) test. Although HCV RNA PCR is...

p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.

Foster, R, Hu, K Q, Shaywitz, D A, Settleman, J

In mitogenically stimulated cells, a specific complex forms between the Ras GTPase-activating protein (RasGAP) and the cellular protein p190. We have previously reported that p190 contains a...

Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.

Hariharan, I K, Hu, K Q, Asha, H, Quintanilla, A, Ezzell, R M, Settleman, J

The rho family of GTPases has been implicated in regulating changes in cell morphology in response to extracellular signals. We have cloned three widely expressed members of this family from...

Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.

Feener, E P, Shiba, T, Hu, K Q, Wilden, P A, White, M F, King, G L

Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial...

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation.

Hu, K Q, Settleman, J

Many cellular signaling proteins contain SH3 (Src homology 3) domains that mediate protein interactions via specific proline-containing peptides. Unlike SH2 domains, whose interactions with...