Anti-oncogenic functions of viral proteins (2008)
Beard, P., Hirt, B., Raj, K., Saudan, P., Ogston, P., Stauffer, Y., ...
Infectious human papillomavirus type 18 pseudovirions (2008)
Stauffer, Y., Raj, K., Masternak, K., Beard, P.
Human papillomavirus type 18 (HPV18) capsid proteins L1 and L2, synthesised in mammalian cells using recombinant vaccinia viral expression vectors, are transported to the nucleus and assembled into...
Fournier, N., Raj, K., Saudan, P., Utzig, S., Sahli, R., Simanis, V., ...
Infection by some types of human papillomavirus (HPV) is associated with the development of cervical cancer. Analysis of viral DNA from cervical tumours shows that the E2 gene is frequently disrupted...
Ogston, P., Raj, K., Beard, P.
We used a sensitive assay to test whether an adeno-associated virus (AAV) productive replication cycle can occur in immortalized human keratinocytes carrying episomal human papillomavirus type 16...
Virus-mediated killing of cells that lack p53 activity (2008)
Raj, K., Ogston, P., Beard, P.
A major goal of molecular oncology is to identify means to kill cells lacking p53 function. Most current cancer therapy is based on damaging cellular DNA by irradiation or chemicals. Recent reports...
Notch1 can contribute to viral-induced transformation of primary human keratinocytes (2008)
Lathion, S., Schaper, J., Beard, P., Raj, K.
The human papillomavirus (HPV) is the most significant causative agent in the development of cervical cancer. Despite its presence in almost all cervical cancers, HPV by itself is unable to transform...
Bechtold, V., Beard, P., Raj, K.
The human papillomavirus (HPV) E2 protein plays an important role in viral DNA replication. Many studies with high-risk HPVs have demonstrated that the E2 protein can also repress transcription of...
E1 empty set E4 protein of human papillomavirus type 16 associates with mitochondria (2008)
Raj, K., Berguerand, S., Southern, S., Doorbar, J., Beard, P.
The human papillomavirus (HPV) E1 empty set E4 protein is the most abundantly expressed viral protein in HPV-infected epithelia. It possesses diverse activities, including the ability to bind to the...
Viral transport of DNA damage that mimics a stalled replication fork (2008)
Jurvansuu, J., Raj, K., Stasiak, A., Beard, P.
Adeno-associated virus type 2 (AAV2) infection incites cells to arrest with 4N DNA content or die if the p53 pathway is defective. This arrest depends on AAV2 DNA, which is single stranded with...
How adeno-associated virus Rep78 protein arrests cells completely in S phase (2008)
Berthet, C., Raj, K., Saudan, P., Beard, P.
Adeno-associated virus Rep78 protein has antiproliferative effects on cells. It inhibits cell cycle progression, and, in particular, Rep78 induces a complete arrest within S phase, a response rarely...
Different modes of human papillomavirus DNA replication during maintenance (2008)
Hoffmann, R., Hirt, B., Bechtold, V., Beard, P., Raj, K.
Human papillomavirus (HPV) begins its life cycle by infecting the basal cells of the epithelium. Within these proliferating cells, the viral genomes are replicated, maintained, and passed on to the...
Garner, E., Martinon, F., Tschopp, J., Beard, P., Raj, K.
Adeno-associated virus (AAV) infection triggers a DNA damage response in the cell. This response is not induced by viral proteins but by virtue of the structure of AAV ssDNA being recognized by the...
Notch1 functions as a tumor suppressor in mouse skin (2006)
Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., Van Noort, M., ...
Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is associated with tumorigenesis. The role of...
Notch1 functions as a tumor suppressor in mouse skin (2003)
Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, P., Noort, M. Van, ...
Budnick, J., Raj, K., Burch, T., Holtzberg, F.
The nuclear magnetic resonance of both Eu and Se nuclei have been observed in powdered EuSe and Eu Se containing approximately 1 % and 10 % GdSe. From the field dependence of the Eu resonance and the...
Budnick, J., Raj, K., Burch, T., Holtzberg, F.
The nuclear magnetic resonance of both Eu and Se nuclei have been observed in powdered EuSe and Eu Se containing approximately 1 % and 10 % GdSe. From the field dependence of the Eu resonance and the...
Budnick, J., Raj, K., Burch, T., Holtzberg, F.
The nuclear magnetic resonance of both Eu and Se nuclei have been observed in powdered EuSe and Eu Se containing approximately 1 % and 10 % GdSe. From the field dependence of the Eu resonance and the...