Scientific Commons: K. S.

The Royal College of Surgeons (RCS) rat is a well-characterized model of autosomal recessive retinitis pigmentosa (RP) due to a defect in the retinal pigment epithelium (RPE). It is homozygous for a...

Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD) (2005)

Turton,
J.P.,
Mehta,
A.,
Raza,
J.,
...

Objective Mutations within the pituitary-specific paired-like homeobox gene PROP1 have been described in 50-100% of patients with familial combined pituitary hormone deficiency (CPHD). We screened a...

Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency (2005)

Turton,
J.P.G.,
Reynaud,
R.,
Mehta,
A.,
...

Context: Mutations within the gene encoding the pituitary-specific transcription factor POU1F1 are associated with combined pituitary hormone deficiency (CPHD). Most of the affected individuals...

Novel mutations within the POU1F1 gene associated with variable Combined Pituitary Hormone Deficiency (CPHD) (2005)

Turton,
J.P.,
Reynaud,
R.,
Mehta,
A.,
...

CONTEXT: Mutations within the gene encoding the pituitary-specific transcription factor POU1F1 are associated with combined pituitary hormone deficiency (CPHD). Most of the affected individuals...

Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism (2005)

Woods,
K.S.,
Cundall,
M.,
Turton,
J.,
...

Serial high resolution CT in non-specific interstitial pneumonia: prognostic value of the initial pattern (2005)

Screaton,
N.J.,
Hiorns,
M.P.,
Lee,
K.S.,
...

Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage (2005)

Broaddus,
V.C.,
Dansen,
T.B.,
Abayasiriwardana,
K.S.,
...

The death ligand, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), has shown great promise for inducing apoptosis selectively in tumors. Although many tumor cells are resistant to...

Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis (2005)

Broderick,
C.A.,
Smith,
A.J.,
Balaggan,
K.S.,
...

Autoimmune posterior uveitis is a chronic, potentially blinding inflammatory disease of the eye. It is commonly treated with immunosuppressive drugs that have adverse long-term effects. Advances in...

Elastic scattering spectroscopy for detection of sentinel lymph node metastases in breast carcinoma (2005)

Chicken,
D.W.,
Lee,
A.C.,
Johnson,
K.S.,
...

Sentinel node biopsy is the new standard for lymphatic staging of breast carcinoma. Intraoperative detection of sentinel node metastases avoids a second operation for those patients with metastatic...

Optical biopsy: breast cancer diagnoses at the speed of light (2005)

Chicken,
D.W.,
Clark,
B.R.,
Johnson,
K.S.,
...

A system for real-time XMR guided cardiovascular intervention (2005)

Rhode,
K.S.,
Sermesant,
M.,
Brogan,
D.,
...

The hybrid magnetic resonance (MR)/X-ray suite (XMR) is a recently introduced imaging solution that provides new possibilities for guidance of cardiovascular catheterization procedures. We have...

Assessment of bony resection margins in oral cancer using elastic scattering spectroscopy: a study on archival material (2005)

Jerjes,
W.,
Swinson,
B.,
Johnson,
K.S.,
...

Novel approaches to the measurement of arterial blood flow from dynamic digital X-ray images (2005)

Rhode,
K.S.,
Lambrou,
T.,
Hawkes,
D.J.,
...

We have developed two new algorithms for the measurement of blood flow from dynamic X-ray angiographic images. Both algorithms aim to improve on existing techniques. First, a model-based (MB)...

Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis (2005)

Broderick,
C.A.,
Smith,
A.J.,
Balaggan,
K.S.,
...

Autoimmune posterior uveitis is a chronic, potentially blinding inflammatory disease of the eye. It is commonly treated with immunosuppressive drugs that have adverse long-term effects. Advances in...

Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy (2005)

Tschernutter,
M.,
Schlichtenbrede,
F.C.,
Howe,
S.,
...

The Royal College of Surgeons (RCS) rat is a well-characterized model of autosomal recessive retinitis pigmentosa (RP) due to a defect in the retinal pigment epithelium (RPE). It is homozygous for a...

Inhibition of Ocular Neovascularization by Hedgehog Blockade (2005)

Surace,
E.M.,
Balaggan,
K.S.,
Tessitore,
A.,
...

Ocular neovascularization associated with proliferative diabetic retinopathy and age-related macular degeneration is the leading cause of severe visual loss in adults in developed countries....

Autofluorescence imaging of choroidal neovascularization due to age-related macular degeneration (2005)

Dandekar,
S.S.,
Jenkins,
S.A.,
Peto,
T.,
...

OBJECTIVE: To describe the autofluorescence (AF) characteristics of choroidal neovascularization (CNV) in patients with age-related macular degeneration. METHODS: Autofluorescence images of 65...

Stable and efficient intraocular gene transfer using pseudotyped EIAV lentiviral vectors (2005)

Balaggan,
K.S.,
Binley,
K.,
Esapa,
M.,
...

BACKGROUND: We have developed minimal non-primate lentiviral vectors based on the equine infectious anaemia virus (EIAV). We evaluated the in vivo expression profiles of these vectors delivered...

The Crystal Structure of KCaF3 at 4.2 and 300 K: A re-evaluation using high-resolution powder neutron diffraction. (2005)

Knight,
K.S.,
Darlington,
C.N.W.,
Wood,
I.G.

Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast (2004)

Johnson,
K.S.,
Chicken,
D.W.,
Pickard,
D.C.,
...

Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast (2004)

Johnson,
K.S.,
Chicken,
D.W.,
Pickard,
D.C.,
...

Optical biopsy utilising elastic scattering spectroscopy for intra-operative diagnosis of sentinel lymph node netastases (2004)

Chicken,
D.W.,
Johnson,
K.S.,
Falzon,
M.R.,
...

Critical Issues in Industrial Land Planning and Development in Korea (2004)

Kim,
K.S.,
Gallent,
N.

The influence of peripheral vascular disease on the carotid and femoral wall mechanics in subjects with abdominal aortic aneurysm (2003)

Cheng,
K.S.,
Tiwari,
A.,
Morris,
R.,
...

Optical biopsy of colonic lesions: Comparison of elastic scattering spectroscopy with histology (2003)

Dhar,
A.,
Johnson,
K.S.,
Novelli,
M.R.,
...

IL-1 gene polymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population (2003)

Peloutzis,
A.,
Lang,
N.P.,
Tonetti,
M.S.,
...

Registration and tracking to integrate X-ray and MR images in an XMR facility (2003)

Rhode,
K.S.,
Hill,
D.L.,
Edwards,
P.J.,
...

We describe a registration and tracking technique to integrate cardiac X-ray images and cardiac magnetic resonance (MR) images acquired from a combined X-ray and MR interventional suite (XMR)....

The temporal lobe (2003)