K. S. Hewitson

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate (2005)

McNeill, L. A., Flashman, E., Buck, M. R. G., Hewitson, K. S., Clifton, I. J., Jeschke, Gunnar, ...

Observation of the iron-sulfur cluster in Escherichia coli biotin synthase by nanoflow electrospray mass spectrometry (2001)

Hernandez, H., Hewitson, K.S., Roach, P., Shaw, N.M., Baldwin, J.E., Robinson, C.V.

Biotin synthase from Escherichia coli was analyzed by nanoflow electrospray ionization mass spectrometry. From solution conditions in which the protein is in its native state, a distribution of...

MioC is an FMN-binding protein that is essential for Escherichia coli biotin synthase activity in vitro (2000)

Birch, O. M., Hewitson, K. S., Fuhrmann, M., Burgdorf, K., Baldwin, J. E., Roach, P. L., ...

Biotin synthase is required for the conversion of dethiobiotin to biotin and requires a number of accessory proteins and small molecule cofactors for activity in vitro. We have previously identified...

Mutagenesis of the proposed iron-sulfur cluster binding ligands in Escherichia coli biotin synthase (2000)

Hewitson, K. S., Baldwin, J. E., Shaw, N. M., Roach, P. L.

Biotin synthase (BioB) is a member of a family of enzymes that includes anaerobic ribonucleotide reductase and pyruvate formate lyase activating enzyme. These enzymes all use S-adenosylmethionine...