Hallaq, Haifa, Yang, Zhenjiang, Viswanathan, Prakash C., Fukuda, Koji, Shen, Wangzhen, Wang, Dao W., ...
Objective: Na+ current derived from expression of the principal cardiac Na+ channel, Nav1.5, is increased by activation of protein kinase A (PKA). This effect is blocked by inhibitors of cell...
Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection (2004)
Sheng, Jinsong, Organ, Edward L, Hao, Chuanming, Wells, K Sam, Ruley, H Earl, Rubin, Donald H
Abstract Background Viruses are obligate intracellular parasites and rely upon the host cell for different steps in their life cycles. The characterization of cellular genes required for virus...
Cardiac-enriched LIM domain protein fhl2 is required to generate IKs in a heterologous system (2002)
Kupershmidt, Sabina, Yang, Iris C.-H., Sutherland, Margaret, Wells, K.Sam, Yang, Tao, Yang, Ping, ...
Objective: Co-expression of the KvLQT1 and minK potassium channel subunits is required to recapitulate IKs, the slow component of the cardiac delayed rectifier current, and mutations in either gene...
Modulation of RNA editing by functional nucleolar sequestration of ADAR2
Sansam, Christopher L., Wells, K. Sam, Emeson, Ronald B.
The adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine (A to I) in primary mRNA transcripts, thereby affecting the splicing pattern or coding...
Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection
Sheng, Jinsong, Organ, Edward L, Hao, Chuanming, Wells, K Sam, Ruley, H Earl, Rubin, Donald H
McIntyre, J Oliver, Fingleton, Barbara, Wells, K Sam, Piston, David W, Lynch, Conor C, Gautam, Shiva, ...
The present study describes the in vivo detection and imaging of tumour-associated MMP-7 (matrix metalloproteinase-7 or matrilysin) activity using a novel polymer-based fluorogenic substrate...
Substrate-dependent Contribution of Double-stranded RNA-binding Motifs to ADAR2 Function
Xu, Ming, Wells, K. Sam, Emeson, Ronald B.
ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-specific conversion of adenosine to inosine (A-to-I). ADAR2 contains two tandem...
Modulation of RNA editing by functional nucleolar sequestration of ADAR2
Sansam, Christopher L., Wells, K. Sam, Emeson, Ronald B.
The adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine (A to I) in primary mRNA transcripts, thereby affecting the splicing pattern or coding...
Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection
Sheng, Jinsong, Organ, Edward L, Hao, Chuanming, Wells, K Sam, Ruley, H Earl, Rubin, Donald H
Structure theorems and the dynamics of nitrogen catabolite repression in yeast
Boczko, Erik M., Cooper, Terrance G., Gedeon, Tomas, Mischaikow, Konstantin, Murdock, Deborah G., Pratap, Siddharth, ...
By using current biological understanding, a conceptually simple, but mathematically complex, model is proposed for the dynamics of the gene circuit responsible for regulating nitrogen catabolite...
McIntyre, J Oliver, Fingleton, Barbara, Wells, K Sam, Piston, David W, Lynch, Conor C, Gautam, Shiva, ...
The present study describes the in vivo detection and imaging of tumour-associated MMP-7 (matrix metalloproteinase-7 or matrilysin) activity using a novel polymer-based fluorogenic substrate...
Substrate-dependent Contribution of Double-stranded RNA-binding Motifs to ADAR2 Function
Xu, Ming, Wells, K. Sam, Emeson, Ronald B.
ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-specific conversion of adenosine to inosine (A-to-I). ADAR2 contains two tandem...
Nyman, Lara R., Wells, K. Sam, Head, W. Steve, McCaughey, Michael, Ford, Eric, Brissova, Marcela, ...
The pancreatic islets of Langerhans are highly vascularized micro-organs that play a key role in the regulation of blood glucose homeostasis. The specific arrangement of endocrine cell types in...