Polman, C., Kappos, L., Freedman, M., Edan, G., Hartung, H.P., Miller, D.H., ...
Background The BENEFIT study examined interferon beta (IFNB)-1b treatment in patients with clinically isolated syndrome (CIS) and ≥ 2 clinically silent brain MRI lesions. Methods Subgroups of 468...
Selmaj, K, Brosnan, C F, Raine, C S
The presence of T lymphocytes bearing the gamma delta T-cell receptor (TCR gamma delta) has been studied immunocyto-chemically in central nervous system (CNS) tissue from 13 patients with multiple...
Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.
Selmaj, K, Raine, C S, Cannella, B, Brosnan, C F
Multiple sclerosis (MS) brain tissue, spleen, and PBMC were studied using immunocytochemistry and FACS for immunoreactivity for lymphotoxin (LT) and TNF. Both cytokines were identified in acute and...
Selmaj, K, Brosnan, C F, Raine, C S
The presence of T lymphocytes bearing the gamma delta T-cell receptor (TCR gamma delta) has been studied immunocyto-chemically in central nervous system (CNS) tissue from 13 patients with multiple...
Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.
Selmaj, K, Raine, C S, Cannella, B, Brosnan, C F
Multiple sclerosis (MS) brain tissue, spleen, and PBMC were studied using immunocytochemistry and FACS for immunoreactivity for lymphotoxin (LT) and TNF. Both cytokines were identified in acute and...
Selmaj, K, Nowak, Z, Tchórzewski, H
The production of interleukin 1 (IL-1) and interleukin 2 (IL-2) by peripheral blood mononuclear cells (PBMC) stimulated with human myelin basic protein (MBP) was assessed in vitro in multiple...
T lymphocyte-derived demyelinating activity in multiple sclerosis patients in relapse.
Selmaj, K, Alam, R, Perkin, G D, Rose, F C
Supernatants of cultured T lymphocytes of multiple sclerosis patients were tested for a demyelinating activity in rat cerebellum explant cultures. Supernatants of unstimulated T lymphocytes in seven...
OBJECTIVES—To assess differences in magnetisation transfer ratio (MTR) analysis of normal appearing white matter (NAWM) in patients with familial multiple sclerosis (MS) and those with sporadic...