Pressure-Induced Superconductivity in Europium Metal (2009)
Debessai, M., Matsuoka, T., Hamlin, J. J., Schilling, J. S., Shimizu, K.
Divalent Eu (4f7, J=7/2) possesses a strong local magnetic moment which suppresses superconductivity. Under sufficient pressure it is anticipated that Eu will become trivalent (4f6, J=0) and a weak...
The unusual phase diagram of CeNiGe2 (2009)
Holmes, A. T., Muramatsu, T., Kaczorowski, D., Bukowski, Z., Kagayama, T., Shimizu, K.
The heavy fermion antiferromagnet CeNiGe2 was investigated under pressure by resistivity and ac calorimetry up to 4 GPa and down to 40 mK. The two magnetic transitions found in both resistivity and...
Habazaki, H., Oikawa, Y., Fushimi, K., Aoki, Y., Shimizu, K., Skeldon, P., ...
Niobium has been anodized at a constant current density to 10 V with a current decay in 0.8 mol dm-3 K2HPO4-glycerol electrolyte containing 0.08 to 0.65 mass% water at 433 K to develop porous anodic...
Edge plasma modelling for transport analysis on JT-60U tokamak (2009)
Chen, YiPing, Kawashima, H., Gao, Xiang, Hua, Liqun, Asakura, N., Shimizu, K., ...
Habazaki, H., Ogasawara, T., Fushimi, K., Shimizu, K., Nagata, S., Izumi, T., ...
The present work demonstrates effective inhibition of field crystallization of amorphous anodic niobium oxide by incorporation of silicon species from substrate. The field crystallization,...
Coherent shear phonon generation and detection with picosecond laser acoustics (2008)
Matsuda, O., Wright, O. B., Hurley, D. H., Gusev, V., Shimizu, K.
Measurements on a film of silica on crystalline zinc using picosecond laser acoustics are theoretically analyzed to quantitatively explain the generation and detection of picosecond shear and...
Kawasaki, S., Yashima, M., Kitaoka, Y., Takeda, K., Shimizu, K., Oishi, Y., ...
We report on the pressure-induced unconventional superconductivity in the heavy-fermion antiferromagnet CeIn3 by means of nuclear-quadrupole-resonance (NQR) studies conducted under a high pressure....
Thermal degradation of anodic niobia on niobium and oxygen-containing niobium (2008)
Habazaki, H., Yamasaki, M., Ogasawara, T., Fushimi, K., Konno, H., Shimizu, K., ...
Thermal treatment of anodized niobium and oxygen-containing niobium has been carried out to elucidate the thermal degradation mechanism of niobium capacitors and to clarify the influence of oxygen...
Simulation Study of Radiative Cooling in the Divertor on JT-60 Super Advanced (JT-60SA) (2008)
Suzuki, Y., Kawashima, H., Coster, D. P., Sakurai, S., Shimizu, K., Takizuka, T.
Hiruma, H., Shimizu, K., Takenami, T., Sugie, H., Kawakami, T.
Background The α2-adrenoceptor agonist clonidine is used in combination with lidocaine for anaesthesia. Lidocaine inhibits axonal transport and neurite growth, whereas α2-adrenoceptor agonists have...
Formation of porous anodic films on Ti-Si alloys in hot phosphate-glycerol electrolyte (2007)
Habazaki, H., Oikawa, Y., Fushimi, K., Shimizu, K., Nagata, S., Skeldon, P., ...
Porous anodic films, with pore size of ~10 nm, have been developed by anodizing of magnetron sputtered Ti-25 at% Si alloy at constant formation voltages in glycerol electrolyte containing dibasic...
Influence of silicon on the growth of barrier-type anodic films on titanium (2007)
Tanvir, M. Tauseef, Fushimi, K., Shimizu, K., Nagata, S., Skeldon, P., Thompson, G.E., ...
Amorphous anodic titania, stabilised by incorporation of silicon species, is shown to grow to high voltages on sputter-deposited, single-phase Ti–Si alloys during anodizing at a constant current...
Influence of silicon on the growth of barrier-type anodic films on titanium (2007)
Tanvir, M. Tauseef, Fushimi, K., Shimizu, K., Nagata, S., Skeldon, P., Thompson, G.E., ...
Amorphous anodic titania, stabilised by incorporation of silicon species, is shown to grow to high voltages on sputter-deposited, single-phase Ti–Si alloys during anodizing at a constant current...
Fast migration of fluoride ions in growing anodic titanium oxide (2007)
Habazaki, H., Fushimi, K., Shimizu, K., Skeldon, P., Thompson, G.E.
The rapid inward migration of fluoride ions in growing anodic titanium oxide under a high electric field has been elucidated by anodizing a Ti–12 at% silicon alloy, where film growth proceeds at...
Fast migration of fluoride ions in growing anodic titanium oxide (2007)
Habazaki, H., Fushimi, K., Shimizu, K., Skeldon, P., Thompson, G.E.
The rapid inward migration of fluoride ions in growing anodic titanium oxide under a high electric field has been elucidated by anodizing a Ti–12 at% silicon alloy, where film growth proceeds at...
Iwata, Y., Ogawa, F., Komura, K., Muroi, E., Hara, T., Shimizu, K., ...
Objectives. To determine the prevalence and clinical correlation of autoantibody to peroxiredoxin (Prx) I, an antioxidant enzyme, in patients with systemic sclerosis (SSc). Methods. Serum samples...
Field crystallization of anodic niobia (2007)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Skeldon, P., ...
Influences of electrolyte, pre-thermal treatment and substrate composition have been examined to elucidate the mechanism of field crystallization of anodic niobia formed on magnetron-sputtered...
Field crystallization of anodic niobia (2007)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Skeldon, P., ...
Influences of electrolyte, pre-thermal treatment and substrate composition have been examined to elucidate the mechanism of field crystallization of anodic niobia formed on magnetron-sputtered...
Freitas,Adilson A., Shimizu,K., Dias,Luís G., Quina,Frank H.
The electronic transitions for flavylium cations and quinonoidal bases of 17 substituted flavylium salts have been studied at semiempirical and DFT (density functional theory) levels. Solvent effect...
Effects of additives and cooling rates on cryopreservation process of rat cortical cells (2007)
Motomura, J., Uchida, T., Nagayama, M., Gohara, K., Taira, T., Shimizu, K., ...
11th International Conference on the Physics and Chemistry of Ice. 23-28 July 2006. Bremerhaven, Germany
Iwata, Y., Ogawa, F., Komura, K., Muroi, E., Hara, T., Shimizu, K., ...
Objectives. To determine the prevalence and clinical correlation of autoantibody to peroxiredoxin (Prx) I, an antioxidant enzyme, in patients with systemic sclerosis (SSc). Methods. Serum samples...
Iwata, Y., Ogawa, F., Komura, K., Muroi, E., Hara, T., Shimizu, K., ...
Objectives. To determine the prevalence and clinical correlation of autoantibody to peroxiredoxin (Prx) I, an antioxidant enzyme, in patients with systemic sclerosis (SSc). Methods. Serum samples...
Suppression of Field Crystallization of Anodic Niobia by Oxygen (2006)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Asami, K., ...
Solid-solution Nb–O films containing up to 50 atom % oxygen, prepared by magnetron sputtering, were used to investigate the influence of the oxygen on field crystallization during anodizing at 100...
Suppression of Field Crystallization of Anodic Niobia by Oxygen (2006)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Asami, K., ...
Solid-solution Nb–O films containing up to 50 atom % oxygen, prepared by magnetron sputtering, were used to investigate the influence of the oxygen on field crystallization during anodizing at 100...
Kalogerakis, G, Marhic, ME, Uesaka, K, Shimizu, K, Wong, KKY, Kazovsky, LG
In fiber optical parametric amplifiers (OPAs), idlers are generated during the amplification process. For very wide and dense signal input spectra, idlers may overlap with signals, thereby...
High-repetition-rate pulsed-pump fiber OPA for amplification of communication signals (2006)
Kalogerakis, G, Shimizu, K, Marhic, ME, Wong, KKY, Uesaka, K, Kazovsky, LG
The use of a high-repetition-rate pulsed-pumped fiber optical parametric amplifier (OPA), followed by a narrow optical filter for transparent signal amplification, was proposed. Theory and...
Ogawa, F., Shimizu, K., Muroi, E., Hara, T., Hasegawa, M., Takehara, K., ...
Objective. To determine serum levels and clinical correlation of 8-isoprostane, which is produced in vivo through free radical-catalysed peroxidation of arachidonic acid and reflects oxidative...
Ogawa, F., Shimizu, K., Muroi, E., Hara, T., Hasegawa, M., Takehara, K., ...
Objective. To determine serum levels and clinical correlation of 8-isoprostane, which is produced in vivo through free radical-catalysed peroxidation of arachidonic acid and reflects oxidative...
Ogawa, F., Shimizu, K., Muroi, E., Hara, T., Hasegawa, M., Takehara, K., ...
Objective. To determine serum levels and clinical correlation of 8-isoprostane, which is produced in vivo through free radical-catalysed peroxidation of arachidonic acid and reflects oxidative...
Anodic oxidation of InAlAs (2005)
Suleiman, A, Liu, Y, Hasimoto, T, Skeldon, P, Thompson, G E, Graham, MJ, ...
The anodic oxidation of InAlAs is investigated by transmission electron microscopy, Rutherford backscattering spectroscopy and medium energy ion scattering in order to elucidate the mechanism of...
Anodic behaviour of a model second phase: Al20at.%Mg20at.%Cu (2005)
Liu, Y, Arenas, MA, Skeldon, P, Thompson, GE, Bailey, P, Noakes, T C Q, ...
The anodic behaviour of sputtering-deposited Al20at.%Mg20at.%Cu alloy is investigated during anodizing and potentiodynamic polarization treatments using transmission electron microscopy, X-ray...
Generation of copper nanoparticles during alkaline etching of an Al30 at.%Cu alloy (2005)
Liu, Y, Arenas, MA, Skeldon, P, Thompson, GE, Habazaki, H, Shimizu, K, ...
A mechanism of formation of copper nanoparticles is proposed for alkaline etching of a sputtering-deposited Al30 at.%Cu alloy, simulating the equilibrium θ phase of 2000 series aluminium...
Classical simulation of quantum algorithms using the tensor product representation (2004)
Kawaguchi, A., Shimizu, K., Tokura, Y., Imoto, N.
Using the tensor product representation in the density matrix renormalization group, we show that a quantum circuit of Grover's algorithm, which has one-qubit unitary gates, generalized Toffoli...
Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation (2004)
Daniels, M., Shimizu, K., Zorn, A.M.
Mesoderm induction and patterning are primarily regulated by the concentration of locally expressed morphogens such as members of the TGFß superfamily. Smad2 functions as a transcription factor to...
Arenas, MA, Inglesias-Rubianes, L, Liu, Y, Skeldon, P, Thompson, GE, Habazaki, H, ...
The enrichments of zinc developed in binary, solid solution Al0.3at.%Zn, Al0.4at.%Zn and Al1at.%Zn alloys by electropolishing and alkaline etching are examined using Rutherford backscattering...
Coherent Shear Phonon Generation and Detection with Ultrashort Optical Pulses (2004)
Matsuda, O., Wright, O. B., Hurley, D. H., Gusev, V. E., Shimizu, K.
Using an optical technique we generate and detect picosecond shear and quasishear coherent acoustic phonon pulses in the time domain. Thermoelastic and piezoelectric generation are directly achieved...
Coherent Shear Phonon Generation and Detection with Ultrashort Optical Pulses (2004)
Matsuda, O., Wright, O. B., Hurley, D. H., Gusev, V. E., Shimizu, K.
Using an optical technique we generate and detect picosecond shear and quasishear coherent acoustic phonon pulses in the time domain. Thermoelastic and piezoelectric generation are directly achieved...
Marinaki, AM, Sumi, S, Arenas, M, Fairbanks, L, Harihara, S, Shimizu, K, ...
The enzyme inosine triphosphate pyrophosphatase (ITPase) catalyses the pyrophosphohydrolysis of ITP to IMP. ITPase deficiency is a clinically benign autosomal recessive condition characterised by the...
Marinaki, AM, Sumi, S, Arenas, M, Fairbanks, L, Harihara, S, Shimizu, K, ...
The enzyme inosine triphosphate pyrophosphatase (ITPase) catalyses the pyrophosphohydrolysis of ITP to IMP. ITPase deficiency is a clinically benign autosomal recessive condition characterised by the...
Rf-GDOES depth profiling analysis of a monolayer of thiourea adsorbed on copper (2004)
Shimizu, K., Payling, R., Habazaki, H., Skeldon, P., Thompson, G. E.
The first example of depth profiling analysis, by rf-GDOES, of a layer of sub-nanometre thickness is presented. The example selected is that of a monolayer of thiourea adsorbed on a mirror-polished...
Rf-GDOES depth profiling analysis of a monolayer of thiourea adsorbed on copper (2004)
Shimizu, K., Payling, R., Habazaki, H., Skeldon, P., Thompson, G. E.
The first example of depth profiling analysis, by rf-GDOES, of a layer of sub-nanometre thickness is presented. The example selected is that of a monolayer of thiourea adsorbed on a mirror-polished...
Anodic film growth in the AlTa alloy system (2003)
Alcala, G, Mato, S, Skeldon, P, Thompson, G E, Bailey, P, Noakes, T C Q, ...
The ionic transport numbers, relative migration rates of cation species and formation ratios are reported for barrier anodic films formed on metastable, solid solution AlTa alloys, with...
Inglesias-Rubianes, L, Skeldon, P, Thompson, GE, Bailey, P, Noakes, T C Q, Habazaki, H, ...
The effect of oxidation rate on enrichment of tungsten in metastable, solid-solution AlW alloys during anodizing has been investigated by Rutherford backscattering spectroscopy and medium energy...
Effect of Copper Enrichment on the Electrochemical Potential of Binary Al-Cu Alloys (2003)
Garcia-Vergara, S, Colin, F, Skeldon, P, Thompson, G E, Bailey, P, Noakes, T C Q, ...
Using Al-Cu alloys, containing between 0.1 and 26 atom % Cu, deposited by magnetron sputtering and etching in sodium hydroxide solution, enrichments of copper have been developed selectively in the...
Anodic oxidation of MgCu and MgZn alloys (2003)
Adulsain, M, Berkani, A, Bonilla, F A, Liu, Y, Skeldon, P, Thompson, G E, ...
Metastable, solidsolution Mg-0.8 at.% Cu and Mg-1.4 at.% Zn alloys have been anodized up to 250 V at 10 mA cm−2 in an alkaline phosphate electrolyte at 293 K in order to investigate the...
Potentiodynamic Polarisation Studies of Aluminium Alloys With Enriching Alloying Elements (2003)
Gracia-Verarga, S, Arenas, MA, Skeldon, P, Thompson, GE, Shimizu, K, Habazaki, H
High mach flow associated with plasma detachment in JT-60U (2003)
Hatayama, A., Hoshino, K., Miyamoto, K., Komatsu, N., Itami, K., Sakurai, S., ...
Recent new results of the high Mach flows associated with plasma detachment are presented on the basis of numerical simulations and their comparisons with experiments in JT-60U divertor plasma. The...
Behavior of Impurity and Minor Alloying Elements during Surface Treatments of Aluminum (2002)
Caicedo-Martinez, C, Koroleva, E, Skeldon, P, Thompson, GE, Hollrigl, G, Bailey, P, ...
The behavior of impurity and minor elements during electropolishing, chemical polishing, and anodizing treatments is examined for 99.99% Al and Al-0.2 atom % Mn alloy containing iron, copper, and...
Detachment of alumina films from aluminium by 100 keV proton bombardment (2002)
Liu, Y, Alexander, M, Koroleva, E, Skeldon, P, Thompson, G E, Bailey, P, ...
rradiation of aluminium covered by anodic oxide films 3-14 nm thick using 100 keV H+ ions is shown to result in detachment of the oxide film. A dose of 6.6 × 1016 H+ ions cm-2 on a 6.5 nm thick film...
Damage of alumina films by medium energy hydrogen and helium ions (2002)
Bailey, P, Noakes, TCQ, Liu, Y, Alexander, M, Koroleva, E, Thompson, G E, ...
Following previous observations of detachment of amorphous, anodic alumina films from aluminium by 100 keV H+ ions, further experiments have been carried out using H+, D+, 3He+ and 4He+ ions, at...
Morphology of enriched alloy layers in an anodized AlCu alloy (2002)
Garcia-Vergara, S, Skeldon, P, Thompson, G E, Bailey, P, Noakes, T C Q, Habazaki, H, ...
Using medium energy ion scattering, combined with Rutherford backscattering spectroscopy, transmission electron microscopy and atomic force microscopy, the development of the copper-enriched alloy...
Plasma etching of SiC surface using NF3 (2002)
Tasaka, A, Takahashi, K, Tanaka, K, Shimizu, K, Mori, K, Tada, S, ...
Feng, D. L., Damascelli, A., Shen, K. M., Motoyama, N., Lu, D. H., Eisaki, H., ...
The low-energy electronic structure of the trilayer cuprate superconductor Bi$_2$Sr$_2$Ca$_2$Cu$_3$O$_{10+\delta}$ near optimal doping is investigated by angle-resolved photoemission spectroscopy....
Bailey, P, Noakes, T C Q, Skeldon, P, Thompson, G E, Sakairi, M, Habazaki, H, ...
The topmost 20 nm of an electropolished Al-1 at.% Cu alloy has been investigated at sub-nanometre resolution using medium-energy ion scattering. Differences in the composition and depth of the...
Cloning and characterization of rat casein kinase 1epsilon (2001)
Takano, A., Shimizu, K., Kani, S., Buijs, R.M., Okada, M., Nagai, K.
High frequency of low-level microsatellite instability in early colorectal cancer (2001)
Kambara, T, Matsubara, N, Nakagawa, H, Notohara, K, Nagasaka, T, Yoshino, T, ...
Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with...
Kubota, M., Oohara, Y., Yoshizawa, H., Fujioka, H., Shimizu, K., Hirota, K., ...
The charge ordering in the bilayer manganite system La$_{2-2x}$Sr$_{1+2x}$Mn$_{2}$O$_{7}$ with $0.30 \le x \le 0.50$ has been studied by neutron diffraction. The charge order is characterized by the...
Strain measurement of a ductile composite Al2O3/Y3Al5O12 (YAG) by neutron diffraction (2000)
Ono, M, Waku, Y, Vrana, M, Mikula, P, Mitani, A, Shimizu, K, ...
Telemedicine by mobile communication (1999)
We have proposed some techniques for mobile telemedicine and have verified their practical feasibility in experiments. This article presents technical considerations required to realize a practical...
Telemedicine by mobile communication (1999)
We have proposed some techniques for mobile telemedicine and have verified their practical feasibility in experiments. This article presents technical considerations required to realize a practical...
On the origin of the short range NN repulsion (1999)
We calculate S-wave singlet and triplet NN phase shifts stemming from the short-range flavor-spin hyperfine interaction between constituent quarks using the resonating group method approach. A strong...
Undifferentiated carcinoma with lymphoid infiltration of the esophagus: a case report (1999)
Shimizu, K, Takiyama, W, Mandai, K, Tanada, M, Kawabuchi, Y, Heike, Y
Chin, K, Kita, H, Noguchi, T, Otsuka, N, Tsuboi, T, Nakamura, T, ...
The use of sequence comparison to detect 'identities' in tRNA genes (1998)
Sagara, JI, Shimizu, S, Kawabata, T, Nakamura, S, Ikeguchi, M, Shimizu, K
Identification of the gene loci that predispose to rheumatoid arthritis (1998)
Shiozawa, S, Hayashi, S, Tsukamoto, Y, Goko, H, Kawasaki, H, Wada, T, ...
The interaction between H-dibaryons (1997)
Sakai, T., Mori, J., Buchmann, A. J., Shimizu, K., Yazaki, K.
We investigate the interaction between H-dibaryons employing a quark cluster model with a one-gluon-exchange potential and an effective meson exchange potential (EMEP). A deeply-bound state of two...
Hypoxaemia in patients with hyperventilation syndrome (1997)
Chin, K, Hirai, M, Kuriyama, T, Kita, H, Nakamura, T, Shimizu, K, ...
Development of the pulse-shape discrimination LSI for Astro-E hard X-ray detector (1996)
Ezawa, H, Hirayama, M, Kamae, T, Kubo, H, Matsuzaki, K, Nagata, K, ...
'SERONEGATTVE' SJOGREN'S SYNDROME MANIFESTED AS A SUBSET OF CHRONIC FATIGUE SYNDROME (1996)
NISHIKAI, M., AKIYA, K., TOJO, T., ONODA, N., TANI, M., SHIMIZU, K.
We determined the extent to which chronic fatigue syndrome (CFS) patients with sicca symptoms fulfil the diagnostic criteria for Sjögren’s syndrome (SS). Three sets of diagnostic criteria for SS,...
Kakeshita, T., Saburi, T., Shimizu, K.
Effects of magnetic fields and hydrostatic pressures on the isothermal martensitic transformation, whose nose temperature is about 140K, in an Fe-25.0Ni-4.0Cr alloy ( mass% ) has been examined by...
Tadaki, T., Nakata, Y., Shimizu, K.
Atomic configurations in β phase Cu-Al-Ni, Cu-Au-Zn and Cu-Zn-Al ternary alloys before and after martensitic transformations, and occupancy sites of third elements X in the B2 parent lattice of...
Kakeshita, T., Saburi, T., Shimizu, K.
Effects of magnetic fields and hydrostatic pressures on the isothermal martensitic transformation, whose nose temperature is about 140K, in an Fe-25.0Ni-4.0Cr alloy ( mass% ) has been examined by...
Tadaki, T., Nakata, Y., Shimizu, K.
Atomic configurations in β phase Cu-Al-Ni, Cu-Au-Zn and Cu-Zn-Al ternary alloys before and after martensitic transformations, and occupancy sites of third elements X in the B2 parent lattice of...
Kakeshita, T., Saburi, T., Shimizu, K.
Effects of magnetic fields and hydrostatic pressures on the isothermal martensitic transformation, whose nose temperature is about 140K, in an Fe-25.0Ni-4.0Cr alloy ( mass% ) has been examined by...
Tadaki, T., Nakata, Y., Shimizu, K.
Atomic configurations in β phase Cu-Al-Ni, Cu-Au-Zn and Cu-Zn-Al ternary alloys before and after martensitic transformations, and occupancy sites of third elements X in the B2 parent lattice of...
Kikuchi, K., Enari, T., Minami, S., Haruki, K., Shibata, Y., Hasegawa, H., ...
We investigated the postantibiotic effects (PAEs) and the postantibiotic sub-MIC effects of benzylpenicillin on three strains of viridans streptococci isolated from infective endocarditis patients....
KAWAGUCHI, M., SAKAMOTO, T., SHIMIZU, K., OHNISHI, H., KARASAWA, J.
We have studied the effect of repeated doses of thiopentone on motor evoked potentials (MEP) after transcranial magnetic stimulation in 13 patients. Thiopentone was administered i.v. in an initial...
Okutsu, I., Hamanaka, I., Ninomiya, S., Takatori, Y., Shimizu, K., Ugawa, Y.
The purpose of this paper is to compare the results of our endoscopic management of carpal-tunnel syndrome caused by long-term haemodialysis to that with no apparent cause (idiopathic). We have...
Fundamental study on measurement of ELF electric field at biological body surfaces (1989)
Shimizu, K., Endo, H., Matsumoto, G., 清水, 孝一
In a study of biological effects of extremely-low-frequency (ELF) electric fields, a few techniques were developed which make it possible to measure the electric field at a biological body surface...
Fundamental study on measurement of ELF electric field at biological body surfaces (1989)
Shimizu, K., Endo, H., Matsumoto, G.
In a study of biological effects of extremely-low-frequency (ELF) electric fields, a few techniques were developed which make it possible to measure the electric field at a biological body surface...
Visualization of electric fields around a biological body (1988)
Shimizu, K., Endo, H., Matsumoto, G., 清水, 孝一
A system was developed that can visualize the spatial distribution of the ELF (extremely low frequency) electric field around an object with a complex shape such as a biological body. A mechanical X-...
Visualization of electric fields around a biological body (1988)
Shimizu, K., Endo, H., Matsumoto, G.
A system was developed that can visualize the spatial distribution of the ELF (extremely low frequency) electric field around an object with a complex shape such as a biological body. A mechanical X-...
Ayusawa, D, Shimizu, K, Seno, T
Murine mammary carcinoma FM3A cells, deficient in cytosol thymidine (dThd) kinase (TK) activity and transformed by the herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) TK gene (designated FM3A...
To establish cell systems appropriate for investigating the mode of action of anti-herpetic nucleoside analogs, mutants were constructed from murine FM3A mammary carcinoma cells, which were deficient...
ELECTRON MICROSCOPE STUDY OF THE MATRIX-MARTENSITE INTERFACE IN Cu-Al-Ni ALLOYS (1982)
Tadaki, T., Kakeshita, T., Shimizu, K.
The matrix-martensite interfaces in Cu-Al-Ni shape memory alloys have been examined by means of transmission electron microscopy. Fine parallel striations were observed on both the interfaces between...
PSEUDOELASTICITY IN A Au-47.5at%Cd ALLOY SINGLE CRYSTAL (1982)
Deformation behavior and its mechanism in a Au-41.5at%Cd alloy single crystal have been investigated at temperatures above and below Ms, by tensile and compressive tests, optical microscopy, X-ray...
ELECTRON MICROSCOPE STUDY OF THE MATRIX-MARTENSITE INTERFACE IN Cu-Al-Ni ALLOYS (1982)
Tadaki, T., Kakeshita, T., Shimizu, K.
The matrix-martensite interfaces in Cu-Al-Ni shape memory alloys have been examined by means of transmission electron microscopy. Fine parallel striations were observed on both the interfaces between...
PSEUDOELASTICITY IN A Au-47.5at%Cd ALLOY SINGLE CRYSTAL (1982)
Deformation behavior and its mechanism in a Au-41.5at%Cd alloy single crystal have been investigated at temperatures above and below Ms, by tensile and compressive tests, optical microscopy, X-ray...
ELECTRON MICROSCOPE STUDY OF THE MATRIX-MARTENSITE INTERFACE IN Cu-Al-Ni ALLOYS (1982)
Tadaki, T., Kakeshita, T., Shimizu, K.
The matrix-martensite interfaces in Cu-Al-Ni shape memory alloys have been examined by means of transmission electron microscopy. Fine parallel striations were observed on both the interfaces between...
PSEUDOELASTICITY IN A Au-47.5at%Cd ALLOY SINGLE CRYSTAL (1982)
Deformation behavior and its mechanism in a Au-41.5at%Cd alloy single crystal have been investigated at temperatures above and below Ms, by tensile and compressive tests, optical microscopy, X-ray...
S. Tajima, K. Shimizu, N. Baba, H. Sakai
Heating of anodic oxide films on aluminium produced irreversible changes in their photoluminescent properties. In the case of oxalic acid films, for instance, PL intensity increased exponentially...
北海道に於ける有反應無病巣牛に關する細菌學的研究 : II. 昭和 27 年度の檢索成績 (1953)
平戸, 勝七, 清水, 龜平次, HIRATO, K., SHIMIZU, K.
In Hokkaido, tuberculin testing of cattle was first started in 1903. At that time, 8,000-20,000 cattle were being tested annually, of which hundreds of head gave postive reactions. The reactors were...
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
Schönbeck, U., Sukhova, G. K., Shimizu, K., Mach, F., Libby, P.
Interruption of inflammatory pathways may provide a novel approach to the therapy of atherosclerosis. Recently, we and others have implicated the immune mediator dyad CD40/CD40L (CD40 ligand), which...
Fields, R. C., Shimizu, K., Mulé, J. J.
The highly efficient nature of dendritic cells (DC) as antigen-presenting cells raises the possibility of uncovering in tumor-bearing hosts very low levels of T cell reactivity to poorly immunogenic...
Shimizu, K., Fields, R. C., Giedlin, M., Mulé, J. J.
We have reported previously that murine bone marrow-derived dendritic cells (DC) pulsed with whole tumor lysates can mediate potent antitumor immune responses both in vitro and in vivo. Because...
Itoh, T, Kaibuchi, K, Masuda, T, Yamamoto, T, Matsuura, Y, Maeda, A, ...
To identify the direct target molecule of ras p21 in higher eukaryotes, we have recently developed the cell-free system in which ras p21 activates mitogen-activated protein (MAP) kinase/extracellular...
Shimizu, K, Ichikawa, H, Tojo, A, Kaneko, Y, Maseki, N, Hayashi, Y, ...
The t(16;21)(p11;q22) translocation is a nonrandom chromosomal abnormality found in several types of myeloid leukemia, which show variable cytomorphological features. We constructed rodent-human...
Ichikawa, H, Shimizu, K, Saito, A, Wang, D N, Oliva, R, Kobayashi, H, ...
Human chromosome 21 is the smallest of the 22 autosomes and 2 sex chromosomes. Hybridization of the human repetitive sequence Alu to pulsed-field gel-fractionated Not I-digested genomic DNA from a...
Miyoshi, H, Shimizu, K, Kozu, T, Maseki, N, Kaneko, Y, Ohki, M
The t(8;21)(q22;q22) translocation is a non-random chromosomal abnormality frequently found in patients with acute myeloid leukemia (AML) with maturation (M2 subtype). We report here the cloning of a...
Okamoto, Y, Minamoto, S, Shimizu, K, Mogami, H, Taniguchi, T
Interleukin 2 (IL-2) is a potent growth factor for T lymphocytes, playing a crucial role in the immune response. In view of the considerable evidence that the immunoregulatory cytokines (or...
The use of sequence comparison to detect 'identities' in tRNA genes.
Sagara, J I, Shimizu, S, Kawabata, T, Nakamura, S, Ikeguchi, M, Shimizu, K
We have developed a computational method that detects 'identities' in tRNA genes by using principal component analysis to classify the sequences of bases in tRNA genes into groups of similar...
Yotsuji, A, Shimizu, K, Araki, H, Fujimaki, K, Nishida, N, Hori, R, ...
T-8581 is a new water-soluble triazole antifungal agent. The geometric mean IC80s (GM-IC80S; where the IC80 is the lowest drug concentration which reduced the optical density at 630 nm by 80%...
Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals.
Hayashi, T, Watanabe, Y, Kumano, K, Kitayama, R, Yasuda, T, Saikawa, I, ...
The protective effect of piperacillin against the nephrotoxicity of cephaloridine and gentamicin was examined in experimental animals. In rabbits, piperacillin was infused at a dose of 1 mg/kg (body...
Protective effect of piperacillin against the nephrotoxicity of cisplatin in rats.
Hayashi, T, Watanabe, Y, Kumano, K, Kitayama, R, Muratani, T, Yasuda, T, ...
The protective effect of piperacillin against the nephrotoxicity of cisplatin was compared with that of fosfomycin in Fischer 344 rats. Blood urea nitrogen, serum creatinine, and morphological...
Shimizu, K, Kumada, T, Hsieh, W C, Chung, H Y, Chong, Y, Hare, R S, ...
The resistance mechanisms of more than 2,000 aminoglycoside-resistant gram-negative aerobic bacteria were estimated by a method that assigned a biochemical mechanism based on susceptibility to...
Carnitine status and safety after administration of S-1108, a new oral cephem, to patients.
Shimizu, K, Saito, A, Shimada, J, Ohmichi, M, Hiraga, Y, Inamatsu, T, ...
The metabolism and clinical safety of the pivalic acid-containing antibiotic S-1108, an orally active pro-drug cephalosporin, were investigated to assess the clinical effects, with special emphasis...
Totsuka, K, Shimizu, K, Konishi, M, Yamamoto, S
The metabolism and pharmacokinetics of pivalic acid, a major metabolite of S-1108, were studied with three healthy volunteers. Concentrations of S-1006 (the active compound), pivalic acid, and...
Existence of the bound form of prolipoprotein in Escherichia coli B cells treated with globomycin.
Inukai, M, Takeuchi, M, Shimizu, K, Arai, M
A murein-bound form of prolipoprotein was found in the cell envelope fraction of globomycin-treated Escherichia coli B. We suggest therefore that proteolytic cleavage of prolipoprotein to mature...
Kikuchi, K, Enari, T, Totsuka, K, Shimizu, K
The rapid ID 32 Strep system (bioMérieux, Marcy l'Etoile, France) was evaluated for its ability to identify 21 species of viridans group streptococci; results were compared with DNA-DNA...
Yasuda, H, Ajiki, Y, Shimozato, T, Kasahara, M, Kawada, H, Iwata, M, ...
The therapeutic efficacy of granulocyte colony-stimulating factor (G-CSF) against an experimental intramuscular infection induced by Pseudomonas aeruginosa in mice was confirmed. Bacterial growth in...
Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.
Miyoshi, H, Ohira, M, Shimizu, K, Mitani, K, Hirai, H, Imai, T, ...
We previously isolated the AML1 gene, which is rearranged by the t(8;21) translocation in acute myeloid leukemia. The AML1 gene is highly homologous to the Drosophila segmentation gene runt and the...
Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.
Sakamoto, H, Mori, M, Taira, M, Yoshida, T, Matsukawa, S, Shimizu, K, ...
DNAs from 21 human stomach cancers, 16 metastatic stomach cancers to lymph nodes, and 21 apparently noncancerous specimens of stomach mucosae from a total of 26 patients with stomach cancer were...
Fucharoen, S, Shimizu, K, Fukumaki, Y
Hereditary persistence of fetal hemoglobin (HPFH) is a condition characterized by the continued expression of the fetal globin gene in adulthood. Both deletional and nondeletional forms have been...
Kaneda, S, Takeishi, K, Ayusawa, D, Shimizu, K, Seno, T, Altman, S
A triple tandem repeat (TTR) consisting of 90 nucleotides exists immediately upstream of the ATG initiator codon in human thymidylate synthase (TS) cDNA (pcHTS-1). To investigate the role of the TTR...
Nucleotide sequence of a functional cDNA for human thymidylate synthase.
Takeishi, K, Kaneda, S, Ayusawa, D, Shimizu, K, Gotoh, O, Seno, T
We have determined the nucleotide sequence of a cDNA clone, pcHTS-1, encoding human thymidylate synthase (5,10-methylenetetrahydrofolate: dUMP C-methyltransferase, EC 2.1.1.45) which was previously...
Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells.
Eisenbarth, G S, Shimizu, K, Bowring, M A, Wells, S
Studies of the reaction of antibody A2B5 and tetanus toxin with pancreatic islet cells, islet cell tumors, and other human amine precursor uptake and decarboxylation (APUD) tumors are described. By...
Okamoto, K, Inoue, T, Shimizu, K, Hara, S, Miyama, A
Heat-stable enterotoxin (ST) of Yersinia enterocolitica was produced under defined conditions. It was first detected in the culture supernatant of the late-logarithmic phase of growth and increased...
Yamada, T, Hitomi, Y, Shimizu, K, Ohki, M, Oikawa, T
To investigate the presence of a negative regulatory factor(s) suppressing T-cell receptor alpha-chain (TCR alpha) gene expression in non-T cells, 10 independent cell hybrid clones were generated...
Ayusawa, D, Koyama, H, Shimizu, K, Kaneda, S, Takeishi, K, Seno, T
Studies were made on the genetic consequences of methotrexate-directed thymidylate stress, focusing attention on a human thymidylate synthase gene that was introduced as a heterologous genetic marker...
Isolation and preliminary characterization of the Chinese hamster thymidine kinase gene.
Lewis, J A, Shimizu, K, Zipser, D
The Chinese hamster thymidine kinase (TK) gene has been isolated from a recombinant phage library constructed with genomic DNA from mouse Ltk- cells transformed to Tk+ by transfection with Chinese...
Chromosomal assignment of a family of human oncogenes.
Ryan, J, Barker, P E, Shimizu, K, Wigler, M, Ruddle, F H
A family of human transforming genes, previously shown to share homology with the ras family of viral oncogenes, maps to three different human chromosomes. A well-characterized mouse-human hybrid...
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer.
Shimizu, K, Nakatsu, Y, Sekiguchi, M, Hokamura, K, Tanaka, K, Terada, M, ...
Transfection with high molecular weight DNA from a primary stomach cancer induced foci of transformed NIH 3T3 cells, and the transformed cells were tumorigenic in nude mice. By screening with a human...
Hirano, T, Taga, T, Nakano, N, Yasukawa, K, Kashiwamura, S, Shimizu, K, ...
Human B-cell differentiation factor (BCDF) was purified to homogeneity by sequential filtration and chromatography of culture supernatants from TCL-Na1 cells on an AcA34 gel column and then on a Mono...
Shimizu, K, Goldfarb, M, Perucho, M, Wigler, M
DNA from the human neuroblastoma cell line SK-N-SH is capable of inducing foci of transformed NIH 3T3 cells after DNA-mediated gene transfer. Using genetic selection with the Escherichia coli sup F...
Three human transforming genes are related to the viral ras oncogenes.
Shimizu, K, Goldfarb, M, Suard, Y, Perucho, M, Li, Y, Kamata, T, ...
Three distinct transforming genes present in human tumor cell lines are all related to the viral oncogenes of Harvey and Kirsten murine sarcoma viruses, designated v-H-ras and v-K-ras, respectively....
Miyoshi, H, Kozu, T, Shimizu, K, Enomoto, K, Maseki, N, Kaneko, Y, ...
The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. It has been shown that the t(8;21) breakpoints on chromosome 21 cluster within a single...
Haynes, B F, Shimizu, K, Eisenbarth, G S
Using a monoclonal antibody (A2B5), which binds to GQ ganglioside, and tetanus toxin, which binds to GD and GT gangliosides, distinct regions of human and rodent thymic epithelial cells have been...
Nishida, Y, Hata, M, Ayaki, T, Ryo, H, Yamagata, M, Shimizu, K, ...
The genomic and cDNA fragments of Drosophila melanogaster, homologous to human c-raf-1, were cloned. The nucleotide sequence predicted the primary structure of a polypeptide of 666 amino acid...
Muraoka, K, Fujimoto, K, Sun, X, Yoshioka, K, Shimizu, K, Yagi, M, ...
FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-kappaB) critical for T cell activation. We...
Studies on the contribution of c-fos/AP-1 to arthritic joint destruction.
Shiozawa, S, Shimizu, K, Tanaka, K, Hino, K
Features characteristic to rheumatoid joint destruction, including synovial overgrowth and bone resorption, are experimentally produced by augmenting c-fos gene expression. We tested here if...
Regulation of influenza virus RNA polymerase activity by cellular and viral factors.
Shimizu, K, Handa, H, Nakada, S, Nagata, K
An in vitro RNA synthesis system mimicking replication of genomic influenza virus RNA was developed with nuclear extracts prepared from influenza virus-infected HeLa cells using exogenously added RNA...
Characterization of proteoglycan degradation by calpain.
Suzuki, K, Shimizu, K, Hamamoto, T, Nakagawa, Y, Murachi, T, Yamamuro, T
Degradation of cartilage proteoglycans was investigated under neutral conditions (pH 7.5) by using pig kidney calpain II (EC 3.4.22.17; Ca(2+)-dependent cysteine proteinase). Aggregate and monomer...
The mechanism of inhibitory action of secretin on gastric acid secretion in conscious rats.
Shimizu, K, Li, P, Lee, K Y, Chang, T M, Chey, W Y
1. Secretin has been recognized as an important enterogastrone. In order to investigate the mechanism of secretin-induced inhibition of gastric acid secretion, the effects of both anti-somatostatin...
Kitabayashi, I, Yokoyama, A, Shimizu, K, Ohki, M
The AML1 transcription factor and the transcriptional coactivators p300 and CBP are the targets of chromosome translocations associated with acute myeloid leukemia and myelodysplastic syndrome. In...
Effect of loss of mechanical distension on collagen degradation in the mouse uterus.
In unilaterally pregnant mice, loss of mechanical distension induced by artificial removal of fetuses from the pregnant uterus was followed by oedema in the endometrium. No endometrial oedema was...
Antibody responses of horses to equine influenza viruses during a postepizootic period in Japan.
Goto, H, Shimizu, K, Taya, Y, Noda, H, Tokunaga, T
The antibody responses to equine influenza viruses were investigated during a postepizootic period of the disease. Serum samples were collected from a total of 128 horses on three occasions during...
In the filamentous fungus Aspergillus nidulans, a heterotrimeric G protein alpha-subunit and an RGS domain protein, encoded by fadA and flbA, respectively, regulate production of the carcinogenic...
Shimizu, K, Harano, T, Harano, K, Miwa, S, Amenomori, Y, Ohba, Y, ...
Data were obtained on blood samples from a relatively large group (264) of healthy Japanese newborns, collected at hospitals in Tokyo, Kurashiki, and Ube. The studies included an evaluation of...
Genetic relationships of Asians and Northern Europeans, revealed by Y-chromosomal DNA analysis.
Zerjal, T, Dashnyam, B, Pandya, A, Kayser, M, Roewer, L, Santos, F R, ...
We have identified a new T-->C transition on the human Y chromosome. C-allele chromosomes have been found only in a subset of the populations from Asia and northern Europe and reach their highest...
Kawaguchi-Miyashita, M, Shimizu, K, Nanno, M, Shimada, S, Watanabe, T, Koga, Y, ...
Intraepithelial T lymphocytes in the small intestine (IEL) consist of alpha beta T-cell receptor (TCR)-bearing T cells (alpha beta-IEL) and gamma delta TCR-bearing T cells (gamma delta-IEL)....
Szomor, Z, Shimizu, K, Fujimori, Y, Yamamoto, S, Yamamuro, T
OBJECTIVES--To determine the relevance of calpain in murine collagen induced arthritis (CIA) and to correlate the presence of m-calpain with the appearance of arthritis and cartilage destruction....
Shimizu, K, Kawasaki, H, Morisawa, T, Nakamura, M, Yamamoto, E, Yoshikawa, N, ...
OBJECTIVE—To study the effect of cytokines on the transactivation of the c-fos gene in relation to the contribution of overexpression of c-fos/AP-1 in rheumatoid joint destruction. METHODS—The...
Sugiyama, S, Itokazu, M, Suzuki, Y, Shimizu, K
Objective: To investigate the prognostic value of procollagen type II carboxy-terminal propeptide (PIICP) level in synovial fluid in relation to early tibiofemoral joint osteoarthritis (OA).
Mukai, M., Torikata, C., Iri, H., Morikawa, Y., Shimizu, K., Shimoda, T., ...
Intermediate filaments which are specific to neural cells, ie, neurofilaments, consist of three subcomponents--68, 150, and 200 kd. Thirty human neural tumors were examined for the presence of these...
Shimizu, M, Sugihara, N, Kita, Y, Shimizu, K, Horita, Y, Nakajima, K, ...
OBJECTIVE--To investigate the relation between regional myocardial sympathetic nerve activity and the electrocardiographic and cardiac functional changes in hypertrophic cardiomyopathy. DESIGN--A...
Increased left atrial chamber stiffness in hypertrophic cardiomyopathy.
Sanada, H, Shimizu, M, Sugihara, N, Shimizu, K, Ino, H, Takeda, R
OBJECTIVE--To investigate left atrial chamber stiffness and its influence on left atrial and left ventricular functions in hypertrophic cardiomyopathy. DESIGN--Prospective study. SETTING--Department...
Mukai, M., Iri, H., Torikata, C., Kageyama, K., Morikawa, Y., Shimizu, K.
Z-protein, a new muscle protein with a molecular weight of 55,000 daltons recently discovered in Japan, is an excellent marker for muscle differentiation in paraffin sections. Positive staining by a...
Differentiation of benign monoclonal gammopathy and smouldering multiple myeloma from frank myeloma.
Shimizu, K, Ohnishi, K, Kunii, A
Circulating immunoglobulin (Ig) secreting cells of each type of the different Ig classes were enumerated using a reverse haemolytic plaque assay in nine subjects with the pre-clinical phase of IgG...
Simulation Study of Radiative Cooling in the Divertor on JT-60 Super Advanced (JT-60SA)
Suzuki, Y., Kawashima, H., Coster, D. P., Sakurai, S., Shimizu, K., Takizuka, T.
Huge epithelium-lined cyst: report of two cases.
Yoshida, T, Nakatani, S, Shimizu, K, Yamada, K, Ushio, Y, Mogami, H
Hereditary pancreatic hypoplasia, diabetes mellitus, and congenital heart disease: a new syndrome?
Yorifuji, T, Matsumura, M, Okuno, T, Shimizu, K, Sonomura, T, Muroi, J, ...
We report on a Japanese family with hereditary pancreatic hypoplasia, diabetes mellitus, and congenital heart disease. The disease was apparently inherited as an autosomal dominant trait. The...
Nephropathy and growth hormone deficiency in a patient with mitochondrial tRNA(Leu(UUR)) mutation.
Yorifuji, T, Kawai, M, Momoi, T, Sasaki, H, Furusho, K, Muroi, J, ...
A mitochondrial A 3243 G mutation in the tRNA(Leu(UUR)) gene was first described as a common cause of MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like...
Kamei, S, Tetsuka, T, Takasu, T, Shimizu, K
A technique for detecting herpes simplex virus (HSV) antigen in CSF by measuring the antigen-antibody complex-activated complement-stimulated chemiluminescence in normal granulocytes was applied to...
Shimizu, K, Chin, K, Nakamura, T, Masuzaki, H, Ogawa, Y, Hosokawa, R, ...
Background: The control of body weight and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) are important because both factors have significant...
Sugamura, K, Shimizu, K, Back, FH
Mice inoculated with ultraviolet light-inactivated Sendai virus mount a cell- mediated immune response to the virus. Cytotoxic T cells specific for Sendai virus can be obtained by in vitro secondary...
Edge Plasma Modelling for Transport Analysis on JT-60U Tokamak
Chen, J., Kawashima, H., Gao, X., Hu, L., Asakura, N., Shimizu, K., ...
Shimizu, K, Bae, S J, Hara, T, Iwata, Y, Yamaoka, T, Komura, K, ...
The deposition of immune complexes (IC) induces an acute inflammatory response with tissue injury, for which the involvement of nitric oxide (NO) and carbon monoxide (CO) has been suggested. NO is...
MAGE-A protein and MAGE-A10 gene expressions in liver metastasis in patients with stomach cancer
Suzuki, S, Sasajima, K, Sato, Y, Watanabe, H, Matsutani, T, Iida, S, ...
Tumour samples from 71 patients with stomach cancer, 41 patients with liver metastasis (group A) and 15 patients each in stages II–IV (group B) and stage I (group C) without liver metastasis were...
Moriuchi, S., Shimizu, K., Miyao, Y., Hayakawa, T.
We developed an IgG1 mouse monoclonal antibody (ONS-M21) directed against a cell surface antigen of medulloblastomas and gliomas in immunisation of mice with the ONS-76 medulloblastoma cell line. The...
Intrathecal chemotherapy with ACNU for meningeal gliomatosis.
Yoshida, T. K., Beuls, E., Shimizu, K., Koulousakis, A., Sturm, V.
ACNU [1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride], one of the chloroethylnitrosoureas (CENUs), is believed to be effective against malignant glioma when...
Enhanced effect of reserpine upon growth-inhibitory action of ACNU on ACNU-resistant C6 glioma.
Yoshida, T., Shimizu, K., Ushio, Y., Hayakawa, T., Mogami, H., Sakamoto, Y.
Reserpine was found to enhance the cytotoxicity of ACNU on ACNU-resistant C6 glioma (C6/ACNU) cells in vitro. When reserpine was added along with ACNU to the C6/ACNU cells in vitro. When reserpine...
Systemic interleukin 12 displays anti-tumour activity in the mouse central nervous system.
Kishima, H., Shimizu, K., Miyao, Y., Mabuchi, E., Tamura, K., Tamura, M., ...
In various systemic cancers, interleukin 12 (IL-12) induces anti-tumour immunity mediated by T lymphocytes and natural killer cells. To determine whether IL-12 has anti-tumour activity against...
Park, K. C., Shimizu, K., Hayakawa, T., Tanaka, N.
Transcriptional activator interferon regulatory factor (IRF)-1 and repressor IRF-2 are known to play a critical role in the regulation of interferon (IFN) responses and oncogenesis in fibroblasts....
Kaira, K, Oriuchi, N, Imai, H, Shimizu, K, Yanagitani, N, Sunaga, N, ...
The clinical significance of L-type amino acid transporter 1 (LAT1) expression remains unclear, whereas many experimental studies have demonstrated that LAT1 is associated with the proliferation of...
Hamaguchi, T, Matsumura, Y, Suzuki, M, Shimizu, K, Goda, R, Nakamura, I, ...
Paclitaxel (PTX) is one of the most effective anticancer agents. In clinical practice, however, high incidences of adverse reactions of the drug, for example, neurotoxicity, myelosuppression, and...
Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas
Kishima, H, Shimizu, K, Tamura, K, Miyao, Y, Mabuchi, E, Tominaga, E, ...
The monoclonal antibody ONS-M21 recognizes an antigen found on the surface of glioma and medulloblastoma cells but does not react with the antigens of normal brain tissue. We purified and identified...
Dohjima, T, Ohno, T, Banno, Y, Nozawa, Y, Wen-yi, Y, Shimizu, K
EWS-Fli-1, a fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumour (PNET), encodes a transcriptional activator and promotes cellular transformation. We have made stable Ewing's...