Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers (2006)
Behrends, C., Langer, C. A., Boteva, R., Bottcher, U. M., Stemp, M. J., Schaffar, G., ...
Sondermann,H., Ho,A. K., Listenberger,L. L., Siegers,K., Moarefi,I., Wente,S. R., ...
Polypeptide binding by the chaperone Hsp70 is regulated by its ATPase activity, which is itself regulated by co-chaperones including the Bag domain nucleotide exchange factors. Here, we tested the...
Sondermann, H., Ho, A. K., Listenberger, L. L., Siegers, K., Moarefi, I., Wente, S. R., ...
Polypeptide binding by the chaperone Hsp70 is regulated by its ATPase activity, which is itself regulated by co-chaperones including the Bag domain nucleotide exchange factors. Here, we tested the...
Genes involved in immunity to the lantibiotic nisin produced by Lactococcus lactis 6F3.
The lantibiotic nisin is produced by several strains of Lactococcus lactis. The complete gene cluster for nisin biosynthesis in L. lactis 6F3 comprises 15 kb of DNA. As described previously, the...
Gutowski-Eckel, Z, Klein, C, Siegers, K, Bohm, K, Hammelmann, M, Entian, K D
The information responsible for biosynthesis of the lantibiotic subtilin is organized in an operon-like structure that starts with the spaB gene. The spaB gene encodes an open reading frame...
Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3.
Engelke, G, Gutowski-Eckel, Z, Kiesau, P, Siegers, K, Hammelmann, M, Entian, K D
The biosynthetic genes of the nisin-producing strain Lactococcus lactis 6F3 are organized in an operon-like structure starting with the structural gene nisA followed by the genes nisB, nisT, and...
A novel protein complex promoting formation of functional alpha- and gamma-tubulin.
Geissler, S, Siegers, K, Schiebel, E
We describe the identification of GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 in a screen for mutants that are synthetically lethal with tub4-1, encoding a mutated yeast gamma-tubulin. The cytoplasmic...
Siegers, K, Waldmann, T, Leroux, M R, Grein, K, Shevchenko, A, Schiebel, E, ...
The functional coupling of protein synthesis and chaperone-assisted folding in vivo has remained largely unexplored. Here we have analysed the chaperonin-dependent folding pathway of actin in yeast....
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
Leroux, M R, Fändrich, M, Klunker, D, Siegers, K, Lupas, A N, Brown, J R, ...
Group II chaperonins in the eukaryotic and archaeal cytosol assist in protein folding independently of the GroES-like cofactors of eubacterial group I chaperonins. Recently, the eukaryotic chaperonin...
Genes involved in immunity to the lantibiotic nisin produced by Lactococcus lactis 6F3.
The lantibiotic nisin is produced by several strains of Lactococcus lactis. The complete gene cluster for nisin biosynthesis in L. lactis 6F3 comprises 15 kb of DNA. As described previously, the...
Gutowski-Eckel, Z, Klein, C, Siegers, K, Bohm, K, Hammelmann, M, Entian, K D
The information responsible for biosynthesis of the lantibiotic subtilin is organized in an operon-like structure that starts with the spaB gene. The spaB gene encodes an open reading frame...
Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3.
Engelke, G, Gutowski-Eckel, Z, Kiesau, P, Siegers, K, Hammelmann, M, Entian, K D
The biosynthetic genes of the nisin-producing strain Lactococcus lactis 6F3 are organized in an operon-like structure starting with the structural gene nisA followed by the genes nisB, nisT, and...
A novel protein complex promoting formation of functional alpha- and gamma-tubulin.
Geissler, S, Siegers, K, Schiebel, E
We describe the identification of GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 in a screen for mutants that are synthetically lethal with tub4-1, encoding a mutated yeast gamma-tubulin. The cytoplasmic...
Siegers, K, Waldmann, T, Leroux, M R, Grein, K, Shevchenko, A, Schiebel, E, ...
The functional coupling of protein synthesis and chaperone-assisted folding in vivo has remained largely unexplored. Here we have analysed the chaperonin-dependent folding pathway of actin in yeast....
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
Leroux, M R, Fändrich, M, Klunker, D, Siegers, K, Lupas, A N, Brown, J R, ...
Group II chaperonins in the eukaryotic and archaeal cytosol assist in protein folding independently of the GroES-like cofactors of eubacterial group I chaperonins. Recently, the eukaryotic chaperonin...