Mathematical modelling of tumour acidity (2008)
Smallbone, K., Gatenby, R.A., Maini, P.K.
Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as...
Herrgård, M.J., Swainston, N., Dobson, P., Dunn, W.B., Arga, K.Y., Arvas, M., ...
Genomic data allow the large-scale manual or semi-automated assembly of metabolic network reconstructions, which provide highly curated organism-specific knowledge bases. Although several...
Tumour glycolysis: the many faces of HIF (2008)
Kelly, C.J., Smallbone, K., Brady, J.M.
We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the...
Mathematical modelling of tumour acidity (2008)
Smallbone, K, Gatenby, R A, Maini, P K
Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as...
Herrgård, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, Mikko, ...
Nature Biotechnology Vol.26 Nr.10, 1155 - 1160
Mathematical modelling of tumour acidity (2008)
Smallbone, K., Gatenby, R. A., Maini, P. K.
Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as...
Something from nothing: bridging the gap between constraint-based and kinetic modelling (2007)
Smallbone, K., Simeonidis, E., Broomhead, D.S., Kell, D.B.
Two divergent modelling methodologies have been adopted to increase our understanding of metabolism and its regulation. Constraint-based modelling highlights the optimal path through a stoichiometric...
Metabolic changes during carcinogenesis: Potential impact on invasiveness (2007)
Smallbone, K, Gatenby, R A, Gillies, R J, Maini, P K, Gavaghan, D J
Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the...
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer (2007)
Gatenby, R A, Smallbone, K, Maini, P K, Rose, F, Averill, J, Nagle, R B, ...
Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are...
Quiescience as a mechanism for cyclical hypoxia and acidosis (2007)
Smallbone, K, Gavaghan, D J, Maini, P K, Brady, J M
Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads...
The role of acidity in tumour development (2007)
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this thesis, we utilise mathematical modelling to examine the...
A model to investigate the feasibility of FDG as a surrogate marker of hypoxia (2007)
Kelly, C.J., Smallbone, K., Roose, T., Brady, J.M.
Fmiso-PET is a non-invasive modality used for the assessment of tumour hypoxia, and increasingly for planning radiotherapy. However, the availability and contrast properties of Fmiso are not ideal....
Metabolic changes during carcinogenesis: Potential impact on invasiveness (2007)
Smallbone, K., Gatenby, R. A., Gillies, R. J., Maini, P. K., Gavaghan, D. J.
Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the...
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer (2007)
Gatenby, R. A., Smallbone, K., Maini, P. K., Rose, F., Averill, J., Nagle, R. B., ...
Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are...
Quiescience as a mechanism for cyclical hypoxia and acidosis (2007)
Smallbone, K., Gavaghan, D. J., Maini, P. K., Brady, J. M.
Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads...
The role of acidity in tumour development (2007)
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this thesis, we utilise mathematical modelling to examine the...
The role of acidity in solid tumour growth and invasion (2005)
Smallbone, K, Gavaghan, D J, Gatenby, R A, Maini, P K
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional...
The role of acidity in solid tumour growth and invasion (2005)
Smallbone, K., Gavaghan, D. J., Gatenby, R. A., Maini, P. K.
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional...
Performance of NO2 passive samplers in ambient air in dense networks. (1995)
Lebret, E., Fischer, P.H., Smallbone, K., Celko, M., Harssema, H.
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
Gatenby, R A, Smallbone, K, Maini, P K, Rose, F, Averill, J, Nagle, R B, ...
Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are...