K. Spanel-Borowski

Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures (2009)

Kosacka, J., Gericke, M., Nowicki, M., Kacza, J., Borlak, J., Spanel-Borowski, K.

Co-cultures of 3T3-L1 adipocytes with neurons from the rat dorsal root ganglia (DRG) showed enhanced neuritogenesis and synaptogenesis. Microarray analysis for upregulated genes in adipocyte/DRG...

Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures (2009)

Nowicki, M., Kosacka, J., Spanel-Borowski, K., Borlak, J.

Deferoxamine (DFO) was granted orphan drug status for the treatment of traumatic spinal cord injury but its neuroprotective mechanism is not well understood. We therefore investigated the mode of...

The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle (2007)

Erdmann, S, Ricken, A, Merkwitz, C, Struman, Ingrid, Castino, R, Hummitzsch, K, ...

In the corpus luteum (CL), blood vessels develop, stabilize, and regress. This process depends on the ratio of pro-and antiangiogenic factors, which change during the ovarian cycle. The present study...

No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy (2007)

Nowicki, M., Zabirnyk, O., Duerrschmidt, N., Borlak, J., Spanel-Borowski, K.

The oxidized low-density lipoprotein (oxLDL)-dependent activation of the lectin-like oxLDL receptor-1 (LOX-1) triggers apoptosis in vascular cells and appears to be involved in atherosclerosis....

The myelin-associated glycoprotein inhibitor BENZ induces outgrowth and survival of rat dorsal root ganglion cell cultures (2007)

Nowicki, M., Kosacka, J., Brossmer, R., Spanel-Borowski, K., Borlak, J.

The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG. Treatment of rat dorsal root ganglion...

Lectin-like oxidized low-density lipoprotein receptor-1-mediated autophagy in human granulosa cells as an alternative of programmed cell death (2006)

Duerrschmidt, N., Zabirnyk, O., Nowicki, M., Ricken, A., Hmeidan, F.A., Blumenauer, V., ...

The LOX-1 receptor, identified on endothelial cells, mediates the uptake of oxidized low-density lipoprotein (oxLDL). The oxLDL-dependent LOX-1 activation causes endothelial cell apoptosis. We here...

Bridging the gap between anatomy and molecular genetics for an improved understanding of congenital heart disease (2006)

Reamon-Buettner, S.M., Spanel-Borowski, K., Borlak, J.

Birth defects are the leading cause of infant mortality and malformations in congenital heart disease (CHD) are among the most prevalent and fatal of all birth defects. Yet the molecular mechanisms...

Adipocyte-derived angiopoietin-1 supports neurite outgrowth and synaptogenesis of sensory neurons (2006)

Kosacka, J., Nowicki, M., Kacza, J., Borlak, J., Engele, J., Spanel-Borowski, K.

Sensory and sympathetic innervation of the white fat tissue (WAT) contributes to lipolysis. In addition, both fiber types adapt in density to weight gain and loss. Because these findings are...

Aberrant lipid metabolism in human diseases - the role of the lectin-like oxidised LDL-receptor (LOX-1) in endothelial dysfunction (2006)

Borlak, J., Spanel-Borowski, K.

Epidermal growth factor-induced hepatocellular carcinoma: Gene expression profiles in precursor lesions, early stage and solitary tumours (2005)

Borlak, J., Meier, T., Halter, R., Spanel, R., Spanel-Borowski, K.

Epidermal growth factor is an important mitogen for hepatocytes. Its overexpression promotes hepatocellular carcinogenesis. To identify the network of genes regulated through EGF, we investigated the...

Evidence for a role of prolactin fragments in corpus luteum function (2005)

Ricken, A, Merkwitz, C, Struman, Ingrid, Martial, Joseph, Spanel-Borowski, K

Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations (2004)

Reamon-Büttner, S.M., Hecker, H., Spanel-Borowski, K., Craatz, S., Kuenzel, E., Borlak, J.

NKX2-5 is a homeodomain-containing transcription factor important in cardiac development. Familial mutations in the NKX2-5 gene are associated with cardiac abnormalities, but mutations are rare in...

Cultured microvascular endothelial cells derived from the bovine corpus luteum possess NCAM-140 (1992)

Mayerhofer, A., Spanel-Borowski, K., Watkins, S., Gratzl, Manfred

Previously, five phenotypically different, stable types of microvascular endothelial cells (MVE) were isolated from the bovine corpus and cultured successfully. We found that three out of these five...

Pulmonary inflammation induced by a recombinant Brugia malayi gamma-glutamyl transpeptidase homolog: involvement of humoral autoimmune responses.

Gounni, A. S., Spanel-Borowski, K., Palacios, M., Heusser, C., Moncada, S., Lobos, E.

BACKGROUND: A major allergen from the lymphatic filarial parasite Brugia malayi implicated in the pathogenesis of tropical pulmonary eosinophilia (TPE) has recently been cloned and identified as the...