Trends in antimicrobial resistance of Streptococcus pneumoniae in Japan.
Yoshida, R, Kaku, M, Kohno, S, Ishida, K, Mizukane, R, Takemura, H, ...
A total of 184 isolates of Streptococcus pneumoniae were recovered from the sputa of patients over a 5-year period in the Nagasaki area and were examined. A total of 30 strains were resistant to...
Takemura, H, Kaku, M, Kohno, S, Hirakata, Y, Tanaka, H, Yoshida, R, ...
Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new...
Sawai, T, Tomono, K, Yanagihara, K, Yamamoto, Y, Kaku, M, Hirakata, Y, ...
We describe a novel mouse model of acute staphylococcal pneumonia induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. For comparison, we also used various strains of...
Kakeya, H, Udono, H, Ikuno, N, Yamamoto, Y, Mitsutake, K, Miyazaki, T, ...
Heat shock proteins (HSPs) from several pathogenic microbes have been shown to be target molecules of humoral responses as well as cellular immune responses. However, little is known about target...
Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.
Hirakata, Y, Kaku, M, Tomono, K, Tateda, K, Furuya, N, Matsumoto, T, ...
We induced endogenous Pseudomonas aeruginosa bacteremia by administering cyclophosphamide and ampicillin to specific pathogen-free mice fed P. aeruginosa. Using this model, we evaluated the efficacy...
Efficacy of intravenous itraconazole against experimental pulmonary aspergillosis.
Miyazaki, H M, Kohno, S, Miyazaki, Y, Mitsutake, K, Tomono, K, Kaku, M, ...
The efficacy of intravenous itraconazole solubilized in hydroxypropyl-beta-cyclodextrin was assessed in a rat model of Aspergillus fumigatus pneumonia. Immunosuppressed rats were infected by...
Yamamoto, Y, Kohno, S, Koga, H, Kakeya, H, Tomono, K, Kaku, M, ...
We examined clinical (pulmonary cryptococcosis and cryptococcal meningitis) and environmental (pigeon excreta) isolates of Cryptococcus neoformans var. neoformans (serotype A) in the southern...
Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia.
Hirakata, Y, Tomono, K, Tateda, K, Matsumoto, T, Furuya, N, Shimoguchi, K, ...
Bacteremia in immunocompromised hosts often arises from their endogenous intestinal flora. We produced experimental endogenous bacteremia by administering cyclophosphamide and ampicillin to...
Detection of Bacteroides fragilis in clinical specimens by PCR.
Yamashita, Y, Kohno, S, Koga, H, Tomono, K, Kaku, M
The direct detection of Bacteroides fragilis from clinical specimens was examined by using the PCR method for amplifying a specific fragment of the glutamine synthetase gene from B. fragilis. By this...
In vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae.
Kaku, M, Ishida, K, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
The in vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae were compared with those of erythromycin, levofloxacin, ofloxacin, and minocycline. The MICs of sparfloxacin,...
In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae.
Ishida, K, Kaku, M, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
We investigated the in vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. In vitro MICs of azithromycin, erythromycin, clarithromycin, and roxithromycin were determined....
Virulence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo
Aoki, S., Hirakata, Y., Kondoh, A., Gotoh, N., Yanagihara, K., Miyazaki, Y., ...
We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia...
Trends in antimicrobial resistance of Streptococcus pneumoniae in Japan.
Yoshida, R, Kaku, M, Kohno, S, Ishida, K, Mizukane, R, Takemura, H, ...
A total of 184 isolates of Streptococcus pneumoniae were recovered from the sputa of patients over a 5-year period in the Nagasaki area and were examined. A total of 30 strains were resistant to...
Takemura, H, Kaku, M, Kohno, S, Hirakata, Y, Tanaka, H, Yoshida, R, ...
Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new...
Sawai, T, Tomono, K, Yanagihara, K, Yamamoto, Y, Kaku, M, Hirakata, Y, ...
We describe a novel mouse model of acute staphylococcal pneumonia induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. For comparison, we also used various strains of...
Kakeya, H, Udono, H, Ikuno, N, Yamamoto, Y, Mitsutake, K, Miyazaki, T, ...
Heat shock proteins (HSPs) from several pathogenic microbes have been shown to be target molecules of humoral responses as well as cellular immune responses. However, little is known about target...
Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.
Hirakata, Y, Kaku, M, Tomono, K, Tateda, K, Furuya, N, Matsumoto, T, ...
We induced endogenous Pseudomonas aeruginosa bacteremia by administering cyclophosphamide and ampicillin to specific pathogen-free mice fed P. aeruginosa. Using this model, we evaluated the efficacy...
Efficacy of intravenous itraconazole against experimental pulmonary aspergillosis.
Miyazaki, H M, Kohno, S, Miyazaki, Y, Mitsutake, K, Tomono, K, Kaku, M, ...
The efficacy of intravenous itraconazole solubilized in hydroxypropyl-beta-cyclodextrin was assessed in a rat model of Aspergillus fumigatus pneumonia. Immunosuppressed rats were infected by...
Yamamoto, Y, Kohno, S, Koga, H, Kakeya, H, Tomono, K, Kaku, M, ...
We examined clinical (pulmonary cryptococcosis and cryptococcal meningitis) and environmental (pigeon excreta) isolates of Cryptococcus neoformans var. neoformans (serotype A) in the southern...
Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia.
Hirakata, Y, Tomono, K, Tateda, K, Matsumoto, T, Furuya, N, Shimoguchi, K, ...
Bacteremia in immunocompromised hosts often arises from their endogenous intestinal flora. We produced experimental endogenous bacteremia by administering cyclophosphamide and ampicillin to...
Detection of Bacteroides fragilis in clinical specimens by PCR.
Yamashita, Y, Kohno, S, Koga, H, Tomono, K, Kaku, M
The direct detection of Bacteroides fragilis from clinical specimens was examined by using the PCR method for amplifying a specific fragment of the glutamine synthetase gene from B. fragilis. By this...
In vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae.
Kaku, M, Ishida, K, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
The in vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae were compared with those of erythromycin, levofloxacin, ofloxacin, and minocycline. The MICs of sparfloxacin,...
In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae.
Ishida, K, Kaku, M, Irifune, K, Mizukane, R, Takemura, H, Yoshida, R, ...
We investigated the in vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. In vitro MICs of azithromycin, erythromycin, clarithromycin, and roxithromycin were determined....
Virulence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo
Aoki, S., Hirakata, Y., Kondoh, A., Gotoh, N., Yanagihara, K., Miyazaki, Y., ...
We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia...
SEKI, M, HIGASHIYAMA, Y, TOMONO, K, YANAGIHARA, K, OHNO, H, KANEKO, Y, ...
We established a mouse model in which fatal pneumonia was induced by pneumococcal superinfection following influenza virus infection in chronic Pseudomonas aeruginosa infected mice. In this mouse...
SHIRAI, R, KADOTA, J, TOMONO, K, OGAWA, K, IIDA, K, KAWAKAMI, K, ...
We investigated the effects of G-CSF in a granulocytopenic mouse model of Pseudomonas aeruginosa lung infection. The model was prepared by intratracheal instillation of the bacteria, while...
Kakeya, H, Udono, H, Maesaki, S, Sasaki, E, Kawamura, S, Hossain, M A, ...
Cryptococcus neoformans causes infection in individuals with defective T cell function, such as AIDS, as well as without underlying disease. It has been suggested that humoral as well as cellular...
Seki, M, Kadota, J-I, Higashiyama, Y, Iida, K, Iwashita, T, Sasaki, E, ...
Pulmonary complications are known to develop in HTLV-1 carriers, including T lymphocytic alveolitis, and increased IL-2 receptor α (CD25)-bearing T cells have been found in BALF. Several chemokines...
Sasaki, E, Tashiro, T, Kuroki, M, Seki, M, Miyazaki, Y, Maesaki, S, ...
Trichosporon asahii is an emerging opportunistic pathogen in immunocompromised patients. Little is known about the mechanisms of host defence against T. asahii. We investigated the fungicidal...