K. Uchida

Publication List Details

Period

1915 - 2009

Number

130

Co-Authors

Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption (2009)

Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., ...

Human subjects drank coffee containing 412 µmol of chlorogenic acids, and plasma and urine were collected 0 to 24 h after ingestion and were analyzed by high-performance liquid...

Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics (2008)

Abat, E., Abbott, B., Abdallah, J., Abdelalim, A. A., Abdesselam, A., ...

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance...

Investigating the temporal transferability of transport modal choice models: an approach based on GIS database (2007)

Andrade, K., Kagaya, S., Uchida, K., Dantas, A., Nicholson, A.

Developing precise travel behavior models and testing its forecasting capability are essential when planning transportation systems. However, emphasis is observed in estimating while forecasting...

A GA-based transport modal choice model (2006)

Andrade, K., Uchida, K., Kagaya, S., Dantas, A., Nicholson, A.

This paper presents a hybrid transport modal choice model in which the genetic algorithm is applied for estimating parameters of a Multinomial Logit Model. The model has a simple decision structure...

A study on network design problems for multi-modal networks by probit-based stochastic user equilibrium (2006)

Uchida, K., Sumalee, A., Watling, D.P., Connors, R.D.

This paper develops a multi-modal transport network model considering various travel modes including railway, bus, auto, and walking. Travellers are assumed to choose their multi-modal routes so as...

A study on network design problems for multi-modal networks by probit-based stochastic user equilibrium (2006)

Uchida, K., Sumalee, A., Watling, D.P., Connors, R.D.

This paper develops a multi-modal transport network model considering various travel modes including railway, bus, auto, and walking. Travellers are assumed to choose their multi-modal routes so as...

A study on network design problems for multi-modal networks by probit-based stochastic user equilibrium (2006)

Uchida, K., Sumalee, A., Watling, D.P., Connors, R.D.

This paper develops a multi-modal transport network model considering various travel modes including railway, bus, auto, and walking. Travellers are assumed to choose their multi-modal routes so as...

ISO Mid-Infrared Spectra of Reflection Nebulae (2004)

Werner, M., Uchida, K., Sellgren, K., Houdashelt, M.

Our goal is to test predictions of models attributing the IEFs to polycyclic aromatic hydrocarbons (PAHs). Interstellar models predict PAHs change from singly ionized to neutral as the UV intensity,...

Mid-Infrared Spectra of Dust Debris Around Main-Sequence Stars (2004)

Jura, M., Chen, C. H., Furlan, E., Green, J., Sargent, B., Forrest, W. J., ...

We report spectra obtained with the Spitzer Space Telescope in the wavelength range between 14 microns and 35 microns of 19 nearby main-sequence stars with infrared excesses. The six stars with...

The 1.4 angstrom crystal structure of kumamolysin: A thermostable serine-carboxyl-type proteinase (2002)

Comellas-Bigler,M., Fuentes-Prior,P., Maskos,K., Huber,R., Oyama,H., Uchida,K., ...

Kumamolysin is a thermostable endopeptidase from Bacillus novosp. MN-32, exhibiting maximal proteolytic activity around pH 3. It belongs to the newly identified family of serine- carboxyl...

The 1.4 angstrom crystal structure of kumamolysin: A thermostable serine-carboxyl-type proteinase (2002)

Comellas-Bigler, M., Fuentes-Prior, P., Maskos, K., Huber, R., Oyama, H., Uchida, K., ...

Kumamolysin is a thermostable endopeptidase from Bacillus novosp. MN-32, exhibiting maximal proteolytic activity around pH 3. It belongs to the newly identified family of serine- carboxyl...

IRS: the Infrared Spectrograph on SIRTF (2000)

Houck, J., Van Cleve, J., Brandl, B., Charmandaris, V., Devost, D., Uchida, K.

The Infrared Spectrograph (IRS)is one of the three instruments on board the Space Infrared Telescope Facility (SIRTF) to be launched in December 2001. The IRS will provide high resolution spectra...

Extragalactic Spectroscopy with SIRTF/IRS (1999)

Brandl, B., Charmandaris, V., Uchida, K., Houck, J. R.

The Infrared Spectrograph (IRS) is one of the three instruments on board the Space Infrared Telescope Facility (SIRTF) to be launched in December 2001. The IRS will provide high resolution spectra (R...

Tribological Characteristics of Polycrystalline Diamond Films Produced by Chemical Vapor Deposition. (1998)

Kohzaki, M., Higuchi, K., Noda, S., Uchida, K.

Effects of surface roughness and crystallinity of polycrystalline diamond films on their tribological characteristics, as well as the effects of test environment, have been investigated. Friction and...

Area and volume effects on breakdown strength in liquid nitrogen (1995)

Goshima, H., Hayakawa, N., Hikita, M., Okubo, H., Uchida, K.

We measured dc and ac breakdown voltages in liquid nitrogen (LN_2) with a sphere-to-plane electrode configuration. Experimental results revealed that the breakdown voltage in LN_2 did not increase...

Weibull statistical analysis of area and volume effects on the breakdown strength in liquid nitrogen (1995)

Goshima, H., Hayakawa, N., Hikita, M., Uchida, K.

In order to examine the area and the volume effects on breakdown strength in liquid nitrogen (LN_2), we measured dc and ac breakdown voltages in LN_2 with sphere to plane and coaxial cylindrical...

Genetic Control of Isozyme Variation in Needle Tissues of Cryptomeria japonica (1989)

Tsumura, Y., Uchida, K., Ohba, K.

Using polyacrylamide vertical slab gel electrophoresis, we developed methods for detecting allozyme variants of Cryptomeria japonica from needle tissues. We ex amined 18 enzyme systems to detect...

Development of Substrate Carrier System (1981)

N. Miura, Y. Fuura, K. Uchida

The Substrate Carrier System (S. C. System) is a new manufacturing technique for small size hybrid IC with IMST (Insulated Metal Substrate Technology)substrate which is used for power hybrid IC (STK...

Über einen Fall hochgradiger leukämischer Infiltration des vorderen Mediastinums / (1915)

Uchida, K.

Thesis (doctoral)--Ludwig-Maximilians Universität München, 1915.

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A, Hattori, N, Uchida, K, Tanaka, M, Stadtman, E R, Mizuno, Y

There is growing evidence that oxidative stress and mitochondrial respiratory failure with attendant decrease in energy output are implicated in nigral neuronal death in Parkinson disease (PD). It is...

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

Toyokuni, S, Uchida, K, Okamoto, K, Hattori-Nakakuki, Y, Hiai, H, Stadtman, E R

An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces proximal tubular necrosis, a consequence of lipid peroxidation, that finally leads to a high incidence of renal adenocarcinoma in rodents....

Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.

Uchida, K, Hanai, S, Ishikawa, K, Ozawa, Y, Uchida, M, Sugimura, T, ...

We have isolated cDNA clones for a Drosophila poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) by screening a lambda gt11 cDNA library with a Drosophila partial cDNA fragment. The Drosophila PARP...

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

Uchida, K, Szweda, L I, Chae, H Z, Stadtman, E R

We report here the development of an immunochemical procedure that uses an antibody specific to the 4-hydroxynonenal (HNE) moiety for the detection of HNE-protein adducts. The HNE-specific antibody...

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

Uchida, K, Stadtman, E R

We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups)...

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

Uchida, K, Stadtman, E R

The peroxidation of polyunsaturated fatty acids leads to numerous products, including 4-hydroxynonenal (HNE). That 4-hydroxy-2-alkenal compounds react with sulfhydryl groups of proteins to form...

Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent.

Niwano, Y, Tabuchi, T, Kanai, K, Hamaguchi, H, Uchida, K, Yamaguchi, H

The therapeutic efficacy of short-term treatment with a 1% cream of lanoconazole, a new imidazole antimycotic agent, in comparison with that of a 1% cream of terbinafine was evaluated in the guinea...

In vitro activity of ME1401, a new antifungal agent.

Yamaguchi, H, Uchida, K, Hiratani, T, Hara, T, Fukuyasu, H, Kazuno, Y, ...

The in vitro antifungal activity of ME1401, a potential topical antifungal agent, was compared with that of haloprogin, clotrimazole, miconazole, tolnaftate, and ciclopirox olamine by using an agar...

Effect of moxalactam on human fecal microflora.

Benno, Y, Shiragami, N, Uchida, K, Yoshida, T, Mitsuoka, T

Five healthy male adults received 2 g of moxalactam every 12 h for 7 days. The alterations of fecal microflora were investigated before, during, and after treatment with moxalactam. On day 7 of...

Intrauterine transmission of human T-cell leukemia virus type I in rats.

Hori, M, Ami, Y, Kushida, S, Kobayashi, M, Uchida, K, Abe, T, ...

To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was...

Correlation between depression of catabolite control of xylose metabolism and a defect in the phosphoenolpyruvate:mannose phosphotransferase system in Pediococcus halophilus.

Abe, K, Uchida, K

Pediococcus halophilus X-160 which lacks catabolite control by glucose was isolated from nature (soy moromi mash). Wild-type strains, in xylose-glucose medium, utilized glucose preferentially over...

Cytoplasmic transfer of oligomycin resistance during protoplast fusion of Saccharomycopsis lipolytica.

Matsuoka, M, Uchida, K, Aiba, S

Mitotic segregation of oligomycin resistance and oligomycin sensitivity was observed among the prototrophic progeny of protoplast fusion between drug-resistant and drug-sensitive complementary...

Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs.

Niwano, Y, Seo, A, Kanai, K, Hamaguchi, H, Uchida, K, Yamaguchi, H

The therapeutic efficacy of 1% cream and 1% solution of lanoconazole, a new imidazole antimycotic agent, in the model of cutaneous candidiasis in prednisolone-treated guinea pigs was evaluated in...

Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.

Uchida, S, Sasaki, S, Nitta, K, Uchida, K, Horita, S, Nihei, H, ...

To investigate the physiological role of a kidney-specific chloride channel (ClC-K1), we sought to determine its exact localization by immunohistochemistry and its functional regulation using Xenopus...

High resolution footprinting of EcoRI and distamycin with Rh(phi)2(bpy)3+, a new photofootprinting reagent.

Uchida, K, Pyle, A M, Morii, T, Barton, J K

The complex bis(phenanthrenequinone diimine)(bipyridyl)rhodium(III), Rh(phi)2(bpy)3+, cleaves DNA efficiently in a sequence-neutral fashion upon photoactivation so as to provide a novel, high...

Selective oxidation of histidine residues in proteins or peptides through the copper(II)-catalysed autoxidation of glucosone.

Cheng, R Z, Uchida, K, Kawakishi, S

Glucosone has been identified as the main intermediate sugar moiety product of the copper(II)-catalysed autoxidation of the Amadori compound [Kawakishi, Tsunehiro & Uchida (1991) Carbohydr. Res. 211,...

Purification and properties of active atrial-natriuretic-peptide receptor (type C) from bovine lung.

Uchida, K, Mizuno, T, Shimonaka, M, Sugiura, N, Nara, K, Ling, N, ...

Atrial-natriuretic-peptide (ANP) receptor, previously identified as a 140 kDa protein with a disulphide-linked homodimeric structure, was purified from bovine lung by (NH4)2SO4 fractionation and...

Effect of modification of thyroid function on cholesterol 7 alpha-hydroxylation in rat liver.

Takeuchi, N, Ito, M, Uchida, K, Yamamura, Y

Hepatic activities of cholesterol synthesis and cholesterol 7 alpha-hydroxylation were determined in hyper- and hypo-thyroid rats after oral administration of glucose or cholesterol. Increases in...

Antiproliferation and colony-forming inhibition activities of recombinant feline interferon (rFeIFN) on various cells in vitro.

Priosoeryanto, B P, Tateyama, S, Yamaguchi, R, Uchida, K

The antiproliferative and colony inhibiting activities of recombinant feline interferon (rFeIFN Type I) against various cells in vitro were examined. Feline and canine cells were both sensitive to...

Subtotal versus total parathyroidectomy with forearm autograft for secondary hyperparathyroidism in chronic renal failure.

Takagi, H, Tominaga, Y, Uchida, K, Yamada, N, Kawai, M, Kano, T, ...

Forty-three patients with chronic renal failure and secondary hyperparathyroidism underwent parathyroidectomy; 20 of the 43 underwent subtotal parathyroidectomy (Group A) and 23 patients underwent...

Image diagnosis of parathyroid glands in chronic renal failure.

Takagi, H, Tominaga, Y, Uchida, K, Yamada, N, Morimoto, T, Yasue, M

Twenty-two out of 31 patients with chronic renal failure and secondary hyperparathyroidism who underwent parathyroidectomy before operation underwent non-invasive image diagnosis of parathyroid...

Surgical treatment of cancer of the pancreas and the periampullary region: cumulative results in 57 institutions in Japan.

Nakase, A, Matsumoto, Y, Uchida, K, Honjo, I

In this study the experiences with carcinomas of the pancreas, ampulla of Vater, terminal comma bile duct, and duodenum found in a series of 3,610 patients collected from 57 major Japanese...

Colon perforation after kidney transplantation.

Carson, S D, Krom, R A, Uchida, K, Yokota, K, West, J C, Weil, R

Between 1962 and 1977 approximately 2% of Denver kidney transplant patients developed colon perforation. The single commonest cause was diverticulitis of the left colon (6/13 cases). In spite of...

Studies of carcinogenicity of sodium chlorite in B6C3F1 mice.

Yokose, Y, Uchida, K, Nakae, D, Shiraiwa, K, Yamamoto, K, Konishi, Y

The carcinogenic activities of sodium chlorite in B6C3F1 mice were examined. Sodium chlorite was given at concentrations of 0 (control), 0.025% (low dose), or 0.05% (high dose) in the drinking water...

Total parathyroidectomy with forearm autograft for secondary hyperparathyroidism in chronic renal failure.

Takagi, H, Tominaga, Y, Tanaka, Y, Uchida, K, Orihara, A, Yamada, N, ...

One hundred twenty-eight patients with chronic renal failure and secondary hyperparathyroidism underwent total parathyroidectomy with forearm autograft. Postoperative clinical improvement was...

Ultrastructural evidence of the existence of the surface connected canalicular system in the thrombocyte of the shark (Triakis scyllia).

Daimon, T, Uchida, K

The existence of the surface-connected canalicular system has been demonstrated ultrastructurally in shark [Triakis scyllia) thrombocytes using the ruthenium red method to fix and stain the...

Electron microscopic and cytochemical observations on the membrane systems of the chicken thrombocyte.

Daimon, T, Uchida, K

A combined electron microscopic and cytochemical study of the thrombocytes of the mature chicken has demonstrated the existence of two membrane systems, the surface connected system (SCS) and the...

Autoradiographic analysis of the uptake of [3H]dopamine, [3H]angiotensin II and [3H]gamma aminobutyric acid by the chicken thrombocyte.

Daimon, T, Kawai, K, Uchida, K

The ability of chicken thrombocytes to take up and store transmitters of different categories, such as dopamine, angiotensin II and gamma aminobutyric acid (GABA), was examined by electron microscope...

Electron microscopic and cytochemical studies of the thrombocytes of the tortoise (Geoclemys reevesii).

Daimon, T, Gotoh, Y, Uchida, K

The thrombocytes of the tortoise (Geoclemys reevesii) were studied at the electron microscopic level. The presence of a surface connected canalicular system, composed of numerous anastomosing...

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A, Hattori, N, Uchida, K, Tanaka, M, Stadtman, E R, Mizuno, Y

There is growing evidence that oxidative stress and mitochondrial respiratory failure with attendant decrease in energy output are implicated in nigral neuronal death in Parkinson disease (PD). It is...

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

Toyokuni, S, Uchida, K, Okamoto, K, Hattori-Nakakuki, Y, Hiai, H, Stadtman, E R

An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces proximal tubular necrosis, a consequence of lipid peroxidation, that finally leads to a high incidence of renal adenocarcinoma in rodents....

Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.

Uchida, K, Hanai, S, Ishikawa, K, Ozawa, Y, Uchida, M, Sugimura, T, ...

We have isolated cDNA clones for a Drosophila poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) by screening a lambda gt11 cDNA library with a Drosophila partial cDNA fragment. The Drosophila PARP...

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

Uchida, K, Szweda, L I, Chae, H Z, Stadtman, E R

We report here the development of an immunochemical procedure that uses an antibody specific to the 4-hydroxynonenal (HNE) moiety for the detection of HNE-protein adducts. The HNE-specific antibody...

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

Uchida, K, Stadtman, E R

We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups)...

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

Uchida, K, Stadtman, E R

The peroxidation of polyunsaturated fatty acids leads to numerous products, including 4-hydroxynonenal (HNE). That 4-hydroxy-2-alkenal compounds react with sulfhydryl groups of proteins to form...

Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent.

Niwano, Y, Tabuchi, T, Kanai, K, Hamaguchi, H, Uchida, K, Yamaguchi, H

The therapeutic efficacy of short-term treatment with a 1% cream of lanoconazole, a new imidazole antimycotic agent, in comparison with that of a 1% cream of terbinafine was evaluated in the guinea...

In vitro activity of ME1401, a new antifungal agent.

Yamaguchi, H, Uchida, K, Hiratani, T, Hara, T, Fukuyasu, H, Kazuno, Y, ...

The in vitro antifungal activity of ME1401, a potential topical antifungal agent, was compared with that of haloprogin, clotrimazole, miconazole, tolnaftate, and ciclopirox olamine by using an agar...

Effect of moxalactam on human fecal microflora.

Benno, Y, Shiragami, N, Uchida, K, Yoshida, T, Mitsuoka, T

Five healthy male adults received 2 g of moxalactam every 12 h for 7 days. The alterations of fecal microflora were investigated before, during, and after treatment with moxalactam. On day 7 of...

Intrauterine transmission of human T-cell leukemia virus type I in rats.

Hori, M, Ami, Y, Kushida, S, Kobayashi, M, Uchida, K, Abe, T, ...

To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was...

Correlation between depression of catabolite control of xylose metabolism and a defect in the phosphoenolpyruvate:mannose phosphotransferase system in Pediococcus halophilus.

Abe, K, Uchida, K

Pediococcus halophilus X-160 which lacks catabolite control by glucose was isolated from nature (soy moromi mash). Wild-type strains, in xylose-glucose medium, utilized glucose preferentially over...

Cytoplasmic transfer of oligomycin resistance during protoplast fusion of Saccharomycopsis lipolytica.

Matsuoka, M, Uchida, K, Aiba, S

Mitotic segregation of oligomycin resistance and oligomycin sensitivity was observed among the prototrophic progeny of protoplast fusion between drug-resistant and drug-sensitive complementary...

Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs.

Niwano, Y, Seo, A, Kanai, K, Hamaguchi, H, Uchida, K, Yamaguchi, H

The therapeutic efficacy of 1% cream and 1% solution of lanoconazole, a new imidazole antimycotic agent, in the model of cutaneous candidiasis in prednisolone-treated guinea pigs was evaluated in...

Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.

Uchida, S, Sasaki, S, Nitta, K, Uchida, K, Horita, S, Nihei, H, ...

To investigate the physiological role of a kidney-specific chloride channel (ClC-K1), we sought to determine its exact localization by immunohistochemistry and its functional regulation using Xenopus...

High resolution footprinting of EcoRI and distamycin with Rh(phi)2(bpy)3+, a new photofootprinting reagent.

Uchida, K, Pyle, A M, Morii, T, Barton, J K

The complex bis(phenanthrenequinone diimine)(bipyridyl)rhodium(III), Rh(phi)2(bpy)3+, cleaves DNA efficiently in a sequence-neutral fashion upon photoactivation so as to provide a novel, high...

Selective oxidation of histidine residues in proteins or peptides through the copper(II)-catalysed autoxidation of glucosone.

Cheng, R Z, Uchida, K, Kawakishi, S

Glucosone has been identified as the main intermediate sugar moiety product of the copper(II)-catalysed autoxidation of the Amadori compound [Kawakishi, Tsunehiro & Uchida (1991) Carbohydr. Res. 211,...

Purification and properties of active atrial-natriuretic-peptide receptor (type C) from bovine lung.

Uchida, K, Mizuno, T, Shimonaka, M, Sugiura, N, Nara, K, Ling, N, ...

Atrial-natriuretic-peptide (ANP) receptor, previously identified as a 140 kDa protein with a disulphide-linked homodimeric structure, was purified from bovine lung by (NH4)2SO4 fractionation and...

Effect of modification of thyroid function on cholesterol 7 alpha-hydroxylation in rat liver.

Takeuchi, N, Ito, M, Uchida, K, Yamamura, Y

Hepatic activities of cholesterol synthesis and cholesterol 7 alpha-hydroxylation were determined in hyper- and hypo-thyroid rats after oral administration of glucose or cholesterol. Increases in...

Ultrastructural evidence of the existence of the surface connected canalicular system in the thrombocyte of the shark (Triakis scyllia).

Daimon, T, Uchida, K

The existence of the surface-connected canalicular system has been demonstrated ultrastructurally in shark [Triakis scyllia) thrombocytes using the ruthenium red method to fix and stain the...

Electron microscopic and cytochemical observations on the membrane systems of the chicken thrombocyte.

Daimon, T, Uchida, K

A combined electron microscopic and cytochemical study of the thrombocytes of the mature chicken has demonstrated the existence of two membrane systems, the surface connected system (SCS) and the...

Subtotal versus total parathyroidectomy with forearm autograft for secondary hyperparathyroidism in chronic renal failure.

Takagi, H, Tominaga, Y, Uchida, K, Yamada, N, Kawai, M, Kano, T, ...

Forty-three patients with chronic renal failure and secondary hyperparathyroidism underwent parathyroidectomy; 20 of the 43 underwent subtotal parathyroidectomy (Group A) and 23 patients underwent...

Autoradiographic analysis of the uptake of [3H]dopamine, [3H]angiotensin II and [3H]gamma aminobutyric acid by the chicken thrombocyte.

Daimon, T, Kawai, K, Uchida, K

The ability of chicken thrombocytes to take up and store transmitters of different categories, such as dopamine, angiotensin II and gamma aminobutyric acid (GABA), was examined by electron microscope...

Electron microscopic and cytochemical studies of the thrombocytes of the tortoise (Geoclemys reevesii).

Daimon, T, Gotoh, Y, Uchida, K

The thrombocytes of the tortoise (Geoclemys reevesii) were studied at the electron microscopic level. The presence of a surface connected canalicular system, composed of numerous anastomosing...

Antiproliferation and colony-forming inhibition activities of recombinant feline interferon (rFeIFN) on various cells in vitro.

Priosoeryanto, B P, Tateyama, S, Yamaguchi, R, Uchida, K

The antiproliferative and colony inhibiting activities of recombinant feline interferon (rFeIFN Type I) against various cells in vitro were examined. Feline and canine cells were both sensitive to...

Image diagnosis of parathyroid glands in chronic renal failure.

Takagi, H, Tominaga, Y, Uchida, K, Yamada, N, Morimoto, T, Yasue, M

Twenty-two out of 31 patients with chronic renal failure and secondary hyperparathyroidism who underwent parathyroidectomy before operation underwent non-invasive image diagnosis of parathyroid...

Surgical treatment of cancer of the pancreas and the periampullary region: cumulative results in 57 institutions in Japan.

Nakase, A, Matsumoto, Y, Uchida, K, Honjo, I

In this study the experiences with carcinomas of the pancreas, ampulla of Vater, terminal comma bile duct, and duodenum found in a series of 3,610 patients collected from 57 major Japanese...

Colon perforation after kidney transplantation.

Carson, S D, Krom, R A, Uchida, K, Yokota, K, West, J C, Weil, R

Between 1962 and 1977 approximately 2% of Denver kidney transplant patients developed colon perforation. The single commonest cause was diverticulitis of the left colon (6/13 cases). In spite of...

Studies of carcinogenicity of sodium chlorite in B6C3F1 mice.

Yokose, Y, Uchida, K, Nakae, D, Shiraiwa, K, Yamamoto, K, Konishi, Y

The carcinogenic activities of sodium chlorite in B6C3F1 mice were examined. Sodium chlorite was given at concentrations of 0 (control), 0.025% (low dose), or 0.05% (high dose) in the drinking water...

Total parathyroidectomy with forearm autograft for secondary hyperparathyroidism in chronic renal failure.

Takagi, H, Tominaga, Y, Tanaka, Y, Uchida, K, Orihara, A, Yamada, N, ...

One hundred twenty-eight patients with chronic renal failure and secondary hyperparathyroidism underwent total parathyroidectomy with forearm autograft. Postoperative clinical improvement was...

Use of the conjugate of disulphated ursodeoxycholic acid with p-aminobenzoic acid for the detection of intestinal bacteria.

Takahashi, M, Konishi, T, Maeda, Y, Matsugu, Y, Akazawa, F, Eto, T, ...

The disulphate ester of ursodeoxycholyl-p-aminobenzoic acid (PABA-UCDA) was synthesised and compared with PABA-UDCA for its use in detection of intestinal bacteria. This compound, PABA-UDCA...

Inhibitory effects of Helicobacter pylori infection on murine autoimmune gastritis

Ohana, M, Okazaki, K, Oshima, C, Kawasaki, K, Fukui, T, Tamaki, H, ...

Background and aim: Long term Helicobacter pylori infection leads to atrophic gastritis but the relation between H pylori infection and autoimmune related atrophic gastritis (AIG) remains unclear. We...

Immune responsiveness in Mycobacterium avium-infected mice: changes in the proportion of T cell subsets and antibody production during the course of infection.

Xu, D L, Goto, Y, Amoako, K K, Nagatomo, T, Uchida, K, Shinjo, T

The C57Bl/6 susceptible (Bcgs) and its resistant (Bcgr) congenic mouse, previously developed by retrogressive backcrossing, were infected with 1 x 10(6) colony-forming units (CFU) of Mycobacterium...

Prevention of B220+ T cell expansion and prolongation of lifespan induced by Lactobacillus casei in MRL/lpr mice

Mike, A, Nagaoka, N, Tagami, Y, Miyashita, M, Shimada, S, Uchida, K, ...

We examined the therapeutic effect of heat-killed Lactobacillus casei (LC) on MRL/lpr mice. Ingestion of a diet containing 0.05% (w/w) LC from the weaning period prolonged the lifespan and tended to...

Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis

Seymour, J, Doyle, I, Nakata, K, Presneill, J, Schoch, O, Hamano, E, ...

Methods: Blood levels of anti-GM-CSF antibodies, SP-A, SP-B, LDH, and [A – a]DO2, VC, and TLCO were measured before rhGM-CSF treatment and every 2 weeks thereafter in 14 patients with AP.

The Wistar Bonn Kobori rat, a unique animal model for autoimmune pancreatitis with extrapancreatic exocrinopathy

Sakaguchi, Y, Inaba, M, Tsuda, M, Quan, G K, Omae, M, Ando, Y, ...

The male Wistar Bonn/Kobori (WBN/Kob) rat is known to be a unique animal model for chronic pancreatitis with widely distributed fibrosis and degeneration of parenchyma because of the infiltration of...

Inhibition by a new bisphosphonate (YM175) of bone resorption induced by the MBT-2 tumour of mice.

Nemoto, R., Nishijima, Y., Uchida, K., Koiso, K.

A new bisphosphonate, disodium dihydrogen (cycloheptylamino) methylene bisphosphonate monohydrate (YM175), was compared with 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (AHPrBP) and...

ras gene alterations in invasive and non-invasive rat bladder carcinomas induced by N-methyl-N-nitrosourea.

Yura, Y., Azuma, M., Uchida, K., Momose, H., Oyasu, R.

We have established a reliable method to induce invasive and non-invasive carcinomas in the heterotopically transplanted urinary bladder of rats by repeated injection of N-methyl-N-nitrosourea (MNU),...

Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma

Tokuhisa, Y, Iizuka, N, Sakaida, I, Moribe, T, Fujita, N, Miura, T, ...

In a previous study, we showed that levels of cell-free DNA (cfDNA) were significantly higher in sera of patients with hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) than in...

Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer

Horiguchi, J, Takei, H, Koibuchi, Y, Iijima, K, Ninomiya, J, Uchida, K, ...

We have investigated dihydropyrimidine dehydrogenase expression as a prognostic marker in breast cancer. A total of 119 women with breast cancer undergoing surgery between 1985 and 1996 were included...